Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vit...

Autores
Freis, Barbara; Ramirez, Maria De Los Angeles; Kiefer, Céline; Harlepp, Sébastien; Iacovita, Cristian; Henoumont, Céline; Affolter Zbaraszczuk, Christine; Meyer, Florent; Mertz, Damien; Boos, Anne; Tasso, Mariana Patricia; Furgiuele, Sonia; Journe, Fabrice; Saussez, Sven; Bégin Colin, Sylvie; Laurent, Sophie
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Functionalized iron oxide nanoparticles (IONPs) are increasingly being designed as a theranostic nanoplatform combining specific targeting, diagnosis by magnetic resonance imaging (MRI), and multimodal therapy by hyperthermia. The effect of the size and the shape of IONPs is of tremendous importance to develop theranostic nanoobjects displaying efficient MRI contrast agents and hyperthermia agent via the combination of magnetic hyperthermia (MH) and/or photothermia (PTT). Another key parameter is that the amount of accumulation of IONPs in cancerous cells is sufficiently high, which often requires the grafting of specific targeting ligands (TLs). Herein, IONPs with nanoplate and nanocube shapes, which are promising to combine magnetic hyperthermia (MH) and photothermia (PTT), were synthesized by the thermal decomposition method and coated with a designed dendron molecule to ensure their biocompatibility and colloidal stability in suspension. Then, the efficiency of these dendronized IONPs as contrast agents (CAs) for MRI and their ability to heat via MH or PTT were investigated. The 22 nm nanospheres and the 19 nm nanocubes presented the most promising theranostic properties (respectively, r2 = 416 s−1·mM−1, SARMH = 580 W·g−1, SARPTT = 800 W·g−1; and r2 = 407 s−1·mM−1, SARMH = 899 W·g−1, SARPTT = 300 W·g−1). MH experiments have proven that the heating power mainly originates from Brownian relaxation and that SAR values can remain high if IONPs are prealigned with a magnet. This raises hope that heating will maintain efficient even in a confined environment, such as in cells or in tumors. Preliminary in vitro MH and PTT experiments have shown the promising effect of the cubic shaped IONPs, even though the experiments should be repeated with an improved set-up. Finally, the grafting of a specific peptide (P22) as a TL for head and neck cancers (HNCs) has shown the positive impact of the TL to enhance IONP accumulation in cells.
Fil: Freis, Barbara. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia. Université de Mons; Bélgica
Fil: Ramirez, Maria De Los Angeles. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia
Fil: Kiefer, Céline. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia
Fil: Harlepp, Sébastien. Inserm; Francia
Fil: Iacovita, Cristian. Iuliu Hatieganu University of Medicine and Pharmacy; Rumania
Fil: Henoumont, Céline. Université de Mons; Bélgica
Fil: Affolter Zbaraszczuk, Christine. Centre de Recherche En Biomédecine de Strasbourg; Francia
Fil: Meyer, Florent. Centre de Recherche En Biomédecine de Strasbourg; Francia
Fil: Mertz, Damien. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia
Fil: Boos, Anne. Centre National de la Recherche Scientifique; Francia
Fil: Tasso, Mariana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Furgiuele, Sonia. Université de Mons; Bélgica
Fil: Journe, Fabrice. Université de Mons; Bélgica
Fil: Saussez, Sven. Université de Mons; Bélgica
Fil: Bégin Colin, Sylvie. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia
Fil: Laurent, Sophie. Université de Mons; Bélgica
Materia
IRON OXIDE NANOCUBES AND NANOPLATES
MAGNETIC HYPERTHERMIA
MRI CONTRAST AGENT
PHOTOTHERMIA
TARGETING LIGAND
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/220359

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network_name_str CONICET Digital (CONICET)
spelling Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro StudiesFreis, BarbaraRamirez, Maria De Los AngelesKiefer, CélineHarlepp, SébastienIacovita, CristianHenoumont, CélineAffolter Zbaraszczuk, ChristineMeyer, FlorentMertz, DamienBoos, AnneTasso, Mariana PatriciaFurgiuele, SoniaJourne, FabriceSaussez, SvenBégin Colin, SylvieLaurent, SophieIRON OXIDE NANOCUBES AND NANOPLATESMAGNETIC HYPERTHERMIAMRI CONTRAST AGENTPHOTOTHERMIATARGETING LIGANDhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Functionalized iron oxide nanoparticles (IONPs) are increasingly being designed as a theranostic nanoplatform combining specific targeting, diagnosis by magnetic resonance imaging (MRI), and multimodal therapy by hyperthermia. The effect of the size and the shape of IONPs is of tremendous importance to develop theranostic nanoobjects displaying efficient MRI contrast agents and hyperthermia agent via the combination of magnetic hyperthermia (MH) and/or photothermia (PTT). Another key parameter is that the amount of accumulation of IONPs in cancerous cells is sufficiently high, which often requires the grafting of specific targeting ligands (TLs). Herein, IONPs with nanoplate and nanocube shapes, which are promising to combine magnetic hyperthermia (MH) and photothermia (PTT), were synthesized by the thermal decomposition method and coated with a designed dendron molecule to ensure their biocompatibility and colloidal stability in suspension. Then, the efficiency of these dendronized IONPs as contrast agents (CAs) for MRI and their ability to heat via MH or PTT were investigated. The 22 nm nanospheres and the 19 nm nanocubes presented the most promising theranostic properties (respectively, r2 = 416 s−1·mM−1, SARMH = 580 W·g−1, SARPTT = 800 W·g−1; and r2 = 407 s−1·mM−1, SARMH = 899 W·g−1, SARPTT = 300 W·g−1). MH experiments have proven that the heating power mainly originates from Brownian relaxation and that SAR values can remain high if IONPs are prealigned with a magnet. This raises hope that heating will maintain efficient even in a confined environment, such as in cells or in tumors. Preliminary in vitro MH and PTT experiments have shown the promising effect of the cubic shaped IONPs, even though the experiments should be repeated with an improved set-up. Finally, the grafting of a specific peptide (P22) as a TL for head and neck cancers (HNCs) has shown the positive impact of the TL to enhance IONP accumulation in cells.Fil: Freis, Barbara. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia. Université de Mons; BélgicaFil: Ramirez, Maria De Los Angeles. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; FranciaFil: Kiefer, Céline. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; FranciaFil: Harlepp, Sébastien. Inserm; FranciaFil: Iacovita, Cristian. Iuliu Hatieganu University of Medicine and Pharmacy; RumaniaFil: Henoumont, Céline. Université de Mons; BélgicaFil: Affolter Zbaraszczuk, Christine. Centre de Recherche En Biomédecine de Strasbourg; FranciaFil: Meyer, Florent. Centre de Recherche En Biomédecine de Strasbourg; FranciaFil: Mertz, Damien. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; FranciaFil: Boos, Anne. Centre National de la Recherche Scientifique; FranciaFil: Tasso, Mariana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Furgiuele, Sonia. Université de Mons; BélgicaFil: Journe, Fabrice. Université de Mons; BélgicaFil: Saussez, Sven. Université de Mons; BélgicaFil: Bégin Colin, Sylvie. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; FranciaFil: Laurent, Sophie. Université de Mons; BélgicaMultidisciplinary Digital Publishing Institute2023-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/220359Freis, Barbara; Ramirez, Maria De Los Angeles; Kiefer, Céline; Harlepp, Sébastien; Iacovita, Cristian; et al.; Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies; Multidisciplinary Digital Publishing Institute; Pharmaceutics; 15; 4; 3-2023; 1-291999-4923CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4923/15/4/1104info:eu-repo/semantics/altIdentifier/doi/10.3390/pharmaceutics15041104info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:32:20Zoai:ri.conicet.gov.ar:11336/220359instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:32:20.464CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies
title Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies
spellingShingle Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies
Freis, Barbara
IRON OXIDE NANOCUBES AND NANOPLATES
MAGNETIC HYPERTHERMIA
MRI CONTRAST AGENT
PHOTOTHERMIA
TARGETING LIGAND
title_short Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies
title_full Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies
title_fullStr Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies
title_full_unstemmed Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies
title_sort Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies
dc.creator.none.fl_str_mv Freis, Barbara
Ramirez, Maria De Los Angeles
Kiefer, Céline
Harlepp, Sébastien
Iacovita, Cristian
Henoumont, Céline
Affolter Zbaraszczuk, Christine
Meyer, Florent
Mertz, Damien
Boos, Anne
Tasso, Mariana Patricia
Furgiuele, Sonia
Journe, Fabrice
Saussez, Sven
Bégin Colin, Sylvie
Laurent, Sophie
author Freis, Barbara
author_facet Freis, Barbara
Ramirez, Maria De Los Angeles
Kiefer, Céline
Harlepp, Sébastien
Iacovita, Cristian
Henoumont, Céline
Affolter Zbaraszczuk, Christine
Meyer, Florent
Mertz, Damien
Boos, Anne
Tasso, Mariana Patricia
Furgiuele, Sonia
Journe, Fabrice
Saussez, Sven
Bégin Colin, Sylvie
Laurent, Sophie
author_role author
author2 Ramirez, Maria De Los Angeles
Kiefer, Céline
Harlepp, Sébastien
Iacovita, Cristian
Henoumont, Céline
Affolter Zbaraszczuk, Christine
Meyer, Florent
Mertz, Damien
Boos, Anne
Tasso, Mariana Patricia
Furgiuele, Sonia
Journe, Fabrice
Saussez, Sven
Bégin Colin, Sylvie
Laurent, Sophie
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv IRON OXIDE NANOCUBES AND NANOPLATES
MAGNETIC HYPERTHERMIA
MRI CONTRAST AGENT
PHOTOTHERMIA
TARGETING LIGAND
topic IRON OXIDE NANOCUBES AND NANOPLATES
MAGNETIC HYPERTHERMIA
MRI CONTRAST AGENT
PHOTOTHERMIA
TARGETING LIGAND
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Functionalized iron oxide nanoparticles (IONPs) are increasingly being designed as a theranostic nanoplatform combining specific targeting, diagnosis by magnetic resonance imaging (MRI), and multimodal therapy by hyperthermia. The effect of the size and the shape of IONPs is of tremendous importance to develop theranostic nanoobjects displaying efficient MRI contrast agents and hyperthermia agent via the combination of magnetic hyperthermia (MH) and/or photothermia (PTT). Another key parameter is that the amount of accumulation of IONPs in cancerous cells is sufficiently high, which often requires the grafting of specific targeting ligands (TLs). Herein, IONPs with nanoplate and nanocube shapes, which are promising to combine magnetic hyperthermia (MH) and photothermia (PTT), were synthesized by the thermal decomposition method and coated with a designed dendron molecule to ensure their biocompatibility and colloidal stability in suspension. Then, the efficiency of these dendronized IONPs as contrast agents (CAs) for MRI and their ability to heat via MH or PTT were investigated. The 22 nm nanospheres and the 19 nm nanocubes presented the most promising theranostic properties (respectively, r2 = 416 s−1·mM−1, SARMH = 580 W·g−1, SARPTT = 800 W·g−1; and r2 = 407 s−1·mM−1, SARMH = 899 W·g−1, SARPTT = 300 W·g−1). MH experiments have proven that the heating power mainly originates from Brownian relaxation and that SAR values can remain high if IONPs are prealigned with a magnet. This raises hope that heating will maintain efficient even in a confined environment, such as in cells or in tumors. Preliminary in vitro MH and PTT experiments have shown the promising effect of the cubic shaped IONPs, even though the experiments should be repeated with an improved set-up. Finally, the grafting of a specific peptide (P22) as a TL for head and neck cancers (HNCs) has shown the positive impact of the TL to enhance IONP accumulation in cells.
Fil: Freis, Barbara. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia. Université de Mons; Bélgica
Fil: Ramirez, Maria De Los Angeles. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia
Fil: Kiefer, Céline. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia
Fil: Harlepp, Sébastien. Inserm; Francia
Fil: Iacovita, Cristian. Iuliu Hatieganu University of Medicine and Pharmacy; Rumania
Fil: Henoumont, Céline. Université de Mons; Bélgica
Fil: Affolter Zbaraszczuk, Christine. Centre de Recherche En Biomédecine de Strasbourg; Francia
Fil: Meyer, Florent. Centre de Recherche En Biomédecine de Strasbourg; Francia
Fil: Mertz, Damien. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia
Fil: Boos, Anne. Centre National de la Recherche Scientifique; Francia
Fil: Tasso, Mariana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Furgiuele, Sonia. Université de Mons; Bélgica
Fil: Journe, Fabrice. Université de Mons; Bélgica
Fil: Saussez, Sven. Université de Mons; Bélgica
Fil: Bégin Colin, Sylvie. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia
Fil: Laurent, Sophie. Université de Mons; Bélgica
description Functionalized iron oxide nanoparticles (IONPs) are increasingly being designed as a theranostic nanoplatform combining specific targeting, diagnosis by magnetic resonance imaging (MRI), and multimodal therapy by hyperthermia. The effect of the size and the shape of IONPs is of tremendous importance to develop theranostic nanoobjects displaying efficient MRI contrast agents and hyperthermia agent via the combination of magnetic hyperthermia (MH) and/or photothermia (PTT). Another key parameter is that the amount of accumulation of IONPs in cancerous cells is sufficiently high, which often requires the grafting of specific targeting ligands (TLs). Herein, IONPs with nanoplate and nanocube shapes, which are promising to combine magnetic hyperthermia (MH) and photothermia (PTT), were synthesized by the thermal decomposition method and coated with a designed dendron molecule to ensure their biocompatibility and colloidal stability in suspension. Then, the efficiency of these dendronized IONPs as contrast agents (CAs) for MRI and their ability to heat via MH or PTT were investigated. The 22 nm nanospheres and the 19 nm nanocubes presented the most promising theranostic properties (respectively, r2 = 416 s−1·mM−1, SARMH = 580 W·g−1, SARPTT = 800 W·g−1; and r2 = 407 s−1·mM−1, SARMH = 899 W·g−1, SARPTT = 300 W·g−1). MH experiments have proven that the heating power mainly originates from Brownian relaxation and that SAR values can remain high if IONPs are prealigned with a magnet. This raises hope that heating will maintain efficient even in a confined environment, such as in cells or in tumors. Preliminary in vitro MH and PTT experiments have shown the promising effect of the cubic shaped IONPs, even though the experiments should be repeated with an improved set-up. Finally, the grafting of a specific peptide (P22) as a TL for head and neck cancers (HNCs) has shown the positive impact of the TL to enhance IONP accumulation in cells.
publishDate 2023
dc.date.none.fl_str_mv 2023-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/220359
Freis, Barbara; Ramirez, Maria De Los Angeles; Kiefer, Céline; Harlepp, Sébastien; Iacovita, Cristian; et al.; Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies; Multidisciplinary Digital Publishing Institute; Pharmaceutics; 15; 4; 3-2023; 1-29
1999-4923
CONICET Digital
CONICET
url http://hdl.handle.net/11336/220359
identifier_str_mv Freis, Barbara; Ramirez, Maria De Los Angeles; Kiefer, Céline; Harlepp, Sébastien; Iacovita, Cristian; et al.; Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies; Multidisciplinary Digital Publishing Institute; Pharmaceutics; 15; 4; 3-2023; 1-29
1999-4923
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4923/15/4/1104
info:eu-repo/semantics/altIdentifier/doi/10.3390/pharmaceutics15041104
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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