Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vit...
- Autores
- Freis, Barbara; Ramirez, Maria De Los Angeles; Kiefer, Céline; Harlepp, Sébastien; Iacovita, Cristian; Henoumont, Céline; Affolter Zbaraszczuk, Christine; Meyer, Florent; Mertz, Damien; Boos, Anne; Tasso, Mariana Patricia; Furgiuele, Sonia; Journe, Fabrice; Saussez, Sven; Bégin Colin, Sylvie; Laurent, Sophie
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Functionalized iron oxide nanoparticles (IONPs) are increasingly being designed as a theranostic nanoplatform combining specific targeting, diagnosis by magnetic resonance imaging (MRI), and multimodal therapy by hyperthermia. The effect of the size and the shape of IONPs is of tremendous importance to develop theranostic nanoobjects displaying efficient MRI contrast agents and hyperthermia agent via the combination of magnetic hyperthermia (MH) and/or photothermia (PTT). Another key parameter is that the amount of accumulation of IONPs in cancerous cells is sufficiently high, which often requires the grafting of specific targeting ligands (TLs). Herein, IONPs with nanoplate and nanocube shapes, which are promising to combine magnetic hyperthermia (MH) and photothermia (PTT), were synthesized by the thermal decomposition method and coated with a designed dendron molecule to ensure their biocompatibility and colloidal stability in suspension. Then, the efficiency of these dendronized IONPs as contrast agents (CAs) for MRI and their ability to heat via MH or PTT were investigated. The 22 nm nanospheres and the 19 nm nanocubes presented the most promising theranostic properties (respectively, r2 = 416 s−1·mM−1, SARMH = 580 W·g−1, SARPTT = 800 W·g−1; and r2 = 407 s−1·mM−1, SARMH = 899 W·g−1, SARPTT = 300 W·g−1). MH experiments have proven that the heating power mainly originates from Brownian relaxation and that SAR values can remain high if IONPs are prealigned with a magnet. This raises hope that heating will maintain efficient even in a confined environment, such as in cells or in tumors. Preliminary in vitro MH and PTT experiments have shown the promising effect of the cubic shaped IONPs, even though the experiments should be repeated with an improved set-up. Finally, the grafting of a specific peptide (P22) as a TL for head and neck cancers (HNCs) has shown the positive impact of the TL to enhance IONP accumulation in cells.
Fil: Freis, Barbara. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia. Université de Mons; Bélgica
Fil: Ramirez, Maria De Los Angeles. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia
Fil: Kiefer, Céline. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia
Fil: Harlepp, Sébastien. Inserm; Francia
Fil: Iacovita, Cristian. Iuliu Hatieganu University of Medicine and Pharmacy; Rumania
Fil: Henoumont, Céline. Université de Mons; Bélgica
Fil: Affolter Zbaraszczuk, Christine. Centre de Recherche En Biomédecine de Strasbourg; Francia
Fil: Meyer, Florent. Centre de Recherche En Biomédecine de Strasbourg; Francia
Fil: Mertz, Damien. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia
Fil: Boos, Anne. Centre National de la Recherche Scientifique; Francia
Fil: Tasso, Mariana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Furgiuele, Sonia. Université de Mons; Bélgica
Fil: Journe, Fabrice. Université de Mons; Bélgica
Fil: Saussez, Sven. Université de Mons; Bélgica
Fil: Bégin Colin, Sylvie. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia
Fil: Laurent, Sophie. Université de Mons; Bélgica - Materia
-
IRON OXIDE NANOCUBES AND NANOPLATES
MAGNETIC HYPERTHERMIA
MRI CONTRAST AGENT
PHOTOTHERMIA
TARGETING LIGAND - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/220359
Ver los metadatos del registro completo
id |
CONICETDig_5e268f529a3c4933a3071c529262b1af |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/220359 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro StudiesFreis, BarbaraRamirez, Maria De Los AngelesKiefer, CélineHarlepp, SébastienIacovita, CristianHenoumont, CélineAffolter Zbaraszczuk, ChristineMeyer, FlorentMertz, DamienBoos, AnneTasso, Mariana PatriciaFurgiuele, SoniaJourne, FabriceSaussez, SvenBégin Colin, SylvieLaurent, SophieIRON OXIDE NANOCUBES AND NANOPLATESMAGNETIC HYPERTHERMIAMRI CONTRAST AGENTPHOTOTHERMIATARGETING LIGANDhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Functionalized iron oxide nanoparticles (IONPs) are increasingly being designed as a theranostic nanoplatform combining specific targeting, diagnosis by magnetic resonance imaging (MRI), and multimodal therapy by hyperthermia. The effect of the size and the shape of IONPs is of tremendous importance to develop theranostic nanoobjects displaying efficient MRI contrast agents and hyperthermia agent via the combination of magnetic hyperthermia (MH) and/or photothermia (PTT). Another key parameter is that the amount of accumulation of IONPs in cancerous cells is sufficiently high, which often requires the grafting of specific targeting ligands (TLs). Herein, IONPs with nanoplate and nanocube shapes, which are promising to combine magnetic hyperthermia (MH) and photothermia (PTT), were synthesized by the thermal decomposition method and coated with a designed dendron molecule to ensure their biocompatibility and colloidal stability in suspension. Then, the efficiency of these dendronized IONPs as contrast agents (CAs) for MRI and their ability to heat via MH or PTT were investigated. The 22 nm nanospheres and the 19 nm nanocubes presented the most promising theranostic properties (respectively, r2 = 416 s−1·mM−1, SARMH = 580 W·g−1, SARPTT = 800 W·g−1; and r2 = 407 s−1·mM−1, SARMH = 899 W·g−1, SARPTT = 300 W·g−1). MH experiments have proven that the heating power mainly originates from Brownian relaxation and that SAR values can remain high if IONPs are prealigned with a magnet. This raises hope that heating will maintain efficient even in a confined environment, such as in cells or in tumors. Preliminary in vitro MH and PTT experiments have shown the promising effect of the cubic shaped IONPs, even though the experiments should be repeated with an improved set-up. Finally, the grafting of a specific peptide (P22) as a TL for head and neck cancers (HNCs) has shown the positive impact of the TL to enhance IONP accumulation in cells.Fil: Freis, Barbara. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia. Université de Mons; BélgicaFil: Ramirez, Maria De Los Angeles. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; FranciaFil: Kiefer, Céline. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; FranciaFil: Harlepp, Sébastien. Inserm; FranciaFil: Iacovita, Cristian. Iuliu Hatieganu University of Medicine and Pharmacy; RumaniaFil: Henoumont, Céline. Université de Mons; BélgicaFil: Affolter Zbaraszczuk, Christine. Centre de Recherche En Biomédecine de Strasbourg; FranciaFil: Meyer, Florent. Centre de Recherche En Biomédecine de Strasbourg; FranciaFil: Mertz, Damien. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; FranciaFil: Boos, Anne. Centre National de la Recherche Scientifique; FranciaFil: Tasso, Mariana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Furgiuele, Sonia. Université de Mons; BélgicaFil: Journe, Fabrice. Université de Mons; BélgicaFil: Saussez, Sven. Université de Mons; BélgicaFil: Bégin Colin, Sylvie. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; FranciaFil: Laurent, Sophie. Université de Mons; BélgicaMultidisciplinary Digital Publishing Institute2023-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/220359Freis, Barbara; Ramirez, Maria De Los Angeles; Kiefer, Céline; Harlepp, Sébastien; Iacovita, Cristian; et al.; Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies; Multidisciplinary Digital Publishing Institute; Pharmaceutics; 15; 4; 3-2023; 1-291999-4923CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4923/15/4/1104info:eu-repo/semantics/altIdentifier/doi/10.3390/pharmaceutics15041104info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:32:20Zoai:ri.conicet.gov.ar:11336/220359instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:32:20.464CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies |
title |
Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies |
spellingShingle |
Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies Freis, Barbara IRON OXIDE NANOCUBES AND NANOPLATES MAGNETIC HYPERTHERMIA MRI CONTRAST AGENT PHOTOTHERMIA TARGETING LIGAND |
title_short |
Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies |
title_full |
Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies |
title_fullStr |
Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies |
title_full_unstemmed |
Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies |
title_sort |
Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies |
dc.creator.none.fl_str_mv |
Freis, Barbara Ramirez, Maria De Los Angeles Kiefer, Céline Harlepp, Sébastien Iacovita, Cristian Henoumont, Céline Affolter Zbaraszczuk, Christine Meyer, Florent Mertz, Damien Boos, Anne Tasso, Mariana Patricia Furgiuele, Sonia Journe, Fabrice Saussez, Sven Bégin Colin, Sylvie Laurent, Sophie |
author |
Freis, Barbara |
author_facet |
Freis, Barbara Ramirez, Maria De Los Angeles Kiefer, Céline Harlepp, Sébastien Iacovita, Cristian Henoumont, Céline Affolter Zbaraszczuk, Christine Meyer, Florent Mertz, Damien Boos, Anne Tasso, Mariana Patricia Furgiuele, Sonia Journe, Fabrice Saussez, Sven Bégin Colin, Sylvie Laurent, Sophie |
author_role |
author |
author2 |
Ramirez, Maria De Los Angeles Kiefer, Céline Harlepp, Sébastien Iacovita, Cristian Henoumont, Céline Affolter Zbaraszczuk, Christine Meyer, Florent Mertz, Damien Boos, Anne Tasso, Mariana Patricia Furgiuele, Sonia Journe, Fabrice Saussez, Sven Bégin Colin, Sylvie Laurent, Sophie |
author2_role |
author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
IRON OXIDE NANOCUBES AND NANOPLATES MAGNETIC HYPERTHERMIA MRI CONTRAST AGENT PHOTOTHERMIA TARGETING LIGAND |
topic |
IRON OXIDE NANOCUBES AND NANOPLATES MAGNETIC HYPERTHERMIA MRI CONTRAST AGENT PHOTOTHERMIA TARGETING LIGAND |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.10 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
Functionalized iron oxide nanoparticles (IONPs) are increasingly being designed as a theranostic nanoplatform combining specific targeting, diagnosis by magnetic resonance imaging (MRI), and multimodal therapy by hyperthermia. The effect of the size and the shape of IONPs is of tremendous importance to develop theranostic nanoobjects displaying efficient MRI contrast agents and hyperthermia agent via the combination of magnetic hyperthermia (MH) and/or photothermia (PTT). Another key parameter is that the amount of accumulation of IONPs in cancerous cells is sufficiently high, which often requires the grafting of specific targeting ligands (TLs). Herein, IONPs with nanoplate and nanocube shapes, which are promising to combine magnetic hyperthermia (MH) and photothermia (PTT), were synthesized by the thermal decomposition method and coated with a designed dendron molecule to ensure their biocompatibility and colloidal stability in suspension. Then, the efficiency of these dendronized IONPs as contrast agents (CAs) for MRI and their ability to heat via MH or PTT were investigated. The 22 nm nanospheres and the 19 nm nanocubes presented the most promising theranostic properties (respectively, r2 = 416 s−1·mM−1, SARMH = 580 W·g−1, SARPTT = 800 W·g−1; and r2 = 407 s−1·mM−1, SARMH = 899 W·g−1, SARPTT = 300 W·g−1). MH experiments have proven that the heating power mainly originates from Brownian relaxation and that SAR values can remain high if IONPs are prealigned with a magnet. This raises hope that heating will maintain efficient even in a confined environment, such as in cells or in tumors. Preliminary in vitro MH and PTT experiments have shown the promising effect of the cubic shaped IONPs, even though the experiments should be repeated with an improved set-up. Finally, the grafting of a specific peptide (P22) as a TL for head and neck cancers (HNCs) has shown the positive impact of the TL to enhance IONP accumulation in cells. Fil: Freis, Barbara. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia. Université de Mons; Bélgica Fil: Ramirez, Maria De Los Angeles. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia Fil: Kiefer, Céline. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia Fil: Harlepp, Sébastien. Inserm; Francia Fil: Iacovita, Cristian. Iuliu Hatieganu University of Medicine and Pharmacy; Rumania Fil: Henoumont, Céline. Université de Mons; Bélgica Fil: Affolter Zbaraszczuk, Christine. Centre de Recherche En Biomédecine de Strasbourg; Francia Fil: Meyer, Florent. Centre de Recherche En Biomédecine de Strasbourg; Francia Fil: Mertz, Damien. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia Fil: Boos, Anne. Centre National de la Recherche Scientifique; Francia Fil: Tasso, Mariana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina Fil: Furgiuele, Sonia. Université de Mons; Bélgica Fil: Journe, Fabrice. Université de Mons; Bélgica Fil: Saussez, Sven. Université de Mons; Bélgica Fil: Bégin Colin, Sylvie. Universite Paul Verlaine-metz. Institut de Physique, Chimie Et Materiaux; Francia Fil: Laurent, Sophie. Université de Mons; Bélgica |
description |
Functionalized iron oxide nanoparticles (IONPs) are increasingly being designed as a theranostic nanoplatform combining specific targeting, diagnosis by magnetic resonance imaging (MRI), and multimodal therapy by hyperthermia. The effect of the size and the shape of IONPs is of tremendous importance to develop theranostic nanoobjects displaying efficient MRI contrast agents and hyperthermia agent via the combination of magnetic hyperthermia (MH) and/or photothermia (PTT). Another key parameter is that the amount of accumulation of IONPs in cancerous cells is sufficiently high, which often requires the grafting of specific targeting ligands (TLs). Herein, IONPs with nanoplate and nanocube shapes, which are promising to combine magnetic hyperthermia (MH) and photothermia (PTT), were synthesized by the thermal decomposition method and coated with a designed dendron molecule to ensure their biocompatibility and colloidal stability in suspension. Then, the efficiency of these dendronized IONPs as contrast agents (CAs) for MRI and their ability to heat via MH or PTT were investigated. The 22 nm nanospheres and the 19 nm nanocubes presented the most promising theranostic properties (respectively, r2 = 416 s−1·mM−1, SARMH = 580 W·g−1, SARPTT = 800 W·g−1; and r2 = 407 s−1·mM−1, SARMH = 899 W·g−1, SARPTT = 300 W·g−1). MH experiments have proven that the heating power mainly originates from Brownian relaxation and that SAR values can remain high if IONPs are prealigned with a magnet. This raises hope that heating will maintain efficient even in a confined environment, such as in cells or in tumors. Preliminary in vitro MH and PTT experiments have shown the promising effect of the cubic shaped IONPs, even though the experiments should be repeated with an improved set-up. Finally, the grafting of a specific peptide (P22) as a TL for head and neck cancers (HNCs) has shown the positive impact of the TL to enhance IONP accumulation in cells. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/220359 Freis, Barbara; Ramirez, Maria De Los Angeles; Kiefer, Céline; Harlepp, Sébastien; Iacovita, Cristian; et al.; Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies; Multidisciplinary Digital Publishing Institute; Pharmaceutics; 15; 4; 3-2023; 1-29 1999-4923 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/220359 |
identifier_str_mv |
Freis, Barbara; Ramirez, Maria De Los Angeles; Kiefer, Céline; Harlepp, Sébastien; Iacovita, Cristian; et al.; Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies; Multidisciplinary Digital Publishing Institute; Pharmaceutics; 15; 4; 3-2023; 1-29 1999-4923 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4923/15/4/1104 info:eu-repo/semantics/altIdentifier/doi/10.3390/pharmaceutics15041104 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844612985571508224 |
score |
13.070432 |