Proton transport in water and DNA components: A Geant4 Monte Carlo simulation

Autores
Champion, C.; Incerti, S.; Tran, H. N.; Karamitros, M.; Shin, J. I.; Lee, S. B.; Lekadir, H.; Bernal, M.; Francis, Z.; Ivanchenko, V.; Fojon, Omar Ariel; Hanssen, J.; Rivarola, Roberto Daniel
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Accurate modeling of DNA damages resulting from ionizing radiation remains a challenge of today's radiobiology research. An original set of physics processes has been recently developed for modeling the detailed transport of protons and neutral hydrogen atoms in liquid water and in DNA nucleobases using the Geant4-DNA extension of the open source Geant4 Monte Carlo simulation toolkit. The theoretical cross sections as well as the mean energy transfers during the different ionizing processes were taken from recent works based on classical as well as quantum mechanical predictions. Furthermore, in order to compare energy deposition patterns in liquid water and DNA material, we here propose a simplified cellular nucleus model made of spherical voxels, each containing randomly oriented nanometer-size cylindrical targets filled with either liquid water or DNA material (DNA nucleobases) both with a density of 1 g/cm3. These cylindrical volumes have dimensions comparable to genetic material units of mammalian cells, namely, 25 nm (diameter) × 25 nm (height) for chromatin fiber segments, 10 nm (d) × 5 nm (h) for nucleosomes and 2 nm (d) × 2 nm (h) for DNA segments. Frequencies of energy deposition in the cylindrical targets are presented and discussed.
Fil: Champion, C.. Universite de Bordeaux; Francia
Fil: Incerti, S.. Universite de Bordeaux; Francia
Fil: Tran, H. N.. Universite de Bordeaux; Francia
Fil: Karamitros, M.. Universite de Bordeaux; Francia
Fil: Shin, J. I.. National Cancer Center. Proton Therapy Center; Corea del Sur
Fil: Lee, S. B.. National Cancer Center. Proton Therapy Center; Corea del Sur
Fil: Lekadir, H.. Université de Lorraine. Laboratoire de Physique Moléculaire et des Collisions; Francia
Fil: Bernal, M.. Universidade Estadual de Campinas; Brasil
Fil: Francis, Z.. Université Saint Joseph. Science Faculty. Department of Physics; Líbano
Fil: Ivanchenko, V.. Ecoanalytica; Rusia
Fil: Fojon, Omar Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Física de Rosario (i); Argentina
Fil: Hanssen, J.. Université de Lorraine. Laboratoire de Physique Moléculaire et des Collisions; Francia
Fil: Rivarola, Roberto Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Física de Rosario (i); Argentina
Materia
Monte Carlo
Geant4-Dna
Nucleobases
Geant4
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/5922
Acceder
id CONICETDig_5d59921ef1239984a1dbc1a150d3c6d7
oai_identifier_str oai:ri.conicet.gov.ar:11336/5922
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Proton transport in water and DNA components: A Geant4 Monte Carlo simulationChampion, C.Incerti, S.Tran, H. N.Karamitros, M.Shin, J. I.Lee, S. B.Lekadir, H.Bernal, M.Francis, Z.Ivanchenko, V.Fojon, Omar ArielHanssen, J.Rivarola, Roberto DanielMonte CarloGeant4-DnaNucleobasesGeant4https://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Accurate modeling of DNA damages resulting from ionizing radiation remains a challenge of today's radiobiology research. An original set of physics processes has been recently developed for modeling the detailed transport of protons and neutral hydrogen atoms in liquid water and in DNA nucleobases using the Geant4-DNA extension of the open source Geant4 Monte Carlo simulation toolkit. The theoretical cross sections as well as the mean energy transfers during the different ionizing processes were taken from recent works based on classical as well as quantum mechanical predictions. Furthermore, in order to compare energy deposition patterns in liquid water and DNA material, we here propose a simplified cellular nucleus model made of spherical voxels, each containing randomly oriented nanometer-size cylindrical targets filled with either liquid water or DNA material (DNA nucleobases) both with a density of 1 g/cm3. These cylindrical volumes have dimensions comparable to genetic material units of mammalian cells, namely, 25 nm (diameter) × 25 nm (height) for chromatin fiber segments, 10 nm (d) × 5 nm (h) for nucleosomes and 2 nm (d) × 2 nm (h) for DNA segments. Frequencies of energy deposition in the cylindrical targets are presented and discussed.Fil: Champion, C.. Universite de Bordeaux; FranciaFil: Incerti, S.. Universite de Bordeaux; FranciaFil: Tran, H. N.. Universite de Bordeaux; FranciaFil: Karamitros, M.. Universite de Bordeaux; FranciaFil: Shin, J. I.. National Cancer Center. Proton Therapy Center; Corea del SurFil: Lee, S. B.. National Cancer Center. Proton Therapy Center; Corea del SurFil: Lekadir, H.. Université de Lorraine. Laboratoire de Physique Moléculaire et des Collisions; FranciaFil: Bernal, M.. Universidade Estadual de Campinas; BrasilFil: Francis, Z.. Université Saint Joseph. Science Faculty. Department of Physics; LíbanoFil: Ivanchenko, V.. Ecoanalytica; RusiaFil: Fojon, Omar Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Física de Rosario (i); ArgentinaFil: Hanssen, J.. Université de Lorraine. Laboratoire de Physique Moléculaire et des Collisions; FranciaFil: Rivarola, Roberto Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Física de Rosario (i); ArgentinaElsevier2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/5922Champion, C.; Incerti, S.; Tran, H. N.; Karamitros, M.; Shin, J. I.; et al.; Proton transport in water and DNA components: A Geant4 Monte Carlo simulation; Elsevier; Nuclear Instruments and Methods in Physics Research B: Beam Interactions with Materials and Atoms; 306; 7-2013; 165-1680168-583Xenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0168583X13000402info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nimb.2012.12.059info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:39:57Zoai:ri.conicet.gov.ar:11336/5922instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:39:57.969CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Proton transport in water and DNA components: A Geant4 Monte Carlo simulation
title Proton transport in water and DNA components: A Geant4 Monte Carlo simulation
spellingShingle Proton transport in water and DNA components: A Geant4 Monte Carlo simulation
Champion, C.
Monte Carlo
Geant4-Dna
Nucleobases
Geant4
title_short Proton transport in water and DNA components: A Geant4 Monte Carlo simulation
title_full Proton transport in water and DNA components: A Geant4 Monte Carlo simulation
title_fullStr Proton transport in water and DNA components: A Geant4 Monte Carlo simulation
title_full_unstemmed Proton transport in water and DNA components: A Geant4 Monte Carlo simulation
title_sort Proton transport in water and DNA components: A Geant4 Monte Carlo simulation
dc.creator.none.fl_str_mv Champion, C.
Incerti, S.
Tran, H. N.
Karamitros, M.
Shin, J. I.
Lee, S. B.
Lekadir, H.
Bernal, M.
Francis, Z.
Ivanchenko, V.
Fojon, Omar Ariel
Hanssen, J.
Rivarola, Roberto Daniel
author Champion, C.
author_facet Champion, C.
Incerti, S.
Tran, H. N.
Karamitros, M.
Shin, J. I.
Lee, S. B.
Lekadir, H.
Bernal, M.
Francis, Z.
Ivanchenko, V.
Fojon, Omar Ariel
Hanssen, J.
Rivarola, Roberto Daniel
author_role author
author2 Incerti, S.
Tran, H. N.
Karamitros, M.
Shin, J. I.
Lee, S. B.
Lekadir, H.
Bernal, M.
Francis, Z.
Ivanchenko, V.
Fojon, Omar Ariel
Hanssen, J.
Rivarola, Roberto Daniel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Monte Carlo
Geant4-Dna
Nucleobases
Geant4
topic Monte Carlo
Geant4-Dna
Nucleobases
Geant4
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Accurate modeling of DNA damages resulting from ionizing radiation remains a challenge of today's radiobiology research. An original set of physics processes has been recently developed for modeling the detailed transport of protons and neutral hydrogen atoms in liquid water and in DNA nucleobases using the Geant4-DNA extension of the open source Geant4 Monte Carlo simulation toolkit. The theoretical cross sections as well as the mean energy transfers during the different ionizing processes were taken from recent works based on classical as well as quantum mechanical predictions. Furthermore, in order to compare energy deposition patterns in liquid water and DNA material, we here propose a simplified cellular nucleus model made of spherical voxels, each containing randomly oriented nanometer-size cylindrical targets filled with either liquid water or DNA material (DNA nucleobases) both with a density of 1 g/cm3. These cylindrical volumes have dimensions comparable to genetic material units of mammalian cells, namely, 25 nm (diameter) × 25 nm (height) for chromatin fiber segments, 10 nm (d) × 5 nm (h) for nucleosomes and 2 nm (d) × 2 nm (h) for DNA segments. Frequencies of energy deposition in the cylindrical targets are presented and discussed.
Fil: Champion, C.. Universite de Bordeaux; Francia
Fil: Incerti, S.. Universite de Bordeaux; Francia
Fil: Tran, H. N.. Universite de Bordeaux; Francia
Fil: Karamitros, M.. Universite de Bordeaux; Francia
Fil: Shin, J. I.. National Cancer Center. Proton Therapy Center; Corea del Sur
Fil: Lee, S. B.. National Cancer Center. Proton Therapy Center; Corea del Sur
Fil: Lekadir, H.. Université de Lorraine. Laboratoire de Physique Moléculaire et des Collisions; Francia
Fil: Bernal, M.. Universidade Estadual de Campinas; Brasil
Fil: Francis, Z.. Université Saint Joseph. Science Faculty. Department of Physics; Líbano
Fil: Ivanchenko, V.. Ecoanalytica; Rusia
Fil: Fojon, Omar Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Física de Rosario (i); Argentina
Fil: Hanssen, J.. Université de Lorraine. Laboratoire de Physique Moléculaire et des Collisions; Francia
Fil: Rivarola, Roberto Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Física de Rosario (i); Argentina
description Accurate modeling of DNA damages resulting from ionizing radiation remains a challenge of today's radiobiology research. An original set of physics processes has been recently developed for modeling the detailed transport of protons and neutral hydrogen atoms in liquid water and in DNA nucleobases using the Geant4-DNA extension of the open source Geant4 Monte Carlo simulation toolkit. The theoretical cross sections as well as the mean energy transfers during the different ionizing processes were taken from recent works based on classical as well as quantum mechanical predictions. Furthermore, in order to compare energy deposition patterns in liquid water and DNA material, we here propose a simplified cellular nucleus model made of spherical voxels, each containing randomly oriented nanometer-size cylindrical targets filled with either liquid water or DNA material (DNA nucleobases) both with a density of 1 g/cm3. These cylindrical volumes have dimensions comparable to genetic material units of mammalian cells, namely, 25 nm (diameter) × 25 nm (height) for chromatin fiber segments, 10 nm (d) × 5 nm (h) for nucleosomes and 2 nm (d) × 2 nm (h) for DNA segments. Frequencies of energy deposition in the cylindrical targets are presented and discussed.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/5922
Champion, C.; Incerti, S.; Tran, H. N.; Karamitros, M.; Shin, J. I.; et al.; Proton transport in water and DNA components: A Geant4 Monte Carlo simulation; Elsevier; Nuclear Instruments and Methods in Physics Research B: Beam Interactions with Materials and Atoms; 306; 7-2013; 165-168
0168-583X
url http://hdl.handle.net/11336/5922
identifier_str_mv Champion, C.; Incerti, S.; Tran, H. N.; Karamitros, M.; Shin, J. I.; et al.; Proton transport in water and DNA components: A Geant4 Monte Carlo simulation; Elsevier; Nuclear Instruments and Methods in Physics Research B: Beam Interactions with Materials and Atoms; 306; 7-2013; 165-168
0168-583X
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0168583X13000402
info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nimb.2012.12.059
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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