Proliferation-apoptosis balance in Staphylococcus aureus chronically infected bovine mammary glands during involution

Autores
Andreotti, Carolina Soledad; Pereyra, Elizabet Amanda Lorena; Sacco, Sofía Clara; Baravalle, Celina; Renna, Maria Sol; Ortega, Hugo Hector; Calvinho, Luis Fernando; Dallard, Bibiana Elisabet
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The objective of this study was to determine whether Staphylococcus aureus chronic intramammaryinfection (IMI) influences expression of proteins related to regulation of proliferation and apoptosisprocesses and proliferation/apoptosis index during active involution in bovine mammary gland.Twenty-one Holstein non-pregnant cows in late lactation either uninfected or with chronic naturallyacquired S. aureus IMI were included in this study. Cows were slaughtered at 7, 14 and 21 d aftercessation of milking and samples for immunohistochemical analysis were taken. Protein expressionof Bcl-2, Bax, Fas and active caspase-3 in mammary tissue was significantly affected by chronic S.aureus IMI, all showing increased immunoexpression in S. aureus-infected quarters at all involutionstages. The percentage of apoptotic cells was increased by IMI in both mammary parenchyma andstroma, and the percentage of parenchymal and stromal cell proliferation was also increased. Theproliferation/apoptosis ratio was significantly increased by IMI only in stromal cells. This imbalanceto favour proliferation in S. aureus-infected mammary quarters could be one of the underlying causesthat induce aberrant involution with permanence of nonsecretory tissue and increase of stromalcomponents.
Fil: Andreotti, Carolina Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
Fil: Pereyra, Elizabet Amanda Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
Fil: Sacco, Sofía Clara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
Fil: Baravalle, Celina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
Fil: Renna, Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
Fil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
Fil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
Fil: Dallard, Bibiana Elisabet. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
Materia
Mastitis
Staphylococcus Aureus
Apoptosis
Proliferacion
Active Involution
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/41853

id CONICETDig_5c1148088ed8927a48f561951448b942
oai_identifier_str oai:ri.conicet.gov.ar:11336/41853
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Proliferation-apoptosis balance in Staphylococcus aureus chronically infected bovine mammary glands during involutionAndreotti, Carolina SoledadPereyra, Elizabet Amanda LorenaSacco, Sofía ClaraBaravalle, CelinaRenna, Maria SolOrtega, Hugo HectorCalvinho, Luis FernandoDallard, Bibiana ElisabetMastitisStaphylococcus AureusApoptosisProliferacionActive Involutionhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The objective of this study was to determine whether Staphylococcus aureus chronic intramammaryinfection (IMI) influences expression of proteins related to regulation of proliferation and apoptosisprocesses and proliferation/apoptosis index during active involution in bovine mammary gland.Twenty-one Holstein non-pregnant cows in late lactation either uninfected or with chronic naturallyacquired S. aureus IMI were included in this study. Cows were slaughtered at 7, 14 and 21 d aftercessation of milking and samples for immunohistochemical analysis were taken. Protein expressionof Bcl-2, Bax, Fas and active caspase-3 in mammary tissue was significantly affected by chronic S.aureus IMI, all showing increased immunoexpression in S. aureus-infected quarters at all involutionstages. The percentage of apoptotic cells was increased by IMI in both mammary parenchyma andstroma, and the percentage of parenchymal and stromal cell proliferation was also increased. Theproliferation/apoptosis ratio was significantly increased by IMI only in stromal cells. This imbalanceto favour proliferation in S. aureus-infected mammary quarters could be one of the underlying causesthat induce aberrant involution with permanence of nonsecretory tissue and increase of stromalcomponents.Fil: Andreotti, Carolina Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; ArgentinaFil: Pereyra, Elizabet Amanda Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; ArgentinaFil: Sacco, Sofía Clara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; ArgentinaFil: Baravalle, Celina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; ArgentinaFil: Renna, Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; ArgentinaFil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; ArgentinaFil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; ArgentinaFil: Dallard, Bibiana Elisabet. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; ArgentinaCambridge University Press2017-03-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/41853Andreotti, Carolina Soledad; Pereyra, Elizabet Amanda Lorena; Sacco, Sofía Clara; Baravalle, Celina; Renna, Maria Sol; et al.; Proliferation-apoptosis balance in Staphylococcus aureus chronically infected bovine mammary glands during involution; Cambridge University Press; Journal of Dairy Research; 84; 2; 13-3-2017; 181-1890022-0299CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1017/S002202991700005Xinfo:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/journal-of-dairy-research/article/proliferationapoptosis-balance-in-staphylococcus-aureus-chronically-infected-bovine-mammary-glands-during-involution/4467554794977FB7203A66B86B492CDEinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:35Zoai:ri.conicet.gov.ar:11336/41853instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:35.963CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Proliferation-apoptosis balance in Staphylococcus aureus chronically infected bovine mammary glands during involution
title Proliferation-apoptosis balance in Staphylococcus aureus chronically infected bovine mammary glands during involution
spellingShingle Proliferation-apoptosis balance in Staphylococcus aureus chronically infected bovine mammary glands during involution
Andreotti, Carolina Soledad
Mastitis
Staphylococcus Aureus
Apoptosis
Proliferacion
Active Involution
title_short Proliferation-apoptosis balance in Staphylococcus aureus chronically infected bovine mammary glands during involution
title_full Proliferation-apoptosis balance in Staphylococcus aureus chronically infected bovine mammary glands during involution
title_fullStr Proliferation-apoptosis balance in Staphylococcus aureus chronically infected bovine mammary glands during involution
title_full_unstemmed Proliferation-apoptosis balance in Staphylococcus aureus chronically infected bovine mammary glands during involution
title_sort Proliferation-apoptosis balance in Staphylococcus aureus chronically infected bovine mammary glands during involution
dc.creator.none.fl_str_mv Andreotti, Carolina Soledad
Pereyra, Elizabet Amanda Lorena
Sacco, Sofía Clara
Baravalle, Celina
Renna, Maria Sol
Ortega, Hugo Hector
Calvinho, Luis Fernando
Dallard, Bibiana Elisabet
author Andreotti, Carolina Soledad
author_facet Andreotti, Carolina Soledad
Pereyra, Elizabet Amanda Lorena
Sacco, Sofía Clara
Baravalle, Celina
Renna, Maria Sol
Ortega, Hugo Hector
Calvinho, Luis Fernando
Dallard, Bibiana Elisabet
author_role author
author2 Pereyra, Elizabet Amanda Lorena
Sacco, Sofía Clara
Baravalle, Celina
Renna, Maria Sol
Ortega, Hugo Hector
Calvinho, Luis Fernando
Dallard, Bibiana Elisabet
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mastitis
Staphylococcus Aureus
Apoptosis
Proliferacion
Active Involution
topic Mastitis
Staphylococcus Aureus
Apoptosis
Proliferacion
Active Involution
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The objective of this study was to determine whether Staphylococcus aureus chronic intramammaryinfection (IMI) influences expression of proteins related to regulation of proliferation and apoptosisprocesses and proliferation/apoptosis index during active involution in bovine mammary gland.Twenty-one Holstein non-pregnant cows in late lactation either uninfected or with chronic naturallyacquired S. aureus IMI were included in this study. Cows were slaughtered at 7, 14 and 21 d aftercessation of milking and samples for immunohistochemical analysis were taken. Protein expressionof Bcl-2, Bax, Fas and active caspase-3 in mammary tissue was significantly affected by chronic S.aureus IMI, all showing increased immunoexpression in S. aureus-infected quarters at all involutionstages. The percentage of apoptotic cells was increased by IMI in both mammary parenchyma andstroma, and the percentage of parenchymal and stromal cell proliferation was also increased. Theproliferation/apoptosis ratio was significantly increased by IMI only in stromal cells. This imbalanceto favour proliferation in S. aureus-infected mammary quarters could be one of the underlying causesthat induce aberrant involution with permanence of nonsecretory tissue and increase of stromalcomponents.
Fil: Andreotti, Carolina Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
Fil: Pereyra, Elizabet Amanda Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
Fil: Sacco, Sofía Clara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
Fil: Baravalle, Celina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
Fil: Renna, Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
Fil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
Fil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
Fil: Dallard, Bibiana Elisabet. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
description The objective of this study was to determine whether Staphylococcus aureus chronic intramammaryinfection (IMI) influences expression of proteins related to regulation of proliferation and apoptosisprocesses and proliferation/apoptosis index during active involution in bovine mammary gland.Twenty-one Holstein non-pregnant cows in late lactation either uninfected or with chronic naturallyacquired S. aureus IMI were included in this study. Cows were slaughtered at 7, 14 and 21 d aftercessation of milking and samples for immunohistochemical analysis were taken. Protein expressionof Bcl-2, Bax, Fas and active caspase-3 in mammary tissue was significantly affected by chronic S.aureus IMI, all showing increased immunoexpression in S. aureus-infected quarters at all involutionstages. The percentage of apoptotic cells was increased by IMI in both mammary parenchyma andstroma, and the percentage of parenchymal and stromal cell proliferation was also increased. Theproliferation/apoptosis ratio was significantly increased by IMI only in stromal cells. This imbalanceto favour proliferation in S. aureus-infected mammary quarters could be one of the underlying causesthat induce aberrant involution with permanence of nonsecretory tissue and increase of stromalcomponents.
publishDate 2017
dc.date.none.fl_str_mv 2017-03-13
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/41853
Andreotti, Carolina Soledad; Pereyra, Elizabet Amanda Lorena; Sacco, Sofía Clara; Baravalle, Celina; Renna, Maria Sol; et al.; Proliferation-apoptosis balance in Staphylococcus aureus chronically infected bovine mammary glands during involution; Cambridge University Press; Journal of Dairy Research; 84; 2; 13-3-2017; 181-189
0022-0299
CONICET Digital
CONICET
url http://hdl.handle.net/11336/41853
identifier_str_mv Andreotti, Carolina Soledad; Pereyra, Elizabet Amanda Lorena; Sacco, Sofía Clara; Baravalle, Celina; Renna, Maria Sol; et al.; Proliferation-apoptosis balance in Staphylococcus aureus chronically infected bovine mammary glands during involution; Cambridge University Press; Journal of Dairy Research; 84; 2; 13-3-2017; 181-189
0022-0299
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1017/S002202991700005X
info:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/journal-of-dairy-research/article/proliferationapoptosis-balance-in-staphylococcus-aureus-chronically-infected-bovine-mammary-glands-during-involution/4467554794977FB7203A66B86B492CDE
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268869947817984
score 13.13397