Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke

Autores
Belayev, Ludmila; Mukherjee, Pranab K; Balaszczuk, Veronica; Calandria, Jorgelina M; Obenaus, Andre; Khoutorova, Larissa; Hong, Sung-Ha; Bazan, Nicolas G.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Ring finger protein 146 (Iduna) facilitates DNA repair and protects against cell death induced by NMDA receptor-mediated glutamate excitotoxicity or by cerebral ischemia. Neuroprotectin D1 (NPD1), a docosahexaenoic acid (DHA)-derived lipid mediator, promotes cell survival under uncompensated oxidative stress (UOS). Our data demonstrate that NPD1 potently upregulates Iduna expression and provides remarkable cell protection against UOS. Iduna, which was increased by the lipid mediator, requires the presence of the poly(ADP-ribose) (PAR) sites. Moreover, astrocytes and neurons in the penumbra display an enhanced abundance of Iduna, followed by remarkable neurological protection when DHA, a precursor of NPD1, is systemically administered 1 h after 2 h of ischemic stroke. These findings provide a conceptual advancement for survival of neural cells undergoing challenges to homeostasis because a lipid mediator, made 'on demand,' modulates the abundance of a critically important protein for cell survival.
Fil: Belayev, Ludmila. Louisiana State University Health Sciences Center; Estados Unidos
Fil: Mukherjee, Pranab K. Louisiana State University Health Sciences Center; Estados Unidos
Fil: Balaszczuk, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Estudio sobre Cultura y Sociedad. Centro de Investigaciones de la Facultad de Psicología - Grupo Vinculado CIPSI; Argentina. Louisiana State University Health Sciences Center; Estados Unidos
Fil: Calandria, Jorgelina M. Louisiana State University Health Sciences Center; Estados Unidos
Fil: Obenaus, Andre. Loma Linda University Adventist Health Sciences Center; Estados Unidos
Fil: Khoutorova, Larissa. Louisiana State University Health Sciences Center; Estados Unidos
Fil: Hong, Sung-Ha. Louisiana State University Health Sciences Center; Estados Unidos
Fil: Bazan, Nicolas G.. Louisiana State University Health Sciences Center; Estados Unidos
Materia
NPD1
IDUNA
STROKE
NEUROPROTECTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/74570
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/74570
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic strokeBelayev, LudmilaMukherjee, Pranab KBalaszczuk, VeronicaCalandria, Jorgelina MObenaus, AndreKhoutorova, LarissaHong, Sung-HaBazan, Nicolas G.NPD1IDUNASTROKENEUROPROTECTIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Ring finger protein 146 (Iduna) facilitates DNA repair and protects against cell death induced by NMDA receptor-mediated glutamate excitotoxicity or by cerebral ischemia. Neuroprotectin D1 (NPD1), a docosahexaenoic acid (DHA)-derived lipid mediator, promotes cell survival under uncompensated oxidative stress (UOS). Our data demonstrate that NPD1 potently upregulates Iduna expression and provides remarkable cell protection against UOS. Iduna, which was increased by the lipid mediator, requires the presence of the poly(ADP-ribose) (PAR) sites. Moreover, astrocytes and neurons in the penumbra display an enhanced abundance of Iduna, followed by remarkable neurological protection when DHA, a precursor of NPD1, is systemically administered 1 h after 2 h of ischemic stroke. These findings provide a conceptual advancement for survival of neural cells undergoing challenges to homeostasis because a lipid mediator, made 'on demand,' modulates the abundance of a critically important protein for cell survival.Fil: Belayev, Ludmila. Louisiana State University Health Sciences Center; Estados UnidosFil: Mukherjee, Pranab K. Louisiana State University Health Sciences Center; Estados UnidosFil: Balaszczuk, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Estudio sobre Cultura y Sociedad. Centro de Investigaciones de la Facultad de Psicología - Grupo Vinculado CIPSI; Argentina. Louisiana State University Health Sciences Center; Estados UnidosFil: Calandria, Jorgelina M. Louisiana State University Health Sciences Center; Estados UnidosFil: Obenaus, Andre. Loma Linda University Adventist Health Sciences Center; Estados UnidosFil: Khoutorova, Larissa. Louisiana State University Health Sciences Center; Estados UnidosFil: Hong, Sung-Ha. Louisiana State University Health Sciences Center; Estados UnidosFil: Bazan, Nicolas G.. Louisiana State University Health Sciences Center; Estados UnidosNature Publishing Group2017-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/74570Belayev, Ludmila; Mukherjee, Pranab K; Balaszczuk, Veronica; Calandria, Jorgelina M; Obenaus, Andre; et al.; Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke; Nature Publishing Group; Cell Death and Differentiation; 24; 6; 6-2017; 1091-10991350-90471476-5403CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/cdd.2017.55info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/cdd201755info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:14:35Zoai:ri.conicet.gov.ar:11336/74570instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:14:35.697CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke
title Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke
spellingShingle Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke
Belayev, Ludmila
NPD1
IDUNA
STROKE
NEUROPROTECTION
title_short Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke
title_full Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke
title_fullStr Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke
title_full_unstemmed Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke
title_sort Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke
dc.creator.none.fl_str_mv Belayev, Ludmila
Mukherjee, Pranab K
Balaszczuk, Veronica
Calandria, Jorgelina M
Obenaus, Andre
Khoutorova, Larissa
Hong, Sung-Ha
Bazan, Nicolas G.
author Belayev, Ludmila
author_facet Belayev, Ludmila
Mukherjee, Pranab K
Balaszczuk, Veronica
Calandria, Jorgelina M
Obenaus, Andre
Khoutorova, Larissa
Hong, Sung-Ha
Bazan, Nicolas G.
author_role author
author2 Mukherjee, Pranab K
Balaszczuk, Veronica
Calandria, Jorgelina M
Obenaus, Andre
Khoutorova, Larissa
Hong, Sung-Ha
Bazan, Nicolas G.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv NPD1
IDUNA
STROKE
NEUROPROTECTION
topic NPD1
IDUNA
STROKE
NEUROPROTECTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Ring finger protein 146 (Iduna) facilitates DNA repair and protects against cell death induced by NMDA receptor-mediated glutamate excitotoxicity or by cerebral ischemia. Neuroprotectin D1 (NPD1), a docosahexaenoic acid (DHA)-derived lipid mediator, promotes cell survival under uncompensated oxidative stress (UOS). Our data demonstrate that NPD1 potently upregulates Iduna expression and provides remarkable cell protection against UOS. Iduna, which was increased by the lipid mediator, requires the presence of the poly(ADP-ribose) (PAR) sites. Moreover, astrocytes and neurons in the penumbra display an enhanced abundance of Iduna, followed by remarkable neurological protection when DHA, a precursor of NPD1, is systemically administered 1 h after 2 h of ischemic stroke. These findings provide a conceptual advancement for survival of neural cells undergoing challenges to homeostasis because a lipid mediator, made 'on demand,' modulates the abundance of a critically important protein for cell survival.
Fil: Belayev, Ludmila. Louisiana State University Health Sciences Center; Estados Unidos
Fil: Mukherjee, Pranab K. Louisiana State University Health Sciences Center; Estados Unidos
Fil: Balaszczuk, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Estudio sobre Cultura y Sociedad. Centro de Investigaciones de la Facultad de Psicología - Grupo Vinculado CIPSI; Argentina. Louisiana State University Health Sciences Center; Estados Unidos
Fil: Calandria, Jorgelina M. Louisiana State University Health Sciences Center; Estados Unidos
Fil: Obenaus, Andre. Loma Linda University Adventist Health Sciences Center; Estados Unidos
Fil: Khoutorova, Larissa. Louisiana State University Health Sciences Center; Estados Unidos
Fil: Hong, Sung-Ha. Louisiana State University Health Sciences Center; Estados Unidos
Fil: Bazan, Nicolas G.. Louisiana State University Health Sciences Center; Estados Unidos
description Ring finger protein 146 (Iduna) facilitates DNA repair and protects against cell death induced by NMDA receptor-mediated glutamate excitotoxicity or by cerebral ischemia. Neuroprotectin D1 (NPD1), a docosahexaenoic acid (DHA)-derived lipid mediator, promotes cell survival under uncompensated oxidative stress (UOS). Our data demonstrate that NPD1 potently upregulates Iduna expression and provides remarkable cell protection against UOS. Iduna, which was increased by the lipid mediator, requires the presence of the poly(ADP-ribose) (PAR) sites. Moreover, astrocytes and neurons in the penumbra display an enhanced abundance of Iduna, followed by remarkable neurological protection when DHA, a precursor of NPD1, is systemically administered 1 h after 2 h of ischemic stroke. These findings provide a conceptual advancement for survival of neural cells undergoing challenges to homeostasis because a lipid mediator, made 'on demand,' modulates the abundance of a critically important protein for cell survival.
publishDate 2017
dc.date.none.fl_str_mv 2017-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/74570
Belayev, Ludmila; Mukherjee, Pranab K; Balaszczuk, Veronica; Calandria, Jorgelina M; Obenaus, Andre; et al.; Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke; Nature Publishing Group; Cell Death and Differentiation; 24; 6; 6-2017; 1091-1099
1350-9047
1476-5403
CONICET Digital
CONICET
url http://hdl.handle.net/11336/74570
identifier_str_mv Belayev, Ludmila; Mukherjee, Pranab K; Balaszczuk, Veronica; Calandria, Jorgelina M; Obenaus, Andre; et al.; Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke; Nature Publishing Group; Cell Death and Differentiation; 24; 6; 6-2017; 1091-1099
1350-9047
1476-5403
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/cdd.2017.55
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/cdd201755
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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