LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL

Autores
Prieto, Daniel; Seija, Noé; Uriepero, Angimar; Souto-Padron, Thais; Oliver, Carolina; Irigoin, Victoria; Guillermo, Cecilia; Navarrete, Marcelo A.; Inés Landoni, Ana; Dighiero, Guillermo; Gabus, Raúl; Giordano, Mirta Nilda; Oppezzo, Pablo
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Lipoprotein lipase (LPL) mRNA expression in chronic lymphocytic leukaemia (CLL) is associated with an unmutated immunoglobulin profile and poor clinical outcome. We evaluated the subcellular localization of LPL protein in CLL cells that did or did not express LPL mRNA. Our results show that LPL protein is differently located in CLL cells depending on whether it is incorporated from the extracellular medium in mutated CLL or generated de novo by leukaemic cells of unmutated patients. The specific quantification of endogenous LPL protein correlates with mRNA expression levels and mutational IGHV status, suggesting LPL protein as a possible reliable prognostic marker in CLL.
Fil: Prieto, Daniel. Instituto Pasteur de Montevideo; Uruguay. Instituto de Investigaciones Biológicas "Clemente Estable"; Uruguay
Fil: Seija, Noé. Instituto Pasteur de Montevideo; Uruguay. Universidad de la República; Uruguay
Fil: Uriepero, Angimar. Instituto Pasteur de Montevideo; Uruguay
Fil: Souto-Padron, Thais. Universidade Federal do Rio de Janeiro; Brasil
Fil: Oliver, Carolina. Universidad de la República; Uruguay
Fil: Irigoin, Victoria. Universidad de la República; Uruguay
Fil: Guillermo, Cecilia. Universidad de la República; Uruguay
Fil: Navarrete, Marcelo A.. Universidad de Magallanes; Chile
Fil: Inés Landoni, Ana. Ministerio de Salud. Administración Servicios de Salud del Estado. Hospital Maciel; Uruguay
Fil: Dighiero, Guillermo. Ministerio de Salud. Administración Servicios de Salud del Estado. Hospital Maciel; Uruguay
Fil: Gabus, Raúl. Ministerio de Salud. Administración Servicios de Salud del Estado. Hospital Maciel; Uruguay
Fil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Oppezzo, Pablo. Instituto Pasteur de Montevideo; Uruguay
Materia
CHRONIC LYMPHOCYTIC LEUKAEMIA
FLOW CYTOMETRY
IGHV PROFILE
LPL
PROGNOSTIC MARKER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/95516
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/95516
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLLPrieto, DanielSeija, NoéUriepero, AngimarSouto-Padron, ThaisOliver, CarolinaIrigoin, VictoriaGuillermo, CeciliaNavarrete, Marcelo A.Inés Landoni, AnaDighiero, GuillermoGabus, RaúlGiordano, Mirta NildaOppezzo, PabloCHRONIC LYMPHOCYTIC LEUKAEMIAFLOW CYTOMETRYIGHV PROFILELPLPROGNOSTIC MARKERhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Lipoprotein lipase (LPL) mRNA expression in chronic lymphocytic leukaemia (CLL) is associated with an unmutated immunoglobulin profile and poor clinical outcome. We evaluated the subcellular localization of LPL protein in CLL cells that did or did not express LPL mRNA. Our results show that LPL protein is differently located in CLL cells depending on whether it is incorporated from the extracellular medium in mutated CLL or generated de novo by leukaemic cells of unmutated patients. The specific quantification of endogenous LPL protein correlates with mRNA expression levels and mutational IGHV status, suggesting LPL protein as a possible reliable prognostic marker in CLL.Fil: Prieto, Daniel. Instituto Pasteur de Montevideo; Uruguay. Instituto de Investigaciones Biológicas "Clemente Estable"; UruguayFil: Seija, Noé. Instituto Pasteur de Montevideo; Uruguay. Universidad de la República; UruguayFil: Uriepero, Angimar. Instituto Pasteur de Montevideo; UruguayFil: Souto-Padron, Thais. Universidade Federal do Rio de Janeiro; BrasilFil: Oliver, Carolina. Universidad de la República; UruguayFil: Irigoin, Victoria. Universidad de la República; UruguayFil: Guillermo, Cecilia. Universidad de la República; UruguayFil: Navarrete, Marcelo A.. Universidad de Magallanes; ChileFil: Inés Landoni, Ana. Ministerio de Salud. Administración Servicios de Salud del Estado. Hospital Maciel; UruguayFil: Dighiero, Guillermo. Ministerio de Salud. Administración Servicios de Salud del Estado. Hospital Maciel; UruguayFil: Gabus, Raúl. Ministerio de Salud. Administración Servicios de Salud del Estado. Hospital Maciel; UruguayFil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Oppezzo, Pablo. Instituto Pasteur de Montevideo; UruguayWiley Blackwell Publishing, Inc2018-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/95516Prieto, Daniel; Seija, Noé; Uriepero, Angimar; Souto-Padron, Thais; Oliver, Carolina; et al.; LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL; Wiley Blackwell Publishing, Inc; British Journal of Haematology; 182; 4; 8-2018; 521-5250007-1048CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/bjh.15427info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.15427info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:25:11Zoai:ri.conicet.gov.ar:11336/95516instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:25:12.254CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL
title LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL
spellingShingle LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL
Prieto, Daniel
CHRONIC LYMPHOCYTIC LEUKAEMIA
FLOW CYTOMETRY
IGHV PROFILE
LPL
PROGNOSTIC MARKER
title_short LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL
title_full LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL
title_fullStr LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL
title_full_unstemmed LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL
title_sort LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL
dc.creator.none.fl_str_mv Prieto, Daniel
Seija, Noé
Uriepero, Angimar
Souto-Padron, Thais
Oliver, Carolina
Irigoin, Victoria
Guillermo, Cecilia
Navarrete, Marcelo A.
Inés Landoni, Ana
Dighiero, Guillermo
Gabus, Raúl
Giordano, Mirta Nilda
Oppezzo, Pablo
author Prieto, Daniel
author_facet Prieto, Daniel
Seija, Noé
Uriepero, Angimar
Souto-Padron, Thais
Oliver, Carolina
Irigoin, Victoria
Guillermo, Cecilia
Navarrete, Marcelo A.
Inés Landoni, Ana
Dighiero, Guillermo
Gabus, Raúl
Giordano, Mirta Nilda
Oppezzo, Pablo
author_role author
author2 Seija, Noé
Uriepero, Angimar
Souto-Padron, Thais
Oliver, Carolina
Irigoin, Victoria
Guillermo, Cecilia
Navarrete, Marcelo A.
Inés Landoni, Ana
Dighiero, Guillermo
Gabus, Raúl
Giordano, Mirta Nilda
Oppezzo, Pablo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CHRONIC LYMPHOCYTIC LEUKAEMIA
FLOW CYTOMETRY
IGHV PROFILE
LPL
PROGNOSTIC MARKER
topic CHRONIC LYMPHOCYTIC LEUKAEMIA
FLOW CYTOMETRY
IGHV PROFILE
LPL
PROGNOSTIC MARKER
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Lipoprotein lipase (LPL) mRNA expression in chronic lymphocytic leukaemia (CLL) is associated with an unmutated immunoglobulin profile and poor clinical outcome. We evaluated the subcellular localization of LPL protein in CLL cells that did or did not express LPL mRNA. Our results show that LPL protein is differently located in CLL cells depending on whether it is incorporated from the extracellular medium in mutated CLL or generated de novo by leukaemic cells of unmutated patients. The specific quantification of endogenous LPL protein correlates with mRNA expression levels and mutational IGHV status, suggesting LPL protein as a possible reliable prognostic marker in CLL.
Fil: Prieto, Daniel. Instituto Pasteur de Montevideo; Uruguay. Instituto de Investigaciones Biológicas "Clemente Estable"; Uruguay
Fil: Seija, Noé. Instituto Pasteur de Montevideo; Uruguay. Universidad de la República; Uruguay
Fil: Uriepero, Angimar. Instituto Pasteur de Montevideo; Uruguay
Fil: Souto-Padron, Thais. Universidade Federal do Rio de Janeiro; Brasil
Fil: Oliver, Carolina. Universidad de la República; Uruguay
Fil: Irigoin, Victoria. Universidad de la República; Uruguay
Fil: Guillermo, Cecilia. Universidad de la República; Uruguay
Fil: Navarrete, Marcelo A.. Universidad de Magallanes; Chile
Fil: Inés Landoni, Ana. Ministerio de Salud. Administración Servicios de Salud del Estado. Hospital Maciel; Uruguay
Fil: Dighiero, Guillermo. Ministerio de Salud. Administración Servicios de Salud del Estado. Hospital Maciel; Uruguay
Fil: Gabus, Raúl. Ministerio de Salud. Administración Servicios de Salud del Estado. Hospital Maciel; Uruguay
Fil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Oppezzo, Pablo. Instituto Pasteur de Montevideo; Uruguay
description Lipoprotein lipase (LPL) mRNA expression in chronic lymphocytic leukaemia (CLL) is associated with an unmutated immunoglobulin profile and poor clinical outcome. We evaluated the subcellular localization of LPL protein in CLL cells that did or did not express LPL mRNA. Our results show that LPL protein is differently located in CLL cells depending on whether it is incorporated from the extracellular medium in mutated CLL or generated de novo by leukaemic cells of unmutated patients. The specific quantification of endogenous LPL protein correlates with mRNA expression levels and mutational IGHV status, suggesting LPL protein as a possible reliable prognostic marker in CLL.
publishDate 2018
dc.date.none.fl_str_mv 2018-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/95516
Prieto, Daniel; Seija, Noé; Uriepero, Angimar; Souto-Padron, Thais; Oliver, Carolina; et al.; LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL; Wiley Blackwell Publishing, Inc; British Journal of Haematology; 182; 4; 8-2018; 521-525
0007-1048
CONICET Digital
CONICET
url http://hdl.handle.net/11336/95516
identifier_str_mv Prieto, Daniel; Seija, Noé; Uriepero, Angimar; Souto-Padron, Thais; Oliver, Carolina; et al.; LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL; Wiley Blackwell Publishing, Inc; British Journal of Haematology; 182; 4; 8-2018; 521-525
0007-1048
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/bjh.15427
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.15427
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614250374365184
score 13.070432

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