Phase transitions in tumor growth VI: Epithelial–Mesenchymal transition

Autores
Guerra, A.; Rodriguez, D. J.; Montero, S.; Betancourt Mar, J. A.; Martín Pardo, Reinaldo Román; Silva Lamar, Eduardo; Bizzarri, María Julia; Cocho, G.; Mansilla, R.; Nieto Villar, José Manuel
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Herewith we discuss a network model of the epithelial–mesenchymal transition (EMT) based on our previous proposed framework. The EMT appears as a “first order” phase transition process, analogous to the transitions observed in the chemical–physical field. Chiefly, EMT should be considered a transition characterized by a supercritical Andronov–Hopf bifurcation, with the emergence of limit cycle and, consequently, a cascade of saddle-foci Shilnikov's bifurcations. We eventually show that the entropy production rate is an EMT-dependent function and, as such, its formalism reminds the van der Waals equation.
Fil: Guerra, A.. Universidad de La Habana; Cuba
Fil: Rodriguez, D. J.. Universidad de La Habana; Cuba
Fil: Montero, S.. Medical Sciences University Of Havana; Cuba
Fil: Betancourt Mar, J. A.. Universidad de La Habana; Cuba
Fil: Martín Pardo, Reinaldo Román. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina. Mexican Institute Of Complex Systems. Tamaulipas; México
Fil: Silva Lamar, Eduardo. Universidad de La Habana; Cuba
Fil: Bizzarri, María Julia. Universidad de La Habana; Cuba
Fil: Cocho, G.. Universidad Nacional Autónoma de México; México
Fil: Mansilla, R.. Universidad Nacional Autónoma de México; México
Fil: Nieto Villar, José Manuel. Universidad de La Habana; Cuba
Materia
BIOLOGICAL PHASE TRANSITION
ENTROPY PRODUCTION RATE
EPITHELIAL–MESENCHYMAL TRANSITION
PHENOTYPIC TRANSITIONS IN CANCER CELL EVOLUTION
TUMOR-MICROENVIRONMENT CROSS-TALK
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/120752
Acceder
id CONICETDig_5aeb3088b6d62b2a3df45d37ae9c8e63
oai_identifier_str oai:ri.conicet.gov.ar:11336/120752
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Phase transitions in tumor growth VI: Epithelial–Mesenchymal transitionGuerra, A.Rodriguez, D. J.Montero, S.Betancourt Mar, J. A.Martín Pardo, Reinaldo RománSilva Lamar, EduardoBizzarri, María JuliaCocho, G.Mansilla, R.Nieto Villar, José ManuelBIOLOGICAL PHASE TRANSITIONENTROPY PRODUCTION RATEEPITHELIAL–MESENCHYMAL TRANSITIONPHENOTYPIC TRANSITIONS IN CANCER CELL EVOLUTIONTUMOR-MICROENVIRONMENT CROSS-TALKhttps://purl.org/becyt/ford/1.1https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Herewith we discuss a network model of the epithelial–mesenchymal transition (EMT) based on our previous proposed framework. The EMT appears as a “first order” phase transition process, analogous to the transitions observed in the chemical–physical field. Chiefly, EMT should be considered a transition characterized by a supercritical Andronov–Hopf bifurcation, with the emergence of limit cycle and, consequently, a cascade of saddle-foci Shilnikov's bifurcations. We eventually show that the entropy production rate is an EMT-dependent function and, as such, its formalism reminds the van der Waals equation.Fil: Guerra, A.. Universidad de La Habana; CubaFil: Rodriguez, D. J.. Universidad de La Habana; CubaFil: Montero, S.. Medical Sciences University Of Havana; CubaFil: Betancourt Mar, J. A.. Universidad de La Habana; CubaFil: Martín Pardo, Reinaldo Román. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina. Mexican Institute Of Complex Systems. Tamaulipas; MéxicoFil: Silva Lamar, Eduardo. Universidad de La Habana; CubaFil: Bizzarri, María Julia. Universidad de La Habana; CubaFil: Cocho, G.. Universidad Nacional Autónoma de México; MéxicoFil: Mansilla, R.. Universidad Nacional Autónoma de México; MéxicoFil: Nieto Villar, José Manuel. Universidad de La Habana; CubaElsevier Science2018-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/120752Guerra, A.; Rodriguez, D. J.; Montero, S.; Betancourt Mar, J. A.; Martín Pardo, Reinaldo Román; et al.; Phase transitions in tumor growth VI: Epithelial–Mesenchymal transition; Elsevier Science; Physica A: Statistical Mechanics and its Applications; 499; 6-2018; 208-2150378-4371CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0378437118300700info:eu-repo/semantics/altIdentifier/doi/10.1016/j.physa.2018.01.040info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:52Zoai:ri.conicet.gov.ar:11336/120752instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:53.051CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Phase transitions in tumor growth VI: Epithelial–Mesenchymal transition
title Phase transitions in tumor growth VI: Epithelial–Mesenchymal transition
spellingShingle Phase transitions in tumor growth VI: Epithelial–Mesenchymal transition
Guerra, A.
BIOLOGICAL PHASE TRANSITION
ENTROPY PRODUCTION RATE
EPITHELIAL–MESENCHYMAL TRANSITION
PHENOTYPIC TRANSITIONS IN CANCER CELL EVOLUTION
TUMOR-MICROENVIRONMENT CROSS-TALK
title_short Phase transitions in tumor growth VI: Epithelial–Mesenchymal transition
title_full Phase transitions in tumor growth VI: Epithelial–Mesenchymal transition
title_fullStr Phase transitions in tumor growth VI: Epithelial–Mesenchymal transition
title_full_unstemmed Phase transitions in tumor growth VI: Epithelial–Mesenchymal transition
title_sort Phase transitions in tumor growth VI: Epithelial–Mesenchymal transition
dc.creator.none.fl_str_mv Guerra, A.
Rodriguez, D. J.
Montero, S.
Betancourt Mar, J. A.
Martín Pardo, Reinaldo Román
Silva Lamar, Eduardo
Bizzarri, María Julia
Cocho, G.
Mansilla, R.
Nieto Villar, José Manuel
author Guerra, A.
author_facet Guerra, A.
Rodriguez, D. J.
Montero, S.
Betancourt Mar, J. A.
Martín Pardo, Reinaldo Román
Silva Lamar, Eduardo
Bizzarri, María Julia
Cocho, G.
Mansilla, R.
Nieto Villar, José Manuel
author_role author
author2 Rodriguez, D. J.
Montero, S.
Betancourt Mar, J. A.
Martín Pardo, Reinaldo Román
Silva Lamar, Eduardo
Bizzarri, María Julia
Cocho, G.
Mansilla, R.
Nieto Villar, José Manuel
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BIOLOGICAL PHASE TRANSITION
ENTROPY PRODUCTION RATE
EPITHELIAL–MESENCHYMAL TRANSITION
PHENOTYPIC TRANSITIONS IN CANCER CELL EVOLUTION
TUMOR-MICROENVIRONMENT CROSS-TALK
topic BIOLOGICAL PHASE TRANSITION
ENTROPY PRODUCTION RATE
EPITHELIAL–MESENCHYMAL TRANSITION
PHENOTYPIC TRANSITIONS IN CANCER CELL EVOLUTION
TUMOR-MICROENVIRONMENT CROSS-TALK
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.1
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Herewith we discuss a network model of the epithelial–mesenchymal transition (EMT) based on our previous proposed framework. The EMT appears as a “first order” phase transition process, analogous to the transitions observed in the chemical–physical field. Chiefly, EMT should be considered a transition characterized by a supercritical Andronov–Hopf bifurcation, with the emergence of limit cycle and, consequently, a cascade of saddle-foci Shilnikov's bifurcations. We eventually show that the entropy production rate is an EMT-dependent function and, as such, its formalism reminds the van der Waals equation.
Fil: Guerra, A.. Universidad de La Habana; Cuba
Fil: Rodriguez, D. J.. Universidad de La Habana; Cuba
Fil: Montero, S.. Medical Sciences University Of Havana; Cuba
Fil: Betancourt Mar, J. A.. Universidad de La Habana; Cuba
Fil: Martín Pardo, Reinaldo Román. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina. Mexican Institute Of Complex Systems. Tamaulipas; México
Fil: Silva Lamar, Eduardo. Universidad de La Habana; Cuba
Fil: Bizzarri, María Julia. Universidad de La Habana; Cuba
Fil: Cocho, G.. Universidad Nacional Autónoma de México; México
Fil: Mansilla, R.. Universidad Nacional Autónoma de México; México
Fil: Nieto Villar, José Manuel. Universidad de La Habana; Cuba
description Herewith we discuss a network model of the epithelial–mesenchymal transition (EMT) based on our previous proposed framework. The EMT appears as a “first order” phase transition process, analogous to the transitions observed in the chemical–physical field. Chiefly, EMT should be considered a transition characterized by a supercritical Andronov–Hopf bifurcation, with the emergence of limit cycle and, consequently, a cascade of saddle-foci Shilnikov's bifurcations. We eventually show that the entropy production rate is an EMT-dependent function and, as such, its formalism reminds the van der Waals equation.
publishDate 2018
dc.date.none.fl_str_mv 2018-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/120752
Guerra, A.; Rodriguez, D. J.; Montero, S.; Betancourt Mar, J. A.; Martín Pardo, Reinaldo Román; et al.; Phase transitions in tumor growth VI: Epithelial–Mesenchymal transition; Elsevier Science; Physica A: Statistical Mechanics and its Applications; 499; 6-2018; 208-215
0378-4371
CONICET Digital
CONICET
url http://hdl.handle.net/11336/120752
identifier_str_mv Guerra, A.; Rodriguez, D. J.; Montero, S.; Betancourt Mar, J. A.; Martín Pardo, Reinaldo Román; et al.; Phase transitions in tumor growth VI: Epithelial–Mesenchymal transition; Elsevier Science; Physica A: Statistical Mechanics and its Applications; 499; 6-2018; 208-215
0378-4371
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0378437118300700
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.physa.2018.01.040
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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