A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells

Autores
Lioudyno, Maria; Hiel, Hakim; Kong, Jee-Hyun; Katz, Eleonora; Waldman, Erik; Parameshwaran Iyer, Suchitra; Glowatzki, Elisabeth; Fuchs, Paul A.
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cochlear hair cells are inhibited by cholinergic efferent neurons. The acetylcholine (ACh) receptor of the hair cell is a ligand-gated cation channel through which calcium enters to activate potassium channels and hyperpolarize the cell. It has been proposed that calcium-induced calcium release (CICR) from a near-membrane postsynaptic store supplements this process. Here, we demonstrate expression of type I ryanodine receptors in outer hair cells in the apical turn of the rat cochlea. Consistent with this finding, ryanodine and other store-active compounds alter the amplitude of transient currents produced by synaptic release of ACh, as well as the response of the hair cell to exogenous ACh. Like the sarcoplasmic reticulum of muscle, the "synaptoplasmic" cistern of the hair cell efficiently couples synaptic input to CICR.
Fil: Lioudyno, Maria. Johns Hopkins University School of Medicine; Estados Unidos
Fil: Hiel, Hakim. Johns Hopkins University School of Medicine; Estados Unidos
Fil: Kong, Jee-Hyun. Johns Hopkins University School of Medicine; Estados Unidos
Fil: Katz, Eleonora. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Waldman, Erik. Johns Hopkins University School of Medicine; Estados Unidos
Fil: Parameshwaran Iyer, Suchitra. Johns Hopkins University School of Medicine; Estados Unidos
Fil: Glowatzki, Elisabeth. Johns Hopkins University School of Medicine; Estados Unidos
Fil: Fuchs, Paul A.. Johns Hopkins University School of Medicine; Estados Unidos
Materia
ACETYLCHOLINE
CALCIUM
COCHLEA
HAIR CELL
INHIBITION
NICOTINIC
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/79904
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/79904
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cellsLioudyno, MariaHiel, HakimKong, Jee-HyunKatz, EleonoraWaldman, ErikParameshwaran Iyer, SuchitraGlowatzki, ElisabethFuchs, Paul A.ACETYLCHOLINECALCIUMCOCHLEAHAIR CELLINHIBITIONNICOTINIChttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Cochlear hair cells are inhibited by cholinergic efferent neurons. The acetylcholine (ACh) receptor of the hair cell is a ligand-gated cation channel through which calcium enters to activate potassium channels and hyperpolarize the cell. It has been proposed that calcium-induced calcium release (CICR) from a near-membrane postsynaptic store supplements this process. Here, we demonstrate expression of type I ryanodine receptors in outer hair cells in the apical turn of the rat cochlea. Consistent with this finding, ryanodine and other store-active compounds alter the amplitude of transient currents produced by synaptic release of ACh, as well as the response of the hair cell to exogenous ACh. Like the sarcoplasmic reticulum of muscle, the "synaptoplasmic" cistern of the hair cell efficiently couples synaptic input to CICR.Fil: Lioudyno, Maria. Johns Hopkins University School of Medicine; Estados UnidosFil: Hiel, Hakim. Johns Hopkins University School of Medicine; Estados UnidosFil: Kong, Jee-Hyun. Johns Hopkins University School of Medicine; Estados UnidosFil: Katz, Eleonora. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Waldman, Erik. Johns Hopkins University School of Medicine; Estados UnidosFil: Parameshwaran Iyer, Suchitra. Johns Hopkins University School of Medicine; Estados UnidosFil: Glowatzki, Elisabeth. Johns Hopkins University School of Medicine; Estados UnidosFil: Fuchs, Paul A.. Johns Hopkins University School of Medicine; Estados UnidosSociety for Neuroscience2004-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79904Lioudyno, Maria; Hiel, Hakim; Kong, Jee-Hyun; Katz, Eleonora; Waldman, Erik; et al.; A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells; Society for Neuroscience; Journal of Neuroscience; 24; 49; 12-2004; 11160-111640270-6474CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.jneurosci.org/content/24/49/11160info:eu-repo/semantics/altIdentifier/doi/10.1523/JNEUROSCI.3674-04.2004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:57Zoai:ri.conicet.gov.ar:11336/79904instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:58.323CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells
title A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells
spellingShingle A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells
Lioudyno, Maria
ACETYLCHOLINE
CALCIUM
COCHLEA
HAIR CELL
INHIBITION
NICOTINIC
title_short A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells
title_full A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells
title_fullStr A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells
title_full_unstemmed A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells
title_sort A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells
dc.creator.none.fl_str_mv Lioudyno, Maria
Hiel, Hakim
Kong, Jee-Hyun
Katz, Eleonora
Waldman, Erik
Parameshwaran Iyer, Suchitra
Glowatzki, Elisabeth
Fuchs, Paul A.
author Lioudyno, Maria
author_facet Lioudyno, Maria
Hiel, Hakim
Kong, Jee-Hyun
Katz, Eleonora
Waldman, Erik
Parameshwaran Iyer, Suchitra
Glowatzki, Elisabeth
Fuchs, Paul A.
author_role author
author2 Hiel, Hakim
Kong, Jee-Hyun
Katz, Eleonora
Waldman, Erik
Parameshwaran Iyer, Suchitra
Glowatzki, Elisabeth
Fuchs, Paul A.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ACETYLCHOLINE
CALCIUM
COCHLEA
HAIR CELL
INHIBITION
NICOTINIC
topic ACETYLCHOLINE
CALCIUM
COCHLEA
HAIR CELL
INHIBITION
NICOTINIC
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Cochlear hair cells are inhibited by cholinergic efferent neurons. The acetylcholine (ACh) receptor of the hair cell is a ligand-gated cation channel through which calcium enters to activate potassium channels and hyperpolarize the cell. It has been proposed that calcium-induced calcium release (CICR) from a near-membrane postsynaptic store supplements this process. Here, we demonstrate expression of type I ryanodine receptors in outer hair cells in the apical turn of the rat cochlea. Consistent with this finding, ryanodine and other store-active compounds alter the amplitude of transient currents produced by synaptic release of ACh, as well as the response of the hair cell to exogenous ACh. Like the sarcoplasmic reticulum of muscle, the "synaptoplasmic" cistern of the hair cell efficiently couples synaptic input to CICR.
Fil: Lioudyno, Maria. Johns Hopkins University School of Medicine; Estados Unidos
Fil: Hiel, Hakim. Johns Hopkins University School of Medicine; Estados Unidos
Fil: Kong, Jee-Hyun. Johns Hopkins University School of Medicine; Estados Unidos
Fil: Katz, Eleonora. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Waldman, Erik. Johns Hopkins University School of Medicine; Estados Unidos
Fil: Parameshwaran Iyer, Suchitra. Johns Hopkins University School of Medicine; Estados Unidos
Fil: Glowatzki, Elisabeth. Johns Hopkins University School of Medicine; Estados Unidos
Fil: Fuchs, Paul A.. Johns Hopkins University School of Medicine; Estados Unidos
description Cochlear hair cells are inhibited by cholinergic efferent neurons. The acetylcholine (ACh) receptor of the hair cell is a ligand-gated cation channel through which calcium enters to activate potassium channels and hyperpolarize the cell. It has been proposed that calcium-induced calcium release (CICR) from a near-membrane postsynaptic store supplements this process. Here, we demonstrate expression of type I ryanodine receptors in outer hair cells in the apical turn of the rat cochlea. Consistent with this finding, ryanodine and other store-active compounds alter the amplitude of transient currents produced by synaptic release of ACh, as well as the response of the hair cell to exogenous ACh. Like the sarcoplasmic reticulum of muscle, the "synaptoplasmic" cistern of the hair cell efficiently couples synaptic input to CICR.
publishDate 2004
dc.date.none.fl_str_mv 2004-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79904
Lioudyno, Maria; Hiel, Hakim; Kong, Jee-Hyun; Katz, Eleonora; Waldman, Erik; et al.; A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells; Society for Neuroscience; Journal of Neuroscience; 24; 49; 12-2004; 11160-11164
0270-6474
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79904
identifier_str_mv Lioudyno, Maria; Hiel, Hakim; Kong, Jee-Hyun; Katz, Eleonora; Waldman, Erik; et al.; A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells; Society for Neuroscience; Journal of Neuroscience; 24; 49; 12-2004; 11160-11164
0270-6474
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.jneurosci.org/content/24/49/11160
info:eu-repo/semantics/altIdentifier/doi/10.1523/JNEUROSCI.3674-04.2004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Society for Neuroscience
publisher.none.fl_str_mv Society for Neuroscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269127474937856
score 13.13397

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