Diversity of Rabies Virus Variants in Insectivorous Bats (Chiroptera: Vespertilionidae and Molossidae): An Epidemiological Study in Central Argentine Patagonia

Autores
Giménez, Analía Laura; Zabalza, Marcelo J.; Novaro, Laura P.; Centurion, Gabriela A.; Barrios Benito, Melanie Y.; Moncá, Ivana; Chaar Letourneau, Fabricio; Casanovas, Román; Russo, Susana E.
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Rabies virus (RABV) causes a fatal infection in the central nervous system of mammals. RABV circulates through two different epidemiological cycles—terrestrial and aerial—with bats being the natural reservoir of the aerial cycle. In Patagonia, only variants (V) associated with insectivorous bats have been detected. The aim of this study was to assess the diversity of circulating RABV variants in bats from Central Patagonia, Argentina. Fifty-six samples of seven bat species from eleven localities in Chubut province were analyzed using a direct immunofluorescence and biological assay, while antigenic variants were determined using an indirect immunofluorescence test. Twelve samples tested positive for RABV (>21%). Variants V4 and V6 were identified in samples of T. brasiliensis and L. varius, respectively. The remaining positive samples did not exhibit any antigenic pattern previously identified in Argentina. These samples were associated with H. macrotus, H. magellanicus, H. montanus, and L. varius. Our results confirm RABV circulation in over 71% of the bat species analyzed and in over 63% of the localities assessed. We recommend maintaining active surveillance at both local and regional levels to ensure the early detection of cases and transmission risks, which is crucial for disease prevention and control.
Fil: Giménez, Analía Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Centro de Investigación Esquel de Montaña y Estepa Patagóica. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Esquel. Centro de Investigación Esquel de Montaña y Estepa Patagónica; Argentina
Fil: Zabalza, Marcelo J.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Novaro, Laura P.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Centurion, Gabriela A.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Barrios Benito, Melanie Y.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Moncá, Ivana. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Chaar Letourneau, Fabricio. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Casanovas, Román. Departamento de Zooantroponosis. Division Cushamen; Argentina
Fil: Russo, Susana E.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Materia
RABIES
INSECTIVOROUS BATS
PATAGONIA
ANTIGENIC VARIANTS
EPIDEMIOLOGICAL SURVEILLANCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/269360
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/269360
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Diversity of Rabies Virus Variants in Insectivorous Bats (Chiroptera: Vespertilionidae and Molossidae): An Epidemiological Study in Central Argentine PatagoniaGiménez, Analía LauraZabalza, Marcelo J.Novaro, Laura P.Centurion, Gabriela A.Barrios Benito, Melanie Y.Moncá, IvanaChaar Letourneau, FabricioCasanovas, RománRusso, Susana E.RABIESINSECTIVOROUS BATSPATAGONIAANTIGENIC VARIANTSEPIDEMIOLOGICAL SURVEILLANCEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Rabies virus (RABV) causes a fatal infection in the central nervous system of mammals. RABV circulates through two different epidemiological cycles—terrestrial and aerial—with bats being the natural reservoir of the aerial cycle. In Patagonia, only variants (V) associated with insectivorous bats have been detected. The aim of this study was to assess the diversity of circulating RABV variants in bats from Central Patagonia, Argentina. Fifty-six samples of seven bat species from eleven localities in Chubut province were analyzed using a direct immunofluorescence and biological assay, while antigenic variants were determined using an indirect immunofluorescence test. Twelve samples tested positive for RABV (>21%). Variants V4 and V6 were identified in samples of T. brasiliensis and L. varius, respectively. The remaining positive samples did not exhibit any antigenic pattern previously identified in Argentina. These samples were associated with H. macrotus, H. magellanicus, H. montanus, and L. varius. Our results confirm RABV circulation in over 71% of the bat species analyzed and in over 63% of the localities assessed. We recommend maintaining active surveillance at both local and regional levels to ensure the early detection of cases and transmission risks, which is crucial for disease prevention and control.Fil: Giménez, Analía Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Centro de Investigación Esquel de Montaña y Estepa Patagóica. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Esquel. Centro de Investigación Esquel de Montaña y Estepa Patagónica; ArgentinaFil: Zabalza, Marcelo J.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; ArgentinaFil: Novaro, Laura P.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; ArgentinaFil: Centurion, Gabriela A.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; ArgentinaFil: Barrios Benito, Melanie Y.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; ArgentinaFil: Moncá, Ivana. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; ArgentinaFil: Chaar Letourneau, Fabricio. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; ArgentinaFil: Casanovas, Román. Departamento de Zooantroponosis. Division Cushamen; ArgentinaFil: Russo, Susana E.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; ArgentinaMultidisciplinary Digital Publishing Institute2025-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/269360Giménez, Analía Laura; Zabalza, Marcelo J.; Novaro, Laura P.; Centurion, Gabriela A.; Barrios Benito, Melanie Y.; et al.; Diversity of Rabies Virus Variants in Insectivorous Bats (Chiroptera: Vespertilionidae and Molossidae): An Epidemiological Study in Central Argentine Patagonia; Multidisciplinary Digital Publishing Institute; Viruses; 17; 6; 5-2025; 1-91999-4915CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/v17060788info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4915/17/6/788info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:05:58Zoai:ri.conicet.gov.ar:11336/269360instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:05:58.789CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Diversity of Rabies Virus Variants in Insectivorous Bats (Chiroptera: Vespertilionidae and Molossidae): An Epidemiological Study in Central Argentine Patagonia
title Diversity of Rabies Virus Variants in Insectivorous Bats (Chiroptera: Vespertilionidae and Molossidae): An Epidemiological Study in Central Argentine Patagonia
spellingShingle Diversity of Rabies Virus Variants in Insectivorous Bats (Chiroptera: Vespertilionidae and Molossidae): An Epidemiological Study in Central Argentine Patagonia
Giménez, Analía Laura
RABIES
INSECTIVOROUS BATS
PATAGONIA
ANTIGENIC VARIANTS
EPIDEMIOLOGICAL SURVEILLANCE
title_short Diversity of Rabies Virus Variants in Insectivorous Bats (Chiroptera: Vespertilionidae and Molossidae): An Epidemiological Study in Central Argentine Patagonia
title_full Diversity of Rabies Virus Variants in Insectivorous Bats (Chiroptera: Vespertilionidae and Molossidae): An Epidemiological Study in Central Argentine Patagonia
title_fullStr Diversity of Rabies Virus Variants in Insectivorous Bats (Chiroptera: Vespertilionidae and Molossidae): An Epidemiological Study in Central Argentine Patagonia
title_full_unstemmed Diversity of Rabies Virus Variants in Insectivorous Bats (Chiroptera: Vespertilionidae and Molossidae): An Epidemiological Study in Central Argentine Patagonia
title_sort Diversity of Rabies Virus Variants in Insectivorous Bats (Chiroptera: Vespertilionidae and Molossidae): An Epidemiological Study in Central Argentine Patagonia
dc.creator.none.fl_str_mv Giménez, Analía Laura
Zabalza, Marcelo J.
Novaro, Laura P.
Centurion, Gabriela A.
Barrios Benito, Melanie Y.
Moncá, Ivana
Chaar Letourneau, Fabricio
Casanovas, Román
Russo, Susana E.
author Giménez, Analía Laura
author_facet Giménez, Analía Laura
Zabalza, Marcelo J.
Novaro, Laura P.
Centurion, Gabriela A.
Barrios Benito, Melanie Y.
Moncá, Ivana
Chaar Letourneau, Fabricio
Casanovas, Román
Russo, Susana E.
author_role author
author2 Zabalza, Marcelo J.
Novaro, Laura P.
Centurion, Gabriela A.
Barrios Benito, Melanie Y.
Moncá, Ivana
Chaar Letourneau, Fabricio
Casanovas, Román
Russo, Susana E.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv RABIES
INSECTIVOROUS BATS
PATAGONIA
ANTIGENIC VARIANTS
EPIDEMIOLOGICAL SURVEILLANCE
topic RABIES
INSECTIVOROUS BATS
PATAGONIA
ANTIGENIC VARIANTS
EPIDEMIOLOGICAL SURVEILLANCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Rabies virus (RABV) causes a fatal infection in the central nervous system of mammals. RABV circulates through two different epidemiological cycles—terrestrial and aerial—with bats being the natural reservoir of the aerial cycle. In Patagonia, only variants (V) associated with insectivorous bats have been detected. The aim of this study was to assess the diversity of circulating RABV variants in bats from Central Patagonia, Argentina. Fifty-six samples of seven bat species from eleven localities in Chubut province were analyzed using a direct immunofluorescence and biological assay, while antigenic variants were determined using an indirect immunofluorescence test. Twelve samples tested positive for RABV (>21%). Variants V4 and V6 were identified in samples of T. brasiliensis and L. varius, respectively. The remaining positive samples did not exhibit any antigenic pattern previously identified in Argentina. These samples were associated with H. macrotus, H. magellanicus, H. montanus, and L. varius. Our results confirm RABV circulation in over 71% of the bat species analyzed and in over 63% of the localities assessed. We recommend maintaining active surveillance at both local and regional levels to ensure the early detection of cases and transmission risks, which is crucial for disease prevention and control.
Fil: Giménez, Analía Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Centro de Investigación Esquel de Montaña y Estepa Patagóica. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Esquel. Centro de Investigación Esquel de Montaña y Estepa Patagónica; Argentina
Fil: Zabalza, Marcelo J.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Novaro, Laura P.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Centurion, Gabriela A.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Barrios Benito, Melanie Y.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Moncá, Ivana. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Chaar Letourneau, Fabricio. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Casanovas, Román. Departamento de Zooantroponosis. Division Cushamen; Argentina
Fil: Russo, Susana E.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
description Rabies virus (RABV) causes a fatal infection in the central nervous system of mammals. RABV circulates through two different epidemiological cycles—terrestrial and aerial—with bats being the natural reservoir of the aerial cycle. In Patagonia, only variants (V) associated with insectivorous bats have been detected. The aim of this study was to assess the diversity of circulating RABV variants in bats from Central Patagonia, Argentina. Fifty-six samples of seven bat species from eleven localities in Chubut province were analyzed using a direct immunofluorescence and biological assay, while antigenic variants were determined using an indirect immunofluorescence test. Twelve samples tested positive for RABV (>21%). Variants V4 and V6 were identified in samples of T. brasiliensis and L. varius, respectively. The remaining positive samples did not exhibit any antigenic pattern previously identified in Argentina. These samples were associated with H. macrotus, H. magellanicus, H. montanus, and L. varius. Our results confirm RABV circulation in over 71% of the bat species analyzed and in over 63% of the localities assessed. We recommend maintaining active surveillance at both local and regional levels to ensure the early detection of cases and transmission risks, which is crucial for disease prevention and control.
publishDate 2025
dc.date.none.fl_str_mv 2025-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/269360
Giménez, Analía Laura; Zabalza, Marcelo J.; Novaro, Laura P.; Centurion, Gabriela A.; Barrios Benito, Melanie Y.; et al.; Diversity of Rabies Virus Variants in Insectivorous Bats (Chiroptera: Vespertilionidae and Molossidae): An Epidemiological Study in Central Argentine Patagonia; Multidisciplinary Digital Publishing Institute; Viruses; 17; 6; 5-2025; 1-9
1999-4915
CONICET Digital
CONICET
url http://hdl.handle.net/11336/269360
identifier_str_mv Giménez, Analía Laura; Zabalza, Marcelo J.; Novaro, Laura P.; Centurion, Gabriela A.; Barrios Benito, Melanie Y.; et al.; Diversity of Rabies Virus Variants in Insectivorous Bats (Chiroptera: Vespertilionidae and Molossidae): An Epidemiological Study in Central Argentine Patagonia; Multidisciplinary Digital Publishing Institute; Viruses; 17; 6; 5-2025; 1-9
1999-4915
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/v17060788
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4915/17/6/788
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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