A, B, C’s of Trk Receptors and Their Ligands in Ocular Repair

Autores
Gupta, Akash; Galletti, Jeremías Gastón; Yu, Zhiyuan; Burgess, Kevin; de Paiva, Cintia S.
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Neurotrophins are a family of closely related secreted proteins that promote differentiation, development, and survival of neurons, which include nerve growth factor (NGF), brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4. All neurotrophins signal through tropomyosin receptor kinases (TrkA, TrkB, and TrkC) which are more selective to NGF, brain-derived neurotrophic factor, and neurotrophin-3, respectively. NGF is the most studied neurotrophin in the ocular surface and a human recombinant NGF has reached clinics, having been approved to treat neurotrophic keratitis. Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are less studied neurotrophins in the ocular surface, even though brain-derived neurotrophic factor is well characterized in glaucoma, retina, and neuroscience. Recently, neurotrophin analogs with panTrk activity and TrkC selectivity have shown promise as novel drugs for treating dry eye disease. In this review, we discuss the biology of the neurotrophin family, its role in corneal homeostasis, and its use in treating ocular surface diseases. There is an unmet need to investigate parenteral neurotrophins and its analogs that activate TrkB and TrkC selectively.
Fil: Gupta, Akash. Baylor College of Medicine; Estados Unidos
Fil: Galletti, Jeremías Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Yu, Zhiyuan. Baylor College of Medicine; Estados Unidos
Fil: Burgess, Kevin. Texas A&M University; Estados Unidos
Fil: de Paiva, Cintia S.. Baylor College of Medicine; Estados Unidos
Materia
NERVE GROWTH FACTOR
NEUROTROPHIC KERATITIS
NEUROTROPHINS
OCULAR SURFACE
TRK RECEPTORS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/210659
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A, B, C’s of Trk Receptors and Their Ligands in Ocular RepairGupta, AkashGalletti, Jeremías GastónYu, ZhiyuanBurgess, Kevinde Paiva, Cintia S.NERVE GROWTH FACTORNEUROTROPHIC KERATITISNEUROTROPHINSOCULAR SURFACETRK RECEPTORShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Neurotrophins are a family of closely related secreted proteins that promote differentiation, development, and survival of neurons, which include nerve growth factor (NGF), brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4. All neurotrophins signal through tropomyosin receptor kinases (TrkA, TrkB, and TrkC) which are more selective to NGF, brain-derived neurotrophic factor, and neurotrophin-3, respectively. NGF is the most studied neurotrophin in the ocular surface and a human recombinant NGF has reached clinics, having been approved to treat neurotrophic keratitis. Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are less studied neurotrophins in the ocular surface, even though brain-derived neurotrophic factor is well characterized in glaucoma, retina, and neuroscience. Recently, neurotrophin analogs with panTrk activity and TrkC selectivity have shown promise as novel drugs for treating dry eye disease. In this review, we discuss the biology of the neurotrophin family, its role in corneal homeostasis, and its use in treating ocular surface diseases. There is an unmet need to investigate parenteral neurotrophins and its analogs that activate TrkB and TrkC selectively.Fil: Gupta, Akash. Baylor College of Medicine; Estados UnidosFil: Galletti, Jeremías Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Yu, Zhiyuan. Baylor College of Medicine; Estados UnidosFil: Burgess, Kevin. Texas A&M University; Estados UnidosFil: de Paiva, Cintia S.. Baylor College of Medicine; Estados UnidosMolecular Diversity Preservation International2022-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/210659Gupta, Akash; Galletti, Jeremías Gastón; Yu, Zhiyuan; Burgess, Kevin; de Paiva, Cintia S.; A, B, C’s of Trk Receptors and Their Ligands in Ocular Repair; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 23; 22; 11-2022; 1-121422-0067CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/23/22/14069info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms232214069info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:12:13Zoai:ri.conicet.gov.ar:11336/210659instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:12:13.443CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A, B, C’s of Trk Receptors and Their Ligands in Ocular Repair
title A, B, C’s of Trk Receptors and Their Ligands in Ocular Repair
spellingShingle A, B, C’s of Trk Receptors and Their Ligands in Ocular Repair
Gupta, Akash
NERVE GROWTH FACTOR
NEUROTROPHIC KERATITIS
NEUROTROPHINS
OCULAR SURFACE
TRK RECEPTORS
title_short A, B, C’s of Trk Receptors and Their Ligands in Ocular Repair
title_full A, B, C’s of Trk Receptors and Their Ligands in Ocular Repair
title_fullStr A, B, C’s of Trk Receptors and Their Ligands in Ocular Repair
title_full_unstemmed A, B, C’s of Trk Receptors and Their Ligands in Ocular Repair
title_sort A, B, C’s of Trk Receptors and Their Ligands in Ocular Repair
dc.creator.none.fl_str_mv Gupta, Akash
Galletti, Jeremías Gastón
Yu, Zhiyuan
Burgess, Kevin
de Paiva, Cintia S.
author Gupta, Akash
author_facet Gupta, Akash
Galletti, Jeremías Gastón
Yu, Zhiyuan
Burgess, Kevin
de Paiva, Cintia S.
author_role author
author2 Galletti, Jeremías Gastón
Yu, Zhiyuan
Burgess, Kevin
de Paiva, Cintia S.
author2_role author
author
author
author
dc.subject.none.fl_str_mv NERVE GROWTH FACTOR
NEUROTROPHIC KERATITIS
NEUROTROPHINS
OCULAR SURFACE
TRK RECEPTORS
topic NERVE GROWTH FACTOR
NEUROTROPHIC KERATITIS
NEUROTROPHINS
OCULAR SURFACE
TRK RECEPTORS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Neurotrophins are a family of closely related secreted proteins that promote differentiation, development, and survival of neurons, which include nerve growth factor (NGF), brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4. All neurotrophins signal through tropomyosin receptor kinases (TrkA, TrkB, and TrkC) which are more selective to NGF, brain-derived neurotrophic factor, and neurotrophin-3, respectively. NGF is the most studied neurotrophin in the ocular surface and a human recombinant NGF has reached clinics, having been approved to treat neurotrophic keratitis. Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are less studied neurotrophins in the ocular surface, even though brain-derived neurotrophic factor is well characterized in glaucoma, retina, and neuroscience. Recently, neurotrophin analogs with panTrk activity and TrkC selectivity have shown promise as novel drugs for treating dry eye disease. In this review, we discuss the biology of the neurotrophin family, its role in corneal homeostasis, and its use in treating ocular surface diseases. There is an unmet need to investigate parenteral neurotrophins and its analogs that activate TrkB and TrkC selectively.
Fil: Gupta, Akash. Baylor College of Medicine; Estados Unidos
Fil: Galletti, Jeremías Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Yu, Zhiyuan. Baylor College of Medicine; Estados Unidos
Fil: Burgess, Kevin. Texas A&M University; Estados Unidos
Fil: de Paiva, Cintia S.. Baylor College of Medicine; Estados Unidos
description Neurotrophins are a family of closely related secreted proteins that promote differentiation, development, and survival of neurons, which include nerve growth factor (NGF), brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4. All neurotrophins signal through tropomyosin receptor kinases (TrkA, TrkB, and TrkC) which are more selective to NGF, brain-derived neurotrophic factor, and neurotrophin-3, respectively. NGF is the most studied neurotrophin in the ocular surface and a human recombinant NGF has reached clinics, having been approved to treat neurotrophic keratitis. Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are less studied neurotrophins in the ocular surface, even though brain-derived neurotrophic factor is well characterized in glaucoma, retina, and neuroscience. Recently, neurotrophin analogs with panTrk activity and TrkC selectivity have shown promise as novel drugs for treating dry eye disease. In this review, we discuss the biology of the neurotrophin family, its role in corneal homeostasis, and its use in treating ocular surface diseases. There is an unmet need to investigate parenteral neurotrophins and its analogs that activate TrkB and TrkC selectively.
publishDate 2022
dc.date.none.fl_str_mv 2022-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/210659
Gupta, Akash; Galletti, Jeremías Gastón; Yu, Zhiyuan; Burgess, Kevin; de Paiva, Cintia S.; A, B, C’s of Trk Receptors and Their Ligands in Ocular Repair; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 23; 22; 11-2022; 1-12
1422-0067
CONICET Digital
CONICET
url http://hdl.handle.net/11336/210659
identifier_str_mv Gupta, Akash; Galletti, Jeremías Gastón; Yu, Zhiyuan; Burgess, Kevin; de Paiva, Cintia S.; A, B, C’s of Trk Receptors and Their Ligands in Ocular Repair; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 23; 22; 11-2022; 1-12
1422-0067
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/23/22/14069
info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms232214069
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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