TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targets

Autores
Danelon, Víctor; Cragnolini, Andrea Beatriz; Masco, Daniel Hugo
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Several neurological conditions share a characteristic feature: an increase in intracellular calcium levels ([Ca2+]i). It has been demonstrated that calcium influx induces changes ranging from an increase in the expression levels of several genes to the activation of proteases such as calpains. Calpains are a family of Ca2+-dependent non-lysosomal cysteine proteases, whose substrates include several proteins that play critical roles in several cellular functions including synaptic plasticity and neuronal apoptosis. TrkB is a type of tyrosine related kinase receptor that can promote neuronal survival and differentiation upon ligand binding. It has been recently shown that in several neurological diseases, the level of full-length TrkB protein decreases before the onset of neuronal death due to one of two different processes: a) a reverse regulation of TrkB isoforms mRNA, or b) calpainmediated processing of TrkB full-length, which yields a truncated form of TrkB (Tc-TrkB). Because the most notorious feature of calpain proteolytic activity is that the products of calpain-mediated leavage may have biological activity, here we review the hypotheses by which calpain- generated isoform Tc-TrkB may perform biological functions.
Fil: Danelon, Víctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Cragnolini, Andrea Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Masco, Daniel Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Materia
TrkB
TrkB-Tk
Tc-TrkB
CALPAIN
NEUROLOGICAL CONDITIONS
INTERECELLULAR CALCIUM LEVELS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/42424
Acceder
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network_name_str CONICET Digital (CONICET)
spelling TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targetsDanelon, VíctorCragnolini, Andrea BeatrizMasco, Daniel HugoTrkBTrkB-TkTc-TrkBCALPAINNEUROLOGICAL CONDITIONSINTERECELLULAR CALCIUM LEVELShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Several neurological conditions share a characteristic feature: an increase in intracellular calcium levels ([Ca2+]i). It has been demonstrated that calcium influx induces changes ranging from an increase in the expression levels of several genes to the activation of proteases such as calpains. Calpains are a family of Ca2+-dependent non-lysosomal cysteine proteases, whose substrates include several proteins that play critical roles in several cellular functions including synaptic plasticity and neuronal apoptosis. TrkB is a type of tyrosine related kinase receptor that can promote neuronal survival and differentiation upon ligand binding. It has been recently shown that in several neurological diseases, the level of full-length TrkB protein decreases before the onset of neuronal death due to one of two different processes: a) a reverse regulation of TrkB isoforms mRNA, or b) calpainmediated processing of TrkB full-length, which yields a truncated form of TrkB (Tc-TrkB). Because the most notorious feature of calpain proteolytic activity is that the products of calpain-mediated leavage may have biological activity, here we review the hypotheses by which calpain- generated isoform Tc-TrkB may perform biological functions.Fil: Danelon, Víctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Cragnolini, Andrea Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Masco, Daniel Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaSciaccess Publishers2016-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/42424Danelon, Víctor; Cragnolini, Andrea Beatriz; Masco, Daniel Hugo; TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targets; Sciaccess Publishers; Journal of Neurology and Neuromedicine; 1; 7; 12-2016; 31-362572-942XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.jneurology.com/articles/trkb-and-the-calpain-dependenttc-trkb-receptor-isoforms-possible-neurological-therapeutic-targets-neuromed-1-1076.phpinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:40:47Zoai:ri.conicet.gov.ar:11336/42424instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:40:47.539CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targets
title TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targets
spellingShingle TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targets
Danelon, Víctor
TrkB
TrkB-Tk
Tc-TrkB
CALPAIN
NEUROLOGICAL CONDITIONS
INTERECELLULAR CALCIUM LEVELS
title_short TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targets
title_full TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targets
title_fullStr TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targets
title_full_unstemmed TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targets
title_sort TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targets
dc.creator.none.fl_str_mv Danelon, Víctor
Cragnolini, Andrea Beatriz
Masco, Daniel Hugo
author Danelon, Víctor
author_facet Danelon, Víctor
Cragnolini, Andrea Beatriz
Masco, Daniel Hugo
author_role author
author2 Cragnolini, Andrea Beatriz
Masco, Daniel Hugo
author2_role author
author
dc.subject.none.fl_str_mv TrkB
TrkB-Tk
Tc-TrkB
CALPAIN
NEUROLOGICAL CONDITIONS
INTERECELLULAR CALCIUM LEVELS
topic TrkB
TrkB-Tk
Tc-TrkB
CALPAIN
NEUROLOGICAL CONDITIONS
INTERECELLULAR CALCIUM LEVELS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Several neurological conditions share a characteristic feature: an increase in intracellular calcium levels ([Ca2+]i). It has been demonstrated that calcium influx induces changes ranging from an increase in the expression levels of several genes to the activation of proteases such as calpains. Calpains are a family of Ca2+-dependent non-lysosomal cysteine proteases, whose substrates include several proteins that play critical roles in several cellular functions including synaptic plasticity and neuronal apoptosis. TrkB is a type of tyrosine related kinase receptor that can promote neuronal survival and differentiation upon ligand binding. It has been recently shown that in several neurological diseases, the level of full-length TrkB protein decreases before the onset of neuronal death due to one of two different processes: a) a reverse regulation of TrkB isoforms mRNA, or b) calpainmediated processing of TrkB full-length, which yields a truncated form of TrkB (Tc-TrkB). Because the most notorious feature of calpain proteolytic activity is that the products of calpain-mediated leavage may have biological activity, here we review the hypotheses by which calpain- generated isoform Tc-TrkB may perform biological functions.
Fil: Danelon, Víctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Cragnolini, Andrea Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Masco, Daniel Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
description Several neurological conditions share a characteristic feature: an increase in intracellular calcium levels ([Ca2+]i). It has been demonstrated that calcium influx induces changes ranging from an increase in the expression levels of several genes to the activation of proteases such as calpains. Calpains are a family of Ca2+-dependent non-lysosomal cysteine proteases, whose substrates include several proteins that play critical roles in several cellular functions including synaptic plasticity and neuronal apoptosis. TrkB is a type of tyrosine related kinase receptor that can promote neuronal survival and differentiation upon ligand binding. It has been recently shown that in several neurological diseases, the level of full-length TrkB protein decreases before the onset of neuronal death due to one of two different processes: a) a reverse regulation of TrkB isoforms mRNA, or b) calpainmediated processing of TrkB full-length, which yields a truncated form of TrkB (Tc-TrkB). Because the most notorious feature of calpain proteolytic activity is that the products of calpain-mediated leavage may have biological activity, here we review the hypotheses by which calpain- generated isoform Tc-TrkB may perform biological functions.
publishDate 2016
dc.date.none.fl_str_mv 2016-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/42424
Danelon, Víctor; Cragnolini, Andrea Beatriz; Masco, Daniel Hugo; TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targets; Sciaccess Publishers; Journal of Neurology and Neuromedicine; 1; 7; 12-2016; 31-36
2572-942X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/42424
identifier_str_mv Danelon, Víctor; Cragnolini, Andrea Beatriz; Masco, Daniel Hugo; TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targets; Sciaccess Publishers; Journal of Neurology and Neuromedicine; 1; 7; 12-2016; 31-36
2572-942X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.jneurology.com/articles/trkb-and-the-calpain-dependenttc-trkb-receptor-isoforms-possible-neurological-therapeutic-targets-neuromed-1-1076.php
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sciaccess Publishers
publisher.none.fl_str_mv Sciaccess Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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