MiRNAfe: A comprehensive tool for feature extraction in microRNA prediction

Autores
Yones, Cristian Ariel; Stegmayer, Georgina; Kamenetzky, Laura; Milone, Diego Humberto
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
miRNAfe is a comprehensive tool to extract features from RNA sequences. It is freely available as a web service, allowing a single access point to almost all state-of-the-art feature extraction methods used today in a variety of works from different authors. It has a very simple user interface, where the user only needs to load a file containing the input sequences and select the features to extract. As a result, the user obtains a text file with the features extracted, which can be used to analyze the sequences or as input to a miRNA prediction software.The tool can calculate up to 80 features where many of them are multidimensional arrays. In order to simplify the web interface, the features have been divided into six pre-defined groups, each one providing information about: primary sequence, secondary structure, thermodynamic stability, statistical stability, conservation between genomes of different species and substrings analysis of the sequences. Additionally, pre-trained classifiers are provided for prediction in different species. All algorithms to extract the features have been validated, comparing the results with the ones obtained from software of the original authors.The source code is freely available for academic use under GPL license at http://sourceforge.net/projects/sourcesinc/files/mirnafe/0.90/. A user-friendly access is provided as web interface at http://fich.unl.edu.ar/sinc/web-demo/mirnafe/. A more configurable web interface can be accessed at http://fich.unl.edu.ar/sinc/web-demo/mirnafe-full/.
Fil: Yones, Cristian Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional; Argentina
Fil: Stegmayer, Georgina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional; Argentina
Fil: Kamenetzky, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Milone, Diego Humberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional; Argentina
Materia
Feature Extraction
Microrna
Web Tool
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38858
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/38858
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling MiRNAfe: A comprehensive tool for feature extraction in microRNA predictionYones, Cristian ArielStegmayer, GeorginaKamenetzky, LauraMilone, Diego HumbertoFeature ExtractionMicrornaWeb Toolhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1miRNAfe is a comprehensive tool to extract features from RNA sequences. It is freely available as a web service, allowing a single access point to almost all state-of-the-art feature extraction methods used today in a variety of works from different authors. It has a very simple user interface, where the user only needs to load a file containing the input sequences and select the features to extract. As a result, the user obtains a text file with the features extracted, which can be used to analyze the sequences or as input to a miRNA prediction software.The tool can calculate up to 80 features where many of them are multidimensional arrays. In order to simplify the web interface, the features have been divided into six pre-defined groups, each one providing information about: primary sequence, secondary structure, thermodynamic stability, statistical stability, conservation between genomes of different species and substrings analysis of the sequences. Additionally, pre-trained classifiers are provided for prediction in different species. All algorithms to extract the features have been validated, comparing the results with the ones obtained from software of the original authors.The source code is freely available for academic use under GPL license at http://sourceforge.net/projects/sourcesinc/files/mirnafe/0.90/. A user-friendly access is provided as web interface at http://fich.unl.edu.ar/sinc/web-demo/mirnafe/. A more configurable web interface can be accessed at http://fich.unl.edu.ar/sinc/web-demo/mirnafe-full/.Fil: Yones, Cristian Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional; ArgentinaFil: Stegmayer, Georgina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional; ArgentinaFil: Kamenetzky, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Milone, Diego Humberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional; ArgentinaElsevier2015-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38858Yones, Cristian Ariel; Stegmayer, Georgina; Kamenetzky, Laura; Milone, Diego Humberto; MiRNAfe: A comprehensive tool for feature extraction in microRNA prediction; Elsevier; Biosystems; 138; 12-2015; 1-50303-2647CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.biosystems.2015.10.003info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0303264715001616info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:44:12Zoai:ri.conicet.gov.ar:11336/38858instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:44:12.488CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv MiRNAfe: A comprehensive tool for feature extraction in microRNA prediction
title MiRNAfe: A comprehensive tool for feature extraction in microRNA prediction
spellingShingle MiRNAfe: A comprehensive tool for feature extraction in microRNA prediction
Yones, Cristian Ariel
Feature Extraction
Microrna
Web Tool
title_short MiRNAfe: A comprehensive tool for feature extraction in microRNA prediction
title_full MiRNAfe: A comprehensive tool for feature extraction in microRNA prediction
title_fullStr MiRNAfe: A comprehensive tool for feature extraction in microRNA prediction
title_full_unstemmed MiRNAfe: A comprehensive tool for feature extraction in microRNA prediction
title_sort MiRNAfe: A comprehensive tool for feature extraction in microRNA prediction
dc.creator.none.fl_str_mv Yones, Cristian Ariel
Stegmayer, Georgina
Kamenetzky, Laura
Milone, Diego Humberto
author Yones, Cristian Ariel
author_facet Yones, Cristian Ariel
Stegmayer, Georgina
Kamenetzky, Laura
Milone, Diego Humberto
author_role author
author2 Stegmayer, Georgina
Kamenetzky, Laura
Milone, Diego Humberto
author2_role author
author
author
dc.subject.none.fl_str_mv Feature Extraction
Microrna
Web Tool
topic Feature Extraction
Microrna
Web Tool
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv miRNAfe is a comprehensive tool to extract features from RNA sequences. It is freely available as a web service, allowing a single access point to almost all state-of-the-art feature extraction methods used today in a variety of works from different authors. It has a very simple user interface, where the user only needs to load a file containing the input sequences and select the features to extract. As a result, the user obtains a text file with the features extracted, which can be used to analyze the sequences or as input to a miRNA prediction software.The tool can calculate up to 80 features where many of them are multidimensional arrays. In order to simplify the web interface, the features have been divided into six pre-defined groups, each one providing information about: primary sequence, secondary structure, thermodynamic stability, statistical stability, conservation between genomes of different species and substrings analysis of the sequences. Additionally, pre-trained classifiers are provided for prediction in different species. All algorithms to extract the features have been validated, comparing the results with the ones obtained from software of the original authors.The source code is freely available for academic use under GPL license at http://sourceforge.net/projects/sourcesinc/files/mirnafe/0.90/. A user-friendly access is provided as web interface at http://fich.unl.edu.ar/sinc/web-demo/mirnafe/. A more configurable web interface can be accessed at http://fich.unl.edu.ar/sinc/web-demo/mirnafe-full/.
Fil: Yones, Cristian Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional; Argentina
Fil: Stegmayer, Georgina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional; Argentina
Fil: Kamenetzky, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Milone, Diego Humberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional; Argentina
description miRNAfe is a comprehensive tool to extract features from RNA sequences. It is freely available as a web service, allowing a single access point to almost all state-of-the-art feature extraction methods used today in a variety of works from different authors. It has a very simple user interface, where the user only needs to load a file containing the input sequences and select the features to extract. As a result, the user obtains a text file with the features extracted, which can be used to analyze the sequences or as input to a miRNA prediction software.The tool can calculate up to 80 features where many of them are multidimensional arrays. In order to simplify the web interface, the features have been divided into six pre-defined groups, each one providing information about: primary sequence, secondary structure, thermodynamic stability, statistical stability, conservation between genomes of different species and substrings analysis of the sequences. Additionally, pre-trained classifiers are provided for prediction in different species. All algorithms to extract the features have been validated, comparing the results with the ones obtained from software of the original authors.The source code is freely available for academic use under GPL license at http://sourceforge.net/projects/sourcesinc/files/mirnafe/0.90/. A user-friendly access is provided as web interface at http://fich.unl.edu.ar/sinc/web-demo/mirnafe/. A more configurable web interface can be accessed at http://fich.unl.edu.ar/sinc/web-demo/mirnafe-full/.
publishDate 2015
dc.date.none.fl_str_mv 2015-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38858
Yones, Cristian Ariel; Stegmayer, Georgina; Kamenetzky, Laura; Milone, Diego Humberto; MiRNAfe: A comprehensive tool for feature extraction in microRNA prediction; Elsevier; Biosystems; 138; 12-2015; 1-5
0303-2647
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38858
identifier_str_mv Yones, Cristian Ariel; Stegmayer, Georgina; Kamenetzky, Laura; Milone, Diego Humberto; MiRNAfe: A comprehensive tool for feature extraction in microRNA prediction; Elsevier; Biosystems; 138; 12-2015; 1-5
0303-2647
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.biosystems.2015.10.003
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0303264715001616
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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