Acute inflammation promotes early cellular stimulation of the epithelial and stromal compartments of the rat prostate

Autores
Quintar, Amado Alfredo; Doll, Andreas; Leimgruber, Carolina; Palmeri, Claudia Mariela; Roth, Félix Daniel; Maccioni, Mariana; Maldonado, Cristina Alicia
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Acute inflammation promotes early cellular stimulation of the epithelial and stromal compartments of the rat prostate Amado A. Quintar1, Andreas Doll2, Carolina Leimgruber1, Claudia M. Palmeri1, Felix D. Roth1, Mariana Maccioni3, Cristina A. Maldonado1* 1Center of Electron Microscopy, School of Medical Sciences, National University of Cordoba, Córdoba, Argentina 2Biomedical Research Unit, Research Institute Vall d´Hebron University Hospital, Barcelona, Spain 3CIBICI-CONICET, Department of Clinical Biochemistry, School of Chemical Sciences, National University of Cordoba, Córdoba, Argentina email: Cristina A. Maldonado (cmaldon@cmefcm.uncor.edu) *Correspondence to Cristina A. Maldonado, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Universidad Nacional de Córdoba, Pab. Biología Celular 1° piso, Haya de La Torre esq. Enrique Barros, Ciudad Universitaria, X5000HRA Córdoba, Argentina. The authors of this manuscript have nothing to declare. Funded by: Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) FONCyT-ANPCyT (PICT grant) KEYWORDS prostate inflammation ? bacterial infection ? cell stimulation ? proliferation ? smooth muscle cells ABSTRACT BACKGROUND It has been proposed that prostatic inflammation plays a pivotal role in the pathophysiology of benign hyperplasia and prostate cancer. However, little information is available about the prostatic reaction to bacterial compounds in vivo. Our aim was therefore to evaluate the early effects of bacterial infection on rat ventral prostate compartments. METHODS Using a rat model of acute bacterial prostatitis by Escherichia coli, we analyzed the histological and ultrastructural changes in the prostate at 24, 48, and 72 hr postinfection. Prostatic tissues were immunostained for prostatic binding protein (PBP), ACTA2, ErbB1, and ErbB2 receptors, TUNEL, and markers of cell proliferation. Dot and Western blots for PBP, ACTA2, ErbB1, ErbB2, and TGF1 were also performed. RESULTS The prostatic epithelium became hypertrophied, with increases in PBP and ErbB1 expression at 24 hr postinfection. Moreover, inflammation induced the expression of ErbB2, a receptor strongly involved in carcinogenesis. These alterations were more pronounced at 48 hr, but the epithelium also showed apoptosis and finally atrophy at 72 hr postinfection, with a decrease in PBP and ErbB receptors. Interestingly, the epithelial cells exhibited a high level of proliferation in response to the bacteria. The stromal reaction to acute inflammation was initially characterized by smooth muscle hypertrophy. Afterwards, muscle cells acquired a secretory phenotype, with a reduction in ACTA2 at 72 hr postinfection. CONCLUSIONS Prostatic inflammation, even at the early stages, promotes atrophic and proliferative changes, and the upregulation of ErbB receptors together with dedifferentiation of smooth muscle cells. These data suggest that repetitive reinfections could lead to uncontrolled growth in the prostate gland.
Fil: Quintar, Amado Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Doll, Andreas. No especifíca;
Fil: Leimgruber, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Palmeri, Claudia Mariela. Universidad Nacional de Córdoba. Rectorado. Centro de Microscopia Electronica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Roth, Félix Daniel. Universidad Nacional de Córdoba. Rectorado. Centro de Microscopia Electronica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Maccioni, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Maldonado, Cristina Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Materia
prostate inflammation
bacterial infection
cell stimulation
smooth muscle cells
proliferation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/242726
Acceder
id CONICETDig_5a0c312274a2625e4c8cc51438cd7702
oai_identifier_str oai:ri.conicet.gov.ar:11336/242726
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Acute inflammation promotes early cellular stimulation of the epithelial and stromal compartments of the rat prostateQuintar, Amado AlfredoDoll, AndreasLeimgruber, CarolinaPalmeri, Claudia MarielaRoth, Félix DanielMaccioni, MarianaMaldonado, Cristina Aliciaprostate inflammationbacterial infectioncell stimulationsmooth muscle cellsproliferationhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Acute inflammation promotes early cellular stimulation of the epithelial and stromal compartments of the rat prostate Amado A. Quintar1, Andreas Doll2, Carolina Leimgruber1, Claudia M. Palmeri1, Felix D. Roth1, Mariana Maccioni3, Cristina A. Maldonado1* 1Center of Electron Microscopy, School of Medical Sciences, National University of Cordoba, Córdoba, Argentina 2Biomedical Research Unit, Research Institute Vall d´Hebron University Hospital, Barcelona, Spain 3CIBICI-CONICET, Department of Clinical Biochemistry, School of Chemical Sciences, National University of Cordoba, Córdoba, Argentina email: Cristina A. Maldonado (cmaldon@cmefcm.uncor.edu) *Correspondence to Cristina A. Maldonado, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Universidad Nacional de Córdoba, Pab. Biología Celular 1° piso, Haya de La Torre esq. Enrique Barros, Ciudad Universitaria, X5000HRA Córdoba, Argentina. The authors of this manuscript have nothing to declare. Funded by: Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) FONCyT-ANPCyT (PICT grant) KEYWORDS prostate inflammation ? bacterial infection ? cell stimulation ? proliferation ? smooth muscle cells ABSTRACT BACKGROUND It has been proposed that prostatic inflammation plays a pivotal role in the pathophysiology of benign hyperplasia and prostate cancer. However, little information is available about the prostatic reaction to bacterial compounds in vivo. Our aim was therefore to evaluate the early effects of bacterial infection on rat ventral prostate compartments. METHODS Using a rat model of acute bacterial prostatitis by Escherichia coli, we analyzed the histological and ultrastructural changes in the prostate at 24, 48, and 72 hr postinfection. Prostatic tissues were immunostained for prostatic binding protein (PBP), ACTA2, ErbB1, and ErbB2 receptors, TUNEL, and markers of cell proliferation. Dot and Western blots for PBP, ACTA2, ErbB1, ErbB2, and TGF1 were also performed. RESULTS The prostatic epithelium became hypertrophied, with increases in PBP and ErbB1 expression at 24 hr postinfection. Moreover, inflammation induced the expression of ErbB2, a receptor strongly involved in carcinogenesis. These alterations were more pronounced at 48 hr, but the epithelium also showed apoptosis and finally atrophy at 72 hr postinfection, with a decrease in PBP and ErbB receptors. Interestingly, the epithelial cells exhibited a high level of proliferation in response to the bacteria. The stromal reaction to acute inflammation was initially characterized by smooth muscle hypertrophy. Afterwards, muscle cells acquired a secretory phenotype, with a reduction in ACTA2 at 72 hr postinfection. CONCLUSIONS Prostatic inflammation, even at the early stages, promotes atrophic and proliferative changes, and the upregulation of ErbB receptors together with dedifferentiation of smooth muscle cells. These data suggest that repetitive reinfections could lead to uncontrolled growth in the prostate gland.Fil: Quintar, Amado Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Doll, Andreas. No especifíca;Fil: Leimgruber, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Palmeri, Claudia Mariela. Universidad Nacional de Córdoba. Rectorado. Centro de Microscopia Electronica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Roth, Félix Daniel. Universidad Nacional de Córdoba. Rectorado. Centro de Microscopia Electronica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Maccioni, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Maldonado, Cristina Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaWiley-liss, div John Wiley & Sons Inc.2010-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/242726Quintar, Amado Alfredo; Doll, Andreas; Leimgruber, Carolina; Palmeri, Claudia Mariela; Roth, Félix Daniel; et al.; Acute inflammation promotes early cellular stimulation of the epithelial and stromal compartments of the rat prostate; Wiley-liss, div John Wiley & Sons Inc.; Prostate; 70; 11; 6-2010; 1153-11650270-4137CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/pros.21150info:eu-repo/semantics/altIdentifier/doi/10.1002/pros.21150info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:57:36Zoai:ri.conicet.gov.ar:11336/242726instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:57:36.633CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Acute inflammation promotes early cellular stimulation of the epithelial and stromal compartments of the rat prostate
title Acute inflammation promotes early cellular stimulation of the epithelial and stromal compartments of the rat prostate
spellingShingle Acute inflammation promotes early cellular stimulation of the epithelial and stromal compartments of the rat prostate
Quintar, Amado Alfredo
prostate inflammation
bacterial infection
cell stimulation
smooth muscle cells
proliferation
title_short Acute inflammation promotes early cellular stimulation of the epithelial and stromal compartments of the rat prostate
title_full Acute inflammation promotes early cellular stimulation of the epithelial and stromal compartments of the rat prostate
title_fullStr Acute inflammation promotes early cellular stimulation of the epithelial and stromal compartments of the rat prostate
title_full_unstemmed Acute inflammation promotes early cellular stimulation of the epithelial and stromal compartments of the rat prostate
title_sort Acute inflammation promotes early cellular stimulation of the epithelial and stromal compartments of the rat prostate
dc.creator.none.fl_str_mv Quintar, Amado Alfredo
Doll, Andreas
Leimgruber, Carolina
Palmeri, Claudia Mariela
Roth, Félix Daniel
Maccioni, Mariana
Maldonado, Cristina Alicia
author Quintar, Amado Alfredo
author_facet Quintar, Amado Alfredo
Doll, Andreas
Leimgruber, Carolina
Palmeri, Claudia Mariela
Roth, Félix Daniel
Maccioni, Mariana
Maldonado, Cristina Alicia
author_role author
author2 Doll, Andreas
Leimgruber, Carolina
Palmeri, Claudia Mariela
Roth, Félix Daniel
Maccioni, Mariana
Maldonado, Cristina Alicia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv prostate inflammation
bacterial infection
cell stimulation
smooth muscle cells
proliferation
topic prostate inflammation
bacterial infection
cell stimulation
smooth muscle cells
proliferation
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Acute inflammation promotes early cellular stimulation of the epithelial and stromal compartments of the rat prostate Amado A. Quintar1, Andreas Doll2, Carolina Leimgruber1, Claudia M. Palmeri1, Felix D. Roth1, Mariana Maccioni3, Cristina A. Maldonado1* 1Center of Electron Microscopy, School of Medical Sciences, National University of Cordoba, Córdoba, Argentina 2Biomedical Research Unit, Research Institute Vall d´Hebron University Hospital, Barcelona, Spain 3CIBICI-CONICET, Department of Clinical Biochemistry, School of Chemical Sciences, National University of Cordoba, Córdoba, Argentina email: Cristina A. Maldonado (cmaldon@cmefcm.uncor.edu) *Correspondence to Cristina A. Maldonado, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Universidad Nacional de Córdoba, Pab. Biología Celular 1° piso, Haya de La Torre esq. Enrique Barros, Ciudad Universitaria, X5000HRA Córdoba, Argentina. The authors of this manuscript have nothing to declare. Funded by: Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) FONCyT-ANPCyT (PICT grant) KEYWORDS prostate inflammation ? bacterial infection ? cell stimulation ? proliferation ? smooth muscle cells ABSTRACT BACKGROUND It has been proposed that prostatic inflammation plays a pivotal role in the pathophysiology of benign hyperplasia and prostate cancer. However, little information is available about the prostatic reaction to bacterial compounds in vivo. Our aim was therefore to evaluate the early effects of bacterial infection on rat ventral prostate compartments. METHODS Using a rat model of acute bacterial prostatitis by Escherichia coli, we analyzed the histological and ultrastructural changes in the prostate at 24, 48, and 72 hr postinfection. Prostatic tissues were immunostained for prostatic binding protein (PBP), ACTA2, ErbB1, and ErbB2 receptors, TUNEL, and markers of cell proliferation. Dot and Western blots for PBP, ACTA2, ErbB1, ErbB2, and TGF1 were also performed. RESULTS The prostatic epithelium became hypertrophied, with increases in PBP and ErbB1 expression at 24 hr postinfection. Moreover, inflammation induced the expression of ErbB2, a receptor strongly involved in carcinogenesis. These alterations were more pronounced at 48 hr, but the epithelium also showed apoptosis and finally atrophy at 72 hr postinfection, with a decrease in PBP and ErbB receptors. Interestingly, the epithelial cells exhibited a high level of proliferation in response to the bacteria. The stromal reaction to acute inflammation was initially characterized by smooth muscle hypertrophy. Afterwards, muscle cells acquired a secretory phenotype, with a reduction in ACTA2 at 72 hr postinfection. CONCLUSIONS Prostatic inflammation, even at the early stages, promotes atrophic and proliferative changes, and the upregulation of ErbB receptors together with dedifferentiation of smooth muscle cells. These data suggest that repetitive reinfections could lead to uncontrolled growth in the prostate gland.
Fil: Quintar, Amado Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Doll, Andreas. No especifíca;
Fil: Leimgruber, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Palmeri, Claudia Mariela. Universidad Nacional de Córdoba. Rectorado. Centro de Microscopia Electronica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Roth, Félix Daniel. Universidad Nacional de Córdoba. Rectorado. Centro de Microscopia Electronica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Maccioni, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Maldonado, Cristina Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
description Acute inflammation promotes early cellular stimulation of the epithelial and stromal compartments of the rat prostate Amado A. Quintar1, Andreas Doll2, Carolina Leimgruber1, Claudia M. Palmeri1, Felix D. Roth1, Mariana Maccioni3, Cristina A. Maldonado1* 1Center of Electron Microscopy, School of Medical Sciences, National University of Cordoba, Córdoba, Argentina 2Biomedical Research Unit, Research Institute Vall d´Hebron University Hospital, Barcelona, Spain 3CIBICI-CONICET, Department of Clinical Biochemistry, School of Chemical Sciences, National University of Cordoba, Córdoba, Argentina email: Cristina A. Maldonado (cmaldon@cmefcm.uncor.edu) *Correspondence to Cristina A. Maldonado, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Universidad Nacional de Córdoba, Pab. Biología Celular 1° piso, Haya de La Torre esq. Enrique Barros, Ciudad Universitaria, X5000HRA Córdoba, Argentina. The authors of this manuscript have nothing to declare. Funded by: Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) FONCyT-ANPCyT (PICT grant) KEYWORDS prostate inflammation ? bacterial infection ? cell stimulation ? proliferation ? smooth muscle cells ABSTRACT BACKGROUND It has been proposed that prostatic inflammation plays a pivotal role in the pathophysiology of benign hyperplasia and prostate cancer. However, little information is available about the prostatic reaction to bacterial compounds in vivo. Our aim was therefore to evaluate the early effects of bacterial infection on rat ventral prostate compartments. METHODS Using a rat model of acute bacterial prostatitis by Escherichia coli, we analyzed the histological and ultrastructural changes in the prostate at 24, 48, and 72 hr postinfection. Prostatic tissues were immunostained for prostatic binding protein (PBP), ACTA2, ErbB1, and ErbB2 receptors, TUNEL, and markers of cell proliferation. Dot and Western blots for PBP, ACTA2, ErbB1, ErbB2, and TGF1 were also performed. RESULTS The prostatic epithelium became hypertrophied, with increases in PBP and ErbB1 expression at 24 hr postinfection. Moreover, inflammation induced the expression of ErbB2, a receptor strongly involved in carcinogenesis. These alterations were more pronounced at 48 hr, but the epithelium also showed apoptosis and finally atrophy at 72 hr postinfection, with a decrease in PBP and ErbB receptors. Interestingly, the epithelial cells exhibited a high level of proliferation in response to the bacteria. The stromal reaction to acute inflammation was initially characterized by smooth muscle hypertrophy. Afterwards, muscle cells acquired a secretory phenotype, with a reduction in ACTA2 at 72 hr postinfection. CONCLUSIONS Prostatic inflammation, even at the early stages, promotes atrophic and proliferative changes, and the upregulation of ErbB receptors together with dedifferentiation of smooth muscle cells. These data suggest that repetitive reinfections could lead to uncontrolled growth in the prostate gland.
publishDate 2010
dc.date.none.fl_str_mv 2010-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/242726
Quintar, Amado Alfredo; Doll, Andreas; Leimgruber, Carolina; Palmeri, Claudia Mariela; Roth, Félix Daniel; et al.; Acute inflammation promotes early cellular stimulation of the epithelial and stromal compartments of the rat prostate; Wiley-liss, div John Wiley & Sons Inc.; Prostate; 70; 11; 6-2010; 1153-1165
0270-4137
CONICET Digital
CONICET
url http://hdl.handle.net/11336/242726
identifier_str_mv Quintar, Amado Alfredo; Doll, Andreas; Leimgruber, Carolina; Palmeri, Claudia Mariela; Roth, Félix Daniel; et al.; Acute inflammation promotes early cellular stimulation of the epithelial and stromal compartments of the rat prostate; Wiley-liss, div John Wiley & Sons Inc.; Prostate; 70; 11; 6-2010; 1153-1165
0270-4137
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1002/pros.21150
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eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Wiley-liss, div John Wiley & Sons Inc.
publisher.none.fl_str_mv Wiley-liss, div John Wiley & Sons Inc.
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reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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