Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells

Autores
Terness, Peter; Kallikourdes, Marinos; Betz, Alexander G.; Rabinovich, Gabriel Adrián; Saito, Shigeru; Clarck, David A.
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Is the concept of maternal tolerance preventing rejection of the semi-allogeneic 'fetal allograft' still valid?. Compilation of expert reviews of literature and recent advances in research on indoleamine-2,3 dioxygenase (IDO), regulatory T cells and galectin-1. A role for IDO in pregnancy success remains speculative, but solid data exist to support a role for Treg cells, and for galectin-1 in induction and action of Treg cells. Just as several signals may need to be simultaneously present to induce Th1 cytokine-triggered abortions, more than 1 signal may need to be simultaneously present to prevent rejection and ensure success. Both complement and coagulation pathways appear necessary for embryo execution.
Fil: Terness, Peter. Universität Heidelberg; Albania
Fil: Kallikourdes, Marinos. MRC Laboratory of Molecular Biology; Reino Unido
Fil: Betz, Alexander G.. MRC Laboratory of Molecular Biology; Reino Unido
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Saito, Shigeru. Universidad de Toyama; Japón
Fil: Clarck, David A.. Mc Master University; Canadá
Materia
Galectin-1
Immune Tolerance
Signal Transduction
Pregnancy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/27508
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/27508
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cellsTerness, PeterKallikourdes, MarinosBetz, Alexander G.Rabinovich, Gabriel AdriánSaito, ShigeruClarck, David A.Galectin-1Immune ToleranceSignal TransductionPregnancyhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Is the concept of maternal tolerance preventing rejection of the semi-allogeneic 'fetal allograft' still valid?. Compilation of expert reviews of literature and recent advances in research on indoleamine-2,3 dioxygenase (IDO), regulatory T cells and galectin-1. A role for IDO in pregnancy success remains speculative, but solid data exist to support a role for Treg cells, and for galectin-1 in induction and action of Treg cells. Just as several signals may need to be simultaneously present to induce Th1 cytokine-triggered abortions, more than 1 signal may need to be simultaneously present to prevent rejection and ensure success. Both complement and coagulation pathways appear necessary for embryo execution.Fil: Terness, Peter. Universität Heidelberg; AlbaniaFil: Kallikourdes, Marinos. MRC Laboratory of Molecular Biology; Reino UnidoFil: Betz, Alexander G.. MRC Laboratory of Molecular Biology; Reino UnidoFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Saito, Shigeru. Universidad de Toyama; JapónFil: Clarck, David A.. Mc Master University; CanadáBlackwell Munksgaard2007info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/27508Terness, Peter; Kallikourdes, Marinos; Betz, Alexander G.; Rabinovich, Gabriel Adrián; Saito, Shigeru; et al.; Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells; Blackwell Munksgaard; American Journal of Reproductive Immunology; 58; 3; -1-2007; 238-2541046-74081600-0897CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.2007.00510.x/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1600-0897.2007.00510.xinfo:eu-repo/semantics/altIdentifier/pmid/17681041info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:43:21Zoai:ri.conicet.gov.ar:11336/27508instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:43:21.881CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells
title Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells
spellingShingle Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells
Terness, Peter
Galectin-1
Immune Tolerance
Signal Transduction
Pregnancy
title_short Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells
title_full Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells
title_fullStr Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells
title_full_unstemmed Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells
title_sort Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells
dc.creator.none.fl_str_mv Terness, Peter
Kallikourdes, Marinos
Betz, Alexander G.
Rabinovich, Gabriel Adrián
Saito, Shigeru
Clarck, David A.
author Terness, Peter
author_facet Terness, Peter
Kallikourdes, Marinos
Betz, Alexander G.
Rabinovich, Gabriel Adrián
Saito, Shigeru
Clarck, David A.
author_role author
author2 Kallikourdes, Marinos
Betz, Alexander G.
Rabinovich, Gabriel Adrián
Saito, Shigeru
Clarck, David A.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Galectin-1
Immune Tolerance
Signal Transduction
Pregnancy
topic Galectin-1
Immune Tolerance
Signal Transduction
Pregnancy
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Is the concept of maternal tolerance preventing rejection of the semi-allogeneic 'fetal allograft' still valid?. Compilation of expert reviews of literature and recent advances in research on indoleamine-2,3 dioxygenase (IDO), regulatory T cells and galectin-1. A role for IDO in pregnancy success remains speculative, but solid data exist to support a role for Treg cells, and for galectin-1 in induction and action of Treg cells. Just as several signals may need to be simultaneously present to induce Th1 cytokine-triggered abortions, more than 1 signal may need to be simultaneously present to prevent rejection and ensure success. Both complement and coagulation pathways appear necessary for embryo execution.
Fil: Terness, Peter. Universität Heidelberg; Albania
Fil: Kallikourdes, Marinos. MRC Laboratory of Molecular Biology; Reino Unido
Fil: Betz, Alexander G.. MRC Laboratory of Molecular Biology; Reino Unido
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Saito, Shigeru. Universidad de Toyama; Japón
Fil: Clarck, David A.. Mc Master University; Canadá
description Is the concept of maternal tolerance preventing rejection of the semi-allogeneic 'fetal allograft' still valid?. Compilation of expert reviews of literature and recent advances in research on indoleamine-2,3 dioxygenase (IDO), regulatory T cells and galectin-1. A role for IDO in pregnancy success remains speculative, but solid data exist to support a role for Treg cells, and for galectin-1 in induction and action of Treg cells. Just as several signals may need to be simultaneously present to induce Th1 cytokine-triggered abortions, more than 1 signal may need to be simultaneously present to prevent rejection and ensure success. Both complement and coagulation pathways appear necessary for embryo execution.
publishDate 2007
dc.date.none.fl_str_mv 2007
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/27508
Terness, Peter; Kallikourdes, Marinos; Betz, Alexander G.; Rabinovich, Gabriel Adrián; Saito, Shigeru; et al.; Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells; Blackwell Munksgaard; American Journal of Reproductive Immunology; 58; 3; -1-2007; 238-254
1046-7408
1600-0897
CONICET Digital
CONICET
url http://hdl.handle.net/11336/27508
identifier_str_mv Terness, Peter; Kallikourdes, Marinos; Betz, Alexander G.; Rabinovich, Gabriel Adrián; Saito, Shigeru; et al.; Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells; Blackwell Munksgaard; American Journal of Reproductive Immunology; 58; 3; -1-2007; 238-254
1046-7408
1600-0897
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.2007.00510.x/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1600-0897.2007.00510.x
info:eu-repo/semantics/altIdentifier/pmid/17681041
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Blackwell Munksgaard
publisher.none.fl_str_mv Blackwell Munksgaard
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268596847247360
score 13.13397

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