Maternal metabolic syndrome affects the progeny's redox balance and increases neuroinflammation with neurodevelopmental and metabolic adverse consequences

Autores
Prado Spalm, Facundo Heber; Cuervo Sánchez, Marié Lucia; Furland, Natalia Edith; Valles, Ana Sofia
Año de publicación
2023
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Various lifestyle factors, including diet, can impact on redox balance and brain health. Consumption of fructose-sweetened beverages has drastically increased in the last decades and is widely associated with metabolic disease, systemic proinflammatory status and adverse transgenerational effects. To date, the impact of maternal fructose intake in brain redox balance and function of the offspring is less explored. We investigated whether the progeny of mothers with Metabolic Syndrome (MetS), induced by ad libitum consumption of a 20% fructose solution, present any redox alteration in the brain as a consequence of being gestated in a metabolic altered intrauterine environment. Wistar rats were randomly separated into two groups with access to water or fructose (20% w/v in water) for 10 weeks. After MetS was confirmed, dams were mated with control males and continued drinking water or fructose solution during gestation. At postnatal day (PN) 1, a subgroup of offspring of each sex was sacrificed and brains were dissected for oxidative stress and inflammatory status analysis. The developmental milestones and behavioral test were also evaluated (PN3-PN100) in another subgroup of offspring to identify any long-term consequence to being gestated by a dam with MetS. Maternal MetS affects the redox balance and increases neuroinflammation in female offspring at birth. Sexually dimorphic effects were also found on the progeny's acquisition of neurodevelopmental milestones and in their psychiatric, cognitive and metabolic state. Although direct extrapolation of our findings cannot be made to humans, the results presented herein reinforce the necessity of considering the potentially negative effects of fructose-induced MetS prior to, and during pregnancy in offspring’s brain and metabolic physiology
Fil: Prado Spalm, Facundo Heber. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Cuervo Sánchez, Marié Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Furland, Natalia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Valles, Ana Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Worshop on Redox Nutrition and Toxicology
Argentina
Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica
Materia
METABOLIC SYNDROME
PROGENY
REDOX
NEURODEVELOPMENTAL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/229103
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Maternal metabolic syndrome affects the progeny's redox balance and increases neuroinflammation with neurodevelopmental and metabolic adverse consequencesPrado Spalm, Facundo HeberCuervo Sánchez, Marié LuciaFurland, Natalia EdithValles, Ana SofiaMETABOLIC SYNDROMEPROGENYREDOXNEURODEVELOPMENTALhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Various lifestyle factors, including diet, can impact on redox balance and brain health. Consumption of fructose-sweetened beverages has drastically increased in the last decades and is widely associated with metabolic disease, systemic proinflammatory status and adverse transgenerational effects. To date, the impact of maternal fructose intake in brain redox balance and function of the offspring is less explored. We investigated whether the progeny of mothers with Metabolic Syndrome (MetS), induced by ad libitum consumption of a 20% fructose solution, present any redox alteration in the brain as a consequence of being gestated in a metabolic altered intrauterine environment. Wistar rats were randomly separated into two groups with access to water or fructose (20% w/v in water) for 10 weeks. After MetS was confirmed, dams were mated with control males and continued drinking water or fructose solution during gestation. At postnatal day (PN) 1, a subgroup of offspring of each sex was sacrificed and brains were dissected for oxidative stress and inflammatory status analysis. The developmental milestones and behavioral test were also evaluated (PN3-PN100) in another subgroup of offspring to identify any long-term consequence to being gestated by a dam with MetS. Maternal MetS affects the redox balance and increases neuroinflammation in female offspring at birth. Sexually dimorphic effects were also found on the progeny's acquisition of neurodevelopmental milestones and in their psychiatric, cognitive and metabolic state. Although direct extrapolation of our findings cannot be made to humans, the results presented herein reinforce the necessity of considering the potentially negative effects of fructose-induced MetS prior to, and during pregnancy in offspring’s brain and metabolic physiologyFil: Prado Spalm, Facundo Heber. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Cuervo Sánchez, Marié Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Furland, Natalia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Valles, Ana Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaWorshop on Redox Nutrition and ToxicologyArgentinaUniversidad de Buenos Aires. Facultad de Farmacia y BioquímicaUniversidad de Buenos Aires. Facultad de Farmacia y Bioquímica2023info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectWorkshopJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/229103Maternal metabolic syndrome affects the progeny's redox balance and increases neuroinflammation with neurodevelopmental and metabolic adverse consequences; Worshop on Redox Nutrition and Toxicology; Argentina; 2023; 12-12CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.redoxba.org/Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:21Zoai:ri.conicet.gov.ar:11336/229103instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:21.794CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Maternal metabolic syndrome affects the progeny's redox balance and increases neuroinflammation with neurodevelopmental and metabolic adverse consequences
title Maternal metabolic syndrome affects the progeny's redox balance and increases neuroinflammation with neurodevelopmental and metabolic adverse consequences
spellingShingle Maternal metabolic syndrome affects the progeny's redox balance and increases neuroinflammation with neurodevelopmental and metabolic adverse consequences
Prado Spalm, Facundo Heber
METABOLIC SYNDROME
PROGENY
REDOX
NEURODEVELOPMENTAL
title_short Maternal metabolic syndrome affects the progeny's redox balance and increases neuroinflammation with neurodevelopmental and metabolic adverse consequences
title_full Maternal metabolic syndrome affects the progeny's redox balance and increases neuroinflammation with neurodevelopmental and metabolic adverse consequences
title_fullStr Maternal metabolic syndrome affects the progeny's redox balance and increases neuroinflammation with neurodevelopmental and metabolic adverse consequences
title_full_unstemmed Maternal metabolic syndrome affects the progeny's redox balance and increases neuroinflammation with neurodevelopmental and metabolic adverse consequences
title_sort Maternal metabolic syndrome affects the progeny's redox balance and increases neuroinflammation with neurodevelopmental and metabolic adverse consequences
dc.creator.none.fl_str_mv Prado Spalm, Facundo Heber
Cuervo Sánchez, Marié Lucia
Furland, Natalia Edith
Valles, Ana Sofia
author Prado Spalm, Facundo Heber
author_facet Prado Spalm, Facundo Heber
Cuervo Sánchez, Marié Lucia
Furland, Natalia Edith
Valles, Ana Sofia
author_role author
author2 Cuervo Sánchez, Marié Lucia
Furland, Natalia Edith
Valles, Ana Sofia
author2_role author
author
author
dc.subject.none.fl_str_mv METABOLIC SYNDROME
PROGENY
REDOX
NEURODEVELOPMENTAL
topic METABOLIC SYNDROME
PROGENY
REDOX
NEURODEVELOPMENTAL
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Various lifestyle factors, including diet, can impact on redox balance and brain health. Consumption of fructose-sweetened beverages has drastically increased in the last decades and is widely associated with metabolic disease, systemic proinflammatory status and adverse transgenerational effects. To date, the impact of maternal fructose intake in brain redox balance and function of the offspring is less explored. We investigated whether the progeny of mothers with Metabolic Syndrome (MetS), induced by ad libitum consumption of a 20% fructose solution, present any redox alteration in the brain as a consequence of being gestated in a metabolic altered intrauterine environment. Wistar rats were randomly separated into two groups with access to water or fructose (20% w/v in water) for 10 weeks. After MetS was confirmed, dams were mated with control males and continued drinking water or fructose solution during gestation. At postnatal day (PN) 1, a subgroup of offspring of each sex was sacrificed and brains were dissected for oxidative stress and inflammatory status analysis. The developmental milestones and behavioral test were also evaluated (PN3-PN100) in another subgroup of offspring to identify any long-term consequence to being gestated by a dam with MetS. Maternal MetS affects the redox balance and increases neuroinflammation in female offspring at birth. Sexually dimorphic effects were also found on the progeny's acquisition of neurodevelopmental milestones and in their psychiatric, cognitive and metabolic state. Although direct extrapolation of our findings cannot be made to humans, the results presented herein reinforce the necessity of considering the potentially negative effects of fructose-induced MetS prior to, and during pregnancy in offspring’s brain and metabolic physiology
Fil: Prado Spalm, Facundo Heber. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Cuervo Sánchez, Marié Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Furland, Natalia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Valles, Ana Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Worshop on Redox Nutrition and Toxicology
Argentina
Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica
description Various lifestyle factors, including diet, can impact on redox balance and brain health. Consumption of fructose-sweetened beverages has drastically increased in the last decades and is widely associated with metabolic disease, systemic proinflammatory status and adverse transgenerational effects. To date, the impact of maternal fructose intake in brain redox balance and function of the offspring is less explored. We investigated whether the progeny of mothers with Metabolic Syndrome (MetS), induced by ad libitum consumption of a 20% fructose solution, present any redox alteration in the brain as a consequence of being gestated in a metabolic altered intrauterine environment. Wistar rats were randomly separated into two groups with access to water or fructose (20% w/v in water) for 10 weeks. After MetS was confirmed, dams were mated with control males and continued drinking water or fructose solution during gestation. At postnatal day (PN) 1, a subgroup of offspring of each sex was sacrificed and brains were dissected for oxidative stress and inflammatory status analysis. The developmental milestones and behavioral test were also evaluated (PN3-PN100) in another subgroup of offspring to identify any long-term consequence to being gestated by a dam with MetS. Maternal MetS affects the redox balance and increases neuroinflammation in female offspring at birth. Sexually dimorphic effects were also found on the progeny's acquisition of neurodevelopmental milestones and in their psychiatric, cognitive and metabolic state. Although direct extrapolation of our findings cannot be made to humans, the results presented herein reinforce the necessity of considering the potentially negative effects of fructose-induced MetS prior to, and during pregnancy in offspring’s brain and metabolic physiology
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Workshop
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/229103
Maternal metabolic syndrome affects the progeny's redox balance and increases neuroinflammation with neurodevelopmental and metabolic adverse consequences; Worshop on Redox Nutrition and Toxicology; Argentina; 2023; 12-12
CONICET Digital
CONICET
url http://hdl.handle.net/11336/229103
identifier_str_mv Maternal metabolic syndrome affects the progeny's redox balance and increases neuroinflammation with neurodevelopmental and metabolic adverse consequences; Worshop on Redox Nutrition and Toxicology; Argentina; 2023; 12-12
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.redoxba.org/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica
publisher.none.fl_str_mv Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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