Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil

Autores
Sales Luiz Vianna, Fernanda; López Camelo, Jorge Santiago; Louguercio Leite, Júlio César; Vieira Sanseverino, Maria Teresa; da Graça Dutra, Maria; Castilla, Eduardo Enrique; Schuler Faccini, Lavínia
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil. Vianna FS, Lopez-Camelo JS, Leite JC, Sanseverino MT, Dutra Mda G, Castilla EE, Schüler-Faccini L. Source Instituto Nacional de Genética Médica Populacional at Teratogen Information Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. Abstract The thalidomide tragedy of the 1960s resulted in thousands of children being born with severe limb reduction defects (LRD), among other malformations. In Brazil, there are still babies born with thalidomide embryopathy (TE) because of leprosy prevalence, availability of thalidomide, and deficiencies in the control of drug dispensation. Our objective was to implement a system of proactive surveillance to identify birth defects compatible with TE. Along one year, newborns with LRD were assessed in the Brazilian hospitals participating in the Latin-American Collaborative Study of Congenital Malformations (ECLAMC). A phenotype of LRD called thalidomide embryopathy phenotype (TEP) was established for surveillance. Children with TEP born between the years 2000-2008 were monitored, and during the 2007-2008 period we clinically investigated in greater detail all cases with TEP (proactive period). The period from 1982 to 1999 was defined as the baseline period for the cumulative sum statistics. The frequency of TEP during the surveillance period, at 3.10/10,000 births (CI 95%: 2.50-3.70), was significantly higher than that observed in the baseline period (1.92/10,000 births; CI 95%: 1.60-2.20), and not uniformly distributed across different Brazilian regions. During the proactive surveillance (2007-2008), two cases of suspected TE were identified, although the two mothers had denied the use of the drug during pregnancy. Our results suggest that TEP has probably increased in recent years, which coincides with the period of greater thalidomide availability. Our proactive surveillance identified two newborns with suspected TE, proving to be a sensitive tool to detect TE. The high frequency of leprosy and the large use of thalidomide reinforce the need for a continuous monitoring of TEP across Brazil.
Fil: Sales Luiz Vianna, Fernanda. Universidade Federal do Rio Grande do Sul; Brasil
Fil: López Camelo, Jorge Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Louguercio Leite, Júlio César. Hospital de Clínicas de Porto Alegre; Brasil
Fil: Vieira Sanseverino, Maria Teresa. Hospital de Clínicas de Porto Alegre; Brasil
Fil: da Graça Dutra, Maria. Ministerio de Salud de Brasil. Fundación Oswaldo Cruz. Instituto Oswaldo Cruz;
Fil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: Schuler Faccini, Lavínia. Hospital de Clínicas de Porto Alegre; Brasil. Universidade Federal do Rio Grande do Sul; Brasil
Materia
Epidemiological
surveillance
Birth
Defects
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/237438

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network_name_str CONICET Digital (CONICET)
spelling Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in BrazilSales Luiz Vianna, FernandaLópez Camelo, Jorge SantiagoLouguercio Leite, Júlio CésarVieira Sanseverino, Maria Teresada Graça Dutra, MariaCastilla, Eduardo EnriqueSchuler Faccini, LavíniaEpidemiologicalsurveillanceBirthDefectshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil. Vianna FS, Lopez-Camelo JS, Leite JC, Sanseverino MT, Dutra Mda G, Castilla EE, Schüler-Faccini L. Source Instituto Nacional de Genética Médica Populacional at Teratogen Information Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. Abstract The thalidomide tragedy of the 1960s resulted in thousands of children being born with severe limb reduction defects (LRD), among other malformations. In Brazil, there are still babies born with thalidomide embryopathy (TE) because of leprosy prevalence, availability of thalidomide, and deficiencies in the control of drug dispensation. Our objective was to implement a system of proactive surveillance to identify birth defects compatible with TE. Along one year, newborns with LRD were assessed in the Brazilian hospitals participating in the Latin-American Collaborative Study of Congenital Malformations (ECLAMC). A phenotype of LRD called thalidomide embryopathy phenotype (TEP) was established for surveillance. Children with TEP born between the years 2000-2008 were monitored, and during the 2007-2008 period we clinically investigated in greater detail all cases with TEP (proactive period). The period from 1982 to 1999 was defined as the baseline period for the cumulative sum statistics. The frequency of TEP during the surveillance period, at 3.10/10,000 births (CI 95%: 2.50-3.70), was significantly higher than that observed in the baseline period (1.92/10,000 births; CI 95%: 1.60-2.20), and not uniformly distributed across different Brazilian regions. During the proactive surveillance (2007-2008), two cases of suspected TE were identified, although the two mothers had denied the use of the drug during pregnancy. Our results suggest that TEP has probably increased in recent years, which coincides with the period of greater thalidomide availability. Our proactive surveillance identified two newborns with suspected TE, proving to be a sensitive tool to detect TE. The high frequency of leprosy and the large use of thalidomide reinforce the need for a continuous monitoring of TEP across Brazil.Fil: Sales Luiz Vianna, Fernanda. Universidade Federal do Rio Grande do Sul; BrasilFil: López Camelo, Jorge Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Louguercio Leite, Júlio César. Hospital de Clínicas de Porto Alegre; BrasilFil: Vieira Sanseverino, Maria Teresa. Hospital de Clínicas de Porto Alegre; BrasilFil: da Graça Dutra, Maria. Ministerio de Salud de Brasil. Fundación Oswaldo Cruz. Instituto Oswaldo Cruz;Fil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: Schuler Faccini, Lavínia. Hospital de Clínicas de Porto Alegre; Brasil. Universidade Federal do Rio Grande do Sul; BrasilPublic Library of Science2011-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/237438Sales Luiz Vianna, Fernanda; López Camelo, Jorge Santiago; Louguercio Leite, Júlio César; Vieira Sanseverino, Maria Teresa; da Graça Dutra, Maria; et al.; Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil; Public Library of Science; Plos One; 6; 7; 7-2011; 1-51932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021735info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0021735info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:38:35Zoai:ri.conicet.gov.ar:11336/237438instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:38:35.291CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
title Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
spellingShingle Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
Sales Luiz Vianna, Fernanda
Epidemiological
surveillance
Birth
Defects
title_short Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
title_full Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
title_fullStr Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
title_full_unstemmed Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
title_sort Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
dc.creator.none.fl_str_mv Sales Luiz Vianna, Fernanda
López Camelo, Jorge Santiago
Louguercio Leite, Júlio César
Vieira Sanseverino, Maria Teresa
da Graça Dutra, Maria
Castilla, Eduardo Enrique
Schuler Faccini, Lavínia
author Sales Luiz Vianna, Fernanda
author_facet Sales Luiz Vianna, Fernanda
López Camelo, Jorge Santiago
Louguercio Leite, Júlio César
Vieira Sanseverino, Maria Teresa
da Graça Dutra, Maria
Castilla, Eduardo Enrique
Schuler Faccini, Lavínia
author_role author
author2 López Camelo, Jorge Santiago
Louguercio Leite, Júlio César
Vieira Sanseverino, Maria Teresa
da Graça Dutra, Maria
Castilla, Eduardo Enrique
Schuler Faccini, Lavínia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Epidemiological
surveillance
Birth
Defects
topic Epidemiological
surveillance
Birth
Defects
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil. Vianna FS, Lopez-Camelo JS, Leite JC, Sanseverino MT, Dutra Mda G, Castilla EE, Schüler-Faccini L. Source Instituto Nacional de Genética Médica Populacional at Teratogen Information Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. Abstract The thalidomide tragedy of the 1960s resulted in thousands of children being born with severe limb reduction defects (LRD), among other malformations. In Brazil, there are still babies born with thalidomide embryopathy (TE) because of leprosy prevalence, availability of thalidomide, and deficiencies in the control of drug dispensation. Our objective was to implement a system of proactive surveillance to identify birth defects compatible with TE. Along one year, newborns with LRD were assessed in the Brazilian hospitals participating in the Latin-American Collaborative Study of Congenital Malformations (ECLAMC). A phenotype of LRD called thalidomide embryopathy phenotype (TEP) was established for surveillance. Children with TEP born between the years 2000-2008 were monitored, and during the 2007-2008 period we clinically investigated in greater detail all cases with TEP (proactive period). The period from 1982 to 1999 was defined as the baseline period for the cumulative sum statistics. The frequency of TEP during the surveillance period, at 3.10/10,000 births (CI 95%: 2.50-3.70), was significantly higher than that observed in the baseline period (1.92/10,000 births; CI 95%: 1.60-2.20), and not uniformly distributed across different Brazilian regions. During the proactive surveillance (2007-2008), two cases of suspected TE were identified, although the two mothers had denied the use of the drug during pregnancy. Our results suggest that TEP has probably increased in recent years, which coincides with the period of greater thalidomide availability. Our proactive surveillance identified two newborns with suspected TE, proving to be a sensitive tool to detect TE. The high frequency of leprosy and the large use of thalidomide reinforce the need for a continuous monitoring of TEP across Brazil.
Fil: Sales Luiz Vianna, Fernanda. Universidade Federal do Rio Grande do Sul; Brasil
Fil: López Camelo, Jorge Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Louguercio Leite, Júlio César. Hospital de Clínicas de Porto Alegre; Brasil
Fil: Vieira Sanseverino, Maria Teresa. Hospital de Clínicas de Porto Alegre; Brasil
Fil: da Graça Dutra, Maria. Ministerio de Salud de Brasil. Fundación Oswaldo Cruz. Instituto Oswaldo Cruz;
Fil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: Schuler Faccini, Lavínia. Hospital de Clínicas de Porto Alegre; Brasil. Universidade Federal do Rio Grande do Sul; Brasil
description Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil. Vianna FS, Lopez-Camelo JS, Leite JC, Sanseverino MT, Dutra Mda G, Castilla EE, Schüler-Faccini L. Source Instituto Nacional de Genética Médica Populacional at Teratogen Information Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. Abstract The thalidomide tragedy of the 1960s resulted in thousands of children being born with severe limb reduction defects (LRD), among other malformations. In Brazil, there are still babies born with thalidomide embryopathy (TE) because of leprosy prevalence, availability of thalidomide, and deficiencies in the control of drug dispensation. Our objective was to implement a system of proactive surveillance to identify birth defects compatible with TE. Along one year, newborns with LRD were assessed in the Brazilian hospitals participating in the Latin-American Collaborative Study of Congenital Malformations (ECLAMC). A phenotype of LRD called thalidomide embryopathy phenotype (TEP) was established for surveillance. Children with TEP born between the years 2000-2008 were monitored, and during the 2007-2008 period we clinically investigated in greater detail all cases with TEP (proactive period). The period from 1982 to 1999 was defined as the baseline period for the cumulative sum statistics. The frequency of TEP during the surveillance period, at 3.10/10,000 births (CI 95%: 2.50-3.70), was significantly higher than that observed in the baseline period (1.92/10,000 births; CI 95%: 1.60-2.20), and not uniformly distributed across different Brazilian regions. During the proactive surveillance (2007-2008), two cases of suspected TE were identified, although the two mothers had denied the use of the drug during pregnancy. Our results suggest that TEP has probably increased in recent years, which coincides with the period of greater thalidomide availability. Our proactive surveillance identified two newborns with suspected TE, proving to be a sensitive tool to detect TE. The high frequency of leprosy and the large use of thalidomide reinforce the need for a continuous monitoring of TEP across Brazil.
publishDate 2011
dc.date.none.fl_str_mv 2011-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/237438
Sales Luiz Vianna, Fernanda; López Camelo, Jorge Santiago; Louguercio Leite, Júlio César; Vieira Sanseverino, Maria Teresa; da Graça Dutra, Maria; et al.; Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil; Public Library of Science; Plos One; 6; 7; 7-2011; 1-5
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/237438
identifier_str_mv Sales Luiz Vianna, Fernanda; López Camelo, Jorge Santiago; Louguercio Leite, Júlio César; Vieira Sanseverino, Maria Teresa; da Graça Dutra, Maria; et al.; Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil; Public Library of Science; Plos One; 6; 7; 7-2011; 1-5
1932-6203
CONICET Digital
CONICET
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language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0021735
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
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publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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