Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
- Autores
- Sales Luiz Vianna, Fernanda; López Camelo, Jorge Santiago; Louguercio Leite, Júlio César; Vieira Sanseverino, Maria Teresa; da Graça Dutra, Maria; Castilla, Eduardo Enrique; Schuler Faccini, Lavínia
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil. Vianna FS, Lopez-Camelo JS, Leite JC, Sanseverino MT, Dutra Mda G, Castilla EE, Schüler-Faccini L. Source Instituto Nacional de Genética Médica Populacional at Teratogen Information Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. Abstract The thalidomide tragedy of the 1960s resulted in thousands of children being born with severe limb reduction defects (LRD), among other malformations. In Brazil, there are still babies born with thalidomide embryopathy (TE) because of leprosy prevalence, availability of thalidomide, and deficiencies in the control of drug dispensation. Our objective was to implement a system of proactive surveillance to identify birth defects compatible with TE. Along one year, newborns with LRD were assessed in the Brazilian hospitals participating in the Latin-American Collaborative Study of Congenital Malformations (ECLAMC). A phenotype of LRD called thalidomide embryopathy phenotype (TEP) was established for surveillance. Children with TEP born between the years 2000-2008 were monitored, and during the 2007-2008 period we clinically investigated in greater detail all cases with TEP (proactive period). The period from 1982 to 1999 was defined as the baseline period for the cumulative sum statistics. The frequency of TEP during the surveillance period, at 3.10/10,000 births (CI 95%: 2.50-3.70), was significantly higher than that observed in the baseline period (1.92/10,000 births; CI 95%: 1.60-2.20), and not uniformly distributed across different Brazilian regions. During the proactive surveillance (2007-2008), two cases of suspected TE were identified, although the two mothers had denied the use of the drug during pregnancy. Our results suggest that TEP has probably increased in recent years, which coincides with the period of greater thalidomide availability. Our proactive surveillance identified two newborns with suspected TE, proving to be a sensitive tool to detect TE. The high frequency of leprosy and the large use of thalidomide reinforce the need for a continuous monitoring of TEP across Brazil.
Fil: Sales Luiz Vianna, Fernanda. Universidade Federal do Rio Grande do Sul; Brasil
Fil: López Camelo, Jorge Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Louguercio Leite, Júlio César. Hospital de Clínicas de Porto Alegre; Brasil
Fil: Vieira Sanseverino, Maria Teresa. Hospital de Clínicas de Porto Alegre; Brasil
Fil: da Graça Dutra, Maria. Ministerio de Salud de Brasil. Fundación Oswaldo Cruz. Instituto Oswaldo Cruz;
Fil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: Schuler Faccini, Lavínia. Hospital de Clínicas de Porto Alegre; Brasil. Universidade Federal do Rio Grande do Sul; Brasil - Materia
-
Epidemiological
surveillance
Birth
Defects - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/237438
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Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in BrazilSales Luiz Vianna, FernandaLópez Camelo, Jorge SantiagoLouguercio Leite, Júlio CésarVieira Sanseverino, Maria Teresada Graça Dutra, MariaCastilla, Eduardo EnriqueSchuler Faccini, LavíniaEpidemiologicalsurveillanceBirthDefectshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil. Vianna FS, Lopez-Camelo JS, Leite JC, Sanseverino MT, Dutra Mda G, Castilla EE, Schüler-Faccini L. Source Instituto Nacional de Genética Médica Populacional at Teratogen Information Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. Abstract The thalidomide tragedy of the 1960s resulted in thousands of children being born with severe limb reduction defects (LRD), among other malformations. In Brazil, there are still babies born with thalidomide embryopathy (TE) because of leprosy prevalence, availability of thalidomide, and deficiencies in the control of drug dispensation. Our objective was to implement a system of proactive surveillance to identify birth defects compatible with TE. Along one year, newborns with LRD were assessed in the Brazilian hospitals participating in the Latin-American Collaborative Study of Congenital Malformations (ECLAMC). A phenotype of LRD called thalidomide embryopathy phenotype (TEP) was established for surveillance. Children with TEP born between the years 2000-2008 were monitored, and during the 2007-2008 period we clinically investigated in greater detail all cases with TEP (proactive period). The period from 1982 to 1999 was defined as the baseline period for the cumulative sum statistics. The frequency of TEP during the surveillance period, at 3.10/10,000 births (CI 95%: 2.50-3.70), was significantly higher than that observed in the baseline period (1.92/10,000 births; CI 95%: 1.60-2.20), and not uniformly distributed across different Brazilian regions. During the proactive surveillance (2007-2008), two cases of suspected TE were identified, although the two mothers had denied the use of the drug during pregnancy. Our results suggest that TEP has probably increased in recent years, which coincides with the period of greater thalidomide availability. Our proactive surveillance identified two newborns with suspected TE, proving to be a sensitive tool to detect TE. The high frequency of leprosy and the large use of thalidomide reinforce the need for a continuous monitoring of TEP across Brazil.Fil: Sales Luiz Vianna, Fernanda. Universidade Federal do Rio Grande do Sul; BrasilFil: López Camelo, Jorge Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Louguercio Leite, Júlio César. Hospital de Clínicas de Porto Alegre; BrasilFil: Vieira Sanseverino, Maria Teresa. Hospital de Clínicas de Porto Alegre; BrasilFil: da Graça Dutra, Maria. Ministerio de Salud de Brasil. Fundación Oswaldo Cruz. Instituto Oswaldo Cruz;Fil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: Schuler Faccini, Lavínia. Hospital de Clínicas de Porto Alegre; Brasil. Universidade Federal do Rio Grande do Sul; BrasilPublic Library of Science2011-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/237438Sales Luiz Vianna, Fernanda; López Camelo, Jorge Santiago; Louguercio Leite, Júlio César; Vieira Sanseverino, Maria Teresa; da Graça Dutra, Maria; et al.; Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil; Public Library of Science; Plos One; 6; 7; 7-2011; 1-51932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021735info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0021735info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:38:35Zoai:ri.conicet.gov.ar:11336/237438instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:38:35.291CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil |
title |
Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil |
spellingShingle |
Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil Sales Luiz Vianna, Fernanda Epidemiological surveillance Birth Defects |
title_short |
Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil |
title_full |
Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil |
title_fullStr |
Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil |
title_full_unstemmed |
Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil |
title_sort |
Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil |
dc.creator.none.fl_str_mv |
Sales Luiz Vianna, Fernanda López Camelo, Jorge Santiago Louguercio Leite, Júlio César Vieira Sanseverino, Maria Teresa da Graça Dutra, Maria Castilla, Eduardo Enrique Schuler Faccini, Lavínia |
author |
Sales Luiz Vianna, Fernanda |
author_facet |
Sales Luiz Vianna, Fernanda López Camelo, Jorge Santiago Louguercio Leite, Júlio César Vieira Sanseverino, Maria Teresa da Graça Dutra, Maria Castilla, Eduardo Enrique Schuler Faccini, Lavínia |
author_role |
author |
author2 |
López Camelo, Jorge Santiago Louguercio Leite, Júlio César Vieira Sanseverino, Maria Teresa da Graça Dutra, Maria Castilla, Eduardo Enrique Schuler Faccini, Lavínia |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
Epidemiological surveillance Birth Defects |
topic |
Epidemiological surveillance Birth Defects |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil. Vianna FS, Lopez-Camelo JS, Leite JC, Sanseverino MT, Dutra Mda G, Castilla EE, Schüler-Faccini L. Source Instituto Nacional de Genética Médica Populacional at Teratogen Information Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. Abstract The thalidomide tragedy of the 1960s resulted in thousands of children being born with severe limb reduction defects (LRD), among other malformations. In Brazil, there are still babies born with thalidomide embryopathy (TE) because of leprosy prevalence, availability of thalidomide, and deficiencies in the control of drug dispensation. Our objective was to implement a system of proactive surveillance to identify birth defects compatible with TE. Along one year, newborns with LRD were assessed in the Brazilian hospitals participating in the Latin-American Collaborative Study of Congenital Malformations (ECLAMC). A phenotype of LRD called thalidomide embryopathy phenotype (TEP) was established for surveillance. Children with TEP born between the years 2000-2008 were monitored, and during the 2007-2008 period we clinically investigated in greater detail all cases with TEP (proactive period). The period from 1982 to 1999 was defined as the baseline period for the cumulative sum statistics. The frequency of TEP during the surveillance period, at 3.10/10,000 births (CI 95%: 2.50-3.70), was significantly higher than that observed in the baseline period (1.92/10,000 births; CI 95%: 1.60-2.20), and not uniformly distributed across different Brazilian regions. During the proactive surveillance (2007-2008), two cases of suspected TE were identified, although the two mothers had denied the use of the drug during pregnancy. Our results suggest that TEP has probably increased in recent years, which coincides with the period of greater thalidomide availability. Our proactive surveillance identified two newborns with suspected TE, proving to be a sensitive tool to detect TE. The high frequency of leprosy and the large use of thalidomide reinforce the need for a continuous monitoring of TEP across Brazil. Fil: Sales Luiz Vianna, Fernanda. Universidade Federal do Rio Grande do Sul; Brasil Fil: López Camelo, Jorge Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina Fil: Louguercio Leite, Júlio César. Hospital de Clínicas de Porto Alegre; Brasil Fil: Vieira Sanseverino, Maria Teresa. Hospital de Clínicas de Porto Alegre; Brasil Fil: da Graça Dutra, Maria. Ministerio de Salud de Brasil. Fundación Oswaldo Cruz. Instituto Oswaldo Cruz; Fil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina Fil: Schuler Faccini, Lavínia. Hospital de Clínicas de Porto Alegre; Brasil. Universidade Federal do Rio Grande do Sul; Brasil |
description |
Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil. Vianna FS, Lopez-Camelo JS, Leite JC, Sanseverino MT, Dutra Mda G, Castilla EE, Schüler-Faccini L. Source Instituto Nacional de Genética Médica Populacional at Teratogen Information Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. Abstract The thalidomide tragedy of the 1960s resulted in thousands of children being born with severe limb reduction defects (LRD), among other malformations. In Brazil, there are still babies born with thalidomide embryopathy (TE) because of leprosy prevalence, availability of thalidomide, and deficiencies in the control of drug dispensation. Our objective was to implement a system of proactive surveillance to identify birth defects compatible with TE. Along one year, newborns with LRD were assessed in the Brazilian hospitals participating in the Latin-American Collaborative Study of Congenital Malformations (ECLAMC). A phenotype of LRD called thalidomide embryopathy phenotype (TEP) was established for surveillance. Children with TEP born between the years 2000-2008 were monitored, and during the 2007-2008 period we clinically investigated in greater detail all cases with TEP (proactive period). The period from 1982 to 1999 was defined as the baseline period for the cumulative sum statistics. The frequency of TEP during the surveillance period, at 3.10/10,000 births (CI 95%: 2.50-3.70), was significantly higher than that observed in the baseline period (1.92/10,000 births; CI 95%: 1.60-2.20), and not uniformly distributed across different Brazilian regions. During the proactive surveillance (2007-2008), two cases of suspected TE were identified, although the two mothers had denied the use of the drug during pregnancy. Our results suggest that TEP has probably increased in recent years, which coincides with the period of greater thalidomide availability. Our proactive surveillance identified two newborns with suspected TE, proving to be a sensitive tool to detect TE. The high frequency of leprosy and the large use of thalidomide reinforce the need for a continuous monitoring of TEP across Brazil. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/237438 Sales Luiz Vianna, Fernanda; López Camelo, Jorge Santiago; Louguercio Leite, Júlio César; Vieira Sanseverino, Maria Teresa; da Graça Dutra, Maria; et al.; Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil; Public Library of Science; Plos One; 6; 7; 7-2011; 1-5 1932-6203 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/237438 |
identifier_str_mv |
Sales Luiz Vianna, Fernanda; López Camelo, Jorge Santiago; Louguercio Leite, Júlio César; Vieira Sanseverino, Maria Teresa; da Graça Dutra, Maria; et al.; Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil; Public Library of Science; Plos One; 6; 7; 7-2011; 1-5 1932-6203 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021735 info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0021735 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Public Library of Science |
publisher.none.fl_str_mv |
Public Library of Science |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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