Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness

Autores
Sanz Perl Hernandez, Yonatan; Pallavicini, Carla; Perez Ipiña, Ignacio Martin; Demertzi, Athena; Bonhomme, Vincent; Martial, Charlotte; Panda, Rajanikant; Annen, Jitka; Ibanez Barassi, Agustin Mariano; Kringelbach, Morten; Deco, Gustavo; Laufs, Helmut; Sitt, Jacobo Diego; Laureys, Steven; Tagliazucchi, Enzo Rodolfo
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Consciousness transiently fades away during deep sleep, more stably under anesthesia, and sometimes permanently due to brain injury. The development of an index to quantify the level of consciousness across these different states is regarded as a key problem both in basic and clinical neuroscience. We argue that this problem is ill-defined since such an index would not exhaust all the relevant information about a given state of consciousness. While the level of consciousness can be taken to describe the actual brain state, a complete characterization should also include its potential behavior against external perturbations. We developed and analyzed whole-brain computational models to show that the stability of conscious states provides information complementary to their similarity to conscious wakefulness. Our work leads to a novel methodological framework to sort out different brain states by their stability and reversibility, and illustrates its usefulness to dissociate between physiological (sleep), pathological (brain-injured patients), and pharmacologically-induced (anesthesia) loss of consciousness.
Fil: Sanz Perl Hernandez, Yonatan. Universitat Pompeu Fabra; España. Universidad de San Andrés; Argentina. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pallavicini, Carla. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Perez Ipiña, Ignacio Martin. Universidad de Buenos Aires; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Demertzi, Athena. Université de Liège; Bélgica
Fil: Bonhomme, Vincent. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica
Fil: Martial, Charlotte. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica
Fil: Panda, Rajanikant. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica
Fil: Annen, Jitka. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica
Fil: Ibanez Barassi, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Universidad Adolfo Ibañez; Chile
Fil: Kringelbach, Morten. University of Oxford; Reino Unido. University Aarhus; Dinamarca
Fil: Deco, Gustavo. Max Planck Institute For Human Cognitive And Brain Sciences; Alemania. Monash University; Australia. Universitat Pompeu Fabra; España. Institucio´ Catalana de la Recerca i Estudis Avancats; España. University of Melbourne; Australia
Fil: Laufs, Helmut. Goethe Universitat Frankfurt; Alemania. Christian Albrechts University; Alemania
Fil: Sitt, Jacobo Diego. Institut Du Cerveau Et de la Moelle Épinière; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Laureys, Steven. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica. Centre Hospitalier Universitaire de Liege; Bélgica
Fil: Tagliazucchi, Enzo Rodolfo. Universidad de Buenos Aires; Argentina. Christian Albrechts University; Alemania. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Materia
PERTURBATION
BRAIN ACTIVITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/166302

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spelling Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousnessSanz Perl Hernandez, YonatanPallavicini, CarlaPerez Ipiña, Ignacio MartinDemertzi, AthenaBonhomme, VincentMartial, CharlottePanda, RajanikantAnnen, JitkaIbanez Barassi, Agustin MarianoKringelbach, MortenDeco, GustavoLaufs, HelmutSitt, Jacobo DiegoLaureys, StevenTagliazucchi, Enzo RodolfoPERTURBATIONBRAIN ACTIVITYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Consciousness transiently fades away during deep sleep, more stably under anesthesia, and sometimes permanently due to brain injury. The development of an index to quantify the level of consciousness across these different states is regarded as a key problem both in basic and clinical neuroscience. We argue that this problem is ill-defined since such an index would not exhaust all the relevant information about a given state of consciousness. While the level of consciousness can be taken to describe the actual brain state, a complete characterization should also include its potential behavior against external perturbations. We developed and analyzed whole-brain computational models to show that the stability of conscious states provides information complementary to their similarity to conscious wakefulness. Our work leads to a novel methodological framework to sort out different brain states by their stability and reversibility, and illustrates its usefulness to dissociate between physiological (sleep), pathological (brain-injured patients), and pharmacologically-induced (anesthesia) loss of consciousness.Fil: Sanz Perl Hernandez, Yonatan. Universitat Pompeu Fabra; España. Universidad de San Andrés; Argentina. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pallavicini, Carla. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Perez Ipiña, Ignacio Martin. Universidad de Buenos Aires; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Demertzi, Athena. Université de Liège; BélgicaFil: Bonhomme, Vincent. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; BélgicaFil: Martial, Charlotte. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; BélgicaFil: Panda, Rajanikant. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; BélgicaFil: Annen, Jitka. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; BélgicaFil: Ibanez Barassi, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Universidad Adolfo Ibañez; ChileFil: Kringelbach, Morten. University of Oxford; Reino Unido. University Aarhus; DinamarcaFil: Deco, Gustavo. Max Planck Institute For Human Cognitive And Brain Sciences; Alemania. Monash University; Australia. Universitat Pompeu Fabra; España. Institucio´ Catalana de la Recerca i Estudis Avancats; España. University of Melbourne; AustraliaFil: Laufs, Helmut. Goethe Universitat Frankfurt; Alemania. Christian Albrechts University; AlemaniaFil: Sitt, Jacobo Diego. Institut Du Cerveau Et de la Moelle Épinière; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; FranciaFil: Laureys, Steven. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica. Centre Hospitalier Universitaire de Liege; BélgicaFil: Tagliazucchi, Enzo Rodolfo. Universidad de Buenos Aires; Argentina. Christian Albrechts University; Alemania. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaPublic Library of Science2021-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/166302Sanz Perl Hernandez, Yonatan; Pallavicini, Carla; Perez Ipiña, Ignacio Martin; Demertzi, Athena; Bonhomme, Vincent; et al.; Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness; Public Library of Science; Plos Computational Biology; 17; 7; 7-2021; 1-241553-7358CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://dx.plos.org/10.1371/journal.pcbi.1009139info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pcbi.1009139info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:30:36Zoai:ri.conicet.gov.ar:11336/166302instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:30:36.446CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness
title Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness
spellingShingle Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness
Sanz Perl Hernandez, Yonatan
PERTURBATION
BRAIN ACTIVITY
title_short Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness
title_full Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness
title_fullStr Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness
title_full_unstemmed Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness
title_sort Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness
dc.creator.none.fl_str_mv Sanz Perl Hernandez, Yonatan
Pallavicini, Carla
Perez Ipiña, Ignacio Martin
Demertzi, Athena
Bonhomme, Vincent
Martial, Charlotte
Panda, Rajanikant
Annen, Jitka
Ibanez Barassi, Agustin Mariano
Kringelbach, Morten
Deco, Gustavo
Laufs, Helmut
Sitt, Jacobo Diego
Laureys, Steven
Tagliazucchi, Enzo Rodolfo
author Sanz Perl Hernandez, Yonatan
author_facet Sanz Perl Hernandez, Yonatan
Pallavicini, Carla
Perez Ipiña, Ignacio Martin
Demertzi, Athena
Bonhomme, Vincent
Martial, Charlotte
Panda, Rajanikant
Annen, Jitka
Ibanez Barassi, Agustin Mariano
Kringelbach, Morten
Deco, Gustavo
Laufs, Helmut
Sitt, Jacobo Diego
Laureys, Steven
Tagliazucchi, Enzo Rodolfo
author_role author
author2 Pallavicini, Carla
Perez Ipiña, Ignacio Martin
Demertzi, Athena
Bonhomme, Vincent
Martial, Charlotte
Panda, Rajanikant
Annen, Jitka
Ibanez Barassi, Agustin Mariano
Kringelbach, Morten
Deco, Gustavo
Laufs, Helmut
Sitt, Jacobo Diego
Laureys, Steven
Tagliazucchi, Enzo Rodolfo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv PERTURBATION
BRAIN ACTIVITY
topic PERTURBATION
BRAIN ACTIVITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Consciousness transiently fades away during deep sleep, more stably under anesthesia, and sometimes permanently due to brain injury. The development of an index to quantify the level of consciousness across these different states is regarded as a key problem both in basic and clinical neuroscience. We argue that this problem is ill-defined since such an index would not exhaust all the relevant information about a given state of consciousness. While the level of consciousness can be taken to describe the actual brain state, a complete characterization should also include its potential behavior against external perturbations. We developed and analyzed whole-brain computational models to show that the stability of conscious states provides information complementary to their similarity to conscious wakefulness. Our work leads to a novel methodological framework to sort out different brain states by their stability and reversibility, and illustrates its usefulness to dissociate between physiological (sleep), pathological (brain-injured patients), and pharmacologically-induced (anesthesia) loss of consciousness.
Fil: Sanz Perl Hernandez, Yonatan. Universitat Pompeu Fabra; España. Universidad de San Andrés; Argentina. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pallavicini, Carla. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Perez Ipiña, Ignacio Martin. Universidad de Buenos Aires; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Demertzi, Athena. Université de Liège; Bélgica
Fil: Bonhomme, Vincent. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica
Fil: Martial, Charlotte. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica
Fil: Panda, Rajanikant. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica
Fil: Annen, Jitka. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica
Fil: Ibanez Barassi, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Universidad Adolfo Ibañez; Chile
Fil: Kringelbach, Morten. University of Oxford; Reino Unido. University Aarhus; Dinamarca
Fil: Deco, Gustavo. Max Planck Institute For Human Cognitive And Brain Sciences; Alemania. Monash University; Australia. Universitat Pompeu Fabra; España. Institucio´ Catalana de la Recerca i Estudis Avancats; España. University of Melbourne; Australia
Fil: Laufs, Helmut. Goethe Universitat Frankfurt; Alemania. Christian Albrechts University; Alemania
Fil: Sitt, Jacobo Diego. Institut Du Cerveau Et de la Moelle Épinière; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Laureys, Steven. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica. Centre Hospitalier Universitaire de Liege; Bélgica
Fil: Tagliazucchi, Enzo Rodolfo. Universidad de Buenos Aires; Argentina. Christian Albrechts University; Alemania. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
description Consciousness transiently fades away during deep sleep, more stably under anesthesia, and sometimes permanently due to brain injury. The development of an index to quantify the level of consciousness across these different states is regarded as a key problem both in basic and clinical neuroscience. We argue that this problem is ill-defined since such an index would not exhaust all the relevant information about a given state of consciousness. While the level of consciousness can be taken to describe the actual brain state, a complete characterization should also include its potential behavior against external perturbations. We developed and analyzed whole-brain computational models to show that the stability of conscious states provides information complementary to their similarity to conscious wakefulness. Our work leads to a novel methodological framework to sort out different brain states by their stability and reversibility, and illustrates its usefulness to dissociate between physiological (sleep), pathological (brain-injured patients), and pharmacologically-induced (anesthesia) loss of consciousness.
publishDate 2021
dc.date.none.fl_str_mv 2021-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/166302
Sanz Perl Hernandez, Yonatan; Pallavicini, Carla; Perez Ipiña, Ignacio Martin; Demertzi, Athena; Bonhomme, Vincent; et al.; Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness; Public Library of Science; Plos Computational Biology; 17; 7; 7-2021; 1-24
1553-7358
CONICET Digital
CONICET
url http://hdl.handle.net/11336/166302
identifier_str_mv Sanz Perl Hernandez, Yonatan; Pallavicini, Carla; Perez Ipiña, Ignacio Martin; Demertzi, Athena; Bonhomme, Vincent; et al.; Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness; Public Library of Science; Plos Computational Biology; 17; 7; 7-2021; 1-24
1553-7358
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://dx.plos.org/10.1371/journal.pcbi.1009139
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pcbi.1009139
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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