Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness
- Autores
- Sanz Perl Hernandez, Yonatan; Pallavicini, Carla; Perez Ipiña, Ignacio Martin; Demertzi, Athena; Bonhomme, Vincent; Martial, Charlotte; Panda, Rajanikant; Annen, Jitka; Ibanez Barassi, Agustin Mariano; Kringelbach, Morten; Deco, Gustavo; Laufs, Helmut; Sitt, Jacobo Diego; Laureys, Steven; Tagliazucchi, Enzo Rodolfo
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Consciousness transiently fades away during deep sleep, more stably under anesthesia, and sometimes permanently due to brain injury. The development of an index to quantify the level of consciousness across these different states is regarded as a key problem both in basic and clinical neuroscience. We argue that this problem is ill-defined since such an index would not exhaust all the relevant information about a given state of consciousness. While the level of consciousness can be taken to describe the actual brain state, a complete characterization should also include its potential behavior against external perturbations. We developed and analyzed whole-brain computational models to show that the stability of conscious states provides information complementary to their similarity to conscious wakefulness. Our work leads to a novel methodological framework to sort out different brain states by their stability and reversibility, and illustrates its usefulness to dissociate between physiological (sleep), pathological (brain-injured patients), and pharmacologically-induced (anesthesia) loss of consciousness.
Fil: Sanz Perl Hernandez, Yonatan. Universitat Pompeu Fabra; España. Universidad de San Andrés; Argentina. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pallavicini, Carla. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Perez Ipiña, Ignacio Martin. Universidad de Buenos Aires; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Demertzi, Athena. Université de Liège; Bélgica
Fil: Bonhomme, Vincent. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica
Fil: Martial, Charlotte. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica
Fil: Panda, Rajanikant. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica
Fil: Annen, Jitka. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica
Fil: Ibanez Barassi, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Universidad Adolfo Ibañez; Chile
Fil: Kringelbach, Morten. University of Oxford; Reino Unido. University Aarhus; Dinamarca
Fil: Deco, Gustavo. Max Planck Institute For Human Cognitive And Brain Sciences; Alemania. Monash University; Australia. Universitat Pompeu Fabra; España. Institucio´ Catalana de la Recerca i Estudis Avancats; España. University of Melbourne; Australia
Fil: Laufs, Helmut. Goethe Universitat Frankfurt; Alemania. Christian Albrechts University; Alemania
Fil: Sitt, Jacobo Diego. Institut Du Cerveau Et de la Moelle Épinière; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Laureys, Steven. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica. Centre Hospitalier Universitaire de Liege; Bélgica
Fil: Tagliazucchi, Enzo Rodolfo. Universidad de Buenos Aires; Argentina. Christian Albrechts University; Alemania. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina - Materia
-
PERTURBATION
BRAIN ACTIVITY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/166302
Ver los metadatos del registro completo
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Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousnessSanz Perl Hernandez, YonatanPallavicini, CarlaPerez Ipiña, Ignacio MartinDemertzi, AthenaBonhomme, VincentMartial, CharlottePanda, RajanikantAnnen, JitkaIbanez Barassi, Agustin MarianoKringelbach, MortenDeco, GustavoLaufs, HelmutSitt, Jacobo DiegoLaureys, StevenTagliazucchi, Enzo RodolfoPERTURBATIONBRAIN ACTIVITYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Consciousness transiently fades away during deep sleep, more stably under anesthesia, and sometimes permanently due to brain injury. The development of an index to quantify the level of consciousness across these different states is regarded as a key problem both in basic and clinical neuroscience. We argue that this problem is ill-defined since such an index would not exhaust all the relevant information about a given state of consciousness. While the level of consciousness can be taken to describe the actual brain state, a complete characterization should also include its potential behavior against external perturbations. We developed and analyzed whole-brain computational models to show that the stability of conscious states provides information complementary to their similarity to conscious wakefulness. Our work leads to a novel methodological framework to sort out different brain states by their stability and reversibility, and illustrates its usefulness to dissociate between physiological (sleep), pathological (brain-injured patients), and pharmacologically-induced (anesthesia) loss of consciousness.Fil: Sanz Perl Hernandez, Yonatan. Universitat Pompeu Fabra; España. Universidad de San Andrés; Argentina. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pallavicini, Carla. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Perez Ipiña, Ignacio Martin. Universidad de Buenos Aires; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Demertzi, Athena. Université de Liège; BélgicaFil: Bonhomme, Vincent. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; BélgicaFil: Martial, Charlotte. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; BélgicaFil: Panda, Rajanikant. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; BélgicaFil: Annen, Jitka. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; BélgicaFil: Ibanez Barassi, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Universidad Adolfo Ibañez; ChileFil: Kringelbach, Morten. University of Oxford; Reino Unido. University Aarhus; DinamarcaFil: Deco, Gustavo. Max Planck Institute For Human Cognitive And Brain Sciences; Alemania. Monash University; Australia. Universitat Pompeu Fabra; España. Institucio´ Catalana de la Recerca i Estudis Avancats; España. University of Melbourne; AustraliaFil: Laufs, Helmut. Goethe Universitat Frankfurt; Alemania. Christian Albrechts University; AlemaniaFil: Sitt, Jacobo Diego. Institut Du Cerveau Et de la Moelle Épinière; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; FranciaFil: Laureys, Steven. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica. Centre Hospitalier Universitaire de Liege; BélgicaFil: Tagliazucchi, Enzo Rodolfo. Universidad de Buenos Aires; Argentina. Christian Albrechts University; Alemania. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaPublic Library of Science2021-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/166302Sanz Perl Hernandez, Yonatan; Pallavicini, Carla; Perez Ipiña, Ignacio Martin; Demertzi, Athena; Bonhomme, Vincent; et al.; Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness; Public Library of Science; Plos Computational Biology; 17; 7; 7-2021; 1-241553-7358CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://dx.plos.org/10.1371/journal.pcbi.1009139info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pcbi.1009139info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:30:36Zoai:ri.conicet.gov.ar:11336/166302instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:30:36.446CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness |
title |
Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness |
spellingShingle |
Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness Sanz Perl Hernandez, Yonatan PERTURBATION BRAIN ACTIVITY |
title_short |
Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness |
title_full |
Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness |
title_fullStr |
Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness |
title_full_unstemmed |
Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness |
title_sort |
Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness |
dc.creator.none.fl_str_mv |
Sanz Perl Hernandez, Yonatan Pallavicini, Carla Perez Ipiña, Ignacio Martin Demertzi, Athena Bonhomme, Vincent Martial, Charlotte Panda, Rajanikant Annen, Jitka Ibanez Barassi, Agustin Mariano Kringelbach, Morten Deco, Gustavo Laufs, Helmut Sitt, Jacobo Diego Laureys, Steven Tagliazucchi, Enzo Rodolfo |
author |
Sanz Perl Hernandez, Yonatan |
author_facet |
Sanz Perl Hernandez, Yonatan Pallavicini, Carla Perez Ipiña, Ignacio Martin Demertzi, Athena Bonhomme, Vincent Martial, Charlotte Panda, Rajanikant Annen, Jitka Ibanez Barassi, Agustin Mariano Kringelbach, Morten Deco, Gustavo Laufs, Helmut Sitt, Jacobo Diego Laureys, Steven Tagliazucchi, Enzo Rodolfo |
author_role |
author |
author2 |
Pallavicini, Carla Perez Ipiña, Ignacio Martin Demertzi, Athena Bonhomme, Vincent Martial, Charlotte Panda, Rajanikant Annen, Jitka Ibanez Barassi, Agustin Mariano Kringelbach, Morten Deco, Gustavo Laufs, Helmut Sitt, Jacobo Diego Laureys, Steven Tagliazucchi, Enzo Rodolfo |
author2_role |
author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
PERTURBATION BRAIN ACTIVITY |
topic |
PERTURBATION BRAIN ACTIVITY |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Consciousness transiently fades away during deep sleep, more stably under anesthesia, and sometimes permanently due to brain injury. The development of an index to quantify the level of consciousness across these different states is regarded as a key problem both in basic and clinical neuroscience. We argue that this problem is ill-defined since such an index would not exhaust all the relevant information about a given state of consciousness. While the level of consciousness can be taken to describe the actual brain state, a complete characterization should also include its potential behavior against external perturbations. We developed and analyzed whole-brain computational models to show that the stability of conscious states provides information complementary to their similarity to conscious wakefulness. Our work leads to a novel methodological framework to sort out different brain states by their stability and reversibility, and illustrates its usefulness to dissociate between physiological (sleep), pathological (brain-injured patients), and pharmacologically-induced (anesthesia) loss of consciousness. Fil: Sanz Perl Hernandez, Yonatan. Universitat Pompeu Fabra; España. Universidad de San Andrés; Argentina. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Pallavicini, Carla. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina Fil: Perez Ipiña, Ignacio Martin. Universidad de Buenos Aires; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina Fil: Demertzi, Athena. Université de Liège; Bélgica Fil: Bonhomme, Vincent. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica Fil: Martial, Charlotte. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica Fil: Panda, Rajanikant. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica Fil: Annen, Jitka. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica Fil: Ibanez Barassi, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Universidad Adolfo Ibañez; Chile Fil: Kringelbach, Morten. University of Oxford; Reino Unido. University Aarhus; Dinamarca Fil: Deco, Gustavo. Max Planck Institute For Human Cognitive And Brain Sciences; Alemania. Monash University; Australia. Universitat Pompeu Fabra; España. Institucio´ Catalana de la Recerca i Estudis Avancats; España. University of Melbourne; Australia Fil: Laufs, Helmut. Goethe Universitat Frankfurt; Alemania. Christian Albrechts University; Alemania Fil: Sitt, Jacobo Diego. Institut Du Cerveau Et de la Moelle Épinière; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia Fil: Laureys, Steven. Centre Hospitalier Universitaire de Liege; Bélgica. Université de Liège; Bélgica. Centre Hospitalier Universitaire de Liege; Bélgica Fil: Tagliazucchi, Enzo Rodolfo. Universidad de Buenos Aires; Argentina. Christian Albrechts University; Alemania. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina |
description |
Consciousness transiently fades away during deep sleep, more stably under anesthesia, and sometimes permanently due to brain injury. The development of an index to quantify the level of consciousness across these different states is regarded as a key problem both in basic and clinical neuroscience. We argue that this problem is ill-defined since such an index would not exhaust all the relevant information about a given state of consciousness. While the level of consciousness can be taken to describe the actual brain state, a complete characterization should also include its potential behavior against external perturbations. We developed and analyzed whole-brain computational models to show that the stability of conscious states provides information complementary to their similarity to conscious wakefulness. Our work leads to a novel methodological framework to sort out different brain states by their stability and reversibility, and illustrates its usefulness to dissociate between physiological (sleep), pathological (brain-injured patients), and pharmacologically-induced (anesthesia) loss of consciousness. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/166302 Sanz Perl Hernandez, Yonatan; Pallavicini, Carla; Perez Ipiña, Ignacio Martin; Demertzi, Athena; Bonhomme, Vincent; et al.; Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness; Public Library of Science; Plos Computational Biology; 17; 7; 7-2021; 1-24 1553-7358 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/166302 |
identifier_str_mv |
Sanz Perl Hernandez, Yonatan; Pallavicini, Carla; Perez Ipiña, Ignacio Martin; Demertzi, Athena; Bonhomme, Vincent; et al.; Perturbations in dynamical models of wholebrain activity dissociate between the level and stability of consciousness; Public Library of Science; Plos Computational Biology; 17; 7; 7-2021; 1-24 1553-7358 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://dx.plos.org/10.1371/journal.pcbi.1009139 info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pcbi.1009139 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Public Library of Science |
publisher.none.fl_str_mv |
Public Library of Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614314518904832 |
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13.070432 |