Toxicological and Safety Considerations of Nanocellulose-Containing Packaging Materials

Autores
Curi, Lucila Marilén; Area, Maria Cristina; Vallejos, María Evangelina
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The global demand for renewable and sustainable non-petroleum-based resources is rapidly increasing. Lignocellulosic biomass is a valuable resource with broad potential for nanocellulose (NC) production. However, limited studies are available regarding the potential toxicological impact of NC. We provide an overview of the nanosafety implications associated mainly with nanofibrillated cellulose (CNF) and identify knowledge gaps. For this purpose, we present an analysis of the studies published from 2014 to 2025 in which the authors mention aspectsrelated to toxicity in the context of packaging. We also analyze the main methods used for toxicity evaluations and the main studies about toxicity evaluation using different biomarkers for a broad interpretation. This comprehensive biblio-graphic review highlights the critical need for further research to elucidate the mechanisms fully underlining NC toxicity, mainly due to its nanofibrillar structure.We focus on the cellular responses across different evaluated cell types through in vitro evaluation, always within the context of the dose used, the type of material or its source, and thetype of biomarkers used in the assessments. The importance of addressing safety considerations and key knowledge gaps for the responsible use of CNF derived fromlignocellulosic biomass and its bionanocomposites in food packaging is highlighted.
Fil: Curi, Lucila Marilén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Materiales de Misiones. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Instituto de Materiales de Misiones; Argentina
Fil: Area, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Materiales de Misiones. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Instituto de Materiales de Misiones; Argentina
Fil: Vallejos, María Evangelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Materiales de Misiones. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Instituto de Materiales de Misiones; Argentina
Materia
CITOTOXICITY STUDIES
NANOFIBRILLATED CELLULOSE
IN VITRO
NANOSAFETY
PACKAGING
TOXICITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/274811
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Toxicological and Safety Considerations of Nanocellulose-Containing Packaging MaterialsCuri, Lucila MarilénArea, Maria CristinaVallejos, María EvangelinaCITOTOXICITY STUDIESNANOFIBRILLATED CELLULOSEIN VITRONANOSAFETYPACKAGINGTOXICITYhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2The global demand for renewable and sustainable non-petroleum-based resources is rapidly increasing. Lignocellulosic biomass is a valuable resource with broad potential for nanocellulose (NC) production. However, limited studies are available regarding the potential toxicological impact of NC. We provide an overview of the nanosafety implications associated mainly with nanofibrillated cellulose (CNF) and identify knowledge gaps. For this purpose, we present an analysis of the studies published from 2014 to 2025 in which the authors mention aspectsrelated to toxicity in the context of packaging. We also analyze the main methods used for toxicity evaluations and the main studies about toxicity evaluation using different biomarkers for a broad interpretation. This comprehensive biblio-graphic review highlights the critical need for further research to elucidate the mechanisms fully underlining NC toxicity, mainly due to its nanofibrillar structure.We focus on the cellular responses across different evaluated cell types through in vitro evaluation, always within the context of the dose used, the type of material or its source, and thetype of biomarkers used in the assessments. The importance of addressing safety considerations and key knowledge gaps for the responsible use of CNF derived fromlignocellulosic biomass and its bionanocomposites in food packaging is highlighted.Fil: Curi, Lucila Marilén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Materiales de Misiones. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Instituto de Materiales de Misiones; ArgentinaFil: Area, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Materiales de Misiones. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Instituto de Materiales de Misiones; ArgentinaFil: Vallejos, María Evangelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Materiales de Misiones. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Instituto de Materiales de Misiones; ArgentinaTech Science Press2025-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/274811Curi, Lucila Marilén; Area, Maria Cristina; Vallejos, María Evangelina; Toxicological and Safety Considerations of Nanocellulose-Containing Packaging Materials; Tech Science Press; Journal of Renewable Materials; 7-2025; 1-102164-6341CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.techscience.com/jrm/online/detail/23905info:eu-repo/semantics/altIdentifier/doi/10.32604/jrm.2025.02025-0069info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-12-23T14:18:54Zoai:ri.conicet.gov.ar:11336/274811instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-12-23 14:18:55.058CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Toxicological and Safety Considerations of Nanocellulose-Containing Packaging Materials
title Toxicological and Safety Considerations of Nanocellulose-Containing Packaging Materials
spellingShingle Toxicological and Safety Considerations of Nanocellulose-Containing Packaging Materials
Curi, Lucila Marilén
CITOTOXICITY STUDIES
NANOFIBRILLATED CELLULOSE
IN VITRO
NANOSAFETY
PACKAGING
TOXICITY
title_short Toxicological and Safety Considerations of Nanocellulose-Containing Packaging Materials
title_full Toxicological and Safety Considerations of Nanocellulose-Containing Packaging Materials
title_fullStr Toxicological and Safety Considerations of Nanocellulose-Containing Packaging Materials
title_full_unstemmed Toxicological and Safety Considerations of Nanocellulose-Containing Packaging Materials
title_sort Toxicological and Safety Considerations of Nanocellulose-Containing Packaging Materials
dc.creator.none.fl_str_mv Curi, Lucila Marilén
Area, Maria Cristina
Vallejos, María Evangelina
author Curi, Lucila Marilén
author_facet Curi, Lucila Marilén
Area, Maria Cristina
Vallejos, María Evangelina
author_role author
author2 Area, Maria Cristina
Vallejos, María Evangelina
author2_role author
author
dc.subject.none.fl_str_mv CITOTOXICITY STUDIES
NANOFIBRILLATED CELLULOSE
IN VITRO
NANOSAFETY
PACKAGING
TOXICITY
topic CITOTOXICITY STUDIES
NANOFIBRILLATED CELLULOSE
IN VITRO
NANOSAFETY
PACKAGING
TOXICITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The global demand for renewable and sustainable non-petroleum-based resources is rapidly increasing. Lignocellulosic biomass is a valuable resource with broad potential for nanocellulose (NC) production. However, limited studies are available regarding the potential toxicological impact of NC. We provide an overview of the nanosafety implications associated mainly with nanofibrillated cellulose (CNF) and identify knowledge gaps. For this purpose, we present an analysis of the studies published from 2014 to 2025 in which the authors mention aspectsrelated to toxicity in the context of packaging. We also analyze the main methods used for toxicity evaluations and the main studies about toxicity evaluation using different biomarkers for a broad interpretation. This comprehensive biblio-graphic review highlights the critical need for further research to elucidate the mechanisms fully underlining NC toxicity, mainly due to its nanofibrillar structure.We focus on the cellular responses across different evaluated cell types through in vitro evaluation, always within the context of the dose used, the type of material or its source, and thetype of biomarkers used in the assessments. The importance of addressing safety considerations and key knowledge gaps for the responsible use of CNF derived fromlignocellulosic biomass and its bionanocomposites in food packaging is highlighted.
Fil: Curi, Lucila Marilén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Materiales de Misiones. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Instituto de Materiales de Misiones; Argentina
Fil: Area, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Materiales de Misiones. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Instituto de Materiales de Misiones; Argentina
Fil: Vallejos, María Evangelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Materiales de Misiones. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Instituto de Materiales de Misiones; Argentina
description The global demand for renewable and sustainable non-petroleum-based resources is rapidly increasing. Lignocellulosic biomass is a valuable resource with broad potential for nanocellulose (NC) production. However, limited studies are available regarding the potential toxicological impact of NC. We provide an overview of the nanosafety implications associated mainly with nanofibrillated cellulose (CNF) and identify knowledge gaps. For this purpose, we present an analysis of the studies published from 2014 to 2025 in which the authors mention aspectsrelated to toxicity in the context of packaging. We also analyze the main methods used for toxicity evaluations and the main studies about toxicity evaluation using different biomarkers for a broad interpretation. This comprehensive biblio-graphic review highlights the critical need for further research to elucidate the mechanisms fully underlining NC toxicity, mainly due to its nanofibrillar structure.We focus on the cellular responses across different evaluated cell types through in vitro evaluation, always within the context of the dose used, the type of material or its source, and thetype of biomarkers used in the assessments. The importance of addressing safety considerations and key knowledge gaps for the responsible use of CNF derived fromlignocellulosic biomass and its bionanocomposites in food packaging is highlighted.
publishDate 2025
dc.date.none.fl_str_mv 2025-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/274811
Curi, Lucila Marilén; Area, Maria Cristina; Vallejos, María Evangelina; Toxicological and Safety Considerations of Nanocellulose-Containing Packaging Materials; Tech Science Press; Journal of Renewable Materials; 7-2025; 1-10
2164-6341
CONICET Digital
CONICET
url http://hdl.handle.net/11336/274811
identifier_str_mv Curi, Lucila Marilén; Area, Maria Cristina; Vallejos, María Evangelina; Toxicological and Safety Considerations of Nanocellulose-Containing Packaging Materials; Tech Science Press; Journal of Renewable Materials; 7-2025; 1-10
2164-6341
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.techscience.com/jrm/online/detail/23905
info:eu-repo/semantics/altIdentifier/doi/10.32604/jrm.2025.02025-0069
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Tech Science Press
publisher.none.fl_str_mv Tech Science Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.952241

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