A 3D Cellular Automaton for Cell Differentiation in a Solid Tumor with Plasticity

Autores
Margarit, David Hipólito; Romanelli, Lilia Mabel; Fendrik, Alejandro José
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A model with spherical symmetry is proposed. We analyze the appropriate parameters of cell dierentiation for different kinds of cells (Cancer Stem Cells (CSC) and Differentiated Cells(DC)). The plasticity (capacity to return from a DC to its previous state of CSC) is taken intoaccount. Following this hypothesis, the dissemination of CSCs to another organ is analyzed. The location of the cells in the tumor and the plasticity range for possible metastasis is discussed.
Fil: Margarit, David Hipólito. Universidad Nacional de General Sarmiento. Instituto de Ciencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Romanelli, Lilia Mabel. Universidad Nacional de General Sarmiento. Instituto de Ciencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fendrik, Alejandro José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de General Sarmiento. Instituto de Ciencias; Argentina
Materia
Celular automaton
Cell differentiation
Cancer stem cells
Plasticity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/97379
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/97379
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A 3D Cellular Automaton for Cell Differentiation in a Solid Tumor with PlasticityMargarit, David HipólitoRomanelli, Lilia MabelFendrik, Alejandro JoséCelular automatonCell differentiationCancer stem cellsPlasticityhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1A model with spherical symmetry is proposed. We analyze the appropriate parameters of cell dierentiation for different kinds of cells (Cancer Stem Cells (CSC) and Differentiated Cells(DC)). The plasticity (capacity to return from a DC to its previous state of CSC) is taken intoaccount. Following this hypothesis, the dissemination of CSCs to another organ is analyzed. The location of the cells in the tumor and the plasticity range for possible metastasis is discussed.Fil: Margarit, David Hipólito. Universidad Nacional de General Sarmiento. Instituto de Ciencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Romanelli, Lilia Mabel. Universidad Nacional de General Sarmiento. Instituto de Ciencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fendrik, Alejandro José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de General Sarmiento. Instituto de Ciencias; ArgentinaWorld Scientific2018-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/97379Margarit, David Hipólito; Romanelli, Lilia Mabel; Fendrik, Alejandro José; A 3D Cellular Automaton for Cell Differentiation in a Solid Tumor with Plasticity; World Scientific; Biophysical Reviews and Letters; 13; 01; 4-2018; 19-281793-7035CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.worldscientific.com/doi/abs/10.1142/S1793048018500029info:eu-repo/semantics/altIdentifier/doi/10.1142/S1793048018500029info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:34:32Zoai:ri.conicet.gov.ar:11336/97379instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:34:33.092CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A 3D Cellular Automaton for Cell Differentiation in a Solid Tumor with Plasticity
title A 3D Cellular Automaton for Cell Differentiation in a Solid Tumor with Plasticity
spellingShingle A 3D Cellular Automaton for Cell Differentiation in a Solid Tumor with Plasticity
Margarit, David Hipólito
Celular automaton
Cell differentiation
Cancer stem cells
Plasticity
title_short A 3D Cellular Automaton for Cell Differentiation in a Solid Tumor with Plasticity
title_full A 3D Cellular Automaton for Cell Differentiation in a Solid Tumor with Plasticity
title_fullStr A 3D Cellular Automaton for Cell Differentiation in a Solid Tumor with Plasticity
title_full_unstemmed A 3D Cellular Automaton for Cell Differentiation in a Solid Tumor with Plasticity
title_sort A 3D Cellular Automaton for Cell Differentiation in a Solid Tumor with Plasticity
dc.creator.none.fl_str_mv Margarit, David Hipólito
Romanelli, Lilia Mabel
Fendrik, Alejandro José
author Margarit, David Hipólito
author_facet Margarit, David Hipólito
Romanelli, Lilia Mabel
Fendrik, Alejandro José
author_role author
author2 Romanelli, Lilia Mabel
Fendrik, Alejandro José
author2_role author
author
dc.subject.none.fl_str_mv Celular automaton
Cell differentiation
Cancer stem cells
Plasticity
topic Celular automaton
Cell differentiation
Cancer stem cells
Plasticity
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A model with spherical symmetry is proposed. We analyze the appropriate parameters of cell dierentiation for different kinds of cells (Cancer Stem Cells (CSC) and Differentiated Cells(DC)). The plasticity (capacity to return from a DC to its previous state of CSC) is taken intoaccount. Following this hypothesis, the dissemination of CSCs to another organ is analyzed. The location of the cells in the tumor and the plasticity range for possible metastasis is discussed.
Fil: Margarit, David Hipólito. Universidad Nacional de General Sarmiento. Instituto de Ciencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Romanelli, Lilia Mabel. Universidad Nacional de General Sarmiento. Instituto de Ciencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fendrik, Alejandro José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de General Sarmiento. Instituto de Ciencias; Argentina
description A model with spherical symmetry is proposed. We analyze the appropriate parameters of cell dierentiation for different kinds of cells (Cancer Stem Cells (CSC) and Differentiated Cells(DC)). The plasticity (capacity to return from a DC to its previous state of CSC) is taken intoaccount. Following this hypothesis, the dissemination of CSCs to another organ is analyzed. The location of the cells in the tumor and the plasticity range for possible metastasis is discussed.
publishDate 2018
dc.date.none.fl_str_mv 2018-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/97379
Margarit, David Hipólito; Romanelli, Lilia Mabel; Fendrik, Alejandro José; A 3D Cellular Automaton for Cell Differentiation in a Solid Tumor with Plasticity; World Scientific; Biophysical Reviews and Letters; 13; 01; 4-2018; 19-28
1793-7035
CONICET Digital
CONICET
url http://hdl.handle.net/11336/97379
identifier_str_mv Margarit, David Hipólito; Romanelli, Lilia Mabel; Fendrik, Alejandro José; A 3D Cellular Automaton for Cell Differentiation in a Solid Tumor with Plasticity; World Scientific; Biophysical Reviews and Letters; 13; 01; 4-2018; 19-28
1793-7035
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.worldscientific.com/doi/abs/10.1142/S1793048018500029
info:eu-repo/semantics/altIdentifier/doi/10.1142/S1793048018500029
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv World Scientific
publisher.none.fl_str_mv World Scientific
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613068777062400
score 13.070432

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