Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig

Autores
García, Enrique N.; Aguirre, María V.; Gimeno, Eduardo Juan; Rios, Elvio E.; Acosta, Ofelia Cristina; Cholich, Luciana Andrea
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Ipomoea carnea subsp. fistulosa (Convolvulaceae) causes poisoning of goats, sheep and cattle in many tropical and subtropical countries. The pathophysiology of this poisoning mainly involves an abnormal glycoprotein metabolism. The aim of this study was to describe the potential toxicity of I. carnea in a guinea pig model through its effect on hematopoiesis in a time course study of 40 days. Experimental poisoning was achieved by feeding animals with "small balls" prepared with milled leaves of I. carnea mixed with commercial crushed pellets for rodents. Hematologic and biochemical parameters, bone marrow and spleencellularities, histopathologic evaluations and lectin-histochemistrywere performed during the scheduled time of the study. The treatment with "small balls" caused significant changes in the weight of spleen, a notable decrease in peripheral red blood cells, and concomitantwith morphological and histopathologicalalterationsin hematopoietic tissues. Overall, the present study suggested that 20 days ofthis treatmentcouldbe enough to develop bone marrow hypoplasia and vacuolation of white cells of spleen, blood and lymph nodes with a transient erythropoietic contribution of the splenic niche. Moreover, this work provides a cheap and simple method for detecting preclinical cases of intoxication by I. carnea in livestock.
Fil: García, Enrique N.. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
Fil: Aguirre, María V.. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rios, Elvio E.. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
Fil: Acosta, Ofelia Cristina. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
Fil: Cholich, Luciana Andrea. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
Materia
Anaemia
Bone Marrow
Guinea Pig
Ipomoea Carnea
Lymph Nodes Spleen
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/53670
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pigGarcía, Enrique N.Aguirre, María V.Gimeno, Eduardo JuanRios, Elvio E.Acosta, Ofelia CristinaCholich, Luciana AndreaAnaemiaBone MarrowGuinea PigIpomoea CarneaLymph Nodes Spleenhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Ipomoea carnea subsp. fistulosa (Convolvulaceae) causes poisoning of goats, sheep and cattle in many tropical and subtropical countries. The pathophysiology of this poisoning mainly involves an abnormal glycoprotein metabolism. The aim of this study was to describe the potential toxicity of I. carnea in a guinea pig model through its effect on hematopoiesis in a time course study of 40 days. Experimental poisoning was achieved by feeding animals with "small balls" prepared with milled leaves of I. carnea mixed with commercial crushed pellets for rodents. Hematologic and biochemical parameters, bone marrow and spleencellularities, histopathologic evaluations and lectin-histochemistrywere performed during the scheduled time of the study. The treatment with "small balls" caused significant changes in the weight of spleen, a notable decrease in peripheral red blood cells, and concomitantwith morphological and histopathologicalalterationsin hematopoietic tissues. Overall, the present study suggested that 20 days ofthis treatmentcouldbe enough to develop bone marrow hypoplasia and vacuolation of white cells of spleen, blood and lymph nodes with a transient erythropoietic contribution of the splenic niche. Moreover, this work provides a cheap and simple method for detecting preclinical cases of intoxication by I. carnea in livestock.Fil: García, Enrique N.. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; ArgentinaFil: Aguirre, María V.. Universidad Nacional del Nordeste. Facultad de Medicina; ArgentinaFil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rios, Elvio E.. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; ArgentinaFil: Acosta, Ofelia Cristina. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; ArgentinaFil: Cholich, Luciana Andrea. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; ArgentinaElsevier Gmbh2015-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/53670García, Enrique N.; Aguirre, María V.; Gimeno, Eduardo Juan; Rios, Elvio E.; Acosta, Ofelia Cristina; et al.; Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig; Elsevier Gmbh; Experimental And Toxicologic Pathology; 67; 10; 10-2015; 483-4900940-2993CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.etp.2015.07.002info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0940299315300087info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:32:19Zoai:ri.conicet.gov.ar:11336/53670instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:32:19.769CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig
title Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig
spellingShingle Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig
García, Enrique N.
Anaemia
Bone Marrow
Guinea Pig
Ipomoea Carnea
Lymph Nodes Spleen
title_short Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig
title_full Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig
title_fullStr Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig
title_full_unstemmed Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig
title_sort Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig
dc.creator.none.fl_str_mv García, Enrique N.
Aguirre, María V.
Gimeno, Eduardo Juan
Rios, Elvio E.
Acosta, Ofelia Cristina
Cholich, Luciana Andrea
author García, Enrique N.
author_facet García, Enrique N.
Aguirre, María V.
Gimeno, Eduardo Juan
Rios, Elvio E.
Acosta, Ofelia Cristina
Cholich, Luciana Andrea
author_role author
author2 Aguirre, María V.
Gimeno, Eduardo Juan
Rios, Elvio E.
Acosta, Ofelia Cristina
Cholich, Luciana Andrea
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Anaemia
Bone Marrow
Guinea Pig
Ipomoea Carnea
Lymph Nodes Spleen
topic Anaemia
Bone Marrow
Guinea Pig
Ipomoea Carnea
Lymph Nodes Spleen
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Ipomoea carnea subsp. fistulosa (Convolvulaceae) causes poisoning of goats, sheep and cattle in many tropical and subtropical countries. The pathophysiology of this poisoning mainly involves an abnormal glycoprotein metabolism. The aim of this study was to describe the potential toxicity of I. carnea in a guinea pig model through its effect on hematopoiesis in a time course study of 40 days. Experimental poisoning was achieved by feeding animals with "small balls" prepared with milled leaves of I. carnea mixed with commercial crushed pellets for rodents. Hematologic and biochemical parameters, bone marrow and spleencellularities, histopathologic evaluations and lectin-histochemistrywere performed during the scheduled time of the study. The treatment with "small balls" caused significant changes in the weight of spleen, a notable decrease in peripheral red blood cells, and concomitantwith morphological and histopathologicalalterationsin hematopoietic tissues. Overall, the present study suggested that 20 days ofthis treatmentcouldbe enough to develop bone marrow hypoplasia and vacuolation of white cells of spleen, blood and lymph nodes with a transient erythropoietic contribution of the splenic niche. Moreover, this work provides a cheap and simple method for detecting preclinical cases of intoxication by I. carnea in livestock.
Fil: García, Enrique N.. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
Fil: Aguirre, María V.. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rios, Elvio E.. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
Fil: Acosta, Ofelia Cristina. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
Fil: Cholich, Luciana Andrea. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
description Ipomoea carnea subsp. fistulosa (Convolvulaceae) causes poisoning of goats, sheep and cattle in many tropical and subtropical countries. The pathophysiology of this poisoning mainly involves an abnormal glycoprotein metabolism. The aim of this study was to describe the potential toxicity of I. carnea in a guinea pig model through its effect on hematopoiesis in a time course study of 40 days. Experimental poisoning was achieved by feeding animals with "small balls" prepared with milled leaves of I. carnea mixed with commercial crushed pellets for rodents. Hematologic and biochemical parameters, bone marrow and spleencellularities, histopathologic evaluations and lectin-histochemistrywere performed during the scheduled time of the study. The treatment with "small balls" caused significant changes in the weight of spleen, a notable decrease in peripheral red blood cells, and concomitantwith morphological and histopathologicalalterationsin hematopoietic tissues. Overall, the present study suggested that 20 days ofthis treatmentcouldbe enough to develop bone marrow hypoplasia and vacuolation of white cells of spleen, blood and lymph nodes with a transient erythropoietic contribution of the splenic niche. Moreover, this work provides a cheap and simple method for detecting preclinical cases of intoxication by I. carnea in livestock.
publishDate 2015
dc.date.none.fl_str_mv 2015-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/53670
García, Enrique N.; Aguirre, María V.; Gimeno, Eduardo Juan; Rios, Elvio E.; Acosta, Ofelia Cristina; et al.; Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig; Elsevier Gmbh; Experimental And Toxicologic Pathology; 67; 10; 10-2015; 483-490
0940-2993
CONICET Digital
CONICET
url http://hdl.handle.net/11336/53670
identifier_str_mv García, Enrique N.; Aguirre, María V.; Gimeno, Eduardo Juan; Rios, Elvio E.; Acosta, Ofelia Cristina; et al.; Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig; Elsevier Gmbh; Experimental And Toxicologic Pathology; 67; 10; 10-2015; 483-490
0940-2993
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.etp.2015.07.002
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0940299315300087
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Gmbh
publisher.none.fl_str_mv Elsevier Gmbh
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083456745865216
score 13.22299

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