Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig
- Autores
- García, Enrique N.; Aguirre, María V.; Gimeno, Eduardo Juan; Rios, Elvio E.; Acosta, Ofelia Cristina; Cholich, Luciana Andrea
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Ipomoea carnea subsp. fistulosa (Convolvulaceae) causes poisoning of goats, sheep and cattle in many tropical and subtropical countries. The pathophysiology of this poisoning mainly involves an abnormal glycoprotein metabolism. The aim of this study was to describe the potential toxicity of I. carnea in a guinea pig model through its effect on hematopoiesis in a time course study of 40 days. Experimental poisoning was achieved by feeding animals with "small balls" prepared with milled leaves of I. carnea mixed with commercial crushed pellets for rodents. Hematologic and biochemical parameters, bone marrow and spleencellularities, histopathologic evaluations and lectin-histochemistrywere performed during the scheduled time of the study. The treatment with "small balls" caused significant changes in the weight of spleen, a notable decrease in peripheral red blood cells, and concomitantwith morphological and histopathologicalalterationsin hematopoietic tissues. Overall, the present study suggested that 20 days ofthis treatmentcouldbe enough to develop bone marrow hypoplasia and vacuolation of white cells of spleen, blood and lymph nodes with a transient erythropoietic contribution of the splenic niche. Moreover, this work provides a cheap and simple method for detecting preclinical cases of intoxication by I. carnea in livestock.
Fil: García, Enrique N.. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
Fil: Aguirre, María V.. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rios, Elvio E.. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
Fil: Acosta, Ofelia Cristina. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
Fil: Cholich, Luciana Andrea. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina - Materia
-
Anaemia
Bone Marrow
Guinea Pig
Ipomoea Carnea
Lymph Nodes Spleen - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/53670
Ver los metadatos del registro completo
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Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pigGarcía, Enrique N.Aguirre, María V.Gimeno, Eduardo JuanRios, Elvio E.Acosta, Ofelia CristinaCholich, Luciana AndreaAnaemiaBone MarrowGuinea PigIpomoea CarneaLymph Nodes Spleenhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Ipomoea carnea subsp. fistulosa (Convolvulaceae) causes poisoning of goats, sheep and cattle in many tropical and subtropical countries. The pathophysiology of this poisoning mainly involves an abnormal glycoprotein metabolism. The aim of this study was to describe the potential toxicity of I. carnea in a guinea pig model through its effect on hematopoiesis in a time course study of 40 days. Experimental poisoning was achieved by feeding animals with "small balls" prepared with milled leaves of I. carnea mixed with commercial crushed pellets for rodents. Hematologic and biochemical parameters, bone marrow and spleencellularities, histopathologic evaluations and lectin-histochemistrywere performed during the scheduled time of the study. The treatment with "small balls" caused significant changes in the weight of spleen, a notable decrease in peripheral red blood cells, and concomitantwith morphological and histopathologicalalterationsin hematopoietic tissues. Overall, the present study suggested that 20 days ofthis treatmentcouldbe enough to develop bone marrow hypoplasia and vacuolation of white cells of spleen, blood and lymph nodes with a transient erythropoietic contribution of the splenic niche. Moreover, this work provides a cheap and simple method for detecting preclinical cases of intoxication by I. carnea in livestock.Fil: García, Enrique N.. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; ArgentinaFil: Aguirre, María V.. Universidad Nacional del Nordeste. Facultad de Medicina; ArgentinaFil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rios, Elvio E.. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; ArgentinaFil: Acosta, Ofelia Cristina. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; ArgentinaFil: Cholich, Luciana Andrea. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; ArgentinaElsevier Gmbh2015-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/53670García, Enrique N.; Aguirre, María V.; Gimeno, Eduardo Juan; Rios, Elvio E.; Acosta, Ofelia Cristina; et al.; Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig; Elsevier Gmbh; Experimental And Toxicologic Pathology; 67; 10; 10-2015; 483-4900940-2993CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.etp.2015.07.002info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0940299315300087info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:07:16Zoai:ri.conicet.gov.ar:11336/53670instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:07:16.383CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig |
title |
Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig |
spellingShingle |
Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig García, Enrique N. Anaemia Bone Marrow Guinea Pig Ipomoea Carnea Lymph Nodes Spleen |
title_short |
Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig |
title_full |
Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig |
title_fullStr |
Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig |
title_full_unstemmed |
Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig |
title_sort |
Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig |
dc.creator.none.fl_str_mv |
García, Enrique N. Aguirre, María V. Gimeno, Eduardo Juan Rios, Elvio E. Acosta, Ofelia Cristina Cholich, Luciana Andrea |
author |
García, Enrique N. |
author_facet |
García, Enrique N. Aguirre, María V. Gimeno, Eduardo Juan Rios, Elvio E. Acosta, Ofelia Cristina Cholich, Luciana Andrea |
author_role |
author |
author2 |
Aguirre, María V. Gimeno, Eduardo Juan Rios, Elvio E. Acosta, Ofelia Cristina Cholich, Luciana Andrea |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Anaemia Bone Marrow Guinea Pig Ipomoea Carnea Lymph Nodes Spleen |
topic |
Anaemia Bone Marrow Guinea Pig Ipomoea Carnea Lymph Nodes Spleen |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 |
dc.description.none.fl_txt_mv |
Ipomoea carnea subsp. fistulosa (Convolvulaceae) causes poisoning of goats, sheep and cattle in many tropical and subtropical countries. The pathophysiology of this poisoning mainly involves an abnormal glycoprotein metabolism. The aim of this study was to describe the potential toxicity of I. carnea in a guinea pig model through its effect on hematopoiesis in a time course study of 40 days. Experimental poisoning was achieved by feeding animals with "small balls" prepared with milled leaves of I. carnea mixed with commercial crushed pellets for rodents. Hematologic and biochemical parameters, bone marrow and spleencellularities, histopathologic evaluations and lectin-histochemistrywere performed during the scheduled time of the study. The treatment with "small balls" caused significant changes in the weight of spleen, a notable decrease in peripheral red blood cells, and concomitantwith morphological and histopathologicalalterationsin hematopoietic tissues. Overall, the present study suggested that 20 days ofthis treatmentcouldbe enough to develop bone marrow hypoplasia and vacuolation of white cells of spleen, blood and lymph nodes with a transient erythropoietic contribution of the splenic niche. Moreover, this work provides a cheap and simple method for detecting preclinical cases of intoxication by I. carnea in livestock. Fil: García, Enrique N.. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina Fil: Aguirre, María V.. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Rios, Elvio E.. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina Fil: Acosta, Ofelia Cristina. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina Fil: Cholich, Luciana Andrea. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina |
description |
Ipomoea carnea subsp. fistulosa (Convolvulaceae) causes poisoning of goats, sheep and cattle in many tropical and subtropical countries. The pathophysiology of this poisoning mainly involves an abnormal glycoprotein metabolism. The aim of this study was to describe the potential toxicity of I. carnea in a guinea pig model through its effect on hematopoiesis in a time course study of 40 days. Experimental poisoning was achieved by feeding animals with "small balls" prepared with milled leaves of I. carnea mixed with commercial crushed pellets for rodents. Hematologic and biochemical parameters, bone marrow and spleencellularities, histopathologic evaluations and lectin-histochemistrywere performed during the scheduled time of the study. The treatment with "small balls" caused significant changes in the weight of spleen, a notable decrease in peripheral red blood cells, and concomitantwith morphological and histopathologicalalterationsin hematopoietic tissues. Overall, the present study suggested that 20 days ofthis treatmentcouldbe enough to develop bone marrow hypoplasia and vacuolation of white cells of spleen, blood and lymph nodes with a transient erythropoietic contribution of the splenic niche. Moreover, this work provides a cheap and simple method for detecting preclinical cases of intoxication by I. carnea in livestock. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/53670 García, Enrique N.; Aguirre, María V.; Gimeno, Eduardo Juan; Rios, Elvio E.; Acosta, Ofelia Cristina; et al.; Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig; Elsevier Gmbh; Experimental And Toxicologic Pathology; 67; 10; 10-2015; 483-490 0940-2993 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/53670 |
identifier_str_mv |
García, Enrique N.; Aguirre, María V.; Gimeno, Eduardo Juan; Rios, Elvio E.; Acosta, Ofelia Cristina; et al.; Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig; Elsevier Gmbh; Experimental And Toxicologic Pathology; 67; 10; 10-2015; 483-490 0940-2993 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.etp.2015.07.002 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0940299315300087 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Gmbh |
publisher.none.fl_str_mv |
Elsevier Gmbh |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1846782436089790464 |
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13.229304 |