Neopterin acts as an endogenous cognitive enhancer

Autores
Ghisoni, Karina; Aguiar, Aderbal S.; Oliveira, Paulo Alexandre de; Matheus, Filipe Carvalho; Gabach, Laura; Perez, Mariela Fernanda; Carlini, Valeria Paola; Barbeito, Luis; Mongeau, Raymond; Lanfumey, Laurence; Prediger, Rui Daniel; Latini, Alexandra
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Neopterin is found at increased levels in biological fluids from individuals with inflammatory disorders. The biological role of this pteridine remains undefined; however, due to its capacity to increase hemeoxygenase-1 content, it has been proposed as a protective agent during cellular stress. Therefore, we investigated the effects of neopterin on motor, emotional and memory functions. To address this question, neopterin (0.4 and/or 4 pmol) was injected intracerebroventricularly before or after the training sessions of step-down inhibitory avoidance and fear conditioning tasks, respectively. Memory-related behaviors were assessed in Swiss and C57BL/6 mice, as well as in Wistar rats. Moreover, the putative effects of neopterin on motor and anxiety-related parameters were addressed in the open field and elevated plus-maze tasks. The effects of neopterin on cognitive performance were also investigated after intraperitoneal lipopolysaccharide (LPS) administration (0.33 mg/kg) in interleukin-10 knockout mice (IL-10-/-). It was consistently observed across rodent species that neopterin facilitated aversive memory acquisition by increasing the latency to step-down in the inhibitory avoidance task. This effect was related to a reduced threshold to generate the hippocampal long-term potentiation (LTP) process, and reduced IL-6 brain levels after the LPS challenge. However, neopterin administration after acquisition did not alter the consolidation of fear memories, neither motor nor anxiety-related parameters. Altogether, neopterin facilitated cognitive processes, probably by inducing an antioxidant/anti-inflammatory state, and by facilitating LTP generation. To our knowledge, this is the first evidence showing the cognitive enhancer property of neopterin.
Fil: Ghisoni, Karina. Universidade Federal de Santa Catarina; Brasil
Fil: Aguiar, Aderbal S.. Universidade Federal de Santa Catarina; Brasil
Fil: Oliveira, Paulo Alexandre de. Universidade Federal de Santa Catarina; Brasil
Fil: Matheus, Filipe Carvalho. Universidade Federal de Santa Catarina; Brasil
Fil: Gabach, Laura. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Perez, Mariela Fernanda. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Carlini, Valeria Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Barbeito, Luis. Instituto Pasteur de Montevideo; Uruguay
Fil: Mongeau, Raymond. Université Paris Descartes. INSERM UMR. Centre de Psychiatrie et Neurosciences; Francia
Fil: Lanfumey, Laurence. Umr S894, Centre de Psychiatrie Et Neurosciences; Francia
Fil: Prediger, Rui Daniel. Universidade Federal de Santa Catarina; Brasil
Fil: Latini, Alexandra. Universidade Federal de Santa Catarina; Brasil
Materia
Learning And Memory
Neopterin
Neuroinflammation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/50686
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Neopterin acts as an endogenous cognitive enhancerGhisoni, KarinaAguiar, Aderbal S.Oliveira, Paulo Alexandre deMatheus, Filipe CarvalhoGabach, LauraPerez, Mariela FernandaCarlini, Valeria PaolaBarbeito, LuisMongeau, RaymondLanfumey, LaurencePrediger, Rui DanielLatini, AlexandraLearning And MemoryNeopterinNeuroinflammationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Neopterin is found at increased levels in biological fluids from individuals with inflammatory disorders. The biological role of this pteridine remains undefined; however, due to its capacity to increase hemeoxygenase-1 content, it has been proposed as a protective agent during cellular stress. Therefore, we investigated the effects of neopterin on motor, emotional and memory functions. To address this question, neopterin (0.4 and/or 4 pmol) was injected intracerebroventricularly before or after the training sessions of step-down inhibitory avoidance and fear conditioning tasks, respectively. Memory-related behaviors were assessed in Swiss and C57BL/6 mice, as well as in Wistar rats. Moreover, the putative effects of neopterin on motor and anxiety-related parameters were addressed in the open field and elevated plus-maze tasks. The effects of neopterin on cognitive performance were also investigated after intraperitoneal lipopolysaccharide (LPS) administration (0.33 mg/kg) in interleukin-10 knockout mice (IL-10-/-). It was consistently observed across rodent species that neopterin facilitated aversive memory acquisition by increasing the latency to step-down in the inhibitory avoidance task. This effect was related to a reduced threshold to generate the hippocampal long-term potentiation (LTP) process, and reduced IL-6 brain levels after the LPS challenge. However, neopterin administration after acquisition did not alter the consolidation of fear memories, neither motor nor anxiety-related parameters. Altogether, neopterin facilitated cognitive processes, probably by inducing an antioxidant/anti-inflammatory state, and by facilitating LTP generation. To our knowledge, this is the first evidence showing the cognitive enhancer property of neopterin.Fil: Ghisoni, Karina. Universidade Federal de Santa Catarina; BrasilFil: Aguiar, Aderbal S.. Universidade Federal de Santa Catarina; BrasilFil: Oliveira, Paulo Alexandre de. Universidade Federal de Santa Catarina; BrasilFil: Matheus, Filipe Carvalho. Universidade Federal de Santa Catarina; BrasilFil: Gabach, Laura. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Perez, Mariela Fernanda. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Carlini, Valeria Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Barbeito, Luis. Instituto Pasteur de Montevideo; UruguayFil: Mongeau, Raymond. Université Paris Descartes. INSERM UMR. Centre de Psychiatrie et Neurosciences; FranciaFil: Lanfumey, Laurence. Umr S894, Centre de Psychiatrie Et Neurosciences; FranciaFil: Prediger, Rui Daniel. Universidade Federal de Santa Catarina; BrasilFil: Latini, Alexandra. Universidade Federal de Santa Catarina; BrasilAcademic Press Inc Elsevier Science2016-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/50686Ghisoni, Karina; Aguiar, Aderbal S.; Oliveira, Paulo Alexandre de; Matheus, Filipe Carvalho; Gabach, Laura; et al.; Neopterin acts as an endogenous cognitive enhancer; Academic Press Inc Elsevier Science; Brain Behavior And Immunity; 56; 8-2016; 156-1640889-1591CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0889159116300393info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbi.2016.02.019info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:10:11Zoai:ri.conicet.gov.ar:11336/50686instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:10:12.033CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neopterin acts as an endogenous cognitive enhancer
title Neopterin acts as an endogenous cognitive enhancer
spellingShingle Neopterin acts as an endogenous cognitive enhancer
Ghisoni, Karina
Learning And Memory
Neopterin
Neuroinflammation
title_short Neopterin acts as an endogenous cognitive enhancer
title_full Neopterin acts as an endogenous cognitive enhancer
title_fullStr Neopterin acts as an endogenous cognitive enhancer
title_full_unstemmed Neopterin acts as an endogenous cognitive enhancer
title_sort Neopterin acts as an endogenous cognitive enhancer
dc.creator.none.fl_str_mv Ghisoni, Karina
Aguiar, Aderbal S.
Oliveira, Paulo Alexandre de
Matheus, Filipe Carvalho
Gabach, Laura
Perez, Mariela Fernanda
Carlini, Valeria Paola
Barbeito, Luis
Mongeau, Raymond
Lanfumey, Laurence
Prediger, Rui Daniel
Latini, Alexandra
author Ghisoni, Karina
author_facet Ghisoni, Karina
Aguiar, Aderbal S.
Oliveira, Paulo Alexandre de
Matheus, Filipe Carvalho
Gabach, Laura
Perez, Mariela Fernanda
Carlini, Valeria Paola
Barbeito, Luis
Mongeau, Raymond
Lanfumey, Laurence
Prediger, Rui Daniel
Latini, Alexandra
author_role author
author2 Aguiar, Aderbal S.
Oliveira, Paulo Alexandre de
Matheus, Filipe Carvalho
Gabach, Laura
Perez, Mariela Fernanda
Carlini, Valeria Paola
Barbeito, Luis
Mongeau, Raymond
Lanfumey, Laurence
Prediger, Rui Daniel
Latini, Alexandra
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Learning And Memory
Neopterin
Neuroinflammation
topic Learning And Memory
Neopterin
Neuroinflammation
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Neopterin is found at increased levels in biological fluids from individuals with inflammatory disorders. The biological role of this pteridine remains undefined; however, due to its capacity to increase hemeoxygenase-1 content, it has been proposed as a protective agent during cellular stress. Therefore, we investigated the effects of neopterin on motor, emotional and memory functions. To address this question, neopterin (0.4 and/or 4 pmol) was injected intracerebroventricularly before or after the training sessions of step-down inhibitory avoidance and fear conditioning tasks, respectively. Memory-related behaviors were assessed in Swiss and C57BL/6 mice, as well as in Wistar rats. Moreover, the putative effects of neopterin on motor and anxiety-related parameters were addressed in the open field and elevated plus-maze tasks. The effects of neopterin on cognitive performance were also investigated after intraperitoneal lipopolysaccharide (LPS) administration (0.33 mg/kg) in interleukin-10 knockout mice (IL-10-/-). It was consistently observed across rodent species that neopterin facilitated aversive memory acquisition by increasing the latency to step-down in the inhibitory avoidance task. This effect was related to a reduced threshold to generate the hippocampal long-term potentiation (LTP) process, and reduced IL-6 brain levels after the LPS challenge. However, neopterin administration after acquisition did not alter the consolidation of fear memories, neither motor nor anxiety-related parameters. Altogether, neopterin facilitated cognitive processes, probably by inducing an antioxidant/anti-inflammatory state, and by facilitating LTP generation. To our knowledge, this is the first evidence showing the cognitive enhancer property of neopterin.
Fil: Ghisoni, Karina. Universidade Federal de Santa Catarina; Brasil
Fil: Aguiar, Aderbal S.. Universidade Federal de Santa Catarina; Brasil
Fil: Oliveira, Paulo Alexandre de. Universidade Federal de Santa Catarina; Brasil
Fil: Matheus, Filipe Carvalho. Universidade Federal de Santa Catarina; Brasil
Fil: Gabach, Laura. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Perez, Mariela Fernanda. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Carlini, Valeria Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Barbeito, Luis. Instituto Pasteur de Montevideo; Uruguay
Fil: Mongeau, Raymond. Université Paris Descartes. INSERM UMR. Centre de Psychiatrie et Neurosciences; Francia
Fil: Lanfumey, Laurence. Umr S894, Centre de Psychiatrie Et Neurosciences; Francia
Fil: Prediger, Rui Daniel. Universidade Federal de Santa Catarina; Brasil
Fil: Latini, Alexandra. Universidade Federal de Santa Catarina; Brasil
description Neopterin is found at increased levels in biological fluids from individuals with inflammatory disorders. The biological role of this pteridine remains undefined; however, due to its capacity to increase hemeoxygenase-1 content, it has been proposed as a protective agent during cellular stress. Therefore, we investigated the effects of neopterin on motor, emotional and memory functions. To address this question, neopterin (0.4 and/or 4 pmol) was injected intracerebroventricularly before or after the training sessions of step-down inhibitory avoidance and fear conditioning tasks, respectively. Memory-related behaviors were assessed in Swiss and C57BL/6 mice, as well as in Wistar rats. Moreover, the putative effects of neopterin on motor and anxiety-related parameters were addressed in the open field and elevated plus-maze tasks. The effects of neopterin on cognitive performance were also investigated after intraperitoneal lipopolysaccharide (LPS) administration (0.33 mg/kg) in interleukin-10 knockout mice (IL-10-/-). It was consistently observed across rodent species that neopterin facilitated aversive memory acquisition by increasing the latency to step-down in the inhibitory avoidance task. This effect was related to a reduced threshold to generate the hippocampal long-term potentiation (LTP) process, and reduced IL-6 brain levels after the LPS challenge. However, neopterin administration after acquisition did not alter the consolidation of fear memories, neither motor nor anxiety-related parameters. Altogether, neopterin facilitated cognitive processes, probably by inducing an antioxidant/anti-inflammatory state, and by facilitating LTP generation. To our knowledge, this is the first evidence showing the cognitive enhancer property of neopterin.
publishDate 2016
dc.date.none.fl_str_mv 2016-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/50686
Ghisoni, Karina; Aguiar, Aderbal S.; Oliveira, Paulo Alexandre de; Matheus, Filipe Carvalho; Gabach, Laura; et al.; Neopterin acts as an endogenous cognitive enhancer; Academic Press Inc Elsevier Science; Brain Behavior And Immunity; 56; 8-2016; 156-164
0889-1591
CONICET Digital
CONICET
url http://hdl.handle.net/11336/50686
identifier_str_mv Ghisoni, Karina; Aguiar, Aderbal S.; Oliveira, Paulo Alexandre de; Matheus, Filipe Carvalho; Gabach, Laura; et al.; Neopterin acts as an endogenous cognitive enhancer; Academic Press Inc Elsevier Science; Brain Behavior And Immunity; 56; 8-2016; 156-164
0889-1591
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0889159116300393
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbi.2016.02.019
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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