Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach

Autores
Villar, Silvina Raquel; Herreros Cabello, Alfonso; Callejas Hernández, Francisco; Maza, María C.; del Moral Salmoral, Javier; Gómez Montes, Mario; Rodríguez Angulo, Héctor O.; Carrillo, Irene; Górgolas, Miguel; Bosch Nicolau, Pau; Molina, Israel; Pérez Molina, José A.; Monge Maillo, Begoña; Bottasso, Oscar Adelmo; Beloscar, Juan; Perez, Ana Rosa; Fresno, Manuel; Gironès, Núria
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chagas disease affects approximately 7 million people worldwide in Latin America and is a neglected tropical disease. Twenty to thirty percent of chronically infected patients develop chronic Chagas cardiomyopathy decades after acute infection. Identifying biomarkers of Chagas disease progression is necessary to develop better therapeutic and preventive strategies. Circulating microRNAs are increasingly reliable biomarkers of disease and therapeutic targets. To identify new circulating microRNAs for Chagas disease, we performed exploratory small RNA sequencing from the plasma of patients and performed de novo miRNA prediction, identifying potential new microRNAs. The levels of the new microRNAs temporarily named miR-Contig-1519 and miR-Contig-3244 and microRNAs that are biomarkers for nonchagasic cardiomyopathies, such as miR-148a-3p and miR-224-5p, were validated by quantitative reverse transcription. We found a specific circulating microRNA signature defined by low miR-Contig-3244, miR-Contig-1519, and miR-148a-3 levels but high miR-224-5p levels for patients with chronic Chagas disease. Finally, we predicted in silico that these altered circulating microRNAs could affect the expression of target genes involved in different cellular pathways and biological processes, which we will explore in the future.
Fil: Villar, Silvina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Herreros Cabello, Alfonso. Universidad Autónoma de Madrid; España
Fil: Callejas Hernández, Francisco. Universidad Autónoma de Madrid; España. University of New York; Estados Unidos
Fil: Maza, María C.. Universidad Autónoma de Madrid; España
Fil: del Moral Salmoral, Javier. Universidad Autónoma de Madrid; España
Fil: Gómez Montes, Mario. Universidad Autónoma de Madrid; España
Fil: Rodríguez Angulo, Héctor O.. Universidad Autónoma de Madrid; España
Fil: Carrillo, Irene. Universidad Autónoma de Madrid; España
Fil: Górgolas, Miguel. Universidad Autónoma de Madrid; España
Fil: Bosch Nicolau, Pau. Instituto de Salud Carlos III; España. Vall d’Hebron University Hospital; España
Fil: Molina, Israel. Instituto de Salud Carlos III; España. Vall d’Hebron University Hospital; España
Fil: Pérez Molina, José A.. Instituto de Salud Carlos III; España. Ramón y Cajal University Hospital; España
Fil: Monge Maillo, Begoña. Instituto de Salud Carlos III; España. Ramón y Cajal University Hospital; España
Fil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Beloscar, Juan. Universidad Autónoma de Madrid; España. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Fil: Perez, Ana Rosa. Universidad Autónoma de Madrid; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Fresno, Manuel. Hospital Universitario de La Princesa; España. Universidad Autónoma de Madrid; España
Fil: Gironès, Núria. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; España
Materia
CHAGAS DESEASE
MicroRNAs
BIOMARKERS
THERAPEUTIC TARGET
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/266656

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network_name_str CONICET Digital (CONICET)
spelling Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approachVillar, Silvina RaquelHerreros Cabello, AlfonsoCallejas Hernández, FranciscoMaza, María C.del Moral Salmoral, JavierGómez Montes, MarioRodríguez Angulo, Héctor O.Carrillo, IreneGórgolas, MiguelBosch Nicolau, PauMolina, IsraelPérez Molina, José A.Monge Maillo, BegoñaBottasso, Oscar AdelmoBeloscar, JuanPerez, Ana RosaFresno, ManuelGironès, NúriaCHAGAS DESEASEMicroRNAsBIOMARKERSTHERAPEUTIC TARGEThttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Chagas disease affects approximately 7 million people worldwide in Latin America and is a neglected tropical disease. Twenty to thirty percent of chronically infected patients develop chronic Chagas cardiomyopathy decades after acute infection. Identifying biomarkers of Chagas disease progression is necessary to develop better therapeutic and preventive strategies. Circulating microRNAs are increasingly reliable biomarkers of disease and therapeutic targets. To identify new circulating microRNAs for Chagas disease, we performed exploratory small RNA sequencing from the plasma of patients and performed de novo miRNA prediction, identifying potential new microRNAs. The levels of the new microRNAs temporarily named miR-Contig-1519 and miR-Contig-3244 and microRNAs that are biomarkers for nonchagasic cardiomyopathies, such as miR-148a-3p and miR-224-5p, were validated by quantitative reverse transcription. We found a specific circulating microRNA signature defined by low miR-Contig-3244, miR-Contig-1519, and miR-148a-3 levels but high miR-224-5p levels for patients with chronic Chagas disease. Finally, we predicted in silico that these altered circulating microRNAs could affect the expression of target genes involved in different cellular pathways and biological processes, which we will explore in the future.Fil: Villar, Silvina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Herreros Cabello, Alfonso. Universidad Autónoma de Madrid; EspañaFil: Callejas Hernández, Francisco. Universidad Autónoma de Madrid; España. University of New York; Estados UnidosFil: Maza, María C.. Universidad Autónoma de Madrid; EspañaFil: del Moral Salmoral, Javier. Universidad Autónoma de Madrid; EspañaFil: Gómez Montes, Mario. Universidad Autónoma de Madrid; EspañaFil: Rodríguez Angulo, Héctor O.. Universidad Autónoma de Madrid; EspañaFil: Carrillo, Irene. Universidad Autónoma de Madrid; EspañaFil: Górgolas, Miguel. Universidad Autónoma de Madrid; EspañaFil: Bosch Nicolau, Pau. Instituto de Salud Carlos III; España. Vall d’Hebron University Hospital; EspañaFil: Molina, Israel. Instituto de Salud Carlos III; España. Vall d’Hebron University Hospital; EspañaFil: Pérez Molina, José A.. Instituto de Salud Carlos III; España. Ramón y Cajal University Hospital; EspañaFil: Monge Maillo, Begoña. Instituto de Salud Carlos III; España. Ramón y Cajal University Hospital; EspañaFil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Beloscar, Juan. Universidad Autónoma de Madrid; España. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; ArgentinaFil: Perez, Ana Rosa. Universidad Autónoma de Madrid; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Fresno, Manuel. Hospital Universitario de La Princesa; España. Universidad Autónoma de Madrid; EspañaFil: Gironès, Núria. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; EspañaNature Research2024-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/266656Villar, Silvina Raquel; Herreros Cabello, Alfonso; Callejas Hernández, Francisco; Maza, María C.; del Moral Salmoral, Javier; et al.; Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach; Nature Research; Scientific Reports; 14; 1; 12-2024; 1-122045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-024-51487-9info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-024-51487-9info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:22:59Zoai:ri.conicet.gov.ar:11336/266656instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:23:00.236CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach
title Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach
spellingShingle Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach
Villar, Silvina Raquel
CHAGAS DESEASE
MicroRNAs
BIOMARKERS
THERAPEUTIC TARGET
title_short Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach
title_full Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach
title_fullStr Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach
title_full_unstemmed Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach
title_sort Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach
dc.creator.none.fl_str_mv Villar, Silvina Raquel
Herreros Cabello, Alfonso
Callejas Hernández, Francisco
Maza, María C.
del Moral Salmoral, Javier
Gómez Montes, Mario
Rodríguez Angulo, Héctor O.
Carrillo, Irene
Górgolas, Miguel
Bosch Nicolau, Pau
Molina, Israel
Pérez Molina, José A.
Monge Maillo, Begoña
Bottasso, Oscar Adelmo
Beloscar, Juan
Perez, Ana Rosa
Fresno, Manuel
Gironès, Núria
author Villar, Silvina Raquel
author_facet Villar, Silvina Raquel
Herreros Cabello, Alfonso
Callejas Hernández, Francisco
Maza, María C.
del Moral Salmoral, Javier
Gómez Montes, Mario
Rodríguez Angulo, Héctor O.
Carrillo, Irene
Górgolas, Miguel
Bosch Nicolau, Pau
Molina, Israel
Pérez Molina, José A.
Monge Maillo, Begoña
Bottasso, Oscar Adelmo
Beloscar, Juan
Perez, Ana Rosa
Fresno, Manuel
Gironès, Núria
author_role author
author2 Herreros Cabello, Alfonso
Callejas Hernández, Francisco
Maza, María C.
del Moral Salmoral, Javier
Gómez Montes, Mario
Rodríguez Angulo, Héctor O.
Carrillo, Irene
Górgolas, Miguel
Bosch Nicolau, Pau
Molina, Israel
Pérez Molina, José A.
Monge Maillo, Begoña
Bottasso, Oscar Adelmo
Beloscar, Juan
Perez, Ana Rosa
Fresno, Manuel
Gironès, Núria
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CHAGAS DESEASE
MicroRNAs
BIOMARKERS
THERAPEUTIC TARGET
topic CHAGAS DESEASE
MicroRNAs
BIOMARKERS
THERAPEUTIC TARGET
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Chagas disease affects approximately 7 million people worldwide in Latin America and is a neglected tropical disease. Twenty to thirty percent of chronically infected patients develop chronic Chagas cardiomyopathy decades after acute infection. Identifying biomarkers of Chagas disease progression is necessary to develop better therapeutic and preventive strategies. Circulating microRNAs are increasingly reliable biomarkers of disease and therapeutic targets. To identify new circulating microRNAs for Chagas disease, we performed exploratory small RNA sequencing from the plasma of patients and performed de novo miRNA prediction, identifying potential new microRNAs. The levels of the new microRNAs temporarily named miR-Contig-1519 and miR-Contig-3244 and microRNAs that are biomarkers for nonchagasic cardiomyopathies, such as miR-148a-3p and miR-224-5p, were validated by quantitative reverse transcription. We found a specific circulating microRNA signature defined by low miR-Contig-3244, miR-Contig-1519, and miR-148a-3 levels but high miR-224-5p levels for patients with chronic Chagas disease. Finally, we predicted in silico that these altered circulating microRNAs could affect the expression of target genes involved in different cellular pathways and biological processes, which we will explore in the future.
Fil: Villar, Silvina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Herreros Cabello, Alfonso. Universidad Autónoma de Madrid; España
Fil: Callejas Hernández, Francisco. Universidad Autónoma de Madrid; España. University of New York; Estados Unidos
Fil: Maza, María C.. Universidad Autónoma de Madrid; España
Fil: del Moral Salmoral, Javier. Universidad Autónoma de Madrid; España
Fil: Gómez Montes, Mario. Universidad Autónoma de Madrid; España
Fil: Rodríguez Angulo, Héctor O.. Universidad Autónoma de Madrid; España
Fil: Carrillo, Irene. Universidad Autónoma de Madrid; España
Fil: Górgolas, Miguel. Universidad Autónoma de Madrid; España
Fil: Bosch Nicolau, Pau. Instituto de Salud Carlos III; España. Vall d’Hebron University Hospital; España
Fil: Molina, Israel. Instituto de Salud Carlos III; España. Vall d’Hebron University Hospital; España
Fil: Pérez Molina, José A.. Instituto de Salud Carlos III; España. Ramón y Cajal University Hospital; España
Fil: Monge Maillo, Begoña. Instituto de Salud Carlos III; España. Ramón y Cajal University Hospital; España
Fil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Beloscar, Juan. Universidad Autónoma de Madrid; España. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Fil: Perez, Ana Rosa. Universidad Autónoma de Madrid; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Fresno, Manuel. Hospital Universitario de La Princesa; España. Universidad Autónoma de Madrid; España
Fil: Gironès, Núria. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; España
description Chagas disease affects approximately 7 million people worldwide in Latin America and is a neglected tropical disease. Twenty to thirty percent of chronically infected patients develop chronic Chagas cardiomyopathy decades after acute infection. Identifying biomarkers of Chagas disease progression is necessary to develop better therapeutic and preventive strategies. Circulating microRNAs are increasingly reliable biomarkers of disease and therapeutic targets. To identify new circulating microRNAs for Chagas disease, we performed exploratory small RNA sequencing from the plasma of patients and performed de novo miRNA prediction, identifying potential new microRNAs. The levels of the new microRNAs temporarily named miR-Contig-1519 and miR-Contig-3244 and microRNAs that are biomarkers for nonchagasic cardiomyopathies, such as miR-148a-3p and miR-224-5p, were validated by quantitative reverse transcription. We found a specific circulating microRNA signature defined by low miR-Contig-3244, miR-Contig-1519, and miR-148a-3 levels but high miR-224-5p levels for patients with chronic Chagas disease. Finally, we predicted in silico that these altered circulating microRNAs could affect the expression of target genes involved in different cellular pathways and biological processes, which we will explore in the future.
publishDate 2024
dc.date.none.fl_str_mv 2024-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/266656
Villar, Silvina Raquel; Herreros Cabello, Alfonso; Callejas Hernández, Francisco; Maza, María C.; del Moral Salmoral, Javier; et al.; Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach; Nature Research; Scientific Reports; 14; 1; 12-2024; 1-12
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/266656
identifier_str_mv Villar, Silvina Raquel; Herreros Cabello, Alfonso; Callejas Hernández, Francisco; Maza, María C.; del Moral Salmoral, Javier; et al.; Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach; Nature Research; Scientific Reports; 14; 1; 12-2024; 1-12
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-024-51487-9
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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