Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach
- Autores
- Villar, Silvina Raquel; Herreros Cabello, Alfonso; Callejas Hernández, Francisco; Maza, María C.; del Moral Salmoral, Javier; Gómez Montes, Mario; Rodríguez Angulo, Héctor O.; Carrillo, Irene; Górgolas, Miguel; Bosch Nicolau, Pau; Molina, Israel; Pérez Molina, José A.; Monge Maillo, Begoña; Bottasso, Oscar Adelmo; Beloscar, Juan; Perez, Ana Rosa; Fresno, Manuel; Gironès, Núria
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Chagas disease affects approximately 7 million people worldwide in Latin America and is a neglected tropical disease. Twenty to thirty percent of chronically infected patients develop chronic Chagas cardiomyopathy decades after acute infection. Identifying biomarkers of Chagas disease progression is necessary to develop better therapeutic and preventive strategies. Circulating microRNAs are increasingly reliable biomarkers of disease and therapeutic targets. To identify new circulating microRNAs for Chagas disease, we performed exploratory small RNA sequencing from the plasma of patients and performed de novo miRNA prediction, identifying potential new microRNAs. The levels of the new microRNAs temporarily named miR-Contig-1519 and miR-Contig-3244 and microRNAs that are biomarkers for nonchagasic cardiomyopathies, such as miR-148a-3p and miR-224-5p, were validated by quantitative reverse transcription. We found a specific circulating microRNA signature defined by low miR-Contig-3244, miR-Contig-1519, and miR-148a-3 levels but high miR-224-5p levels for patients with chronic Chagas disease. Finally, we predicted in silico that these altered circulating microRNAs could affect the expression of target genes involved in different cellular pathways and biological processes, which we will explore in the future.
Fil: Villar, Silvina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Herreros Cabello, Alfonso. Universidad Autónoma de Madrid; España
Fil: Callejas Hernández, Francisco. Universidad Autónoma de Madrid; España. University of New York; Estados Unidos
Fil: Maza, María C.. Universidad Autónoma de Madrid; España
Fil: del Moral Salmoral, Javier. Universidad Autónoma de Madrid; España
Fil: Gómez Montes, Mario. Universidad Autónoma de Madrid; España
Fil: Rodríguez Angulo, Héctor O.. Universidad Autónoma de Madrid; España
Fil: Carrillo, Irene. Universidad Autónoma de Madrid; España
Fil: Górgolas, Miguel. Universidad Autónoma de Madrid; España
Fil: Bosch Nicolau, Pau. Instituto de Salud Carlos III; España. Vall d’Hebron University Hospital; España
Fil: Molina, Israel. Instituto de Salud Carlos III; España. Vall d’Hebron University Hospital; España
Fil: Pérez Molina, José A.. Instituto de Salud Carlos III; España. Ramón y Cajal University Hospital; España
Fil: Monge Maillo, Begoña. Instituto de Salud Carlos III; España. Ramón y Cajal University Hospital; España
Fil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Beloscar, Juan. Universidad Autónoma de Madrid; España. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Fil: Perez, Ana Rosa. Universidad Autónoma de Madrid; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Fresno, Manuel. Hospital Universitario de La Princesa; España. Universidad Autónoma de Madrid; España
Fil: Gironès, Núria. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; España - Materia
-
CHAGAS DESEASE
MicroRNAs
BIOMARKERS
THERAPEUTIC TARGET - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/266656
Ver los metadatos del registro completo
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Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approachVillar, Silvina RaquelHerreros Cabello, AlfonsoCallejas Hernández, FranciscoMaza, María C.del Moral Salmoral, JavierGómez Montes, MarioRodríguez Angulo, Héctor O.Carrillo, IreneGórgolas, MiguelBosch Nicolau, PauMolina, IsraelPérez Molina, José A.Monge Maillo, BegoñaBottasso, Oscar AdelmoBeloscar, JuanPerez, Ana RosaFresno, ManuelGironès, NúriaCHAGAS DESEASEMicroRNAsBIOMARKERSTHERAPEUTIC TARGEThttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Chagas disease affects approximately 7 million people worldwide in Latin America and is a neglected tropical disease. Twenty to thirty percent of chronically infected patients develop chronic Chagas cardiomyopathy decades after acute infection. Identifying biomarkers of Chagas disease progression is necessary to develop better therapeutic and preventive strategies. Circulating microRNAs are increasingly reliable biomarkers of disease and therapeutic targets. To identify new circulating microRNAs for Chagas disease, we performed exploratory small RNA sequencing from the plasma of patients and performed de novo miRNA prediction, identifying potential new microRNAs. The levels of the new microRNAs temporarily named miR-Contig-1519 and miR-Contig-3244 and microRNAs that are biomarkers for nonchagasic cardiomyopathies, such as miR-148a-3p and miR-224-5p, were validated by quantitative reverse transcription. We found a specific circulating microRNA signature defined by low miR-Contig-3244, miR-Contig-1519, and miR-148a-3 levels but high miR-224-5p levels for patients with chronic Chagas disease. Finally, we predicted in silico that these altered circulating microRNAs could affect the expression of target genes involved in different cellular pathways and biological processes, which we will explore in the future.Fil: Villar, Silvina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Herreros Cabello, Alfonso. Universidad Autónoma de Madrid; EspañaFil: Callejas Hernández, Francisco. Universidad Autónoma de Madrid; España. University of New York; Estados UnidosFil: Maza, María C.. Universidad Autónoma de Madrid; EspañaFil: del Moral Salmoral, Javier. Universidad Autónoma de Madrid; EspañaFil: Gómez Montes, Mario. Universidad Autónoma de Madrid; EspañaFil: Rodríguez Angulo, Héctor O.. Universidad Autónoma de Madrid; EspañaFil: Carrillo, Irene. Universidad Autónoma de Madrid; EspañaFil: Górgolas, Miguel. Universidad Autónoma de Madrid; EspañaFil: Bosch Nicolau, Pau. Instituto de Salud Carlos III; España. Vall d’Hebron University Hospital; EspañaFil: Molina, Israel. Instituto de Salud Carlos III; España. Vall d’Hebron University Hospital; EspañaFil: Pérez Molina, José A.. Instituto de Salud Carlos III; España. Ramón y Cajal University Hospital; EspañaFil: Monge Maillo, Begoña. Instituto de Salud Carlos III; España. Ramón y Cajal University Hospital; EspañaFil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Beloscar, Juan. Universidad Autónoma de Madrid; España. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; ArgentinaFil: Perez, Ana Rosa. Universidad Autónoma de Madrid; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Fresno, Manuel. Hospital Universitario de La Princesa; España. Universidad Autónoma de Madrid; EspañaFil: Gironès, Núria. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; EspañaNature Research2024-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/266656Villar, Silvina Raquel; Herreros Cabello, Alfonso; Callejas Hernández, Francisco; Maza, María C.; del Moral Salmoral, Javier; et al.; Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach; Nature Research; Scientific Reports; 14; 1; 12-2024; 1-122045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-024-51487-9info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-024-51487-9info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:22:59Zoai:ri.conicet.gov.ar:11336/266656instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:23:00.236CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach |
title |
Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach |
spellingShingle |
Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach Villar, Silvina Raquel CHAGAS DESEASE MicroRNAs BIOMARKERS THERAPEUTIC TARGET |
title_short |
Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach |
title_full |
Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach |
title_fullStr |
Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach |
title_full_unstemmed |
Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach |
title_sort |
Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach |
dc.creator.none.fl_str_mv |
Villar, Silvina Raquel Herreros Cabello, Alfonso Callejas Hernández, Francisco Maza, María C. del Moral Salmoral, Javier Gómez Montes, Mario Rodríguez Angulo, Héctor O. Carrillo, Irene Górgolas, Miguel Bosch Nicolau, Pau Molina, Israel Pérez Molina, José A. Monge Maillo, Begoña Bottasso, Oscar Adelmo Beloscar, Juan Perez, Ana Rosa Fresno, Manuel Gironès, Núria |
author |
Villar, Silvina Raquel |
author_facet |
Villar, Silvina Raquel Herreros Cabello, Alfonso Callejas Hernández, Francisco Maza, María C. del Moral Salmoral, Javier Gómez Montes, Mario Rodríguez Angulo, Héctor O. Carrillo, Irene Górgolas, Miguel Bosch Nicolau, Pau Molina, Israel Pérez Molina, José A. Monge Maillo, Begoña Bottasso, Oscar Adelmo Beloscar, Juan Perez, Ana Rosa Fresno, Manuel Gironès, Núria |
author_role |
author |
author2 |
Herreros Cabello, Alfonso Callejas Hernández, Francisco Maza, María C. del Moral Salmoral, Javier Gómez Montes, Mario Rodríguez Angulo, Héctor O. Carrillo, Irene Górgolas, Miguel Bosch Nicolau, Pau Molina, Israel Pérez Molina, José A. Monge Maillo, Begoña Bottasso, Oscar Adelmo Beloscar, Juan Perez, Ana Rosa Fresno, Manuel Gironès, Núria |
author2_role |
author author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
CHAGAS DESEASE MicroRNAs BIOMARKERS THERAPEUTIC TARGET |
topic |
CHAGAS DESEASE MicroRNAs BIOMARKERS THERAPEUTIC TARGET |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Chagas disease affects approximately 7 million people worldwide in Latin America and is a neglected tropical disease. Twenty to thirty percent of chronically infected patients develop chronic Chagas cardiomyopathy decades after acute infection. Identifying biomarkers of Chagas disease progression is necessary to develop better therapeutic and preventive strategies. Circulating microRNAs are increasingly reliable biomarkers of disease and therapeutic targets. To identify new circulating microRNAs for Chagas disease, we performed exploratory small RNA sequencing from the plasma of patients and performed de novo miRNA prediction, identifying potential new microRNAs. The levels of the new microRNAs temporarily named miR-Contig-1519 and miR-Contig-3244 and microRNAs that are biomarkers for nonchagasic cardiomyopathies, such as miR-148a-3p and miR-224-5p, were validated by quantitative reverse transcription. We found a specific circulating microRNA signature defined by low miR-Contig-3244, miR-Contig-1519, and miR-148a-3 levels but high miR-224-5p levels for patients with chronic Chagas disease. Finally, we predicted in silico that these altered circulating microRNAs could affect the expression of target genes involved in different cellular pathways and biological processes, which we will explore in the future. Fil: Villar, Silvina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina Fil: Herreros Cabello, Alfonso. Universidad Autónoma de Madrid; España Fil: Callejas Hernández, Francisco. Universidad Autónoma de Madrid; España. University of New York; Estados Unidos Fil: Maza, María C.. Universidad Autónoma de Madrid; España Fil: del Moral Salmoral, Javier. Universidad Autónoma de Madrid; España Fil: Gómez Montes, Mario. Universidad Autónoma de Madrid; España Fil: Rodríguez Angulo, Héctor O.. Universidad Autónoma de Madrid; España Fil: Carrillo, Irene. Universidad Autónoma de Madrid; España Fil: Górgolas, Miguel. Universidad Autónoma de Madrid; España Fil: Bosch Nicolau, Pau. Instituto de Salud Carlos III; España. Vall d’Hebron University Hospital; España Fil: Molina, Israel. Instituto de Salud Carlos III; España. Vall d’Hebron University Hospital; España Fil: Pérez Molina, José A.. Instituto de Salud Carlos III; España. Ramón y Cajal University Hospital; España Fil: Monge Maillo, Begoña. Instituto de Salud Carlos III; España. Ramón y Cajal University Hospital; España Fil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina Fil: Beloscar, Juan. Universidad Autónoma de Madrid; España. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina Fil: Perez, Ana Rosa. Universidad Autónoma de Madrid; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina Fil: Fresno, Manuel. Hospital Universitario de La Princesa; España. Universidad Autónoma de Madrid; España Fil: Gironès, Núria. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; España |
description |
Chagas disease affects approximately 7 million people worldwide in Latin America and is a neglected tropical disease. Twenty to thirty percent of chronically infected patients develop chronic Chagas cardiomyopathy decades after acute infection. Identifying biomarkers of Chagas disease progression is necessary to develop better therapeutic and preventive strategies. Circulating microRNAs are increasingly reliable biomarkers of disease and therapeutic targets. To identify new circulating microRNAs for Chagas disease, we performed exploratory small RNA sequencing from the plasma of patients and performed de novo miRNA prediction, identifying potential new microRNAs. The levels of the new microRNAs temporarily named miR-Contig-1519 and miR-Contig-3244 and microRNAs that are biomarkers for nonchagasic cardiomyopathies, such as miR-148a-3p and miR-224-5p, were validated by quantitative reverse transcription. We found a specific circulating microRNA signature defined by low miR-Contig-3244, miR-Contig-1519, and miR-148a-3 levels but high miR-224-5p levels for patients with chronic Chagas disease. Finally, we predicted in silico that these altered circulating microRNAs could affect the expression of target genes involved in different cellular pathways and biological processes, which we will explore in the future. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/266656 Villar, Silvina Raquel; Herreros Cabello, Alfonso; Callejas Hernández, Francisco; Maza, María C.; del Moral Salmoral, Javier; et al.; Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach; Nature Research; Scientific Reports; 14; 1; 12-2024; 1-12 2045-2322 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/266656 |
identifier_str_mv |
Villar, Silvina Raquel; Herreros Cabello, Alfonso; Callejas Hernández, Francisco; Maza, María C.; del Moral Salmoral, Javier; et al.; Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach; Nature Research; Scientific Reports; 14; 1; 12-2024; 1-12 2045-2322 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-024-51487-9 info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-024-51487-9 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Nature Research |
publisher.none.fl_str_mv |
Nature Research |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |