Getting too sweet: galectin-1 dysregulation in gestational diabetes mellitus

Autores
Blois, Sandra M.; Gueuvoghlanian Silva, Barbara Y.; Tirado González, Irene; Torloni, Maria R.; Freitag, Nancy; Mattar, Rosiane; Conrad, Melanie L.; Unverdorben, Laura; Barrientos, Gabriela Laura; Knabl, Julia; Toldi, Gergely; Molvarec, Attila; Rose, Matthias; Markert, Udo R.; Jeschke, Udo; Daher, Silvia
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Galectin-1 (gal-1) is a prototype carbohydrate-binding protein, whose dysregulation is associated with adverse pregnancy outcomes such as spontaneous abortion and pre-eclampsia. Furthermore, it is known that faulty gal-1 protein production or gene regulation can be caused by single-nucleotide polymorphisms in the LGALS1 gene. Gestational diabetes mellitus (GDM) is also an adverse pregnancy outcome and the most common metabolic disorder during gestation. However, gal-1 expression patterns during GDM remain largely unknown. Our aims were to define local and peripheral gal-1 expression patterns during pregnancy, and to investigate LGALS1 gene polymorphisms in GDM patients. Circulating gal-1 levels were determined by ELISA in GDM patients and normal pregnant controls, and LGALS1 gene polymorphisms were assessed for association with GDM. Placental tissues were collected from control and GDM term pregnancies to evaluate local gal-1 expression by immunofluorescence. Our results show that GDM is associated with a failure to increase circulating gal-1 levels during the second and third trimester, as well as overexpression of gal-1 in placental tissue. Additionally, the LGALS1 polymorphism rs4820294 was associated with the development of GDM. In pregnancies complicated by GDM, we observed gal-1 dysregulation both locally in the placenta and peripherally in the circulation. Furthermore, the association between the LGALS1 polymorphism and GDM may indicate a genetic contribution to this adverse pregnancy outcome.
Fil: Blois, Sandra M.. Medicine University Berlin; Alemania
Fil: Gueuvoghlanian Silva, Barbara Y.. Universidade Federal de Sao Paulo; Brasil. Universitat Jena; Alemania
Fil: Tirado González, Irene. Medicine University Berlin; Alemania
Fil: Torloni, Maria R.. Universidade Federal de Sao Paulo; Brasil
Fil: Freitag, Nancy. Medicine University Berlin; Alemania
Fil: Mattar, Rosiane. Universidade Federal de Sao Paulo; Brasil
Fil: Conrad, Melanie L.. Medicine University Berlin; Alemania
Fil: Unverdorben, Laura. Ludwig Maximilians Universitat; Alemania
Fil: Barrientos, Gabriela Laura. Medicine University Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Knabl, Julia. Ludwig Maximilians Universitat; Alemania
Fil: Toldi, Gergely. Semmelweis University; Hungría
Fil: Molvarec, Attila. Semmelweis University; Hungría
Fil: Rose, Matthias. Medicine University Berlin; Alemania
Fil: Markert, Udo R.. Universitat Jena; Alemania
Fil: Jeschke, Udo. Ludwig Maximilians Universitat; Alemania
Fil: Daher, Silvia. Universidade Federal de Sao Paulo; Brasil
Materia
Galectin-1
Gestational Diabetes
Glucose
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/32177
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Getting too sweet: galectin-1 dysregulation in gestational diabetes mellitusBlois, Sandra M.Gueuvoghlanian Silva, Barbara Y.Tirado González, IreneTorloni, Maria R.Freitag, NancyMattar, RosianeConrad, Melanie L.Unverdorben, LauraBarrientos, Gabriela LauraKnabl, JuliaToldi, GergelyMolvarec, AttilaRose, MatthiasMarkert, Udo R.Jeschke, UdoDaher, SilviaGalectin-1Gestational DiabetesGlucosehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Galectin-1 (gal-1) is a prototype carbohydrate-binding protein, whose dysregulation is associated with adverse pregnancy outcomes such as spontaneous abortion and pre-eclampsia. Furthermore, it is known that faulty gal-1 protein production or gene regulation can be caused by single-nucleotide polymorphisms in the LGALS1 gene. Gestational diabetes mellitus (GDM) is also an adverse pregnancy outcome and the most common metabolic disorder during gestation. However, gal-1 expression patterns during GDM remain largely unknown. Our aims were to define local and peripheral gal-1 expression patterns during pregnancy, and to investigate LGALS1 gene polymorphisms in GDM patients. Circulating gal-1 levels were determined by ELISA in GDM patients and normal pregnant controls, and LGALS1 gene polymorphisms were assessed for association with GDM. Placental tissues were collected from control and GDM term pregnancies to evaluate local gal-1 expression by immunofluorescence. Our results show that GDM is associated with a failure to increase circulating gal-1 levels during the second and third trimester, as well as overexpression of gal-1 in placental tissue. Additionally, the LGALS1 polymorphism rs4820294 was associated with the development of GDM. In pregnancies complicated by GDM, we observed gal-1 dysregulation both locally in the placenta and peripherally in the circulation. Furthermore, the association between the LGALS1 polymorphism and GDM may indicate a genetic contribution to this adverse pregnancy outcome.Fil: Blois, Sandra M.. Medicine University Berlin; AlemaniaFil: Gueuvoghlanian Silva, Barbara Y.. Universidade Federal de Sao Paulo; Brasil. Universitat Jena; AlemaniaFil: Tirado González, Irene. Medicine University Berlin; AlemaniaFil: Torloni, Maria R.. Universidade Federal de Sao Paulo; BrasilFil: Freitag, Nancy. Medicine University Berlin; AlemaniaFil: Mattar, Rosiane. Universidade Federal de Sao Paulo; BrasilFil: Conrad, Melanie L.. Medicine University Berlin; AlemaniaFil: Unverdorben, Laura. Ludwig Maximilians Universitat; AlemaniaFil: Barrientos, Gabriela Laura. Medicine University Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Knabl, Julia. Ludwig Maximilians Universitat; AlemaniaFil: Toldi, Gergely. Semmelweis University; HungríaFil: Molvarec, Attila. Semmelweis University; HungríaFil: Rose, Matthias. Medicine University Berlin; AlemaniaFil: Markert, Udo R.. Universitat Jena; AlemaniaFil: Jeschke, Udo. Ludwig Maximilians Universitat; AlemaniaFil: Daher, Silvia. Universidade Federal de Sao Paulo; BrasilOxford University Press2014-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttp://hdl.handle.net/11336/32177Blois, Sandra M.; Gueuvoghlanian Silva, Barbara Y.; Tirado González, Irene; Torloni, Maria R.; Freitag, Nancy; et al.; Getting too sweet: galectin-1 dysregulation in gestational diabetes mellitus; Oxford University Press; Molecular Human Reproduction; 20; 7; 3-2014; 644-6491360-9947CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/molehr/gau021info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/molehr/article/20/7/644/2459753info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:48Zoai:ri.conicet.gov.ar:11336/32177instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:48.723CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Getting too sweet: galectin-1 dysregulation in gestational diabetes mellitus
title Getting too sweet: galectin-1 dysregulation in gestational diabetes mellitus
spellingShingle Getting too sweet: galectin-1 dysregulation in gestational diabetes mellitus
Blois, Sandra M.
Galectin-1
Gestational Diabetes
Glucose
title_short Getting too sweet: galectin-1 dysregulation in gestational diabetes mellitus
title_full Getting too sweet: galectin-1 dysregulation in gestational diabetes mellitus
title_fullStr Getting too sweet: galectin-1 dysregulation in gestational diabetes mellitus
title_full_unstemmed Getting too sweet: galectin-1 dysregulation in gestational diabetes mellitus
title_sort Getting too sweet: galectin-1 dysregulation in gestational diabetes mellitus
dc.creator.none.fl_str_mv Blois, Sandra M.
Gueuvoghlanian Silva, Barbara Y.
Tirado González, Irene
Torloni, Maria R.
Freitag, Nancy
Mattar, Rosiane
Conrad, Melanie L.
Unverdorben, Laura
Barrientos, Gabriela Laura
Knabl, Julia
Toldi, Gergely
Molvarec, Attila
Rose, Matthias
Markert, Udo R.
Jeschke, Udo
Daher, Silvia
author Blois, Sandra M.
author_facet Blois, Sandra M.
Gueuvoghlanian Silva, Barbara Y.
Tirado González, Irene
Torloni, Maria R.
Freitag, Nancy
Mattar, Rosiane
Conrad, Melanie L.
Unverdorben, Laura
Barrientos, Gabriela Laura
Knabl, Julia
Toldi, Gergely
Molvarec, Attila
Rose, Matthias
Markert, Udo R.
Jeschke, Udo
Daher, Silvia
author_role author
author2 Gueuvoghlanian Silva, Barbara Y.
Tirado González, Irene
Torloni, Maria R.
Freitag, Nancy
Mattar, Rosiane
Conrad, Melanie L.
Unverdorben, Laura
Barrientos, Gabriela Laura
Knabl, Julia
Toldi, Gergely
Molvarec, Attila
Rose, Matthias
Markert, Udo R.
Jeschke, Udo
Daher, Silvia
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Galectin-1
Gestational Diabetes
Glucose
topic Galectin-1
Gestational Diabetes
Glucose
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Galectin-1 (gal-1) is a prototype carbohydrate-binding protein, whose dysregulation is associated with adverse pregnancy outcomes such as spontaneous abortion and pre-eclampsia. Furthermore, it is known that faulty gal-1 protein production or gene regulation can be caused by single-nucleotide polymorphisms in the LGALS1 gene. Gestational diabetes mellitus (GDM) is also an adverse pregnancy outcome and the most common metabolic disorder during gestation. However, gal-1 expression patterns during GDM remain largely unknown. Our aims were to define local and peripheral gal-1 expression patterns during pregnancy, and to investigate LGALS1 gene polymorphisms in GDM patients. Circulating gal-1 levels were determined by ELISA in GDM patients and normal pregnant controls, and LGALS1 gene polymorphisms were assessed for association with GDM. Placental tissues were collected from control and GDM term pregnancies to evaluate local gal-1 expression by immunofluorescence. Our results show that GDM is associated with a failure to increase circulating gal-1 levels during the second and third trimester, as well as overexpression of gal-1 in placental tissue. Additionally, the LGALS1 polymorphism rs4820294 was associated with the development of GDM. In pregnancies complicated by GDM, we observed gal-1 dysregulation both locally in the placenta and peripherally in the circulation. Furthermore, the association between the LGALS1 polymorphism and GDM may indicate a genetic contribution to this adverse pregnancy outcome.
Fil: Blois, Sandra M.. Medicine University Berlin; Alemania
Fil: Gueuvoghlanian Silva, Barbara Y.. Universidade Federal de Sao Paulo; Brasil. Universitat Jena; Alemania
Fil: Tirado González, Irene. Medicine University Berlin; Alemania
Fil: Torloni, Maria R.. Universidade Federal de Sao Paulo; Brasil
Fil: Freitag, Nancy. Medicine University Berlin; Alemania
Fil: Mattar, Rosiane. Universidade Federal de Sao Paulo; Brasil
Fil: Conrad, Melanie L.. Medicine University Berlin; Alemania
Fil: Unverdorben, Laura. Ludwig Maximilians Universitat; Alemania
Fil: Barrientos, Gabriela Laura. Medicine University Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Knabl, Julia. Ludwig Maximilians Universitat; Alemania
Fil: Toldi, Gergely. Semmelweis University; Hungría
Fil: Molvarec, Attila. Semmelweis University; Hungría
Fil: Rose, Matthias. Medicine University Berlin; Alemania
Fil: Markert, Udo R.. Universitat Jena; Alemania
Fil: Jeschke, Udo. Ludwig Maximilians Universitat; Alemania
Fil: Daher, Silvia. Universidade Federal de Sao Paulo; Brasil
description Galectin-1 (gal-1) is a prototype carbohydrate-binding protein, whose dysregulation is associated with adverse pregnancy outcomes such as spontaneous abortion and pre-eclampsia. Furthermore, it is known that faulty gal-1 protein production or gene regulation can be caused by single-nucleotide polymorphisms in the LGALS1 gene. Gestational diabetes mellitus (GDM) is also an adverse pregnancy outcome and the most common metabolic disorder during gestation. However, gal-1 expression patterns during GDM remain largely unknown. Our aims were to define local and peripheral gal-1 expression patterns during pregnancy, and to investigate LGALS1 gene polymorphisms in GDM patients. Circulating gal-1 levels were determined by ELISA in GDM patients and normal pregnant controls, and LGALS1 gene polymorphisms were assessed for association with GDM. Placental tissues were collected from control and GDM term pregnancies to evaluate local gal-1 expression by immunofluorescence. Our results show that GDM is associated with a failure to increase circulating gal-1 levels during the second and third trimester, as well as overexpression of gal-1 in placental tissue. Additionally, the LGALS1 polymorphism rs4820294 was associated with the development of GDM. In pregnancies complicated by GDM, we observed gal-1 dysregulation both locally in the placenta and peripherally in the circulation. Furthermore, the association between the LGALS1 polymorphism and GDM may indicate a genetic contribution to this adverse pregnancy outcome.
publishDate 2014
dc.date.none.fl_str_mv 2014-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/32177
Blois, Sandra M.; Gueuvoghlanian Silva, Barbara Y.; Tirado González, Irene; Torloni, Maria R.; Freitag, Nancy; et al.; Getting too sweet: galectin-1 dysregulation in gestational diabetes mellitus; Oxford University Press; Molecular Human Reproduction; 20; 7; 3-2014; 644-649
1360-9947
CONICET Digital
CONICET
url http://hdl.handle.net/11336/32177
identifier_str_mv Blois, Sandra M.; Gueuvoghlanian Silva, Barbara Y.; Tirado González, Irene; Torloni, Maria R.; Freitag, Nancy; et al.; Getting too sweet: galectin-1 dysregulation in gestational diabetes mellitus; Oxford University Press; Molecular Human Reproduction; 20; 7; 3-2014; 644-649
1360-9947
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/molehr/gau021
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/molehr/article/20/7/644/2459753
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/vnd.openxmlformats-officedocument.wordprocessingml.document
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269929401745408
score 13.13397

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