Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiency

Autores
Freitag, Nancy; Tirado González, Irene; Barrientos, Gabriela Laura; Powell, Katie L.; Boehm Sturm, Philipp; Koch, Stefan P.; Hecher, Kurt; Staff, Anne C.; Arck, Petra Clara; Diemert, Anke; Blois, Sandra M.
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fetal growth restriction (FGR) is the most common pregnancy complication in developed countries. Pregnancies affected by FGR, frequently concur with complications and high risk of neonatal morbidity and mortality. To date, no approved treatment is available for pregnant women affected with FGR. The objective of this study was to investigate the contribution of galectin-3 (gal-3), a β-galactoside binding protein involved in pregnancy, placental function and fetal growth. We demonstrated that lack of gal-3 during mouse pregnancy leads to placental dysfunction and drives FGR in the absence of a maternal preeclampsia syndrome. Analysis of gal-3 deficient dams revealed placental inflammation and malperfusion, as well as uterine natural killer cell infiltration with aberrant activation. Our results also show that FGR is associated with a failure to increase maternal circulating gal-3 levels during the second and third trimester in human pregnancies. Placentas from human pregnancies affected by FGR displayed lower gal-3 expression, which correlated with placental dysfunction. These data highlight the importance of gal-3 in the promotion of proper placental function, as its absence leads to placental disease and subsequent FGR.
Fil: Freitag, Nancy. Charité Universitätsmedizin Berlin; Alemania. Freie Universität Berlin; Alemania. Humboldt-Universität zu Berlin; Alemania. Max Delbrück Center for Molecular Medicine; Alemania. Berlin Institute of Health; Alemania
Fil: Tirado González, Irene. Charité Universitätsmedizin Berlin; Alemania. Max Delbrück Center for Molecular Medicine; Alemania
Fil: Barrientos, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Alemán. Laboratorio de Medicina Experimental; Argentina
Fil: Powell, Katie L.. Kolling Institute Of Medical Research; Australia
Fil: Boehm Sturm, Philipp. Charité Universitätsmedizin Berlin; Alemania. Freie Universität Berlin; Alemania. Humboldt-Universität zu Berlin; Alemania. Berlin Institute of Health; Alemania
Fil: Koch, Stefan P.. Charité Universitätsmedizin Berlin; Alemania. Freie Universität Berlin; Alemania. Humboldt-Universität zu Berlin; Alemania. Berlin Institute of Health; Alemania
Fil: Hecher, Kurt. Universitat Hamburg; Alemania
Fil: Staff, Anne C.. University of Oslo; Noruega. Oslo University Hospital; Noruega
Fil: Arck, Petra Clara. Universitat Hamburg; Alemania
Fil: Diemert, Anke. Universitat Hamburg; Alemania
Fil: Blois, Sandra M.. Universitat Hamburg; Alemania. Max Delbruck Center For Molecular Medicine; Alemania. Charité - Universitätsmedizin Berlin; Alemania
Materia
ENDOCRINE REPRODUCTIVE DISORDERS
REPRODUCTIVE DISORDERS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/169995
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/169995
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiencyFreitag, NancyTirado González, IreneBarrientos, Gabriela LauraPowell, Katie L.Boehm Sturm, PhilippKoch, Stefan P.Hecher, KurtStaff, Anne C.Arck, Petra ClaraDiemert, AnkeBlois, Sandra M.ENDOCRINE REPRODUCTIVE DISORDERSREPRODUCTIVE DISORDERShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Fetal growth restriction (FGR) is the most common pregnancy complication in developed countries. Pregnancies affected by FGR, frequently concur with complications and high risk of neonatal morbidity and mortality. To date, no approved treatment is available for pregnant women affected with FGR. The objective of this study was to investigate the contribution of galectin-3 (gal-3), a β-galactoside binding protein involved in pregnancy, placental function and fetal growth. We demonstrated that lack of gal-3 during mouse pregnancy leads to placental dysfunction and drives FGR in the absence of a maternal preeclampsia syndrome. Analysis of gal-3 deficient dams revealed placental inflammation and malperfusion, as well as uterine natural killer cell infiltration with aberrant activation. Our results also show that FGR is associated with a failure to increase maternal circulating gal-3 levels during the second and third trimester in human pregnancies. Placentas from human pregnancies affected by FGR displayed lower gal-3 expression, which correlated with placental dysfunction. These data highlight the importance of gal-3 in the promotion of proper placental function, as its absence leads to placental disease and subsequent FGR.Fil: Freitag, Nancy. Charité Universitätsmedizin Berlin; Alemania. Freie Universität Berlin; Alemania. Humboldt-Universität zu Berlin; Alemania. Max Delbrück Center for Molecular Medicine; Alemania. Berlin Institute of Health; AlemaniaFil: Tirado González, Irene. Charité Universitätsmedizin Berlin; Alemania. Max Delbrück Center for Molecular Medicine; AlemaniaFil: Barrientos, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Alemán. Laboratorio de Medicina Experimental; ArgentinaFil: Powell, Katie L.. Kolling Institute Of Medical Research; AustraliaFil: Boehm Sturm, Philipp. Charité Universitätsmedizin Berlin; Alemania. Freie Universität Berlin; Alemania. Humboldt-Universität zu Berlin; Alemania. Berlin Institute of Health; AlemaniaFil: Koch, Stefan P.. Charité Universitätsmedizin Berlin; Alemania. Freie Universität Berlin; Alemania. Humboldt-Universität zu Berlin; Alemania. Berlin Institute of Health; AlemaniaFil: Hecher, Kurt. Universitat Hamburg; AlemaniaFil: Staff, Anne C.. University of Oslo; Noruega. Oslo University Hospital; NoruegaFil: Arck, Petra Clara. Universitat Hamburg; AlemaniaFil: Diemert, Anke. Universitat Hamburg; AlemaniaFil: Blois, Sandra M.. Universitat Hamburg; Alemania. Max Delbruck Center For Molecular Medicine; Alemania. Charité - Universitätsmedizin Berlin; AlemaniaNature Publishing Group2020-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/169995Freitag, Nancy; Tirado González, Irene; Barrientos, Gabriela Laura; Powell, Katie L.; Boehm Sturm, Philipp; et al.; Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiency; Nature Publishing Group; Cell Death and Disease; 11; 7; 7-2020; 1-92041-4889CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41419-020-02791-5info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41419-020-02791-5info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:57:27Zoai:ri.conicet.gov.ar:11336/169995instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:57:27.401CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiency
title Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiency
spellingShingle Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiency
Freitag, Nancy
ENDOCRINE REPRODUCTIVE DISORDERS
REPRODUCTIVE DISORDERS
title_short Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiency
title_full Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiency
title_fullStr Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiency
title_full_unstemmed Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiency
title_sort Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiency
dc.creator.none.fl_str_mv Freitag, Nancy
Tirado González, Irene
Barrientos, Gabriela Laura
Powell, Katie L.
Boehm Sturm, Philipp
Koch, Stefan P.
Hecher, Kurt
Staff, Anne C.
Arck, Petra Clara
Diemert, Anke
Blois, Sandra M.
author Freitag, Nancy
author_facet Freitag, Nancy
Tirado González, Irene
Barrientos, Gabriela Laura
Powell, Katie L.
Boehm Sturm, Philipp
Koch, Stefan P.
Hecher, Kurt
Staff, Anne C.
Arck, Petra Clara
Diemert, Anke
Blois, Sandra M.
author_role author
author2 Tirado González, Irene
Barrientos, Gabriela Laura
Powell, Katie L.
Boehm Sturm, Philipp
Koch, Stefan P.
Hecher, Kurt
Staff, Anne C.
Arck, Petra Clara
Diemert, Anke
Blois, Sandra M.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ENDOCRINE REPRODUCTIVE DISORDERS
REPRODUCTIVE DISORDERS
topic ENDOCRINE REPRODUCTIVE DISORDERS
REPRODUCTIVE DISORDERS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Fetal growth restriction (FGR) is the most common pregnancy complication in developed countries. Pregnancies affected by FGR, frequently concur with complications and high risk of neonatal morbidity and mortality. To date, no approved treatment is available for pregnant women affected with FGR. The objective of this study was to investigate the contribution of galectin-3 (gal-3), a β-galactoside binding protein involved in pregnancy, placental function and fetal growth. We demonstrated that lack of gal-3 during mouse pregnancy leads to placental dysfunction and drives FGR in the absence of a maternal preeclampsia syndrome. Analysis of gal-3 deficient dams revealed placental inflammation and malperfusion, as well as uterine natural killer cell infiltration with aberrant activation. Our results also show that FGR is associated with a failure to increase maternal circulating gal-3 levels during the second and third trimester in human pregnancies. Placentas from human pregnancies affected by FGR displayed lower gal-3 expression, which correlated with placental dysfunction. These data highlight the importance of gal-3 in the promotion of proper placental function, as its absence leads to placental disease and subsequent FGR.
Fil: Freitag, Nancy. Charité Universitätsmedizin Berlin; Alemania. Freie Universität Berlin; Alemania. Humboldt-Universität zu Berlin; Alemania. Max Delbrück Center for Molecular Medicine; Alemania. Berlin Institute of Health; Alemania
Fil: Tirado González, Irene. Charité Universitätsmedizin Berlin; Alemania. Max Delbrück Center for Molecular Medicine; Alemania
Fil: Barrientos, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Alemán. Laboratorio de Medicina Experimental; Argentina
Fil: Powell, Katie L.. Kolling Institute Of Medical Research; Australia
Fil: Boehm Sturm, Philipp. Charité Universitätsmedizin Berlin; Alemania. Freie Universität Berlin; Alemania. Humboldt-Universität zu Berlin; Alemania. Berlin Institute of Health; Alemania
Fil: Koch, Stefan P.. Charité Universitätsmedizin Berlin; Alemania. Freie Universität Berlin; Alemania. Humboldt-Universität zu Berlin; Alemania. Berlin Institute of Health; Alemania
Fil: Hecher, Kurt. Universitat Hamburg; Alemania
Fil: Staff, Anne C.. University of Oslo; Noruega. Oslo University Hospital; Noruega
Fil: Arck, Petra Clara. Universitat Hamburg; Alemania
Fil: Diemert, Anke. Universitat Hamburg; Alemania
Fil: Blois, Sandra M.. Universitat Hamburg; Alemania. Max Delbruck Center For Molecular Medicine; Alemania. Charité - Universitätsmedizin Berlin; Alemania
description Fetal growth restriction (FGR) is the most common pregnancy complication in developed countries. Pregnancies affected by FGR, frequently concur with complications and high risk of neonatal morbidity and mortality. To date, no approved treatment is available for pregnant women affected with FGR. The objective of this study was to investigate the contribution of galectin-3 (gal-3), a β-galactoside binding protein involved in pregnancy, placental function and fetal growth. We demonstrated that lack of gal-3 during mouse pregnancy leads to placental dysfunction and drives FGR in the absence of a maternal preeclampsia syndrome. Analysis of gal-3 deficient dams revealed placental inflammation and malperfusion, as well as uterine natural killer cell infiltration with aberrant activation. Our results also show that FGR is associated with a failure to increase maternal circulating gal-3 levels during the second and third trimester in human pregnancies. Placentas from human pregnancies affected by FGR displayed lower gal-3 expression, which correlated with placental dysfunction. These data highlight the importance of gal-3 in the promotion of proper placental function, as its absence leads to placental disease and subsequent FGR.
publishDate 2020
dc.date.none.fl_str_mv 2020-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/169995
Freitag, Nancy; Tirado González, Irene; Barrientos, Gabriela Laura; Powell, Katie L.; Boehm Sturm, Philipp; et al.; Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiency; Nature Publishing Group; Cell Death and Disease; 11; 7; 7-2020; 1-9
2041-4889
CONICET Digital
CONICET
url http://hdl.handle.net/11336/169995
identifier_str_mv Freitag, Nancy; Tirado González, Irene; Barrientos, Gabriela Laura; Powell, Katie L.; Boehm Sturm, Philipp; et al.; Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiency; Nature Publishing Group; Cell Death and Disease; 11; 7; 7-2020; 1-9
2041-4889
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/s41419-020-02791-5
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41419-020-02791-5
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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