Curcumin/Gd Loaded Apoferritin: A Novel "Theranostic" Agent To Prevent Hepatocellular Damage in Toxic Induced Acute Hepatitis

Autores
Cutrin, Juan Carlos; Geninatti Crich, Simonetta; Burghelea, Diana; Dastrù, Walter; Aime, Silvio
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Apoferritin has been exploited to deliver simultaneously therapeutic and imaging agents (loaded into its internal cavity) to hepatocytes as this protein is efficiently taken up from blood by hepatocyte scavenger receptor class A type 5 via the ferritin transporting route. To this purpose the protein has been loaded with the magnetic resonance imaging (MRI) contrast agent GdHPDO3A and curcumin, a polyphenolic substance endowed with multiple pharmacological actions, namely: antioxidant, anti-inflammatory, antineoplastic. Curcumin and GdHPDO3A loaded apoferritin has been used with the aim to attenuate the thioacetamide-induced hepatitis together with the evaluation by MRI of drug delivery efficiency. Mice pretreated by intraperitoneal administration showed significantly attenuated hepatic injury as assessed by measuring alanine aminotransferase (ALT) activity in plasma and by histology assessment. The encapsulation of curcumin inside the apoferritin cavity significantly increases its stability and bioavailability while maintaining its therapeutic anti-inflammatory properties.
Fil: Cutrin, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Universita di Torino; Italia
Fil: Geninatti Crich, Simonetta. Universitã â  Di Torino; Italia
Fil: Burghelea, Diana. Universitã â  Di Torino; Italia
Fil: Dastrù, Walter. Universitã â  Di Torino; Italia
Fil: Aime, Silvio. Universitã â  Di Torino; Italia
Materia
Curcumin
Apoferritin
Mri
Hepatitis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/7912
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Curcumin/Gd Loaded Apoferritin: A Novel "Theranostic" Agent To Prevent Hepatocellular Damage in Toxic Induced Acute HepatitisCutrin, Juan CarlosGeninatti Crich, SimonettaBurghelea, DianaDastrù, WalterAime, SilvioCurcuminApoferritinMriHepatitishttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Apoferritin has been exploited to deliver simultaneously therapeutic and imaging agents (loaded into its internal cavity) to hepatocytes as this protein is efficiently taken up from blood by hepatocyte scavenger receptor class A type 5 via the ferritin transporting route. To this purpose the protein has been loaded with the magnetic resonance imaging (MRI) contrast agent GdHPDO3A and curcumin, a polyphenolic substance endowed with multiple pharmacological actions, namely: antioxidant, anti-inflammatory, antineoplastic. Curcumin and GdHPDO3A loaded apoferritin has been used with the aim to attenuate the thioacetamide-induced hepatitis together with the evaluation by MRI of drug delivery efficiency. Mice pretreated by intraperitoneal administration showed significantly attenuated hepatic injury as assessed by measuring alanine aminotransferase (ALT) activity in plasma and by histology assessment. The encapsulation of curcumin inside the apoferritin cavity significantly increases its stability and bioavailability while maintaining its therapeutic anti-inflammatory properties.Fil: Cutrin, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Universita di Torino; ItaliaFil: Geninatti Crich, Simonetta. Universitã â  Di Torino; ItaliaFil: Burghelea, Diana. Universitã â  Di Torino; ItaliaFil: Dastrù, Walter. Universitã â  Di Torino; ItaliaFil: Aime, Silvio. Universitã â  Di Torino; ItaliaAmerican Chemical Society2013-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7912Cutrin, Juan Carlos; Geninatti Crich, Simonetta; Burghelea, Diana; Dastrù, Walter; Aime, Silvio; Curcumin/Gd Loaded Apoferritin: A Novel "Theranostic" Agent To Prevent Hepatocellular Damage in Toxic Induced Acute Hepatitis; American Chemical Society; Molecular Pharmaceutics; 10; 5; 4-2013; 2079-20851543-8384enginfo:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/mp3006177info:eu-repo/semantics/altIdentifier/doi/10.1021/mp3006177info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:06:34Zoai:ri.conicet.gov.ar:11336/7912instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:06:34.296CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Curcumin/Gd Loaded Apoferritin: A Novel "Theranostic" Agent To Prevent Hepatocellular Damage in Toxic Induced Acute Hepatitis
title Curcumin/Gd Loaded Apoferritin: A Novel "Theranostic" Agent To Prevent Hepatocellular Damage in Toxic Induced Acute Hepatitis
spellingShingle Curcumin/Gd Loaded Apoferritin: A Novel "Theranostic" Agent To Prevent Hepatocellular Damage in Toxic Induced Acute Hepatitis
Cutrin, Juan Carlos
Curcumin
Apoferritin
Mri
Hepatitis
title_short Curcumin/Gd Loaded Apoferritin: A Novel "Theranostic" Agent To Prevent Hepatocellular Damage in Toxic Induced Acute Hepatitis
title_full Curcumin/Gd Loaded Apoferritin: A Novel "Theranostic" Agent To Prevent Hepatocellular Damage in Toxic Induced Acute Hepatitis
title_fullStr Curcumin/Gd Loaded Apoferritin: A Novel "Theranostic" Agent To Prevent Hepatocellular Damage in Toxic Induced Acute Hepatitis
title_full_unstemmed Curcumin/Gd Loaded Apoferritin: A Novel "Theranostic" Agent To Prevent Hepatocellular Damage in Toxic Induced Acute Hepatitis
title_sort Curcumin/Gd Loaded Apoferritin: A Novel "Theranostic" Agent To Prevent Hepatocellular Damage in Toxic Induced Acute Hepatitis
dc.creator.none.fl_str_mv Cutrin, Juan Carlos
Geninatti Crich, Simonetta
Burghelea, Diana
Dastrù, Walter
Aime, Silvio
author Cutrin, Juan Carlos
author_facet Cutrin, Juan Carlos
Geninatti Crich, Simonetta
Burghelea, Diana
Dastrù, Walter
Aime, Silvio
author_role author
author2 Geninatti Crich, Simonetta
Burghelea, Diana
Dastrù, Walter
Aime, Silvio
author2_role author
author
author
author
dc.subject.none.fl_str_mv Curcumin
Apoferritin
Mri
Hepatitis
topic Curcumin
Apoferritin
Mri
Hepatitis
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Apoferritin has been exploited to deliver simultaneously therapeutic and imaging agents (loaded into its internal cavity) to hepatocytes as this protein is efficiently taken up from blood by hepatocyte scavenger receptor class A type 5 via the ferritin transporting route. To this purpose the protein has been loaded with the magnetic resonance imaging (MRI) contrast agent GdHPDO3A and curcumin, a polyphenolic substance endowed with multiple pharmacological actions, namely: antioxidant, anti-inflammatory, antineoplastic. Curcumin and GdHPDO3A loaded apoferritin has been used with the aim to attenuate the thioacetamide-induced hepatitis together with the evaluation by MRI of drug delivery efficiency. Mice pretreated by intraperitoneal administration showed significantly attenuated hepatic injury as assessed by measuring alanine aminotransferase (ALT) activity in plasma and by histology assessment. The encapsulation of curcumin inside the apoferritin cavity significantly increases its stability and bioavailability while maintaining its therapeutic anti-inflammatory properties.
Fil: Cutrin, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Universita di Torino; Italia
Fil: Geninatti Crich, Simonetta. Universitã â  Di Torino; Italia
Fil: Burghelea, Diana. Universitã â  Di Torino; Italia
Fil: Dastrù, Walter. Universitã â  Di Torino; Italia
Fil: Aime, Silvio. Universitã â  Di Torino; Italia
description Apoferritin has been exploited to deliver simultaneously therapeutic and imaging agents (loaded into its internal cavity) to hepatocytes as this protein is efficiently taken up from blood by hepatocyte scavenger receptor class A type 5 via the ferritin transporting route. To this purpose the protein has been loaded with the magnetic resonance imaging (MRI) contrast agent GdHPDO3A and curcumin, a polyphenolic substance endowed with multiple pharmacological actions, namely: antioxidant, anti-inflammatory, antineoplastic. Curcumin and GdHPDO3A loaded apoferritin has been used with the aim to attenuate the thioacetamide-induced hepatitis together with the evaluation by MRI of drug delivery efficiency. Mice pretreated by intraperitoneal administration showed significantly attenuated hepatic injury as assessed by measuring alanine aminotransferase (ALT) activity in plasma and by histology assessment. The encapsulation of curcumin inside the apoferritin cavity significantly increases its stability and bioavailability while maintaining its therapeutic anti-inflammatory properties.
publishDate 2013
dc.date.none.fl_str_mv 2013-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/7912
Cutrin, Juan Carlos; Geninatti Crich, Simonetta; Burghelea, Diana; Dastrù, Walter; Aime, Silvio; Curcumin/Gd Loaded Apoferritin: A Novel "Theranostic" Agent To Prevent Hepatocellular Damage in Toxic Induced Acute Hepatitis; American Chemical Society; Molecular Pharmaceutics; 10; 5; 4-2013; 2079-2085
1543-8384
url http://hdl.handle.net/11336/7912
identifier_str_mv Cutrin, Juan Carlos; Geninatti Crich, Simonetta; Burghelea, Diana; Dastrù, Walter; Aime, Silvio; Curcumin/Gd Loaded Apoferritin: A Novel "Theranostic" Agent To Prevent Hepatocellular Damage in Toxic Induced Acute Hepatitis; American Chemical Society; Molecular Pharmaceutics; 10; 5; 4-2013; 2079-2085
1543-8384
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/mp3006177
info:eu-repo/semantics/altIdentifier/doi/10.1021/mp3006177
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613915765374976
score 13.070432

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