Genotoxic Effect of Aqueous Extracts from South American Achyrocline and Gnaphalium Species (Asteraceae:Gnaphalieae) on Human Lymphocytes

Autores
Carballo, Marta Ana; Cortada, Catalina María; Gadano, Alicia; del Vitto, Luis Angel; Petenatti, Elisa Margarita
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Crude drug and different extracts of Achyrocline satureioides (Lam.) DC., A. tomentosa Rusby, Gnaphalium cheiranthifolium Lam. and G. gaudichaudianum DC. (Gnaphalieae: Asteraceae) are widely used in South America mainly as digestives and hepatics. These are raw material for phytotherapics preparations and the manufacture of traditional bitter drinks. In order to establish some aspects on their safety, we have evaluated four different concentrations (1, 10, 100, and 1000 μL.mL–1) of the aqueous extracts of these plants against Single Cell Gel Electrophoresis Assay (SCGEA) in human peripheral blood lymphocytes. Results show a significant increase in damage index (p < 0.001) for all aqueous extracts concentrations assayed of the four plant species, in relation to negative control values. This is a contribution to the development of screenings related to the potential health risk associated with the consumption of South American medicinal plants, especially taking in mind that these plants are widely used as over-thecounter herbs.
Fil: Carballo, Marta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Cortada, Catalina María. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Gadano, Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: del Vitto, Luis Angel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Luis; Argentina
Fil: Petenatti, Elisa Margarita. Universidad Nacional de San Luis; Argentina
Materia
Achyrocline
Genotoxicity
Gnaphalium
Asteraceae
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67282
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Genotoxic Effect of Aqueous Extracts from South American Achyrocline and Gnaphalium Species (Asteraceae:Gnaphalieae) on Human LymphocytesCarballo, Marta AnaCortada, Catalina MaríaGadano, Aliciadel Vitto, Luis AngelPetenatti, Elisa MargaritaAchyroclineGenotoxicityGnaphaliumAsteraceaehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Crude drug and different extracts of Achyrocline satureioides (Lam.) DC., A. tomentosa Rusby, Gnaphalium cheiranthifolium Lam. and G. gaudichaudianum DC. (Gnaphalieae: Asteraceae) are widely used in South America mainly as digestives and hepatics. These are raw material for phytotherapics preparations and the manufacture of traditional bitter drinks. In order to establish some aspects on their safety, we have evaluated four different concentrations (1, 10, 100, and 1000 μL.mL–1) of the aqueous extracts of these plants against Single Cell Gel Electrophoresis Assay (SCGEA) in human peripheral blood lymphocytes. Results show a significant increase in damage index (p < 0.001) for all aqueous extracts concentrations assayed of the four plant species, in relation to negative control values. This is a contribution to the development of screenings related to the potential health risk associated with the consumption of South American medicinal plants, especially taking in mind that these plants are widely used as over-thecounter herbs.Fil: Carballo, Marta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Cortada, Catalina María. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Gadano, Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: del Vitto, Luis Angel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Luis; ArgentinaFil: Petenatti, Elisa Margarita. Universidad Nacional de San Luis; ArgentinaColegio de Farmacéuticos de la Provincia de Buenos Aires2010-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67282Carballo, Marta Ana; Cortada, Catalina María; Gadano, Alicia; del Vitto, Luis Angel; Petenatti, Elisa Margarita; Genotoxic Effect of Aqueous Extracts from South American Achyrocline and Gnaphalium Species (Asteraceae:Gnaphalieae) on Human Lymphocytes; Colegio de Farmacéuticos de la Provincia de Buenos Aires; Acta Farmacéutica Bonaerense; 29; 7; 9-2010; 1088-10920326-2383CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_5.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:14:34Zoai:ri.conicet.gov.ar:11336/67282instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:14:35.046CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Genotoxic Effect of Aqueous Extracts from South American Achyrocline and Gnaphalium Species (Asteraceae:Gnaphalieae) on Human Lymphocytes
title Genotoxic Effect of Aqueous Extracts from South American Achyrocline and Gnaphalium Species (Asteraceae:Gnaphalieae) on Human Lymphocytes
spellingShingle Genotoxic Effect of Aqueous Extracts from South American Achyrocline and Gnaphalium Species (Asteraceae:Gnaphalieae) on Human Lymphocytes
Carballo, Marta Ana
Achyrocline
Genotoxicity
Gnaphalium
Asteraceae
title_short Genotoxic Effect of Aqueous Extracts from South American Achyrocline and Gnaphalium Species (Asteraceae:Gnaphalieae) on Human Lymphocytes
title_full Genotoxic Effect of Aqueous Extracts from South American Achyrocline and Gnaphalium Species (Asteraceae:Gnaphalieae) on Human Lymphocytes
title_fullStr Genotoxic Effect of Aqueous Extracts from South American Achyrocline and Gnaphalium Species (Asteraceae:Gnaphalieae) on Human Lymphocytes
title_full_unstemmed Genotoxic Effect of Aqueous Extracts from South American Achyrocline and Gnaphalium Species (Asteraceae:Gnaphalieae) on Human Lymphocytes
title_sort Genotoxic Effect of Aqueous Extracts from South American Achyrocline and Gnaphalium Species (Asteraceae:Gnaphalieae) on Human Lymphocytes
dc.creator.none.fl_str_mv Carballo, Marta Ana
Cortada, Catalina María
Gadano, Alicia
del Vitto, Luis Angel
Petenatti, Elisa Margarita
author Carballo, Marta Ana
author_facet Carballo, Marta Ana
Cortada, Catalina María
Gadano, Alicia
del Vitto, Luis Angel
Petenatti, Elisa Margarita
author_role author
author2 Cortada, Catalina María
Gadano, Alicia
del Vitto, Luis Angel
Petenatti, Elisa Margarita
author2_role author
author
author
author
dc.subject.none.fl_str_mv Achyrocline
Genotoxicity
Gnaphalium
Asteraceae
topic Achyrocline
Genotoxicity
Gnaphalium
Asteraceae
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Crude drug and different extracts of Achyrocline satureioides (Lam.) DC., A. tomentosa Rusby, Gnaphalium cheiranthifolium Lam. and G. gaudichaudianum DC. (Gnaphalieae: Asteraceae) are widely used in South America mainly as digestives and hepatics. These are raw material for phytotherapics preparations and the manufacture of traditional bitter drinks. In order to establish some aspects on their safety, we have evaluated four different concentrations (1, 10, 100, and 1000 μL.mL–1) of the aqueous extracts of these plants against Single Cell Gel Electrophoresis Assay (SCGEA) in human peripheral blood lymphocytes. Results show a significant increase in damage index (p < 0.001) for all aqueous extracts concentrations assayed of the four plant species, in relation to negative control values. This is a contribution to the development of screenings related to the potential health risk associated with the consumption of South American medicinal plants, especially taking in mind that these plants are widely used as over-thecounter herbs.
Fil: Carballo, Marta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Cortada, Catalina María. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Gadano, Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: del Vitto, Luis Angel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Luis; Argentina
Fil: Petenatti, Elisa Margarita. Universidad Nacional de San Luis; Argentina
description Crude drug and different extracts of Achyrocline satureioides (Lam.) DC., A. tomentosa Rusby, Gnaphalium cheiranthifolium Lam. and G. gaudichaudianum DC. (Gnaphalieae: Asteraceae) are widely used in South America mainly as digestives and hepatics. These are raw material for phytotherapics preparations and the manufacture of traditional bitter drinks. In order to establish some aspects on their safety, we have evaluated four different concentrations (1, 10, 100, and 1000 μL.mL–1) of the aqueous extracts of these plants against Single Cell Gel Electrophoresis Assay (SCGEA) in human peripheral blood lymphocytes. Results show a significant increase in damage index (p < 0.001) for all aqueous extracts concentrations assayed of the four plant species, in relation to negative control values. This is a contribution to the development of screenings related to the potential health risk associated with the consumption of South American medicinal plants, especially taking in mind that these plants are widely used as over-thecounter herbs.
publishDate 2010
dc.date.none.fl_str_mv 2010-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67282
Carballo, Marta Ana; Cortada, Catalina María; Gadano, Alicia; del Vitto, Luis Angel; Petenatti, Elisa Margarita; Genotoxic Effect of Aqueous Extracts from South American Achyrocline and Gnaphalium Species (Asteraceae:Gnaphalieae) on Human Lymphocytes; Colegio de Farmacéuticos de la Provincia de Buenos Aires; Acta Farmacéutica Bonaerense; 29; 7; 9-2010; 1088-1092
0326-2383
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67282
identifier_str_mv Carballo, Marta Ana; Cortada, Catalina María; Gadano, Alicia; del Vitto, Luis Angel; Petenatti, Elisa Margarita; Genotoxic Effect of Aqueous Extracts from South American Achyrocline and Gnaphalium Species (Asteraceae:Gnaphalieae) on Human Lymphocytes; Colegio de Farmacéuticos de la Provincia de Buenos Aires; Acta Farmacéutica Bonaerense; 29; 7; 9-2010; 1088-1092
0326-2383
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_5.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Colegio de Farmacéuticos de la Provincia de Buenos Aires
publisher.none.fl_str_mv Colegio de Farmacéuticos de la Provincia de Buenos Aires
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083293133406208
score 13.22299

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