Zebra alphaherpesviruses (EHV-1 and EHV-9): Genetic diversity, Latency and co-infections

Autores
Abdelgawad, Azza; Damiani, Armando Mario; Ho, Simón Y. W.; Strauss, Gunter; Szentiks, Claudia A.; East, Marion L.; Osterrieder, Nikolaus; Alex Greenwood
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Alphaherpesviruses are highly prevalent in equine populations and co-infections with more than one of these viruses’ strains frequently diagnosed. Lytic replication and latency with subsequent reactivation, along with new episodes of disease, can be influenced by genetic diversity generated by spontaneous mutation and recombination. Latency enhances virus survival by providing an epidemiological strategy for long-term maintenance of divergent strains in animal populations. The alphaherpesviruses equine herpesvirus 1 (EHV-1) and 9 (EHV-9) have recently been shown to cross species barriers, including a recombinant EHV-1 observed in fatal infections of a polar bear and Asian rhinoceros. Little is known about the latency and genetic diversity of EHV-1 and EHV-9, especially among zoo and wild equids. Here, we report evidence of limited genetic diversity in EHV-9 in zebras, whereas there is substantial genetic variability in EHV-1. We demonstrate that zebras can be lytically and latently infected with both viruses concurrently. Such a co-occurrence of infection in zebras suggests that even relatively slow-evolving viruses such as equine herpesviruses have the potential to diversify rapidly by recombination. This has potential consequences for the diagnosis of these viruses and their management in wild and captive equid populations.
Fil: Abdelgawad, Azza. Leibniz Institute For Zoo And Wildlife Research; Alemania
Fil: Damiani, Armando Mario. Freie University Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Ho, Simón Y. W.. University of Sydney; Australia
Fil: Strauss, Gunter. Tierpark Berlin-Friedrichsfelde; Alemania
Fil: Szentiks, Claudia A.. Leibniz Institute For Zoo And Wildlife Research; Alemania
Fil: East, Marion L.. Leibniz Institute For Zoo And Wildlife Research; Alemania
Fil: Osterrieder, Nikolaus. Freie University Berlin; Alemania
Fil: Alex Greenwood. Leibniz Institute For Zoo And Wildlife Research; Alemania. Freie University Berlin; Alemania
Materia
CO-OCCURRENCE
DIVERSITY
EHV-1
EHV-9
LATENCY
ZEBRA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/49706
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/49706
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Zebra alphaherpesviruses (EHV-1 and EHV-9): Genetic diversity, Latency and co-infectionsAbdelgawad, AzzaDamiani, Armando MarioHo, Simón Y. W.Strauss, GunterSzentiks, Claudia A.East, Marion L.Osterrieder, NikolausAlex GreenwoodCO-OCCURRENCEDIVERSITYEHV-1EHV-9LATENCYZEBRAhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Alphaherpesviruses are highly prevalent in equine populations and co-infections with more than one of these viruses’ strains frequently diagnosed. Lytic replication and latency with subsequent reactivation, along with new episodes of disease, can be influenced by genetic diversity generated by spontaneous mutation and recombination. Latency enhances virus survival by providing an epidemiological strategy for long-term maintenance of divergent strains in animal populations. The alphaherpesviruses equine herpesvirus 1 (EHV-1) and 9 (EHV-9) have recently been shown to cross species barriers, including a recombinant EHV-1 observed in fatal infections of a polar bear and Asian rhinoceros. Little is known about the latency and genetic diversity of EHV-1 and EHV-9, especially among zoo and wild equids. Here, we report evidence of limited genetic diversity in EHV-9 in zebras, whereas there is substantial genetic variability in EHV-1. We demonstrate that zebras can be lytically and latently infected with both viruses concurrently. Such a co-occurrence of infection in zebras suggests that even relatively slow-evolving viruses such as equine herpesviruses have the potential to diversify rapidly by recombination. This has potential consequences for the diagnosis of these viruses and their management in wild and captive equid populations.Fil: Abdelgawad, Azza. Leibniz Institute For Zoo And Wildlife Research; AlemaniaFil: Damiani, Armando Mario. Freie University Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Ho, Simón Y. W.. University of Sydney; AustraliaFil: Strauss, Gunter. Tierpark Berlin-Friedrichsfelde; AlemaniaFil: Szentiks, Claudia A.. Leibniz Institute For Zoo And Wildlife Research; AlemaniaFil: East, Marion L.. Leibniz Institute For Zoo And Wildlife Research; AlemaniaFil: Osterrieder, Nikolaus. Freie University Berlin; AlemaniaFil: Alex Greenwood. Leibniz Institute For Zoo And Wildlife Research; Alemania. Freie University Berlin; AlemaniaMDPI2016-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/49706Abdelgawad, Azza; Damiani, Armando Mario; Ho, Simón Y. W.; Strauss, Gunter; Szentiks, Claudia A.; et al.; Zebra alphaherpesviruses (EHV-1 and EHV-9): Genetic diversity, Latency and co-infections; MDPI; Viruses; 8; 9; 9-2016; 1-131999-4915CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/v8090262info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1999-4915/8/9/262info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:36Zoai:ri.conicet.gov.ar:11336/49706instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:36.371CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Zebra alphaherpesviruses (EHV-1 and EHV-9): Genetic diversity, Latency and co-infections
title Zebra alphaherpesviruses (EHV-1 and EHV-9): Genetic diversity, Latency and co-infections
spellingShingle Zebra alphaherpesviruses (EHV-1 and EHV-9): Genetic diversity, Latency and co-infections
Abdelgawad, Azza
CO-OCCURRENCE
DIVERSITY
EHV-1
EHV-9
LATENCY
ZEBRA
title_short Zebra alphaherpesviruses (EHV-1 and EHV-9): Genetic diversity, Latency and co-infections
title_full Zebra alphaherpesviruses (EHV-1 and EHV-9): Genetic diversity, Latency and co-infections
title_fullStr Zebra alphaherpesviruses (EHV-1 and EHV-9): Genetic diversity, Latency and co-infections
title_full_unstemmed Zebra alphaherpesviruses (EHV-1 and EHV-9): Genetic diversity, Latency and co-infections
title_sort Zebra alphaherpesviruses (EHV-1 and EHV-9): Genetic diversity, Latency and co-infections
dc.creator.none.fl_str_mv Abdelgawad, Azza
Damiani, Armando Mario
Ho, Simón Y. W.
Strauss, Gunter
Szentiks, Claudia A.
East, Marion L.
Osterrieder, Nikolaus
Alex Greenwood
author Abdelgawad, Azza
author_facet Abdelgawad, Azza
Damiani, Armando Mario
Ho, Simón Y. W.
Strauss, Gunter
Szentiks, Claudia A.
East, Marion L.
Osterrieder, Nikolaus
Alex Greenwood
author_role author
author2 Damiani, Armando Mario
Ho, Simón Y. W.
Strauss, Gunter
Szentiks, Claudia A.
East, Marion L.
Osterrieder, Nikolaus
Alex Greenwood
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CO-OCCURRENCE
DIVERSITY
EHV-1
EHV-9
LATENCY
ZEBRA
topic CO-OCCURRENCE
DIVERSITY
EHV-1
EHV-9
LATENCY
ZEBRA
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Alphaherpesviruses are highly prevalent in equine populations and co-infections with more than one of these viruses’ strains frequently diagnosed. Lytic replication and latency with subsequent reactivation, along with new episodes of disease, can be influenced by genetic diversity generated by spontaneous mutation and recombination. Latency enhances virus survival by providing an epidemiological strategy for long-term maintenance of divergent strains in animal populations. The alphaherpesviruses equine herpesvirus 1 (EHV-1) and 9 (EHV-9) have recently been shown to cross species barriers, including a recombinant EHV-1 observed in fatal infections of a polar bear and Asian rhinoceros. Little is known about the latency and genetic diversity of EHV-1 and EHV-9, especially among zoo and wild equids. Here, we report evidence of limited genetic diversity in EHV-9 in zebras, whereas there is substantial genetic variability in EHV-1. We demonstrate that zebras can be lytically and latently infected with both viruses concurrently. Such a co-occurrence of infection in zebras suggests that even relatively slow-evolving viruses such as equine herpesviruses have the potential to diversify rapidly by recombination. This has potential consequences for the diagnosis of these viruses and their management in wild and captive equid populations.
Fil: Abdelgawad, Azza. Leibniz Institute For Zoo And Wildlife Research; Alemania
Fil: Damiani, Armando Mario. Freie University Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Ho, Simón Y. W.. University of Sydney; Australia
Fil: Strauss, Gunter. Tierpark Berlin-Friedrichsfelde; Alemania
Fil: Szentiks, Claudia A.. Leibniz Institute For Zoo And Wildlife Research; Alemania
Fil: East, Marion L.. Leibniz Institute For Zoo And Wildlife Research; Alemania
Fil: Osterrieder, Nikolaus. Freie University Berlin; Alemania
Fil: Alex Greenwood. Leibniz Institute For Zoo And Wildlife Research; Alemania. Freie University Berlin; Alemania
description Alphaherpesviruses are highly prevalent in equine populations and co-infections with more than one of these viruses’ strains frequently diagnosed. Lytic replication and latency with subsequent reactivation, along with new episodes of disease, can be influenced by genetic diversity generated by spontaneous mutation and recombination. Latency enhances virus survival by providing an epidemiological strategy for long-term maintenance of divergent strains in animal populations. The alphaherpesviruses equine herpesvirus 1 (EHV-1) and 9 (EHV-9) have recently been shown to cross species barriers, including a recombinant EHV-1 observed in fatal infections of a polar bear and Asian rhinoceros. Little is known about the latency and genetic diversity of EHV-1 and EHV-9, especially among zoo and wild equids. Here, we report evidence of limited genetic diversity in EHV-9 in zebras, whereas there is substantial genetic variability in EHV-1. We demonstrate that zebras can be lytically and latently infected with both viruses concurrently. Such a co-occurrence of infection in zebras suggests that even relatively slow-evolving viruses such as equine herpesviruses have the potential to diversify rapidly by recombination. This has potential consequences for the diagnosis of these viruses and their management in wild and captive equid populations.
publishDate 2016
dc.date.none.fl_str_mv 2016-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/49706
Abdelgawad, Azza; Damiani, Armando Mario; Ho, Simón Y. W.; Strauss, Gunter; Szentiks, Claudia A.; et al.; Zebra alphaherpesviruses (EHV-1 and EHV-9): Genetic diversity, Latency and co-infections; MDPI; Viruses; 8; 9; 9-2016; 1-13
1999-4915
CONICET Digital
CONICET
url http://hdl.handle.net/11336/49706
identifier_str_mv Abdelgawad, Azza; Damiani, Armando Mario; Ho, Simón Y. W.; Strauss, Gunter; Szentiks, Claudia A.; et al.; Zebra alphaherpesviruses (EHV-1 and EHV-9): Genetic diversity, Latency and co-infections; MDPI; Viruses; 8; 9; 9-2016; 1-13
1999-4915
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/v8090262
info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1999-4915/8/9/262
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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