Translational cancer research comes of age in Latin America.

Autores
Llera, Andrea Sabina; Podhajcer, Osvaldo Luis; Breitenbach, M. M.; Santini, L.; Muller, B.; Daneri Navarro, A.; Velázquez, C. A.; Artagaveytia, N.; Gómez, J.; Frech, M. S.; Brown, T.; Gross, T.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Ambitious efforts to characterize the genomics of cancer, made by initiatives such as the Cancer Genome Atlas and the Global Cancer Genomics Consortium, have highlighted the disease’s complexity and exposed how far we are from understanding the intrinsic molecular mechanisms that govern cancer outcome and response to therapy. Many of these cost-intensive studies used cutting-edge genomic technologies and were performed in developed countries with the support of national and regional agencies. Since then, investigators have delved more deeply into the ef ects of race and ethnic origin, and their intrinsic human genetic variation, on cancer susceptibility, prognosis, and response to therapy. Thus, cancer’s complexity has created a challenge that encouraged concerted international efforts to improve the capacity for excellence in translational medicine research in developing countries. This unmet need spurred the Center for Global Health of the U.S. National Cancer Institute (NCI) to create the U.S.–Latin America Cancer Research Network (LACRN), with the aim of strengthening collaborative research efforts among the participating countries, advancing translational cancer research, and reducing the global cancer burden. Here, we describe the implementation of the network’s first translational study on breast cancer genomics.
Fil: Llera, Andrea Sabina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Podhajcer, Osvaldo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Breitenbach, M. M.. Ministerio de Salud de Brasil; Brasil
Fil: Santini, L.. Ministerio de Salud de Brasil; Brasil
Fil: Muller, B.. Instituto Nacional de Cáncer; Chile
Fil: Daneri Navarro, A.. Universidad de Guadalajara; México
Fil: Velázquez, C. A.. Universidad de Sonora; México
Fil: Artagaveytia, N.. Universidad de la República; Uruguay
Fil: Gómez, J.. National Institutes of Health; Estados Unidos
Fil: Frech, M. S.. National Institutes of Health; Estados Unidos
Fil: Brown, T.. National Institutes of Health; Estados Unidos
Fil: Gross, T.. National Institutes of Health; Estados Unidos
Materia
Genomics
Translational
Breast
Cancer
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/23145
Acceder
id CONICETDig_54d61de9eeb42030b25d1893d31920bd
oai_identifier_str oai:ri.conicet.gov.ar:11336/23145
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Translational cancer research comes of age in Latin America.Llera, Andrea SabinaPodhajcer, Osvaldo LuisBreitenbach, M. M.Santini, L.Muller, B.Daneri Navarro, A.Velázquez, C. A.Artagaveytia, N.Gómez, J.Frech, M. S.Brown, T.Gross, T.GenomicsTranslationalBreastCancerhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Ambitious efforts to characterize the genomics of cancer, made by initiatives such as the Cancer Genome Atlas and the Global Cancer Genomics Consortium, have highlighted the disease’s complexity and exposed how far we are from understanding the intrinsic molecular mechanisms that govern cancer outcome and response to therapy. Many of these cost-intensive studies used cutting-edge genomic technologies and were performed in developed countries with the support of national and regional agencies. Since then, investigators have delved more deeply into the ef ects of race and ethnic origin, and their intrinsic human genetic variation, on cancer susceptibility, prognosis, and response to therapy. Thus, cancer’s complexity has created a challenge that encouraged concerted international efforts to improve the capacity for excellence in translational medicine research in developing countries. This unmet need spurred the Center for Global Health of the U.S. National Cancer Institute (NCI) to create the U.S.–Latin America Cancer Research Network (LACRN), with the aim of strengthening collaborative research efforts among the participating countries, advancing translational cancer research, and reducing the global cancer burden. Here, we describe the implementation of the network’s first translational study on breast cancer genomics.Fil: Llera, Andrea Sabina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Podhajcer, Osvaldo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Breitenbach, M. M.. Ministerio de Salud de Brasil; BrasilFil: Santini, L.. Ministerio de Salud de Brasil; BrasilFil: Muller, B.. Instituto Nacional de Cáncer; ChileFil: Daneri Navarro, A.. Universidad de Guadalajara; MéxicoFil: Velázquez, C. A.. Universidad de Sonora; MéxicoFil: Artagaveytia, N.. Universidad de la República; UruguayFil: Gómez, J.. National Institutes of Health; Estados UnidosFil: Frech, M. S.. National Institutes of Health; Estados UnidosFil: Brown, T.. National Institutes of Health; Estados UnidosFil: Gross, T.. National Institutes of Health; Estados UnidosAmerican Association for the Advancement of Science2015-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/23145Llera, Andrea Sabina; Podhajcer, Osvaldo Luis; Breitenbach, M. M.; Santini, L.; Muller, B.; et al.; Translational cancer research comes of age in Latin America.; American Association for the Advancement of Science; Science Translational Medicine; 7; 319; 12-2015; 1-9; 319fs501946-62341946-6242CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://stm.sciencemag.org/content/7/319/319fs50info:eu-repo/semantics/altIdentifier/doi/ 10.1126/scitranslmed.aad5859info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:49:20Zoai:ri.conicet.gov.ar:11336/23145instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:49:20.691CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Translational cancer research comes of age in Latin America.
title Translational cancer research comes of age in Latin America.
spellingShingle Translational cancer research comes of age in Latin America.
Llera, Andrea Sabina
Genomics
Translational
Breast
Cancer
title_short Translational cancer research comes of age in Latin America.
title_full Translational cancer research comes of age in Latin America.
title_fullStr Translational cancer research comes of age in Latin America.
title_full_unstemmed Translational cancer research comes of age in Latin America.
title_sort Translational cancer research comes of age in Latin America.
dc.creator.none.fl_str_mv Llera, Andrea Sabina
Podhajcer, Osvaldo Luis
Breitenbach, M. M.
Santini, L.
Muller, B.
Daneri Navarro, A.
Velázquez, C. A.
Artagaveytia, N.
Gómez, J.
Frech, M. S.
Brown, T.
Gross, T.
author Llera, Andrea Sabina
author_facet Llera, Andrea Sabina
Podhajcer, Osvaldo Luis
Breitenbach, M. M.
Santini, L.
Muller, B.
Daneri Navarro, A.
Velázquez, C. A.
Artagaveytia, N.
Gómez, J.
Frech, M. S.
Brown, T.
Gross, T.
author_role author
author2 Podhajcer, Osvaldo Luis
Breitenbach, M. M.
Santini, L.
Muller, B.
Daneri Navarro, A.
Velázquez, C. A.
Artagaveytia, N.
Gómez, J.
Frech, M. S.
Brown, T.
Gross, T.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Genomics
Translational
Breast
Cancer
topic Genomics
Translational
Breast
Cancer
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Ambitious efforts to characterize the genomics of cancer, made by initiatives such as the Cancer Genome Atlas and the Global Cancer Genomics Consortium, have highlighted the disease’s complexity and exposed how far we are from understanding the intrinsic molecular mechanisms that govern cancer outcome and response to therapy. Many of these cost-intensive studies used cutting-edge genomic technologies and were performed in developed countries with the support of national and regional agencies. Since then, investigators have delved more deeply into the ef ects of race and ethnic origin, and their intrinsic human genetic variation, on cancer susceptibility, prognosis, and response to therapy. Thus, cancer’s complexity has created a challenge that encouraged concerted international efforts to improve the capacity for excellence in translational medicine research in developing countries. This unmet need spurred the Center for Global Health of the U.S. National Cancer Institute (NCI) to create the U.S.–Latin America Cancer Research Network (LACRN), with the aim of strengthening collaborative research efforts among the participating countries, advancing translational cancer research, and reducing the global cancer burden. Here, we describe the implementation of the network’s first translational study on breast cancer genomics.
Fil: Llera, Andrea Sabina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Podhajcer, Osvaldo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Breitenbach, M. M.. Ministerio de Salud de Brasil; Brasil
Fil: Santini, L.. Ministerio de Salud de Brasil; Brasil
Fil: Muller, B.. Instituto Nacional de Cáncer; Chile
Fil: Daneri Navarro, A.. Universidad de Guadalajara; México
Fil: Velázquez, C. A.. Universidad de Sonora; México
Fil: Artagaveytia, N.. Universidad de la República; Uruguay
Fil: Gómez, J.. National Institutes of Health; Estados Unidos
Fil: Frech, M. S.. National Institutes of Health; Estados Unidos
Fil: Brown, T.. National Institutes of Health; Estados Unidos
Fil: Gross, T.. National Institutes of Health; Estados Unidos
description Ambitious efforts to characterize the genomics of cancer, made by initiatives such as the Cancer Genome Atlas and the Global Cancer Genomics Consortium, have highlighted the disease’s complexity and exposed how far we are from understanding the intrinsic molecular mechanisms that govern cancer outcome and response to therapy. Many of these cost-intensive studies used cutting-edge genomic technologies and were performed in developed countries with the support of national and regional agencies. Since then, investigators have delved more deeply into the ef ects of race and ethnic origin, and their intrinsic human genetic variation, on cancer susceptibility, prognosis, and response to therapy. Thus, cancer’s complexity has created a challenge that encouraged concerted international efforts to improve the capacity for excellence in translational medicine research in developing countries. This unmet need spurred the Center for Global Health of the U.S. National Cancer Institute (NCI) to create the U.S.–Latin America Cancer Research Network (LACRN), with the aim of strengthening collaborative research efforts among the participating countries, advancing translational cancer research, and reducing the global cancer burden. Here, we describe the implementation of the network’s first translational study on breast cancer genomics.
publishDate 2015
dc.date.none.fl_str_mv 2015-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/23145
Llera, Andrea Sabina; Podhajcer, Osvaldo Luis; Breitenbach, M. M.; Santini, L.; Muller, B.; et al.; Translational cancer research comes of age in Latin America.; American Association for the Advancement of Science; Science Translational Medicine; 7; 319; 12-2015; 1-9; 319fs50
1946-6234
1946-6242
CONICET Digital
CONICET
url http://hdl.handle.net/11336/23145
identifier_str_mv Llera, Andrea Sabina; Podhajcer, Osvaldo Luis; Breitenbach, M. M.; Santini, L.; Muller, B.; et al.; Translational cancer research comes of age in Latin America.; American Association for the Advancement of Science; Science Translational Medicine; 7; 319; 12-2015; 1-9; 319fs50
1946-6234
1946-6242
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://stm.sciencemag.org/content/7/319/319fs50
info:eu-repo/semantics/altIdentifier/doi/ 10.1126/scitranslmed.aad5859
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association for the Advancement of Science
publisher.none.fl_str_mv American Association for the Advancement of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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