Implementing Standard Diagnosis and Treatment for Locally Advanced Breast Cancer Through Global Research in Latin America: Results From a Multicountry Pragmatic Trial
- Autores
- Retamales, Javier; Daneri Navarro, Adrián; Artagaveytia, Nora; Alves Da Quinta, Daniela Belén; Abdelhay, Eliana; Podhajcer, Osvaldo Luis; Velázquez, Carlos; Giunta, Diego Hernan; Crocamo, Susanne; Garibay Escobar, Adriana; Del Toro Arreola, Alicia; Rodriguez, Robinson; Aghazarian, Marta; Alcoba, Elsa; Alonso, Isabel; Binato, Renata; Bravo, Alicia I.; Canton Romero, Juan; Carraro, Dirce M.; Castro, Mónica; Castro Cervantes, Juan; Cataldi, Sandra; Camejo, Natalia; Cortes Sanabria, Laura; Valenzuela Antelo, Olivia; Venegas Godinez, Laura; Zagame, Livia; Gomez, Jorge; Llera, Andrea Sabina; Müller, Bettina
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Purpose Breast cancer mortality rates in Latin America (LA) are higher than those in the United States, possibly because of advanced disease presentation, health care disparities, or unfavorable molecular subtypes. The Latin American Cancer Research Network was established to address these challenges and to promote collaborative clinical research. The Molecular Profiling of Breast Cancer Study (MPBCS) aimed to evaluate the clinical characteristics and treatment outcomes of LA participants with locally advanced breast cancer (LABC). Patients and Methods The MPBCS enrolled 1,449 participants from Argentina, Brazil, Chile, Mexico, and Uruguay. Through harmonized procedures and quality assurance measures, this study evaluated clinicopathologic characteristics, neoadjuvant chemotherapy response, and survival outcomes according to residual cancer burden (RCB) and the type of surgery. Results Overall, 711 and 480 participants in the primary surgery and neoadjuvant arms, respectively, completed the 5-year follow-up period. Overall survival was independently associated with RCB (worse survival for RCBIII-adjusted hazard ratio, 8.19, P < .001, and RCBII [adjusted hazard ratio, 3.69, P < .008] compared with RCB0 [pathologic complete response or pCR]) and type of surgery (worse survival in mastectomy than in breast-conserving surgery [BCS], adjusted hazard ratio, 2.97, P = .001). The hormone receptor–negative-human epidermal growth factor receptor 2–positive group had the highest proportion of pCR (48.9%). The analysis of the ASCO Quality Oncology Practice Initiative breast module revealed high compliance with pathologic standards but lower adherence to treatment administration standards. Notably, compliance with trastuzumab administration varied widely among countries (33.3%-88.7%). Conclusion In LABC, we demonstrated the survival benefit of BCS and the prognostic effect of the response to available neoadjuvant treatments despite an important variability in access to key treatments. The MPBCS represents a significant step forward in understanding the real-world implementation of oncologic procedures in LA.
Fil: Retamales, Javier. Grupo Oncológico Cooperativo Chileno de Investigación; Chile
Fil: Daneri Navarro, Adrián. Universidad de Guadalajara; México
Fil: Artagaveytia, Nora. Hospital Universitario de Clínicas “Manuel Quintela”; Uruguay
Fil: Alves Da Quinta, Daniela Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad Argentina de la Empresa; Argentina
Fil: Abdelhay, Eliana. Instituto Nacional de Câncer Rio de Janeiro; Brasil
Fil: Podhajcer, Osvaldo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Velázquez, Carlos. Universidad de Sonora; México
Fil: Giunta, Diego Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Instituto Universitario Hospital Italiano de Buenos Aires. Departamento de Posgrado.; Argentina
Fil: Crocamo, Susanne. Instituto Nacional de Câncer Rio de Janeiro; Brasil
Fil: Garibay Escobar, Adriana. Universidad de Sonora; México
Fil: Del Toro Arreola, Alicia. Universidad de Guadalajara; México
Fil: Rodriguez, Robinson. Hospital Universitario de Clínicas “Manuel Quintela”; Uruguay
Fil: Aghazarian, Marta. Instituto Nacional de Cancer; Uruguay
Fil: Alcoba, Elsa. Hospital Municipal de Oncologia Maria Curie ; Gobierno de la Ciudad Autonoma de Buenos Aires;
Fil: Alonso, Isabel. Centro Hospitalario Pereira Rossell; Uruguay
Fil: Binato, Renata. Instituto Nacional de Câncer Rio de Janeiro; Brasil
Fil: Bravo, Alicia I.. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Canton Romero, Juan. Hospital de Gineco-Obstricia CMNO-IMSS; México
Fil: Carraro, Dirce M.. AC Camargo Cancer Center; Bahamas
Fil: Castro, Mónica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Castro Cervantes, Juan. Hospital de Gineco-Obstricia CMNO-IMSS; México
Fil: Cataldi, Sandra. Instituto Nacional de Cancer; Uruguay
Fil: Camejo, Natalia. Hospital Universitario de Clínicas “Manuel Quintela”; Uruguay
Fil: Cortes Sanabria, Laura. Hospital de Gineco-Obstricia CMNO-IMSS; México
Fil: Valenzuela Antelo, Olivia. Universidad de Sonora; México
Fil: Venegas Godinez, Laura. Universidad de Guadalajara; México
Fil: Zagame, Livia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Gomez, Jorge. Texas A&M University; Estados Unidos
Fil: Llera, Andrea Sabina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Müller, Bettina. Grupo Oncológico Cooperativo Chileno de Investigación; Chile. Instituto Nacional del Cáncer; Chile - Materia
- Breast cancer
- Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/240970
Ver los metadatos del registro completo
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Implementing Standard Diagnosis and Treatment for Locally Advanced Breast Cancer Through Global Research in Latin America: Results From a Multicountry Pragmatic TrialRetamales, JavierDaneri Navarro, AdriánArtagaveytia, NoraAlves Da Quinta, Daniela BelénAbdelhay, ElianaPodhajcer, Osvaldo LuisVelázquez, CarlosGiunta, Diego HernanCrocamo, SusanneGaribay Escobar, AdrianaDel Toro Arreola, AliciaRodriguez, RobinsonAghazarian, MartaAlcoba, ElsaAlonso, IsabelBinato, RenataBravo, Alicia I.Canton Romero, JuanCarraro, Dirce M.Castro, MónicaCastro Cervantes, JuanCataldi, SandraCamejo, NataliaCortes Sanabria, LauraValenzuela Antelo, OliviaVenegas Godinez, LauraZagame, LiviaGomez, JorgeLlera, Andrea SabinaMüller, BettinaBreast cancerhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Purpose Breast cancer mortality rates in Latin America (LA) are higher than those in the United States, possibly because of advanced disease presentation, health care disparities, or unfavorable molecular subtypes. The Latin American Cancer Research Network was established to address these challenges and to promote collaborative clinical research. The Molecular Profiling of Breast Cancer Study (MPBCS) aimed to evaluate the clinical characteristics and treatment outcomes of LA participants with locally advanced breast cancer (LABC). Patients and Methods The MPBCS enrolled 1,449 participants from Argentina, Brazil, Chile, Mexico, and Uruguay. Through harmonized procedures and quality assurance measures, this study evaluated clinicopathologic characteristics, neoadjuvant chemotherapy response, and survival outcomes according to residual cancer burden (RCB) and the type of surgery. Results Overall, 711 and 480 participants in the primary surgery and neoadjuvant arms, respectively, completed the 5-year follow-up period. Overall survival was independently associated with RCB (worse survival for RCBIII-adjusted hazard ratio, 8.19, P < .001, and RCBII [adjusted hazard ratio, 3.69, P < .008] compared with RCB0 [pathologic complete response or pCR]) and type of surgery (worse survival in mastectomy than in breast-conserving surgery [BCS], adjusted hazard ratio, 2.97, P = .001). The hormone receptor–negative-human epidermal growth factor receptor 2–positive group had the highest proportion of pCR (48.9%). The analysis of the ASCO Quality Oncology Practice Initiative breast module revealed high compliance with pathologic standards but lower adherence to treatment administration standards. Notably, compliance with trastuzumab administration varied widely among countries (33.3%-88.7%). Conclusion In LABC, we demonstrated the survival benefit of BCS and the prognostic effect of the response to available neoadjuvant treatments despite an important variability in access to key treatments. The MPBCS represents a significant step forward in understanding the real-world implementation of oncologic procedures in LA.Fil: Retamales, Javier. Grupo Oncológico Cooperativo Chileno de Investigación; ChileFil: Daneri Navarro, Adrián. Universidad de Guadalajara; MéxicoFil: Artagaveytia, Nora. Hospital Universitario de Clínicas “Manuel Quintela”; UruguayFil: Alves Da Quinta, Daniela Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad Argentina de la Empresa; ArgentinaFil: Abdelhay, Eliana. Instituto Nacional de Câncer Rio de Janeiro; BrasilFil: Podhajcer, Osvaldo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Velázquez, Carlos. Universidad de Sonora; MéxicoFil: Giunta, Diego Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Instituto Universitario Hospital Italiano de Buenos Aires. Departamento de Posgrado.; ArgentinaFil: Crocamo, Susanne. Instituto Nacional de Câncer Rio de Janeiro; BrasilFil: Garibay Escobar, Adriana. Universidad de Sonora; MéxicoFil: Del Toro Arreola, Alicia. Universidad de Guadalajara; MéxicoFil: Rodriguez, Robinson. Hospital Universitario de Clínicas “Manuel Quintela”; UruguayFil: Aghazarian, Marta. Instituto Nacional de Cancer; UruguayFil: Alcoba, Elsa. Hospital Municipal de Oncologia Maria Curie ; Gobierno de la Ciudad Autonoma de Buenos Aires;Fil: Alonso, Isabel. Centro Hospitalario Pereira Rossell; UruguayFil: Binato, Renata. Instituto Nacional de Câncer Rio de Janeiro; BrasilFil: Bravo, Alicia I.. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; ArgentinaFil: Canton Romero, Juan. Hospital de Gineco-Obstricia CMNO-IMSS; MéxicoFil: Carraro, Dirce M.. AC Camargo Cancer Center; BahamasFil: Castro, Mónica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Castro Cervantes, Juan. Hospital de Gineco-Obstricia CMNO-IMSS; MéxicoFil: Cataldi, Sandra. Instituto Nacional de Cancer; UruguayFil: Camejo, Natalia. Hospital Universitario de Clínicas “Manuel Quintela”; UruguayFil: Cortes Sanabria, Laura. Hospital de Gineco-Obstricia CMNO-IMSS; MéxicoFil: Valenzuela Antelo, Olivia. Universidad de Sonora; MéxicoFil: Venegas Godinez, Laura. Universidad de Guadalajara; MéxicoFil: Zagame, Livia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Gomez, Jorge. Texas A&M University; Estados UnidosFil: Llera, Andrea Sabina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Müller, Bettina. Grupo Oncológico Cooperativo Chileno de Investigación; Chile. Instituto Nacional del Cáncer; ChileAmerican Society of Clinical Oncology2024-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/240970Retamales, Javier; Daneri Navarro, Adrián; Artagaveytia, Nora; Alves Da Quinta, Daniela Belén; Abdelhay, Eliana; et al.; Implementing Standard Diagnosis and Treatment for Locally Advanced Breast Cancer Through Global Research in Latin America: Results From a Multicountry Pragmatic Trial; American Society of Clinical Oncology; JCO Global Oncology; 10; 5-2024; 1-152687-8941CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://ascopubs.org/doi/10.1200/GO.23.00216info:eu-repo/semantics/altIdentifier/doi/10.1200/GO.23.00216info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:26:18Zoai:ri.conicet.gov.ar:11336/240970instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:26:18.749CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Implementing Standard Diagnosis and Treatment for Locally Advanced Breast Cancer Through Global Research in Latin America: Results From a Multicountry Pragmatic Trial |
| title |
Implementing Standard Diagnosis and Treatment for Locally Advanced Breast Cancer Through Global Research in Latin America: Results From a Multicountry Pragmatic Trial |
| spellingShingle |
Implementing Standard Diagnosis and Treatment for Locally Advanced Breast Cancer Through Global Research in Latin America: Results From a Multicountry Pragmatic Trial Retamales, Javier Breast cancer |
| title_short |
Implementing Standard Diagnosis and Treatment for Locally Advanced Breast Cancer Through Global Research in Latin America: Results From a Multicountry Pragmatic Trial |
| title_full |
Implementing Standard Diagnosis and Treatment for Locally Advanced Breast Cancer Through Global Research in Latin America: Results From a Multicountry Pragmatic Trial |
| title_fullStr |
Implementing Standard Diagnosis and Treatment for Locally Advanced Breast Cancer Through Global Research in Latin America: Results From a Multicountry Pragmatic Trial |
| title_full_unstemmed |
Implementing Standard Diagnosis and Treatment for Locally Advanced Breast Cancer Through Global Research in Latin America: Results From a Multicountry Pragmatic Trial |
| title_sort |
Implementing Standard Diagnosis and Treatment for Locally Advanced Breast Cancer Through Global Research in Latin America: Results From a Multicountry Pragmatic Trial |
| dc.creator.none.fl_str_mv |
Retamales, Javier Daneri Navarro, Adrián Artagaveytia, Nora Alves Da Quinta, Daniela Belén Abdelhay, Eliana Podhajcer, Osvaldo Luis Velázquez, Carlos Giunta, Diego Hernan Crocamo, Susanne Garibay Escobar, Adriana Del Toro Arreola, Alicia Rodriguez, Robinson Aghazarian, Marta Alcoba, Elsa Alonso, Isabel Binato, Renata Bravo, Alicia I. Canton Romero, Juan Carraro, Dirce M. Castro, Mónica Castro Cervantes, Juan Cataldi, Sandra Camejo, Natalia Cortes Sanabria, Laura Valenzuela Antelo, Olivia Venegas Godinez, Laura Zagame, Livia Gomez, Jorge Llera, Andrea Sabina Müller, Bettina |
| author |
Retamales, Javier |
| author_facet |
Retamales, Javier Daneri Navarro, Adrián Artagaveytia, Nora Alves Da Quinta, Daniela Belén Abdelhay, Eliana Podhajcer, Osvaldo Luis Velázquez, Carlos Giunta, Diego Hernan Crocamo, Susanne Garibay Escobar, Adriana Del Toro Arreola, Alicia Rodriguez, Robinson Aghazarian, Marta Alcoba, Elsa Alonso, Isabel Binato, Renata Bravo, Alicia I. Canton Romero, Juan Carraro, Dirce M. Castro, Mónica Castro Cervantes, Juan Cataldi, Sandra Camejo, Natalia Cortes Sanabria, Laura Valenzuela Antelo, Olivia Venegas Godinez, Laura Zagame, Livia Gomez, Jorge Llera, Andrea Sabina Müller, Bettina |
| author_role |
author |
| author2 |
Daneri Navarro, Adrián Artagaveytia, Nora Alves Da Quinta, Daniela Belén Abdelhay, Eliana Podhajcer, Osvaldo Luis Velázquez, Carlos Giunta, Diego Hernan Crocamo, Susanne Garibay Escobar, Adriana Del Toro Arreola, Alicia Rodriguez, Robinson Aghazarian, Marta Alcoba, Elsa Alonso, Isabel Binato, Renata Bravo, Alicia I. Canton Romero, Juan Carraro, Dirce M. Castro, Mónica Castro Cervantes, Juan Cataldi, Sandra Camejo, Natalia Cortes Sanabria, Laura Valenzuela Antelo, Olivia Venegas Godinez, Laura Zagame, Livia Gomez, Jorge Llera, Andrea Sabina Müller, Bettina |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Breast cancer |
| topic |
Breast cancer |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Purpose Breast cancer mortality rates in Latin America (LA) are higher than those in the United States, possibly because of advanced disease presentation, health care disparities, or unfavorable molecular subtypes. The Latin American Cancer Research Network was established to address these challenges and to promote collaborative clinical research. The Molecular Profiling of Breast Cancer Study (MPBCS) aimed to evaluate the clinical characteristics and treatment outcomes of LA participants with locally advanced breast cancer (LABC). Patients and Methods The MPBCS enrolled 1,449 participants from Argentina, Brazil, Chile, Mexico, and Uruguay. Through harmonized procedures and quality assurance measures, this study evaluated clinicopathologic characteristics, neoadjuvant chemotherapy response, and survival outcomes according to residual cancer burden (RCB) and the type of surgery. Results Overall, 711 and 480 participants in the primary surgery and neoadjuvant arms, respectively, completed the 5-year follow-up period. Overall survival was independently associated with RCB (worse survival for RCBIII-adjusted hazard ratio, 8.19, P < .001, and RCBII [adjusted hazard ratio, 3.69, P < .008] compared with RCB0 [pathologic complete response or pCR]) and type of surgery (worse survival in mastectomy than in breast-conserving surgery [BCS], adjusted hazard ratio, 2.97, P = .001). The hormone receptor–negative-human epidermal growth factor receptor 2–positive group had the highest proportion of pCR (48.9%). The analysis of the ASCO Quality Oncology Practice Initiative breast module revealed high compliance with pathologic standards but lower adherence to treatment administration standards. Notably, compliance with trastuzumab administration varied widely among countries (33.3%-88.7%). Conclusion In LABC, we demonstrated the survival benefit of BCS and the prognostic effect of the response to available neoadjuvant treatments despite an important variability in access to key treatments. The MPBCS represents a significant step forward in understanding the real-world implementation of oncologic procedures in LA. Fil: Retamales, Javier. Grupo Oncológico Cooperativo Chileno de Investigación; Chile Fil: Daneri Navarro, Adrián. Universidad de Guadalajara; México Fil: Artagaveytia, Nora. Hospital Universitario de Clínicas “Manuel Quintela”; Uruguay Fil: Alves Da Quinta, Daniela Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad Argentina de la Empresa; Argentina Fil: Abdelhay, Eliana. Instituto Nacional de Câncer Rio de Janeiro; Brasil Fil: Podhajcer, Osvaldo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Velázquez, Carlos. Universidad de Sonora; México Fil: Giunta, Diego Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Instituto Universitario Hospital Italiano de Buenos Aires. Departamento de Posgrado.; Argentina Fil: Crocamo, Susanne. Instituto Nacional de Câncer Rio de Janeiro; Brasil Fil: Garibay Escobar, Adriana. Universidad de Sonora; México Fil: Del Toro Arreola, Alicia. Universidad de Guadalajara; México Fil: Rodriguez, Robinson. Hospital Universitario de Clínicas “Manuel Quintela”; Uruguay Fil: Aghazarian, Marta. Instituto Nacional de Cancer; Uruguay Fil: Alcoba, Elsa. Hospital Municipal de Oncologia Maria Curie ; Gobierno de la Ciudad Autonoma de Buenos Aires; Fil: Alonso, Isabel. Centro Hospitalario Pereira Rossell; Uruguay Fil: Binato, Renata. Instituto Nacional de Câncer Rio de Janeiro; Brasil Fil: Bravo, Alicia I.. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina Fil: Canton Romero, Juan. Hospital de Gineco-Obstricia CMNO-IMSS; México Fil: Carraro, Dirce M.. AC Camargo Cancer Center; Bahamas Fil: Castro, Mónica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina Fil: Castro Cervantes, Juan. Hospital de Gineco-Obstricia CMNO-IMSS; México Fil: Cataldi, Sandra. Instituto Nacional de Cancer; Uruguay Fil: Camejo, Natalia. Hospital Universitario de Clínicas “Manuel Quintela”; Uruguay Fil: Cortes Sanabria, Laura. Hospital de Gineco-Obstricia CMNO-IMSS; México Fil: Valenzuela Antelo, Olivia. Universidad de Sonora; México Fil: Venegas Godinez, Laura. Universidad de Guadalajara; México Fil: Zagame, Livia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Gomez, Jorge. Texas A&M University; Estados Unidos Fil: Llera, Andrea Sabina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Müller, Bettina. Grupo Oncológico Cooperativo Chileno de Investigación; Chile. Instituto Nacional del Cáncer; Chile |
| description |
Purpose Breast cancer mortality rates in Latin America (LA) are higher than those in the United States, possibly because of advanced disease presentation, health care disparities, or unfavorable molecular subtypes. The Latin American Cancer Research Network was established to address these challenges and to promote collaborative clinical research. The Molecular Profiling of Breast Cancer Study (MPBCS) aimed to evaluate the clinical characteristics and treatment outcomes of LA participants with locally advanced breast cancer (LABC). Patients and Methods The MPBCS enrolled 1,449 participants from Argentina, Brazil, Chile, Mexico, and Uruguay. Through harmonized procedures and quality assurance measures, this study evaluated clinicopathologic characteristics, neoadjuvant chemotherapy response, and survival outcomes according to residual cancer burden (RCB) and the type of surgery. Results Overall, 711 and 480 participants in the primary surgery and neoadjuvant arms, respectively, completed the 5-year follow-up period. Overall survival was independently associated with RCB (worse survival for RCBIII-adjusted hazard ratio, 8.19, P < .001, and RCBII [adjusted hazard ratio, 3.69, P < .008] compared with RCB0 [pathologic complete response or pCR]) and type of surgery (worse survival in mastectomy than in breast-conserving surgery [BCS], adjusted hazard ratio, 2.97, P = .001). The hormone receptor–negative-human epidermal growth factor receptor 2–positive group had the highest proportion of pCR (48.9%). The analysis of the ASCO Quality Oncology Practice Initiative breast module revealed high compliance with pathologic standards but lower adherence to treatment administration standards. Notably, compliance with trastuzumab administration varied widely among countries (33.3%-88.7%). Conclusion In LABC, we demonstrated the survival benefit of BCS and the prognostic effect of the response to available neoadjuvant treatments despite an important variability in access to key treatments. The MPBCS represents a significant step forward in understanding the real-world implementation of oncologic procedures in LA. |
| publishDate |
2024 |
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2024-05 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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http://hdl.handle.net/11336/240970 Retamales, Javier; Daneri Navarro, Adrián; Artagaveytia, Nora; Alves Da Quinta, Daniela Belén; Abdelhay, Eliana; et al.; Implementing Standard Diagnosis and Treatment for Locally Advanced Breast Cancer Through Global Research in Latin America: Results From a Multicountry Pragmatic Trial; American Society of Clinical Oncology; JCO Global Oncology; 10; 5-2024; 1-15 2687-8941 CONICET Digital CONICET |
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Retamales, Javier; Daneri Navarro, Adrián; Artagaveytia, Nora; Alves Da Quinta, Daniela Belén; Abdelhay, Eliana; et al.; Implementing Standard Diagnosis and Treatment for Locally Advanced Breast Cancer Through Global Research in Latin America: Results From a Multicountry Pragmatic Trial; American Society of Clinical Oncology; JCO Global Oncology; 10; 5-2024; 1-15 2687-8941 CONICET Digital CONICET |
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eng |
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eng |
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American Society of Clinical Oncology |
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American Society of Clinical Oncology |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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