One-Pot Synthesis of Core-Shell Au@mSiO2 Nanoparticles for Photothermal Applications

Autores
Montero Oleas, Andrea Cristina; Martinez Ricci, Maria Luz; Ortiz, Guillermo Pablo; Trens, Phillippe; Roupioz, Yoann; Kodjikian, Stéphanie; Marchi, María Claudia; Cattoen, Xavier; Aldabe, Sara Alfonsina
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Gold-mesoporous silica (Au@mSiO2) core-shell nanoparticles (NPs) hold great promise for application in nanomedicine, as they enable the photostimulated release of guest molecules located within their pores. In this study, prioritizing the achievement of atom economy, we used a one-pot synthesis protocol, to produce core-shell Au@mSiO2 NPs from a properly defined precursor state. Upon sodium hydroxide addition, the formation of gold NPs occurs quickly, followed by the formation of a silica shell, eliminating the need to isolate the gold cores. We conducted a comprehensive mechanistic analysis that elucidates the relative kinetics of gold and silica formation, identifying key factors for fine-tuning NPs within the size range of 50 to 100 nm, ideal for biological applications. The photothermal properties of such Au@mSiO2 were characterized and modelled. Under the experimental conditions typically used for cargo release experiments, the model predicts a temperature increase for a single particle of less than 10^(-4) °C, demonstrating that the release is due to the collective heating of the medium by a myriad of NPs rather than by the temperature elevation of individual NPs under irradiation. Overall, the studies developed here will enable more effective design and preparation of Au@mSiO₂ particles, optimizing them for a broad range of photothermal applications.
Fil: Montero Oleas, Andrea Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina. Universite Grenoble Alpes; Francia. Universidad San Francisco de Quito; Ecuador
Fil: Martinez Ricci, Maria Luz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Ortiz, Guillermo Pablo. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas y Naturales y Agrimensura. Departamento de Física; Argentina
Fil: Trens, Phillippe. National Research Institute of Science and Technology. Centre de Montpellier; Francia
Fil: Roupioz, Yoann. Universite Grenoble Alpes. Institut Nanosciences Et Cryogenie. - Commissariat A L Energie Atomique Et Aux Energies Alternatives. Institut Nanosciences Et Cryogenie.; Francia
Fil: Kodjikian, Stéphanie. Universite Grenoble Alpes; Francia
Fil: Marchi, María Claudia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Microscopías Avanzadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Cattoen, Xavier. Universite Grenoble Alpes; Francia
Fil: Aldabe, Sara Alfonsina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Materia
Gold-mesoporous silica nanoparticles
Core-shell nanoparticles
Photothermal conversion
One-pot synthesis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/269223
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/269223
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling One-Pot Synthesis of Core-Shell Au@mSiO2 Nanoparticles for Photothermal ApplicationsMontero Oleas, Andrea CristinaMartinez Ricci, Maria LuzOrtiz, Guillermo PabloTrens, PhillippeRoupioz, YoannKodjikian, StéphanieMarchi, María ClaudiaCattoen, XavierAldabe, Sara AlfonsinaGold-mesoporous silica nanoparticlesCore-shell nanoparticlesPhotothermal conversionOne-pot synthesishttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Gold-mesoporous silica (Au@mSiO2) core-shell nanoparticles (NPs) hold great promise for application in nanomedicine, as they enable the photostimulated release of guest molecules located within their pores. In this study, prioritizing the achievement of atom economy, we used a one-pot synthesis protocol, to produce core-shell Au@mSiO2 NPs from a properly defined precursor state. Upon sodium hydroxide addition, the formation of gold NPs occurs quickly, followed by the formation of a silica shell, eliminating the need to isolate the gold cores. We conducted a comprehensive mechanistic analysis that elucidates the relative kinetics of gold and silica formation, identifying key factors for fine-tuning NPs within the size range of 50 to 100 nm, ideal for biological applications. The photothermal properties of such Au@mSiO2 were characterized and modelled. Under the experimental conditions typically used for cargo release experiments, the model predicts a temperature increase for a single particle of less than 10^(-4) °C, demonstrating that the release is due to the collective heating of the medium by a myriad of NPs rather than by the temperature elevation of individual NPs under irradiation. Overall, the studies developed here will enable more effective design and preparation of Au@mSiO₂ particles, optimizing them for a broad range of photothermal applications.Fil: Montero Oleas, Andrea Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina. Universite Grenoble Alpes; Francia. Universidad San Francisco de Quito; EcuadorFil: Martinez Ricci, Maria Luz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Ortiz, Guillermo Pablo. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas y Naturales y Agrimensura. Departamento de Física; ArgentinaFil: Trens, Phillippe. National Research Institute of Science and Technology. Centre de Montpellier; FranciaFil: Roupioz, Yoann. Universite Grenoble Alpes. Institut Nanosciences Et Cryogenie. - Commissariat A L Energie Atomique Et Aux Energies Alternatives. Institut Nanosciences Et Cryogenie.; FranciaFil: Kodjikian, Stéphanie. Universite Grenoble Alpes; FranciaFil: Marchi, María Claudia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Microscopías Avanzadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Cattoen, Xavier. Universite Grenoble Alpes; FranciaFil: Aldabe, Sara Alfonsina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaAmerican Chemical Society2024-10-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/269223Montero Oleas, Andrea Cristina; Martinez Ricci, Maria Luz; Ortiz, Guillermo Pablo; Trens, Phillippe; Roupioz, Yoann; et al.; One-Pot Synthesis of Core-Shell Au@mSiO2 Nanoparticles for Photothermal Applications; American Chemical Society; ChemRxiv; 15-10-2024; 1-422573-2293CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://chemrxiv.org/engage/chemrxiv/article-details/670beb0d51558a15eff1eaf9info:eu-repo/semantics/altIdentifier/doi/10.26434/chemrxiv-2024-8lrxpinfo:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acsanm.4c07241info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:04:30Zoai:ri.conicet.gov.ar:11336/269223instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:04:31.276CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv One-Pot Synthesis of Core-Shell Au@mSiO2 Nanoparticles for Photothermal Applications
title One-Pot Synthesis of Core-Shell Au@mSiO2 Nanoparticles for Photothermal Applications
spellingShingle One-Pot Synthesis of Core-Shell Au@mSiO2 Nanoparticles for Photothermal Applications
Montero Oleas, Andrea Cristina
Gold-mesoporous silica nanoparticles
Core-shell nanoparticles
Photothermal conversion
One-pot synthesis
title_short One-Pot Synthesis of Core-Shell Au@mSiO2 Nanoparticles for Photothermal Applications
title_full One-Pot Synthesis of Core-Shell Au@mSiO2 Nanoparticles for Photothermal Applications
title_fullStr One-Pot Synthesis of Core-Shell Au@mSiO2 Nanoparticles for Photothermal Applications
title_full_unstemmed One-Pot Synthesis of Core-Shell Au@mSiO2 Nanoparticles for Photothermal Applications
title_sort One-Pot Synthesis of Core-Shell Au@mSiO2 Nanoparticles for Photothermal Applications
dc.creator.none.fl_str_mv Montero Oleas, Andrea Cristina
Martinez Ricci, Maria Luz
Ortiz, Guillermo Pablo
Trens, Phillippe
Roupioz, Yoann
Kodjikian, Stéphanie
Marchi, María Claudia
Cattoen, Xavier
Aldabe, Sara Alfonsina
author Montero Oleas, Andrea Cristina
author_facet Montero Oleas, Andrea Cristina
Martinez Ricci, Maria Luz
Ortiz, Guillermo Pablo
Trens, Phillippe
Roupioz, Yoann
Kodjikian, Stéphanie
Marchi, María Claudia
Cattoen, Xavier
Aldabe, Sara Alfonsina
author_role author
author2 Martinez Ricci, Maria Luz
Ortiz, Guillermo Pablo
Trens, Phillippe
Roupioz, Yoann
Kodjikian, Stéphanie
Marchi, María Claudia
Cattoen, Xavier
Aldabe, Sara Alfonsina
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Gold-mesoporous silica nanoparticles
Core-shell nanoparticles
Photothermal conversion
One-pot synthesis
topic Gold-mesoporous silica nanoparticles
Core-shell nanoparticles
Photothermal conversion
One-pot synthesis
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Gold-mesoporous silica (Au@mSiO2) core-shell nanoparticles (NPs) hold great promise for application in nanomedicine, as they enable the photostimulated release of guest molecules located within their pores. In this study, prioritizing the achievement of atom economy, we used a one-pot synthesis protocol, to produce core-shell Au@mSiO2 NPs from a properly defined precursor state. Upon sodium hydroxide addition, the formation of gold NPs occurs quickly, followed by the formation of a silica shell, eliminating the need to isolate the gold cores. We conducted a comprehensive mechanistic analysis that elucidates the relative kinetics of gold and silica formation, identifying key factors for fine-tuning NPs within the size range of 50 to 100 nm, ideal for biological applications. The photothermal properties of such Au@mSiO2 were characterized and modelled. Under the experimental conditions typically used for cargo release experiments, the model predicts a temperature increase for a single particle of less than 10^(-4) °C, demonstrating that the release is due to the collective heating of the medium by a myriad of NPs rather than by the temperature elevation of individual NPs under irradiation. Overall, the studies developed here will enable more effective design and preparation of Au@mSiO₂ particles, optimizing them for a broad range of photothermal applications.
Fil: Montero Oleas, Andrea Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina. Universite Grenoble Alpes; Francia. Universidad San Francisco de Quito; Ecuador
Fil: Martinez Ricci, Maria Luz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Ortiz, Guillermo Pablo. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas y Naturales y Agrimensura. Departamento de Física; Argentina
Fil: Trens, Phillippe. National Research Institute of Science and Technology. Centre de Montpellier; Francia
Fil: Roupioz, Yoann. Universite Grenoble Alpes. Institut Nanosciences Et Cryogenie. - Commissariat A L Energie Atomique Et Aux Energies Alternatives. Institut Nanosciences Et Cryogenie.; Francia
Fil: Kodjikian, Stéphanie. Universite Grenoble Alpes; Francia
Fil: Marchi, María Claudia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Microscopías Avanzadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Cattoen, Xavier. Universite Grenoble Alpes; Francia
Fil: Aldabe, Sara Alfonsina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
description Gold-mesoporous silica (Au@mSiO2) core-shell nanoparticles (NPs) hold great promise for application in nanomedicine, as they enable the photostimulated release of guest molecules located within their pores. In this study, prioritizing the achievement of atom economy, we used a one-pot synthesis protocol, to produce core-shell Au@mSiO2 NPs from a properly defined precursor state. Upon sodium hydroxide addition, the formation of gold NPs occurs quickly, followed by the formation of a silica shell, eliminating the need to isolate the gold cores. We conducted a comprehensive mechanistic analysis that elucidates the relative kinetics of gold and silica formation, identifying key factors for fine-tuning NPs within the size range of 50 to 100 nm, ideal for biological applications. The photothermal properties of such Au@mSiO2 were characterized and modelled. Under the experimental conditions typically used for cargo release experiments, the model predicts a temperature increase for a single particle of less than 10^(-4) °C, demonstrating that the release is due to the collective heating of the medium by a myriad of NPs rather than by the temperature elevation of individual NPs under irradiation. Overall, the studies developed here will enable more effective design and preparation of Au@mSiO₂ particles, optimizing them for a broad range of photothermal applications.
publishDate 2024
dc.date.none.fl_str_mv 2024-10-15
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/269223
Montero Oleas, Andrea Cristina; Martinez Ricci, Maria Luz; Ortiz, Guillermo Pablo; Trens, Phillippe; Roupioz, Yoann; et al.; One-Pot Synthesis of Core-Shell Au@mSiO2 Nanoparticles for Photothermal Applications; American Chemical Society; ChemRxiv; 15-10-2024; 1-42
2573-2293
CONICET Digital
CONICET
url http://hdl.handle.net/11336/269223
identifier_str_mv Montero Oleas, Andrea Cristina; Martinez Ricci, Maria Luz; Ortiz, Guillermo Pablo; Trens, Phillippe; Roupioz, Yoann; et al.; One-Pot Synthesis of Core-Shell Au@mSiO2 Nanoparticles for Photothermal Applications; American Chemical Society; ChemRxiv; 15-10-2024; 1-42
2573-2293
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://chemrxiv.org/engage/chemrxiv/article-details/670beb0d51558a15eff1eaf9
info:eu-repo/semantics/altIdentifier/doi/10.26434/chemrxiv-2024-8lrxp
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acsanm.4c07241
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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