Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging
- Autores
- Roy, Jeremy; Kim, Bongki; Hill, Eric; Visconti, Pablo; Krapf, Dario; Vinegoni, Claudio; Weissleder, Ralph; Brown, Dennis; Breton, Sylvie
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Epithelial cells are generally considered to be static relative to their neighbours. Basal cells in pseudostratified epithelia display a single long cytoplasmic process that can cross the tight junction barrier to reach the lumen. Using in vivo microscopy to visualize the epididymis, a model system for the study of pseudostratified epithelia, we report here the surprising discovery that these basal cell projections-which we call axiopodia-periodically extend and retract over time. We found that axiopodia extensions and retractions follow an oscillatory pattern. This movement, which we refer to as periodic axial motility (PAM), is controlled by c-Src and MEK1/2-ERK1/2. Therapeutic inhibition of tyrosine kinase activity induces a retraction of these projections. Such unexpected cell motility may reflect a novel mechanism by which specialized epithelial cells sample the luminal environment.
Fil: Roy, Jeremy. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos. AGADA Biosciences Inc.; Canadá
Fil: Kim, Bongki. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos
Fil: Hill, Eric. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos
Fil: Visconti, Pablo. University of Massachussets; Estados Unidos
Fil: Krapf, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina. University of Massachussets; Estados Unidos
Fil: Vinegoni, Claudio. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos
Fil: Weissleder, Ralph. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos
Fil: Brown, Dennis. Harvard Medical School; Estados Unidos. University of Massachussets; Estados Unidos. Massachusetts General Hospital; Estados Unidos
Fil: Breton, Sylvie. Massachusetts General Hospital; Estados Unidos. Harvard Medical School; Estados Unidos - Materia
-
Src
PAM
Principal cells
Epididymis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/50382
Ver los metadatos del registro completo
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Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imagingRoy, JeremyKim, BongkiHill, EricVisconti, PabloKrapf, DarioVinegoni, ClaudioWeissleder, RalphBrown, DennisBreton, SylvieSrcPAMPrincipal cellsEpididymishttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Epithelial cells are generally considered to be static relative to their neighbours. Basal cells in pseudostratified epithelia display a single long cytoplasmic process that can cross the tight junction barrier to reach the lumen. Using in vivo microscopy to visualize the epididymis, a model system for the study of pseudostratified epithelia, we report here the surprising discovery that these basal cell projections-which we call axiopodia-periodically extend and retract over time. We found that axiopodia extensions and retractions follow an oscillatory pattern. This movement, which we refer to as periodic axial motility (PAM), is controlled by c-Src and MEK1/2-ERK1/2. Therapeutic inhibition of tyrosine kinase activity induces a retraction of these projections. Such unexpected cell motility may reflect a novel mechanism by which specialized epithelial cells sample the luminal environment.Fil: Roy, Jeremy. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos. AGADA Biosciences Inc.; CanadáFil: Kim, Bongki. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados UnidosFil: Hill, Eric. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados UnidosFil: Visconti, Pablo. University of Massachussets; Estados UnidosFil: Krapf, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina. University of Massachussets; Estados UnidosFil: Vinegoni, Claudio. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados UnidosFil: Weissleder, Ralph. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados UnidosFil: Brown, Dennis. Harvard Medical School; Estados Unidos. University of Massachussets; Estados Unidos. Massachusetts General Hospital; Estados UnidosFil: Breton, Sylvie. Massachusetts General Hospital; Estados Unidos. Harvard Medical School; Estados UnidosNature Publishing Group2016-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/50382Roy, Jeremy; Kim, Bongki; Hill, Eric; Visconti, Pablo; Krapf, Dario; et al.; Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging; Nature Publishing Group; Nature Communications; 7; 2-2016; 1-11; 106662041-1723CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/ncomms10666info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/ncomms10666info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:46:45Zoai:ri.conicet.gov.ar:11336/50382instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:46:45.712CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging |
title |
Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging |
spellingShingle |
Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging Roy, Jeremy Src PAM Principal cells Epididymis |
title_short |
Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging |
title_full |
Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging |
title_fullStr |
Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging |
title_full_unstemmed |
Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging |
title_sort |
Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging |
dc.creator.none.fl_str_mv |
Roy, Jeremy Kim, Bongki Hill, Eric Visconti, Pablo Krapf, Dario Vinegoni, Claudio Weissleder, Ralph Brown, Dennis Breton, Sylvie |
author |
Roy, Jeremy |
author_facet |
Roy, Jeremy Kim, Bongki Hill, Eric Visconti, Pablo Krapf, Dario Vinegoni, Claudio Weissleder, Ralph Brown, Dennis Breton, Sylvie |
author_role |
author |
author2 |
Kim, Bongki Hill, Eric Visconti, Pablo Krapf, Dario Vinegoni, Claudio Weissleder, Ralph Brown, Dennis Breton, Sylvie |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Src PAM Principal cells Epididymis |
topic |
Src PAM Principal cells Epididymis |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Epithelial cells are generally considered to be static relative to their neighbours. Basal cells in pseudostratified epithelia display a single long cytoplasmic process that can cross the tight junction barrier to reach the lumen. Using in vivo microscopy to visualize the epididymis, a model system for the study of pseudostratified epithelia, we report here the surprising discovery that these basal cell projections-which we call axiopodia-periodically extend and retract over time. We found that axiopodia extensions and retractions follow an oscillatory pattern. This movement, which we refer to as periodic axial motility (PAM), is controlled by c-Src and MEK1/2-ERK1/2. Therapeutic inhibition of tyrosine kinase activity induces a retraction of these projections. Such unexpected cell motility may reflect a novel mechanism by which specialized epithelial cells sample the luminal environment. Fil: Roy, Jeremy. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos. AGADA Biosciences Inc.; Canadá Fil: Kim, Bongki. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos Fil: Hill, Eric. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos Fil: Visconti, Pablo. University of Massachussets; Estados Unidos Fil: Krapf, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina. University of Massachussets; Estados Unidos Fil: Vinegoni, Claudio. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos Fil: Weissleder, Ralph. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos Fil: Brown, Dennis. Harvard Medical School; Estados Unidos. University of Massachussets; Estados Unidos. Massachusetts General Hospital; Estados Unidos Fil: Breton, Sylvie. Massachusetts General Hospital; Estados Unidos. Harvard Medical School; Estados Unidos |
description |
Epithelial cells are generally considered to be static relative to their neighbours. Basal cells in pseudostratified epithelia display a single long cytoplasmic process that can cross the tight junction barrier to reach the lumen. Using in vivo microscopy to visualize the epididymis, a model system for the study of pseudostratified epithelia, we report here the surprising discovery that these basal cell projections-which we call axiopodia-periodically extend and retract over time. We found that axiopodia extensions and retractions follow an oscillatory pattern. This movement, which we refer to as periodic axial motility (PAM), is controlled by c-Src and MEK1/2-ERK1/2. Therapeutic inhibition of tyrosine kinase activity induces a retraction of these projections. Such unexpected cell motility may reflect a novel mechanism by which specialized epithelial cells sample the luminal environment. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/50382 Roy, Jeremy; Kim, Bongki; Hill, Eric; Visconti, Pablo; Krapf, Dario; et al.; Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging; Nature Publishing Group; Nature Communications; 7; 2-2016; 1-11; 10666 2041-1723 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/50382 |
identifier_str_mv |
Roy, Jeremy; Kim, Bongki; Hill, Eric; Visconti, Pablo; Krapf, Dario; et al.; Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging; Nature Publishing Group; Nature Communications; 7; 2-2016; 1-11; 10666 2041-1723 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1038/ncomms10666 info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/ncomms10666 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614509923139584 |
score |
13.070432 |