Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging

Autores
Roy, Jeremy; Kim, Bongki; Hill, Eric; Visconti, Pablo; Krapf, Dario; Vinegoni, Claudio; Weissleder, Ralph; Brown, Dennis; Breton, Sylvie
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Epithelial cells are generally considered to be static relative to their neighbours. Basal cells in pseudostratified epithelia display a single long cytoplasmic process that can cross the tight junction barrier to reach the lumen. Using in vivo microscopy to visualize the epididymis, a model system for the study of pseudostratified epithelia, we report here the surprising discovery that these basal cell projections-which we call axiopodia-periodically extend and retract over time. We found that axiopodia extensions and retractions follow an oscillatory pattern. This movement, which we refer to as periodic axial motility (PAM), is controlled by c-Src and MEK1/2-ERK1/2. Therapeutic inhibition of tyrosine kinase activity induces a retraction of these projections. Such unexpected cell motility may reflect a novel mechanism by which specialized epithelial cells sample the luminal environment.
Fil: Roy, Jeremy. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos. AGADA Biosciences Inc.; Canadá
Fil: Kim, Bongki. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos
Fil: Hill, Eric. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos
Fil: Visconti, Pablo. University of Massachussets; Estados Unidos
Fil: Krapf, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina. University of Massachussets; Estados Unidos
Fil: Vinegoni, Claudio. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos
Fil: Weissleder, Ralph. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos
Fil: Brown, Dennis. Harvard Medical School; Estados Unidos. University of Massachussets; Estados Unidos. Massachusetts General Hospital; Estados Unidos
Fil: Breton, Sylvie. Massachusetts General Hospital; Estados Unidos. Harvard Medical School; Estados Unidos
Materia
Src
PAM
Principal cells
Epididymis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/50382

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network_name_str CONICET Digital (CONICET)
spelling Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imagingRoy, JeremyKim, BongkiHill, EricVisconti, PabloKrapf, DarioVinegoni, ClaudioWeissleder, RalphBrown, DennisBreton, SylvieSrcPAMPrincipal cellsEpididymishttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Epithelial cells are generally considered to be static relative to their neighbours. Basal cells in pseudostratified epithelia display a single long cytoplasmic process that can cross the tight junction barrier to reach the lumen. Using in vivo microscopy to visualize the epididymis, a model system for the study of pseudostratified epithelia, we report here the surprising discovery that these basal cell projections-which we call axiopodia-periodically extend and retract over time. We found that axiopodia extensions and retractions follow an oscillatory pattern. This movement, which we refer to as periodic axial motility (PAM), is controlled by c-Src and MEK1/2-ERK1/2. Therapeutic inhibition of tyrosine kinase activity induces a retraction of these projections. Such unexpected cell motility may reflect a novel mechanism by which specialized epithelial cells sample the luminal environment.Fil: Roy, Jeremy. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos. AGADA Biosciences Inc.; CanadáFil: Kim, Bongki. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados UnidosFil: Hill, Eric. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados UnidosFil: Visconti, Pablo. University of Massachussets; Estados UnidosFil: Krapf, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina. University of Massachussets; Estados UnidosFil: Vinegoni, Claudio. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados UnidosFil: Weissleder, Ralph. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados UnidosFil: Brown, Dennis. Harvard Medical School; Estados Unidos. University of Massachussets; Estados Unidos. Massachusetts General Hospital; Estados UnidosFil: Breton, Sylvie. Massachusetts General Hospital; Estados Unidos. Harvard Medical School; Estados UnidosNature Publishing Group2016-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/50382Roy, Jeremy; Kim, Bongki; Hill, Eric; Visconti, Pablo; Krapf, Dario; et al.; Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging; Nature Publishing Group; Nature Communications; 7; 2-2016; 1-11; 106662041-1723CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/ncomms10666info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/ncomms10666info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:46:45Zoai:ri.conicet.gov.ar:11336/50382instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:46:45.712CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging
title Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging
spellingShingle Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging
Roy, Jeremy
Src
PAM
Principal cells
Epididymis
title_short Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging
title_full Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging
title_fullStr Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging
title_full_unstemmed Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging
title_sort Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging
dc.creator.none.fl_str_mv Roy, Jeremy
Kim, Bongki
Hill, Eric
Visconti, Pablo
Krapf, Dario
Vinegoni, Claudio
Weissleder, Ralph
Brown, Dennis
Breton, Sylvie
author Roy, Jeremy
author_facet Roy, Jeremy
Kim, Bongki
Hill, Eric
Visconti, Pablo
Krapf, Dario
Vinegoni, Claudio
Weissleder, Ralph
Brown, Dennis
Breton, Sylvie
author_role author
author2 Kim, Bongki
Hill, Eric
Visconti, Pablo
Krapf, Dario
Vinegoni, Claudio
Weissleder, Ralph
Brown, Dennis
Breton, Sylvie
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Src
PAM
Principal cells
Epididymis
topic Src
PAM
Principal cells
Epididymis
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Epithelial cells are generally considered to be static relative to their neighbours. Basal cells in pseudostratified epithelia display a single long cytoplasmic process that can cross the tight junction barrier to reach the lumen. Using in vivo microscopy to visualize the epididymis, a model system for the study of pseudostratified epithelia, we report here the surprising discovery that these basal cell projections-which we call axiopodia-periodically extend and retract over time. We found that axiopodia extensions and retractions follow an oscillatory pattern. This movement, which we refer to as periodic axial motility (PAM), is controlled by c-Src and MEK1/2-ERK1/2. Therapeutic inhibition of tyrosine kinase activity induces a retraction of these projections. Such unexpected cell motility may reflect a novel mechanism by which specialized epithelial cells sample the luminal environment.
Fil: Roy, Jeremy. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos. AGADA Biosciences Inc.; Canadá
Fil: Kim, Bongki. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos
Fil: Hill, Eric. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos
Fil: Visconti, Pablo. University of Massachussets; Estados Unidos
Fil: Krapf, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina. University of Massachussets; Estados Unidos
Fil: Vinegoni, Claudio. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos
Fil: Weissleder, Ralph. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos
Fil: Brown, Dennis. Harvard Medical School; Estados Unidos. University of Massachussets; Estados Unidos. Massachusetts General Hospital; Estados Unidos
Fil: Breton, Sylvie. Massachusetts General Hospital; Estados Unidos. Harvard Medical School; Estados Unidos
description Epithelial cells are generally considered to be static relative to their neighbours. Basal cells in pseudostratified epithelia display a single long cytoplasmic process that can cross the tight junction barrier to reach the lumen. Using in vivo microscopy to visualize the epididymis, a model system for the study of pseudostratified epithelia, we report here the surprising discovery that these basal cell projections-which we call axiopodia-periodically extend and retract over time. We found that axiopodia extensions and retractions follow an oscillatory pattern. This movement, which we refer to as periodic axial motility (PAM), is controlled by c-Src and MEK1/2-ERK1/2. Therapeutic inhibition of tyrosine kinase activity induces a retraction of these projections. Such unexpected cell motility may reflect a novel mechanism by which specialized epithelial cells sample the luminal environment.
publishDate 2016
dc.date.none.fl_str_mv 2016-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/50382
Roy, Jeremy; Kim, Bongki; Hill, Eric; Visconti, Pablo; Krapf, Dario; et al.; Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging; Nature Publishing Group; Nature Communications; 7; 2-2016; 1-11; 10666
2041-1723
CONICET Digital
CONICET
url http://hdl.handle.net/11336/50382
identifier_str_mv Roy, Jeremy; Kim, Bongki; Hill, Eric; Visconti, Pablo; Krapf, Dario; et al.; Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging; Nature Publishing Group; Nature Communications; 7; 2-2016; 1-11; 10666
2041-1723
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/ncomms10666
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/ncomms10666
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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