Overexpression of the truncated form of high mobility group a proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation

Autores
Mas, Aymara; Cervelló, Irene; Fernández Alvarez, Ana Julia; Faus, Amparo; Díaz, Ana; Burgués, Octavio; Casado, Marta; Simón, Carlos
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The pathogenesis of uterine leiomyomas, the most common benign tumor in women, is still unknown. This lack of basic knowledge limits the development of novel non-invasive therapies. Our group has previously demonstrated that leiomyoma side population (SP) cells are present in tumor lesions and act like putative tumor-initiating stemcells in human leiomyoma. Moreover, accumulated evidence demonstrates that these benign tumors of mesenchymal origin are characterized by rearrangements of the High Mobility Group A proteins (HMGA). In this work, we tested the hypothesis that leiomyoma development may be due to overexpression of HMGA2 (encoding high mobility group AT-hook2) in myometrial stem cells using in vitro and in vivo approaches. Our work demonstrates that the truncated/short form of HMGA2 induces myometrial cell transformation toward putative tumor-initiating leiomyoma cells and opens up new possibilities to understand the origin of leiomyomas and the development of new therapeutic approaches.
Fil: Mas, Aymara. Universidad de Valencia; España
Fil: Cervelló, Irene. Universidad de Valencia; España
Fil: Fernández Alvarez, Ana Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Faus, Amparo. Universidad de Valencia; España
Fil: Díaz, Ana. Universidad de Valencia; España
Fil: Burgués, Octavio. Universidad de Valencia; España
Fil: Casado, Marta. University of Stanford; Estados Unidos
Fil: Simón, Carlos. Universidad de Valencia; España
Materia
HIGH MOBILITY GROUP A PROTEINS
HUMAN MYOMETRIUM
SIDE POPULATION
SOMATIC STEM CELLS
UTERINE LEIOMYOMAS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/84331
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Overexpression of the truncated form of high mobility group a proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formationMas, AymaraCervelló, IreneFernández Alvarez, Ana JuliaFaus, AmparoDíaz, AnaBurgués, OctavioCasado, MartaSimón, CarlosHIGH MOBILITY GROUP A PROTEINSHUMAN MYOMETRIUMSIDE POPULATIONSOMATIC STEM CELLSUTERINE LEIOMYOMAShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The pathogenesis of uterine leiomyomas, the most common benign tumor in women, is still unknown. This lack of basic knowledge limits the development of novel non-invasive therapies. Our group has previously demonstrated that leiomyoma side population (SP) cells are present in tumor lesions and act like putative tumor-initiating stemcells in human leiomyoma. Moreover, accumulated evidence demonstrates that these benign tumors of mesenchymal origin are characterized by rearrangements of the High Mobility Group A proteins (HMGA). In this work, we tested the hypothesis that leiomyoma development may be due to overexpression of HMGA2 (encoding high mobility group AT-hook2) in myometrial stem cells using in vitro and in vivo approaches. Our work demonstrates that the truncated/short form of HMGA2 induces myometrial cell transformation toward putative tumor-initiating leiomyoma cells and opens up new possibilities to understand the origin of leiomyomas and the development of new therapeutic approaches.Fil: Mas, Aymara. Universidad de Valencia; EspañaFil: Cervelló, Irene. Universidad de Valencia; EspañaFil: Fernández Alvarez, Ana Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Faus, Amparo. Universidad de Valencia; EspañaFil: Díaz, Ana. Universidad de Valencia; EspañaFil: Burgués, Octavio. Universidad de Valencia; EspañaFil: Casado, Marta. University of Stanford; Estados UnidosFil: Simón, Carlos. Universidad de Valencia; EspañaOxford University Press2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/84331Mas, Aymara; Cervelló, Irene; Fernández Alvarez, Ana Julia; Faus, Amparo; Díaz, Ana; et al.; Overexpression of the truncated form of high mobility group a proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation; Oxford University Press; Molecular Human Reproduction; 21; 4; 12-2014; 330-3381360-9947CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/molehr/gau114info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/molehr/article/21/4/330/983207info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:17:13Zoai:ri.conicet.gov.ar:11336/84331instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:17:13.912CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Overexpression of the truncated form of high mobility group a proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation
title Overexpression of the truncated form of high mobility group a proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation
spellingShingle Overexpression of the truncated form of high mobility group a proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation
Mas, Aymara
HIGH MOBILITY GROUP A PROTEINS
HUMAN MYOMETRIUM
SIDE POPULATION
SOMATIC STEM CELLS
UTERINE LEIOMYOMAS
title_short Overexpression of the truncated form of high mobility group a proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation
title_full Overexpression of the truncated form of high mobility group a proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation
title_fullStr Overexpression of the truncated form of high mobility group a proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation
title_full_unstemmed Overexpression of the truncated form of high mobility group a proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation
title_sort Overexpression of the truncated form of high mobility group a proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation
dc.creator.none.fl_str_mv Mas, Aymara
Cervelló, Irene
Fernández Alvarez, Ana Julia
Faus, Amparo
Díaz, Ana
Burgués, Octavio
Casado, Marta
Simón, Carlos
author Mas, Aymara
author_facet Mas, Aymara
Cervelló, Irene
Fernández Alvarez, Ana Julia
Faus, Amparo
Díaz, Ana
Burgués, Octavio
Casado, Marta
Simón, Carlos
author_role author
author2 Cervelló, Irene
Fernández Alvarez, Ana Julia
Faus, Amparo
Díaz, Ana
Burgués, Octavio
Casado, Marta
Simón, Carlos
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HIGH MOBILITY GROUP A PROTEINS
HUMAN MYOMETRIUM
SIDE POPULATION
SOMATIC STEM CELLS
UTERINE LEIOMYOMAS
topic HIGH MOBILITY GROUP A PROTEINS
HUMAN MYOMETRIUM
SIDE POPULATION
SOMATIC STEM CELLS
UTERINE LEIOMYOMAS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The pathogenesis of uterine leiomyomas, the most common benign tumor in women, is still unknown. This lack of basic knowledge limits the development of novel non-invasive therapies. Our group has previously demonstrated that leiomyoma side population (SP) cells are present in tumor lesions and act like putative tumor-initiating stemcells in human leiomyoma. Moreover, accumulated evidence demonstrates that these benign tumors of mesenchymal origin are characterized by rearrangements of the High Mobility Group A proteins (HMGA). In this work, we tested the hypothesis that leiomyoma development may be due to overexpression of HMGA2 (encoding high mobility group AT-hook2) in myometrial stem cells using in vitro and in vivo approaches. Our work demonstrates that the truncated/short form of HMGA2 induces myometrial cell transformation toward putative tumor-initiating leiomyoma cells and opens up new possibilities to understand the origin of leiomyomas and the development of new therapeutic approaches.
Fil: Mas, Aymara. Universidad de Valencia; España
Fil: Cervelló, Irene. Universidad de Valencia; España
Fil: Fernández Alvarez, Ana Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Faus, Amparo. Universidad de Valencia; España
Fil: Díaz, Ana. Universidad de Valencia; España
Fil: Burgués, Octavio. Universidad de Valencia; España
Fil: Casado, Marta. University of Stanford; Estados Unidos
Fil: Simón, Carlos. Universidad de Valencia; España
description The pathogenesis of uterine leiomyomas, the most common benign tumor in women, is still unknown. This lack of basic knowledge limits the development of novel non-invasive therapies. Our group has previously demonstrated that leiomyoma side population (SP) cells are present in tumor lesions and act like putative tumor-initiating stemcells in human leiomyoma. Moreover, accumulated evidence demonstrates that these benign tumors of mesenchymal origin are characterized by rearrangements of the High Mobility Group A proteins (HMGA). In this work, we tested the hypothesis that leiomyoma development may be due to overexpression of HMGA2 (encoding high mobility group AT-hook2) in myometrial stem cells using in vitro and in vivo approaches. Our work demonstrates that the truncated/short form of HMGA2 induces myometrial cell transformation toward putative tumor-initiating leiomyoma cells and opens up new possibilities to understand the origin of leiomyomas and the development of new therapeutic approaches.
publishDate 2014
dc.date.none.fl_str_mv 2014-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/84331
Mas, Aymara; Cervelló, Irene; Fernández Alvarez, Ana Julia; Faus, Amparo; Díaz, Ana; et al.; Overexpression of the truncated form of high mobility group a proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation; Oxford University Press; Molecular Human Reproduction; 21; 4; 12-2014; 330-338
1360-9947
CONICET Digital
CONICET
url http://hdl.handle.net/11336/84331
identifier_str_mv Mas, Aymara; Cervelló, Irene; Fernández Alvarez, Ana Julia; Faus, Amparo; Díaz, Ana; et al.; Overexpression of the truncated form of high mobility group a proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation; Oxford University Press; Molecular Human Reproduction; 21; 4; 12-2014; 330-338
1360-9947
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/molehr/gau114
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/molehr/article/21/4/330/983207
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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