Epigenetic Alterations in a Gastric Leiomyoma

Autores
Branham, Maria Teresita; Pellicer, Monica; Campoy, Emanuel Martin; Palma, Marcelo; Correa, Agustín; Roqué, Monica Laura
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Leiomyomas constitute 2.5% of all resected neoplasms of the stomach. They are usually asymptomatic, but may present mucosal ulceration. Aberrant DNA methylation is a well-defined epigenetic change in human neoplasms; however, gene-acquired methylation may not necessarily be related with a malignant phenotype. In this report we analyzed in a gastric leiomyoma, the methylation status of 84 CpGI in tumor suppressor and DNA repair genes. We analyzed the tumor center (TC) and tumor periphery (TP) separately. We found aberrant methylation in 2/84 CpGI in the TC portion, that is, MLH1 and MSH3, and 5/84 CpGI in the TP, that is, MLH1, MSH3, APC, MSH6, and MGMT.The gene with the highest methylation percentage in the TC and TP was MLH1. Given that MLH1methylation has been associated withmicrosatellite instability, we analyzed the status of themicrosatellite Bat-26. We found that neither the TC nor the TP presented instability.The methylation of MLH1, MGMT, and APC has been described in GISTs, but to the best of our knowledge this is the first time that the methylation of these genes has been associated with gastric leiomyoma. Further research should be conducted to identify reliable molecular markers that could differentiate between GISTs and gastric leiomyomas.
Fil: Branham, Maria Teresita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Pellicer, Monica. Laboratorio de Patología; Argentina
Fil: Campoy, Emanuel Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Palma, Marcelo. Provincia de Entre Rios. Hospital San Martin; Argentina
Fil: Correa, Agustín. Hospital Español; Argentina
Fil: Roqué, Monica Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Materia
GASTRIC LEIOMYOMA
EPIGENETIC
DNA METHYLATION
MLH1
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/107192
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/107192
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Epigenetic Alterations in a Gastric LeiomyomaBranham, Maria TeresitaPellicer, MonicaCampoy, Emanuel MartinPalma, MarceloCorrea, AgustínRoqué, Monica LauraGASTRIC LEIOMYOMAEPIGENETICDNA METHYLATIONMLH1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Leiomyomas constitute 2.5% of all resected neoplasms of the stomach. They are usually asymptomatic, but may present mucosal ulceration. Aberrant DNA methylation is a well-defined epigenetic change in human neoplasms; however, gene-acquired methylation may not necessarily be related with a malignant phenotype. In this report we analyzed in a gastric leiomyoma, the methylation status of 84 CpGI in tumor suppressor and DNA repair genes. We analyzed the tumor center (TC) and tumor periphery (TP) separately. We found aberrant methylation in 2/84 CpGI in the TC portion, that is, MLH1 and MSH3, and 5/84 CpGI in the TP, that is, MLH1, MSH3, APC, MSH6, and MGMT.The gene with the highest methylation percentage in the TC and TP was MLH1. Given that MLH1methylation has been associated withmicrosatellite instability, we analyzed the status of themicrosatellite Bat-26. We found that neither the TC nor the TP presented instability.The methylation of MLH1, MGMT, and APC has been described in GISTs, but to the best of our knowledge this is the first time that the methylation of these genes has been associated with gastric leiomyoma. Further research should be conducted to identify reliable molecular markers that could differentiate between GISTs and gastric leiomyomas.Fil: Branham, Maria Teresita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Pellicer, Monica. Laboratorio de Patología; ArgentinaFil: Campoy, Emanuel Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Palma, Marcelo. Provincia de Entre Rios. Hospital San Martin; ArgentinaFil: Correa, Agustín. Hospital Español; ArgentinaFil: Roqué, Monica Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaHindawi Publishing Corporation2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/107192Branham, Maria Teresita; Pellicer, Monica; Campoy, Emanuel Martin; Palma, Marcelo; Correa, Agustín; et al.; Epigenetic Alterations in a Gastric Leiomyoma; Hindawi Publishing Corporation; Case Reports in Gastrointestinal Medicine; 2014; 12-2014; 1-52090-6536CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.hindawi.com/journals/crigm/2014/371638/info:eu-repo/semantics/altIdentifier/doi/10.1155/2014/371638info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:43:56Zoai:ri.conicet.gov.ar:11336/107192instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:43:56.321CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Epigenetic Alterations in a Gastric Leiomyoma
title Epigenetic Alterations in a Gastric Leiomyoma
spellingShingle Epigenetic Alterations in a Gastric Leiomyoma
Branham, Maria Teresita
GASTRIC LEIOMYOMA
EPIGENETIC
DNA METHYLATION
MLH1
title_short Epigenetic Alterations in a Gastric Leiomyoma
title_full Epigenetic Alterations in a Gastric Leiomyoma
title_fullStr Epigenetic Alterations in a Gastric Leiomyoma
title_full_unstemmed Epigenetic Alterations in a Gastric Leiomyoma
title_sort Epigenetic Alterations in a Gastric Leiomyoma
dc.creator.none.fl_str_mv Branham, Maria Teresita
Pellicer, Monica
Campoy, Emanuel Martin
Palma, Marcelo
Correa, Agustín
Roqué, Monica Laura
author Branham, Maria Teresita
author_facet Branham, Maria Teresita
Pellicer, Monica
Campoy, Emanuel Martin
Palma, Marcelo
Correa, Agustín
Roqué, Monica Laura
author_role author
author2 Pellicer, Monica
Campoy, Emanuel Martin
Palma, Marcelo
Correa, Agustín
Roqué, Monica Laura
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv GASTRIC LEIOMYOMA
EPIGENETIC
DNA METHYLATION
MLH1
topic GASTRIC LEIOMYOMA
EPIGENETIC
DNA METHYLATION
MLH1
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Leiomyomas constitute 2.5% of all resected neoplasms of the stomach. They are usually asymptomatic, but may present mucosal ulceration. Aberrant DNA methylation is a well-defined epigenetic change in human neoplasms; however, gene-acquired methylation may not necessarily be related with a malignant phenotype. In this report we analyzed in a gastric leiomyoma, the methylation status of 84 CpGI in tumor suppressor and DNA repair genes. We analyzed the tumor center (TC) and tumor periphery (TP) separately. We found aberrant methylation in 2/84 CpGI in the TC portion, that is, MLH1 and MSH3, and 5/84 CpGI in the TP, that is, MLH1, MSH3, APC, MSH6, and MGMT.The gene with the highest methylation percentage in the TC and TP was MLH1. Given that MLH1methylation has been associated withmicrosatellite instability, we analyzed the status of themicrosatellite Bat-26. We found that neither the TC nor the TP presented instability.The methylation of MLH1, MGMT, and APC has been described in GISTs, but to the best of our knowledge this is the first time that the methylation of these genes has been associated with gastric leiomyoma. Further research should be conducted to identify reliable molecular markers that could differentiate between GISTs and gastric leiomyomas.
Fil: Branham, Maria Teresita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Pellicer, Monica. Laboratorio de Patología; Argentina
Fil: Campoy, Emanuel Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Palma, Marcelo. Provincia de Entre Rios. Hospital San Martin; Argentina
Fil: Correa, Agustín. Hospital Español; Argentina
Fil: Roqué, Monica Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
description Leiomyomas constitute 2.5% of all resected neoplasms of the stomach. They are usually asymptomatic, but may present mucosal ulceration. Aberrant DNA methylation is a well-defined epigenetic change in human neoplasms; however, gene-acquired methylation may not necessarily be related with a malignant phenotype. In this report we analyzed in a gastric leiomyoma, the methylation status of 84 CpGI in tumor suppressor and DNA repair genes. We analyzed the tumor center (TC) and tumor periphery (TP) separately. We found aberrant methylation in 2/84 CpGI in the TC portion, that is, MLH1 and MSH3, and 5/84 CpGI in the TP, that is, MLH1, MSH3, APC, MSH6, and MGMT.The gene with the highest methylation percentage in the TC and TP was MLH1. Given that MLH1methylation has been associated withmicrosatellite instability, we analyzed the status of themicrosatellite Bat-26. We found that neither the TC nor the TP presented instability.The methylation of MLH1, MGMT, and APC has been described in GISTs, but to the best of our knowledge this is the first time that the methylation of these genes has been associated with gastric leiomyoma. Further research should be conducted to identify reliable molecular markers that could differentiate between GISTs and gastric leiomyomas.
publishDate 2014
dc.date.none.fl_str_mv 2014-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/107192
Branham, Maria Teresita; Pellicer, Monica; Campoy, Emanuel Martin; Palma, Marcelo; Correa, Agustín; et al.; Epigenetic Alterations in a Gastric Leiomyoma; Hindawi Publishing Corporation; Case Reports in Gastrointestinal Medicine; 2014; 12-2014; 1-5
2090-6536
CONICET Digital
CONICET
url http://hdl.handle.net/11336/107192
identifier_str_mv Branham, Maria Teresita; Pellicer, Monica; Campoy, Emanuel Martin; Palma, Marcelo; Correa, Agustín; et al.; Epigenetic Alterations in a Gastric Leiomyoma; Hindawi Publishing Corporation; Case Reports in Gastrointestinal Medicine; 2014; 12-2014; 1-5
2090-6536
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.hindawi.com/journals/crigm/2014/371638/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2014/371638
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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