Vectorcardiography-derived index allows a robust quantification of ventricular electrical synchrony

Autores
Fernández, Juan Manuel Francisco; Spagnuolo, Damián N.; Politi, María T.; Tello Santacruz, Iván A.; Schiavone, Miguel; Cáceres Monié, César; Avaca, Horacio A.; Chara, Osvaldo
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Alteration of muscle activation sequence is a key mechanism in heart failure with reduced ejection fraction. Successful cardiac resynchronization therapy (CRT), which has become standard therapy in these patients, is limited by the lack of precise dyssynchrony quantification. We implemented a computational pipeline that allows assessment of ventricular dyssynchrony by vectorcardiogram reconstruction from the patient’s electrocardiogram. We defined a ventricular dyssynchrony index as the distance between the voltage and speed time integrals of an individual observation and the linear fit of these variables obtained from a healthy population. The pipeline was tested in a 1914-patient population. The dyssynchrony index showed minimum values in heathy controls and maximum values in patients with left bundle branch block (LBBB) or with a pacemaker (PM). We established a critical dyssynchrony index value that discriminates electrical dyssynchronous patterns (LBBB and PM) from ventricular synchrony. In 10 patients with PM or CRT devices, dyssynchrony indexes above the critical value were associated with high time to peak strain standard deviation, an echocardiographic measure of mechanical dyssynchrony. Our index proves to be a promising tool to evaluate ventricular activation dyssynchrony, potentially enhancing the selection of candidates for CRT, device configuration during implantation, and post-implant optimization.
Fil: Fernández, Juan Manuel Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina
Fil: Spagnuolo, Damián N.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina
Fil: Politi, María T.. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Fil: Tello Santacruz, Iván A.. Hospital Británico de Buenos Aires; Argentina
Fil: Schiavone, Miguel. Hospital Británico de Buenos Aires; Argentina
Fil: Cáceres Monié, César. Hospital Británico de Buenos Aires; Argentina
Fil: Avaca, Horacio A.. Hospital Británico de Buenos Aires; Argentina
Fil: Chara, Osvaldo. Universidad Argentina de la Empresa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina. Technische Universität Dresden; Alemania
Materia
ECG
VECTOCARDIOGRAPHY
CRT
SYNCHRONY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/212648
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/212648
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Vectorcardiography-derived index allows a robust quantification of ventricular electrical synchronyFernández, Juan Manuel FranciscoSpagnuolo, Damián N.Politi, María T.Tello Santacruz, Iván A.Schiavone, MiguelCáceres Monié, CésarAvaca, Horacio A.Chara, OsvaldoECGVECTOCARDIOGRAPHYCRTSYNCHRONYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Alteration of muscle activation sequence is a key mechanism in heart failure with reduced ejection fraction. Successful cardiac resynchronization therapy (CRT), which has become standard therapy in these patients, is limited by the lack of precise dyssynchrony quantification. We implemented a computational pipeline that allows assessment of ventricular dyssynchrony by vectorcardiogram reconstruction from the patient’s electrocardiogram. We defined a ventricular dyssynchrony index as the distance between the voltage and speed time integrals of an individual observation and the linear fit of these variables obtained from a healthy population. The pipeline was tested in a 1914-patient population. The dyssynchrony index showed minimum values in heathy controls and maximum values in patients with left bundle branch block (LBBB) or with a pacemaker (PM). We established a critical dyssynchrony index value that discriminates electrical dyssynchronous patterns (LBBB and PM) from ventricular synchrony. In 10 patients with PM or CRT devices, dyssynchrony indexes above the critical value were associated with high time to peak strain standard deviation, an echocardiographic measure of mechanical dyssynchrony. Our index proves to be a promising tool to evaluate ventricular activation dyssynchrony, potentially enhancing the selection of candidates for CRT, device configuration during implantation, and post-implant optimization.Fil: Fernández, Juan Manuel Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; ArgentinaFil: Spagnuolo, Damián N.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; ArgentinaFil: Politi, María T.. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Tello Santacruz, Iván A.. Hospital Británico de Buenos Aires; ArgentinaFil: Schiavone, Miguel. Hospital Británico de Buenos Aires; ArgentinaFil: Cáceres Monié, César. Hospital Británico de Buenos Aires; ArgentinaFil: Avaca, Horacio A.. Hospital Británico de Buenos Aires; ArgentinaFil: Chara, Osvaldo. Universidad Argentina de la Empresa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina. Technische Universität Dresden; AlemaniaNature Research2022-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/212648Fernández, Juan Manuel Francisco; Spagnuolo, Damián N.; Politi, María T.; Tello Santacruz, Iván A.; Schiavone, Miguel; et al.; Vectorcardiography-derived index allows a robust quantification of ventricular electrical synchrony; Nature Research; Scientific Reports; 12; 1; 12-2022; 1-122045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-022-14000-8info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-022-14000-8info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:32:26Zoai:ri.conicet.gov.ar:11336/212648instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:32:26.334CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Vectorcardiography-derived index allows a robust quantification of ventricular electrical synchrony
title Vectorcardiography-derived index allows a robust quantification of ventricular electrical synchrony
spellingShingle Vectorcardiography-derived index allows a robust quantification of ventricular electrical synchrony
Fernández, Juan Manuel Francisco
ECG
VECTOCARDIOGRAPHY
CRT
SYNCHRONY
title_short Vectorcardiography-derived index allows a robust quantification of ventricular electrical synchrony
title_full Vectorcardiography-derived index allows a robust quantification of ventricular electrical synchrony
title_fullStr Vectorcardiography-derived index allows a robust quantification of ventricular electrical synchrony
title_full_unstemmed Vectorcardiography-derived index allows a robust quantification of ventricular electrical synchrony
title_sort Vectorcardiography-derived index allows a robust quantification of ventricular electrical synchrony
dc.creator.none.fl_str_mv Fernández, Juan Manuel Francisco
Spagnuolo, Damián N.
Politi, María T.
Tello Santacruz, Iván A.
Schiavone, Miguel
Cáceres Monié, César
Avaca, Horacio A.
Chara, Osvaldo
author Fernández, Juan Manuel Francisco
author_facet Fernández, Juan Manuel Francisco
Spagnuolo, Damián N.
Politi, María T.
Tello Santacruz, Iván A.
Schiavone, Miguel
Cáceres Monié, César
Avaca, Horacio A.
Chara, Osvaldo
author_role author
author2 Spagnuolo, Damián N.
Politi, María T.
Tello Santacruz, Iván A.
Schiavone, Miguel
Cáceres Monié, César
Avaca, Horacio A.
Chara, Osvaldo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ECG
VECTOCARDIOGRAPHY
CRT
SYNCHRONY
topic ECG
VECTOCARDIOGRAPHY
CRT
SYNCHRONY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Alteration of muscle activation sequence is a key mechanism in heart failure with reduced ejection fraction. Successful cardiac resynchronization therapy (CRT), which has become standard therapy in these patients, is limited by the lack of precise dyssynchrony quantification. We implemented a computational pipeline that allows assessment of ventricular dyssynchrony by vectorcardiogram reconstruction from the patient’s electrocardiogram. We defined a ventricular dyssynchrony index as the distance between the voltage and speed time integrals of an individual observation and the linear fit of these variables obtained from a healthy population. The pipeline was tested in a 1914-patient population. The dyssynchrony index showed minimum values in heathy controls and maximum values in patients with left bundle branch block (LBBB) or with a pacemaker (PM). We established a critical dyssynchrony index value that discriminates electrical dyssynchronous patterns (LBBB and PM) from ventricular synchrony. In 10 patients with PM or CRT devices, dyssynchrony indexes above the critical value were associated with high time to peak strain standard deviation, an echocardiographic measure of mechanical dyssynchrony. Our index proves to be a promising tool to evaluate ventricular activation dyssynchrony, potentially enhancing the selection of candidates for CRT, device configuration during implantation, and post-implant optimization.
Fil: Fernández, Juan Manuel Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina
Fil: Spagnuolo, Damián N.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina
Fil: Politi, María T.. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Fil: Tello Santacruz, Iván A.. Hospital Británico de Buenos Aires; Argentina
Fil: Schiavone, Miguel. Hospital Británico de Buenos Aires; Argentina
Fil: Cáceres Monié, César. Hospital Británico de Buenos Aires; Argentina
Fil: Avaca, Horacio A.. Hospital Británico de Buenos Aires; Argentina
Fil: Chara, Osvaldo. Universidad Argentina de la Empresa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina. Technische Universität Dresden; Alemania
description Alteration of muscle activation sequence is a key mechanism in heart failure with reduced ejection fraction. Successful cardiac resynchronization therapy (CRT), which has become standard therapy in these patients, is limited by the lack of precise dyssynchrony quantification. We implemented a computational pipeline that allows assessment of ventricular dyssynchrony by vectorcardiogram reconstruction from the patient’s electrocardiogram. We defined a ventricular dyssynchrony index as the distance between the voltage and speed time integrals of an individual observation and the linear fit of these variables obtained from a healthy population. The pipeline was tested in a 1914-patient population. The dyssynchrony index showed minimum values in heathy controls and maximum values in patients with left bundle branch block (LBBB) or with a pacemaker (PM). We established a critical dyssynchrony index value that discriminates electrical dyssynchronous patterns (LBBB and PM) from ventricular synchrony. In 10 patients with PM or CRT devices, dyssynchrony indexes above the critical value were associated with high time to peak strain standard deviation, an echocardiographic measure of mechanical dyssynchrony. Our index proves to be a promising tool to evaluate ventricular activation dyssynchrony, potentially enhancing the selection of candidates for CRT, device configuration during implantation, and post-implant optimization.
publishDate 2022
dc.date.none.fl_str_mv 2022-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/212648
Fernández, Juan Manuel Francisco; Spagnuolo, Damián N.; Politi, María T.; Tello Santacruz, Iván A.; Schiavone, Miguel; et al.; Vectorcardiography-derived index allows a robust quantification of ventricular electrical synchrony; Nature Research; Scientific Reports; 12; 1; 12-2022; 1-12
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/212648
identifier_str_mv Fernández, Juan Manuel Francisco; Spagnuolo, Damián N.; Politi, María T.; Tello Santacruz, Iván A.; Schiavone, Miguel; et al.; Vectorcardiography-derived index allows a robust quantification of ventricular electrical synchrony; Nature Research; Scientific Reports; 12; 1; 12-2022; 1-12
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-022-14000-8
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-022-14000-8
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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