Disruption of zinc and copper interactions with Ab(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer’s disease therapy?...

Autores
Hauser Davis, R.A.; De Freitas, L. V.; Cukierman, D. S.; Cruz, W. S.; Miotto, Marco César; Fernandez, Claudio Oscar; Valiente Gabioud, Ariel Alejandro; Fernández, C. O.; Rey, N. A.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Disruptions of biometal-Aβ(1-40) interactions by an isoniazid-derived hydrazone, INHHQ, were demonstrated via in vitro NMR titrations. The compound has adequate theoretical BBB absorption properties, assessed by in silico studies. In vivo acute toxicity assays indicate that INHHQ is innocuous up to 300 mg kg-1, showing potential as an anti-Alzheimer's drug.
Fil: Hauser Davis, R.A.. Pontifícia Universidade Católica do Rio de Janeiro; Brasil
Fil: De Freitas, L. V.. Pontifícia Universidade Católica do Rio de Janeiro; Brasil
Fil: Cukierman, D. S.. Pontifícia Universidade Católica do Rio de Janeiro; Brasil
Fil: Cruz, W. S.. Pontifícia Universidade Católica do Rio de Janeiro; Brasil
Fil: Miotto, Marco César. Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Fernandez, Claudio Oscar. Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Valiente Gabioud, Ariel Alejandro. Laboratorio Max Planck de Biología Estructural, Química y Biofísica Molecular de Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Fernández, C. O.. Laboratorio Max Planck de Biología Estructural, Química y Biofísica Molecular de Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Rey, N. A.. Pontifícia Universidade Católica do Rio de Janeiro; Brasil
Materia
Alzheimer
Zinc
Copper
Therapy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/163597
Acceder
id CONICETDig_50b2214ff034df4efcaba71b3e31e017
oai_identifier_str oai:ri.conicet.gov.ar:11336/163597
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Disruption of zinc and copper interactions with Ab(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer’s disease therapy?Hauser Davis, R.A.De Freitas, L. V.Cukierman, D. S.Cruz, W. S.Miotto, Marco CésarFernandez, Claudio OscarValiente Gabioud, Ariel AlejandroFernández, C. O.Rey, N. A.AlzheimerZincCopperTherapyhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Disruptions of biometal-Aβ(1-40) interactions by an isoniazid-derived hydrazone, INHHQ, were demonstrated via in vitro NMR titrations. The compound has adequate theoretical BBB absorption properties, assessed by in silico studies. In vivo acute toxicity assays indicate that INHHQ is innocuous up to 300 mg kg-1, showing potential as an anti-Alzheimer's drug.Fil: Hauser Davis, R.A.. Pontifícia Universidade Católica do Rio de Janeiro; BrasilFil: De Freitas, L. V.. Pontifícia Universidade Católica do Rio de Janeiro; BrasilFil: Cukierman, D. S.. Pontifícia Universidade Católica do Rio de Janeiro; BrasilFil: Cruz, W. S.. Pontifícia Universidade Católica do Rio de Janeiro; BrasilFil: Miotto, Marco César. Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario; Argentina. Universidad Nacional de Rosario; ArgentinaFil: Fernandez, Claudio Oscar. Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario; Argentina. Universidad Nacional de Rosario; ArgentinaFil: Valiente Gabioud, Ariel Alejandro. Laboratorio Max Planck de Biología Estructural, Química y Biofísica Molecular de Rosario; Argentina. Universidad Nacional de Rosario; ArgentinaFil: Fernández, C. O.. Laboratorio Max Planck de Biología Estructural, Química y Biofísica Molecular de Rosario; Argentina. Universidad Nacional de Rosario; ArgentinaFil: Rey, N. A.. Pontifícia Universidade Católica do Rio de Janeiro; BrasilRoyal Society of Chemistry2015-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/163597Hauser Davis, R.A.; De Freitas, L. V.; Cukierman, D. S.; Cruz, W. S.; Miotto, Marco César; et al.; Disruption of zinc and copper interactions with Ab(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer’s disease therapy?; Royal Society of Chemistry; Metallomics; 7; 5; 4-2015; 743-7471756-5901CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1039/c5mt00003cinfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/metallomics/article/7/5/743/6015152info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:47:40Zoai:ri.conicet.gov.ar:11336/163597instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:47:40.764CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Disruption of zinc and copper interactions with Ab(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer’s disease therapy?
title Disruption of zinc and copper interactions with Ab(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer’s disease therapy?
spellingShingle Disruption of zinc and copper interactions with Ab(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer’s disease therapy?
Hauser Davis, R.A.
Alzheimer
Zinc
Copper
Therapy
title_short Disruption of zinc and copper interactions with Ab(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer’s disease therapy?
title_full Disruption of zinc and copper interactions with Ab(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer’s disease therapy?
title_fullStr Disruption of zinc and copper interactions with Ab(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer’s disease therapy?
title_full_unstemmed Disruption of zinc and copper interactions with Ab(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer’s disease therapy?
title_sort Disruption of zinc and copper interactions with Ab(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer’s disease therapy?
dc.creator.none.fl_str_mv Hauser Davis, R.A.
De Freitas, L. V.
Cukierman, D. S.
Cruz, W. S.
Miotto, Marco César
Fernandez, Claudio Oscar
Valiente Gabioud, Ariel Alejandro
Fernández, C. O.
Rey, N. A.
author Hauser Davis, R.A.
author_facet Hauser Davis, R.A.
De Freitas, L. V.
Cukierman, D. S.
Cruz, W. S.
Miotto, Marco César
Fernandez, Claudio Oscar
Valiente Gabioud, Ariel Alejandro
Fernández, C. O.
Rey, N. A.
author_role author
author2 De Freitas, L. V.
Cukierman, D. S.
Cruz, W. S.
Miotto, Marco César
Fernandez, Claudio Oscar
Valiente Gabioud, Ariel Alejandro
Fernández, C. O.
Rey, N. A.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Alzheimer
Zinc
Copper
Therapy
topic Alzheimer
Zinc
Copper
Therapy
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Disruptions of biometal-Aβ(1-40) interactions by an isoniazid-derived hydrazone, INHHQ, were demonstrated via in vitro NMR titrations. The compound has adequate theoretical BBB absorption properties, assessed by in silico studies. In vivo acute toxicity assays indicate that INHHQ is innocuous up to 300 mg kg-1, showing potential as an anti-Alzheimer's drug.
Fil: Hauser Davis, R.A.. Pontifícia Universidade Católica do Rio de Janeiro; Brasil
Fil: De Freitas, L. V.. Pontifícia Universidade Católica do Rio de Janeiro; Brasil
Fil: Cukierman, D. S.. Pontifícia Universidade Católica do Rio de Janeiro; Brasil
Fil: Cruz, W. S.. Pontifícia Universidade Católica do Rio de Janeiro; Brasil
Fil: Miotto, Marco César. Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Fernandez, Claudio Oscar. Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Valiente Gabioud, Ariel Alejandro. Laboratorio Max Planck de Biología Estructural, Química y Biofísica Molecular de Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Fernández, C. O.. Laboratorio Max Planck de Biología Estructural, Química y Biofísica Molecular de Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Rey, N. A.. Pontifícia Universidade Católica do Rio de Janeiro; Brasil
description Disruptions of biometal-Aβ(1-40) interactions by an isoniazid-derived hydrazone, INHHQ, were demonstrated via in vitro NMR titrations. The compound has adequate theoretical BBB absorption properties, assessed by in silico studies. In vivo acute toxicity assays indicate that INHHQ is innocuous up to 300 mg kg-1, showing potential as an anti-Alzheimer's drug.
publishDate 2015
dc.date.none.fl_str_mv 2015-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/163597
Hauser Davis, R.A.; De Freitas, L. V.; Cukierman, D. S.; Cruz, W. S.; Miotto, Marco César; et al.; Disruption of zinc and copper interactions with Ab(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer’s disease therapy?; Royal Society of Chemistry; Metallomics; 7; 5; 4-2015; 743-747
1756-5901
CONICET Digital
CONICET
url http://hdl.handle.net/11336/163597
identifier_str_mv Hauser Davis, R.A.; De Freitas, L. V.; Cukierman, D. S.; Cruz, W. S.; Miotto, Marco César; et al.; Disruption of zinc and copper interactions with Ab(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer’s disease therapy?; Royal Society of Chemistry; Metallomics; 7; 5; 4-2015; 743-747
1756-5901
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1039/c5mt00003c
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/metallomics/article/7/5/743/6015152
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782182223249408
score 12.982451

Publicaciones similares