Behavioral and neurophysiological signatures of interoceptive enhancements following vagus nerve stimulation

Autores
Richter, Fabian; García, Adolfo Martín; Rodríguez Arriagada, Nicolás; Yoris, Adrián Isidro; Birba, Agustina; Huepe, David; Zimmer, Heinz; Ibañez, Agustin Mariano; Sedeño, Lucas
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
An accruing body of research has shown that interoception (the sensing of signals from the body's internal milieu) relies on both a direct route (afforded by the vagus nerve) and a secondary route (supported by somatosensory mechanisms). However, no study has causally tested the differential role of these pathways, let alone via direct stimulation. To bridge this gap, we tested whether multidimensional signatures of interoception are modulated by noninvasive vagus nerve stimulation (nVNS). Sixty-three participants were divided into an nVNS and a sham-stimulation group. Before and after stimulation, both groups performed a validated heartbeat detection (HBD) task including a genuinely interoceptive condition (monitoring one's own heartbeat) and a control exteroceptive condition (tracking an aurally presented heartbeat). Electroencephalographic signals were obtained during both conditions to examine modulations of the heartbeat-evoked potential (HEP). Moreover, before and after stimulation, participants were asked to complete a somatosensory heartbeat localization task. Results from the interoceptive condition revealed that, after treatment, only the nVNS group exhibited improved performance and greater HEP modulations. No behavioral differences were found for the exteroceptive control condition, which was nonetheless associated with significant HEP modulations. Finally, no between-group differences were observed regarding the localization of the heartbeat sensations or relevant cardiodynamic variables (heart rate and or heart rate variability). Taken together, these results constitute unprecedented evidence that the vagus nerve plays a direct role in neurovisceral integration during interoception. This finding can constrain mechanistic models of the domain while informing a promising transdiagnostic agenda for interoceptive impairments across neuropsychiatric conditions.
Fil: Richter, Fabian. Universitat zu Köln; Alemania
Fil: García, Adolfo Martín. Universidad Nacional de Cuyo. Facultad de Educación Elemental y Especial; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina
Fil: Rodríguez Arriagada, Nicolás. Universidad de San Andrés; Argentina. Universidad de Buenos Aires; Argentina
Fil: Yoris, Adrián Isidro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Birba, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina
Fil: Huepe, David. Universidad Adolfo Ibañez; Chile
Fil: Zimmer, Heinz. Universitat zu Köln; Alemania
Fil: Ibañez, Agustin Mariano. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
HEARTBEAT DETECTION TASK
HEARTBEAT-EVOKED POTENTIAL
INTEROCEPTION
NEUROVISCERAL COMMUNICATION
NONINVASIVE VAGUS NERVE STIMULATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/169065
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/169065
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Behavioral and neurophysiological signatures of interoceptive enhancements following vagus nerve stimulationRichter, FabianGarcía, Adolfo MartínRodríguez Arriagada, NicolásYoris, Adrián IsidroBirba, AgustinaHuepe, DavidZimmer, HeinzIbañez, Agustin MarianoSedeño, LucasHEARTBEAT DETECTION TASKHEARTBEAT-EVOKED POTENTIALINTEROCEPTIONNEUROVISCERAL COMMUNICATIONNONINVASIVE VAGUS NERVE STIMULATIONhttps://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5An accruing body of research has shown that interoception (the sensing of signals from the body's internal milieu) relies on both a direct route (afforded by the vagus nerve) and a secondary route (supported by somatosensory mechanisms). However, no study has causally tested the differential role of these pathways, let alone via direct stimulation. To bridge this gap, we tested whether multidimensional signatures of interoception are modulated by noninvasive vagus nerve stimulation (nVNS). Sixty-three participants were divided into an nVNS and a sham-stimulation group. Before and after stimulation, both groups performed a validated heartbeat detection (HBD) task including a genuinely interoceptive condition (monitoring one's own heartbeat) and a control exteroceptive condition (tracking an aurally presented heartbeat). Electroencephalographic signals were obtained during both conditions to examine modulations of the heartbeat-evoked potential (HEP). Moreover, before and after stimulation, participants were asked to complete a somatosensory heartbeat localization task. Results from the interoceptive condition revealed that, after treatment, only the nVNS group exhibited improved performance and greater HEP modulations. No behavioral differences were found for the exteroceptive control condition, which was nonetheless associated with significant HEP modulations. Finally, no between-group differences were observed regarding the localization of the heartbeat sensations or relevant cardiodynamic variables (heart rate and or heart rate variability). Taken together, these results constitute unprecedented evidence that the vagus nerve plays a direct role in neurovisceral integration during interoception. This finding can constrain mechanistic models of the domain while informing a promising transdiagnostic agenda for interoceptive impairments across neuropsychiatric conditions.Fil: Richter, Fabian. Universitat zu Köln; AlemaniaFil: García, Adolfo Martín. Universidad Nacional de Cuyo. Facultad de Educación Elemental y Especial; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; ArgentinaFil: Rodríguez Arriagada, Nicolás. Universidad de San Andrés; Argentina. Universidad de Buenos Aires; ArgentinaFil: Yoris, Adrián Isidro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Birba, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; ArgentinaFil: Huepe, David. Universidad Adolfo Ibañez; ChileFil: Zimmer, Heinz. Universitat zu Köln; AlemaniaFil: Ibañez, Agustin Mariano. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley-liss, div John Wiley & Sons Inc.2020-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/169065Richter, Fabian; García, Adolfo Martín; Rodríguez Arriagada, Nicolás; Yoris, Adrián Isidro; Birba, Agustina; et al.; Behavioral and neurophysiological signatures of interoceptive enhancements following vagus nerve stimulation; Wiley-liss, div John Wiley & Sons Inc.; Human Brain Mapping; 42; 5; 10-2020; 1227-12421065-9471CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/hbm.25288?af=Rinfo:eu-repo/semantics/altIdentifier/doi/10.1002/hbm.25288info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:18Zoai:ri.conicet.gov.ar:11336/169065instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:19.049CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Behavioral and neurophysiological signatures of interoceptive enhancements following vagus nerve stimulation
title Behavioral and neurophysiological signatures of interoceptive enhancements following vagus nerve stimulation
spellingShingle Behavioral and neurophysiological signatures of interoceptive enhancements following vagus nerve stimulation
Richter, Fabian
HEARTBEAT DETECTION TASK
HEARTBEAT-EVOKED POTENTIAL
INTEROCEPTION
NEUROVISCERAL COMMUNICATION
NONINVASIVE VAGUS NERVE STIMULATION
title_short Behavioral and neurophysiological signatures of interoceptive enhancements following vagus nerve stimulation
title_full Behavioral and neurophysiological signatures of interoceptive enhancements following vagus nerve stimulation
title_fullStr Behavioral and neurophysiological signatures of interoceptive enhancements following vagus nerve stimulation
title_full_unstemmed Behavioral and neurophysiological signatures of interoceptive enhancements following vagus nerve stimulation
title_sort Behavioral and neurophysiological signatures of interoceptive enhancements following vagus nerve stimulation
dc.creator.none.fl_str_mv Richter, Fabian
García, Adolfo Martín
Rodríguez Arriagada, Nicolás
Yoris, Adrián Isidro
Birba, Agustina
Huepe, David
Zimmer, Heinz
Ibañez, Agustin Mariano
Sedeño, Lucas
author Richter, Fabian
author_facet Richter, Fabian
García, Adolfo Martín
Rodríguez Arriagada, Nicolás
Yoris, Adrián Isidro
Birba, Agustina
Huepe, David
Zimmer, Heinz
Ibañez, Agustin Mariano
Sedeño, Lucas
author_role author
author2 García, Adolfo Martín
Rodríguez Arriagada, Nicolás
Yoris, Adrián Isidro
Birba, Agustina
Huepe, David
Zimmer, Heinz
Ibañez, Agustin Mariano
Sedeño, Lucas
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HEARTBEAT DETECTION TASK
HEARTBEAT-EVOKED POTENTIAL
INTEROCEPTION
NEUROVISCERAL COMMUNICATION
NONINVASIVE VAGUS NERVE STIMULATION
topic HEARTBEAT DETECTION TASK
HEARTBEAT-EVOKED POTENTIAL
INTEROCEPTION
NEUROVISCERAL COMMUNICATION
NONINVASIVE VAGUS NERVE STIMULATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
dc.description.none.fl_txt_mv An accruing body of research has shown that interoception (the sensing of signals from the body's internal milieu) relies on both a direct route (afforded by the vagus nerve) and a secondary route (supported by somatosensory mechanisms). However, no study has causally tested the differential role of these pathways, let alone via direct stimulation. To bridge this gap, we tested whether multidimensional signatures of interoception are modulated by noninvasive vagus nerve stimulation (nVNS). Sixty-three participants were divided into an nVNS and a sham-stimulation group. Before and after stimulation, both groups performed a validated heartbeat detection (HBD) task including a genuinely interoceptive condition (monitoring one's own heartbeat) and a control exteroceptive condition (tracking an aurally presented heartbeat). Electroencephalographic signals were obtained during both conditions to examine modulations of the heartbeat-evoked potential (HEP). Moreover, before and after stimulation, participants were asked to complete a somatosensory heartbeat localization task. Results from the interoceptive condition revealed that, after treatment, only the nVNS group exhibited improved performance and greater HEP modulations. No behavioral differences were found for the exteroceptive control condition, which was nonetheless associated with significant HEP modulations. Finally, no between-group differences were observed regarding the localization of the heartbeat sensations or relevant cardiodynamic variables (heart rate and or heart rate variability). Taken together, these results constitute unprecedented evidence that the vagus nerve plays a direct role in neurovisceral integration during interoception. This finding can constrain mechanistic models of the domain while informing a promising transdiagnostic agenda for interoceptive impairments across neuropsychiatric conditions.
Fil: Richter, Fabian. Universitat zu Köln; Alemania
Fil: García, Adolfo Martín. Universidad Nacional de Cuyo. Facultad de Educación Elemental y Especial; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina
Fil: Rodríguez Arriagada, Nicolás. Universidad de San Andrés; Argentina. Universidad de Buenos Aires; Argentina
Fil: Yoris, Adrián Isidro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Birba, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina
Fil: Huepe, David. Universidad Adolfo Ibañez; Chile
Fil: Zimmer, Heinz. Universitat zu Köln; Alemania
Fil: Ibañez, Agustin Mariano. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description An accruing body of research has shown that interoception (the sensing of signals from the body's internal milieu) relies on both a direct route (afforded by the vagus nerve) and a secondary route (supported by somatosensory mechanisms). However, no study has causally tested the differential role of these pathways, let alone via direct stimulation. To bridge this gap, we tested whether multidimensional signatures of interoception are modulated by noninvasive vagus nerve stimulation (nVNS). Sixty-three participants were divided into an nVNS and a sham-stimulation group. Before and after stimulation, both groups performed a validated heartbeat detection (HBD) task including a genuinely interoceptive condition (monitoring one's own heartbeat) and a control exteroceptive condition (tracking an aurally presented heartbeat). Electroencephalographic signals were obtained during both conditions to examine modulations of the heartbeat-evoked potential (HEP). Moreover, before and after stimulation, participants were asked to complete a somatosensory heartbeat localization task. Results from the interoceptive condition revealed that, after treatment, only the nVNS group exhibited improved performance and greater HEP modulations. No behavioral differences were found for the exteroceptive control condition, which was nonetheless associated with significant HEP modulations. Finally, no between-group differences were observed regarding the localization of the heartbeat sensations or relevant cardiodynamic variables (heart rate and or heart rate variability). Taken together, these results constitute unprecedented evidence that the vagus nerve plays a direct role in neurovisceral integration during interoception. This finding can constrain mechanistic models of the domain while informing a promising transdiagnostic agenda for interoceptive impairments across neuropsychiatric conditions.
publishDate 2020
dc.date.none.fl_str_mv 2020-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/169065
Richter, Fabian; García, Adolfo Martín; Rodríguez Arriagada, Nicolás; Yoris, Adrián Isidro; Birba, Agustina; et al.; Behavioral and neurophysiological signatures of interoceptive enhancements following vagus nerve stimulation; Wiley-liss, div John Wiley & Sons Inc.; Human Brain Mapping; 42; 5; 10-2020; 1227-1242
1065-9471
CONICET Digital
CONICET
url http://hdl.handle.net/11336/169065
identifier_str_mv Richter, Fabian; García, Adolfo Martín; Rodríguez Arriagada, Nicolás; Yoris, Adrián Isidro; Birba, Agustina; et al.; Behavioral and neurophysiological signatures of interoceptive enhancements following vagus nerve stimulation; Wiley-liss, div John Wiley & Sons Inc.; Human Brain Mapping; 42; 5; 10-2020; 1227-1242
1065-9471
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/hbm.25288?af=R
info:eu-repo/semantics/altIdentifier/doi/10.1002/hbm.25288
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, div John Wiley & Sons Inc.
publisher.none.fl_str_mv Wiley-liss, div John Wiley & Sons Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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