Activity-Driven Dendritic Remodeling Requires Microtubule-Associated Protein 1A

Autores
Szebenyi, Györgyi; Bollati, Flavia Andrea; Bisbal, Mariano; Sheridan, Shelley; Faas, Laura; Wray, Robin; Haferkamp, Scott; Nguyen, Sapril; Caceres, Alfredo Oscar; Brady, Scott T.
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Activity-prompted dendritic remodeling leads to calcium-influx-dependent activation of signaling pathways within minutes and gene transcription within hours. However, dendrite growth continues for days and requires extension and stabilization of the cytoskeleton in nascent processes. In addition to binding microtubules, microtubule-associated proteins (MAPs) associate with the actin cytoskeleton, anchor ion channels and signaling complexes, and modulate synaptic growth. MAP2 is predominantly dendritic. MAP1B is at postsynaptic densities (PSD) and modulates ion channel activity, in addition to affecting axon growth. Less is known about MAP1A, but it is also enriched in dendrites at input locations, including PSDs where MAP1A associates with channel complexes and the calcium sensor caldendrin. MAP1A rescued hearing loss in tubby mice. Here we show that MAP1A becomes enriched in dendrites concurrently with dendritic branching and synapse formation in the developing brain; that synaptic activity is required for establishing mature MAP1A expression levels; and that MAP1A expression is required for activity-dependent growth, branching, and stabilization of the dendritic arbor.
Fil: Szebenyi, Györgyi. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Bollati, Flavia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Bisbal, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Sheridan, Shelley. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Faas, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Wray, Robin. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Haferkamp, Scott. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Nguyen, Sapril. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Caceres, Alfredo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Brady, Scott T.. Anatomy And Cell Biology, University Of Illinois; Estados Unidos
Materia
NEURONAL POLARITY
DENDRITOGENESIS
SIGNALING MECHANISMS
MAP1A
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/242021
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/242021
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Activity-Driven Dendritic Remodeling Requires Microtubule-Associated Protein 1ASzebenyi, GyörgyiBollati, Flavia AndreaBisbal, MarianoSheridan, ShelleyFaas, LauraWray, RobinHaferkamp, ScottNguyen, SaprilCaceres, Alfredo OscarBrady, Scott T.NEURONAL POLARITYDENDRITOGENESISSIGNALING MECHANISMSMAP1Ahttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Activity-prompted dendritic remodeling leads to calcium-influx-dependent activation of signaling pathways within minutes and gene transcription within hours. However, dendrite growth continues for days and requires extension and stabilization of the cytoskeleton in nascent processes. In addition to binding microtubules, microtubule-associated proteins (MAPs) associate with the actin cytoskeleton, anchor ion channels and signaling complexes, and modulate synaptic growth. MAP2 is predominantly dendritic. MAP1B is at postsynaptic densities (PSD) and modulates ion channel activity, in addition to affecting axon growth. Less is known about MAP1A, but it is also enriched in dendrites at input locations, including PSDs where MAP1A associates with channel complexes and the calcium sensor caldendrin. MAP1A rescued hearing loss in tubby mice. Here we show that MAP1A becomes enriched in dendrites concurrently with dendritic branching and synapse formation in the developing brain; that synaptic activity is required for establishing mature MAP1A expression levels; and that MAP1A expression is required for activity-dependent growth, branching, and stabilization of the dendritic arbor.Fil: Szebenyi, Györgyi. University of Texas. Southwestern Medical Center; Estados UnidosFil: Bollati, Flavia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Bisbal, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Sheridan, Shelley. University of Texas. Southwestern Medical Center; Estados UnidosFil: Faas, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Wray, Robin. University of Texas. Southwestern Medical Center; Estados UnidosFil: Haferkamp, Scott. University of Texas. Southwestern Medical Center; Estados UnidosFil: Nguyen, Sapril. University of Texas. Southwestern Medical Center; Estados UnidosFil: Caceres, Alfredo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Brady, Scott T.. Anatomy And Cell Biology, University Of Illinois; Estados UnidosCell Press2005-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/242021Szebenyi, Györgyi; Bollati, Flavia Andrea; Bisbal, Mariano; Sheridan, Shelley; Faas, Laura; et al.; Activity-Driven Dendritic Remodeling Requires Microtubule-Associated Protein 1A; Cell Press; Current Biology; 15; 20; 10-2005; 1820-18260960-9822CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cub.2005.08.069info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960982205012157info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:43Zoai:ri.conicet.gov.ar:11336/242021instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:43.874CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Activity-Driven Dendritic Remodeling Requires Microtubule-Associated Protein 1A
title Activity-Driven Dendritic Remodeling Requires Microtubule-Associated Protein 1A
spellingShingle Activity-Driven Dendritic Remodeling Requires Microtubule-Associated Protein 1A
Szebenyi, Györgyi
NEURONAL POLARITY
DENDRITOGENESIS
SIGNALING MECHANISMS
MAP1A
title_short Activity-Driven Dendritic Remodeling Requires Microtubule-Associated Protein 1A
title_full Activity-Driven Dendritic Remodeling Requires Microtubule-Associated Protein 1A
title_fullStr Activity-Driven Dendritic Remodeling Requires Microtubule-Associated Protein 1A
title_full_unstemmed Activity-Driven Dendritic Remodeling Requires Microtubule-Associated Protein 1A
title_sort Activity-Driven Dendritic Remodeling Requires Microtubule-Associated Protein 1A
dc.creator.none.fl_str_mv Szebenyi, Györgyi
Bollati, Flavia Andrea
Bisbal, Mariano
Sheridan, Shelley
Faas, Laura
Wray, Robin
Haferkamp, Scott
Nguyen, Sapril
Caceres, Alfredo Oscar
Brady, Scott T.
author Szebenyi, Györgyi
author_facet Szebenyi, Györgyi
Bollati, Flavia Andrea
Bisbal, Mariano
Sheridan, Shelley
Faas, Laura
Wray, Robin
Haferkamp, Scott
Nguyen, Sapril
Caceres, Alfredo Oscar
Brady, Scott T.
author_role author
author2 Bollati, Flavia Andrea
Bisbal, Mariano
Sheridan, Shelley
Faas, Laura
Wray, Robin
Haferkamp, Scott
Nguyen, Sapril
Caceres, Alfredo Oscar
Brady, Scott T.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv NEURONAL POLARITY
DENDRITOGENESIS
SIGNALING MECHANISMS
MAP1A
topic NEURONAL POLARITY
DENDRITOGENESIS
SIGNALING MECHANISMS
MAP1A
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Activity-prompted dendritic remodeling leads to calcium-influx-dependent activation of signaling pathways within minutes and gene transcription within hours. However, dendrite growth continues for days and requires extension and stabilization of the cytoskeleton in nascent processes. In addition to binding microtubules, microtubule-associated proteins (MAPs) associate with the actin cytoskeleton, anchor ion channels and signaling complexes, and modulate synaptic growth. MAP2 is predominantly dendritic. MAP1B is at postsynaptic densities (PSD) and modulates ion channel activity, in addition to affecting axon growth. Less is known about MAP1A, but it is also enriched in dendrites at input locations, including PSDs where MAP1A associates with channel complexes and the calcium sensor caldendrin. MAP1A rescued hearing loss in tubby mice. Here we show that MAP1A becomes enriched in dendrites concurrently with dendritic branching and synapse formation in the developing brain; that synaptic activity is required for establishing mature MAP1A expression levels; and that MAP1A expression is required for activity-dependent growth, branching, and stabilization of the dendritic arbor.
Fil: Szebenyi, Györgyi. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Bollati, Flavia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Bisbal, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Sheridan, Shelley. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Faas, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Wray, Robin. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Haferkamp, Scott. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Nguyen, Sapril. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Caceres, Alfredo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Brady, Scott T.. Anatomy And Cell Biology, University Of Illinois; Estados Unidos
description Activity-prompted dendritic remodeling leads to calcium-influx-dependent activation of signaling pathways within minutes and gene transcription within hours. However, dendrite growth continues for days and requires extension and stabilization of the cytoskeleton in nascent processes. In addition to binding microtubules, microtubule-associated proteins (MAPs) associate with the actin cytoskeleton, anchor ion channels and signaling complexes, and modulate synaptic growth. MAP2 is predominantly dendritic. MAP1B is at postsynaptic densities (PSD) and modulates ion channel activity, in addition to affecting axon growth. Less is known about MAP1A, but it is also enriched in dendrites at input locations, including PSDs where MAP1A associates with channel complexes and the calcium sensor caldendrin. MAP1A rescued hearing loss in tubby mice. Here we show that MAP1A becomes enriched in dendrites concurrently with dendritic branching and synapse formation in the developing brain; that synaptic activity is required for establishing mature MAP1A expression levels; and that MAP1A expression is required for activity-dependent growth, branching, and stabilization of the dendritic arbor.
publishDate 2005
dc.date.none.fl_str_mv 2005-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/242021
Szebenyi, Györgyi; Bollati, Flavia Andrea; Bisbal, Mariano; Sheridan, Shelley; Faas, Laura; et al.; Activity-Driven Dendritic Remodeling Requires Microtubule-Associated Protein 1A; Cell Press; Current Biology; 15; 20; 10-2005; 1820-1826
0960-9822
CONICET Digital
CONICET
url http://hdl.handle.net/11336/242021
identifier_str_mv Szebenyi, Györgyi; Bollati, Flavia Andrea; Bisbal, Mariano; Sheridan, Shelley; Faas, Laura; et al.; Activity-Driven Dendritic Remodeling Requires Microtubule-Associated Protein 1A; Cell Press; Current Biology; 15; 20; 10-2005; 1820-1826
0960-9822
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cub.2005.08.069
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960982205012157
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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