Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases
- Autores
- Dos Santos, Célia; Castera, Santiago; Fernandez, José; Rosales, Julieta Soledad; Crescitelli, Franco Jose; Boughen, Santiago; Iastrebner, Marcelo; Guerrero, Osvaldo; Amell Menco, Carlos; Gomez, Mariela; Gonzalez, Natalia Jacqueline; Alberto, Maria Fabiana; Sánchez Luceros, Analía Gabriela
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to vaccine deployment in record time.1 Very rare cases of thrombotic events associated with thrombocytopenia have only emerged after vaccination of millions of people.2 Acquired Thrombotic Thrombocytopenic Purpura (aTTP) is one of the adverse syndromes that has been progressively reported in the literature. This form of thrombotic microangiopathy (TMA) is associated with presence of autoantibodies against ADAMTS13,3 resulting in formation of platelet thrombi within the microcirculation. Case reports showed that several vaccines against SARS-CoV-2 triggered a de novo or relapse episode of aTTP as summarized by Buetler et al.4 Effective treatment needs to be provided as soon as possible to patients with TTP as it can be a fatal disease. Here, we describe four cases of a newly aTTP diagnosis who had received ChAdOx1 nCov-19, the heterologous recombinant adenovirus combination rAd26 and rAd5 (Gam-COVID-Vac, Sputnik-V) or the inactivated whole virus (BBIBP-CorV, Sinopharm) vaccines...
Fil: Dos Santos, Célia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Castera, Santiago. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Fernandez, José. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Rosales, Julieta Soledad. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Crescitelli, Franco Jose. Hospital Italiano Regional del Sur; Argentina
Fil: Boughen, Santiago. Hospital Italiano Regional del Sur; Argentina
Fil: Iastrebner, Marcelo. Sanatorio Sagrado Corazón; Argentina
Fil: Guerrero, Osvaldo. Sanatorio Sagrado Corazón; Argentina
Fil: Amell Menco, Carlos. Sanatorio Sagrado Corazón; Argentina
Fil: Gomez, Mariela. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Gonzalez, Natalia Jacqueline. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Carlos Durand; Argentina
Fil: Alberto, Maria Fabiana. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Sánchez Luceros, Analía Gabriela. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina - Materia
-
TTP
COVID-19
Vaccines - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/265943
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Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 casesDos Santos, CéliaCastera, SantiagoFernandez, JoséRosales, Julieta SoledadCrescitelli, Franco JoseBoughen, SantiagoIastrebner, MarceloGuerrero, OsvaldoAmell Menco, CarlosGomez, MarielaGonzalez, Natalia JacquelineAlberto, Maria FabianaSánchez Luceros, Analía GabrielaTTPCOVID-19Vaccineshttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3The global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to vaccine deployment in record time.1 Very rare cases of thrombotic events associated with thrombocytopenia have only emerged after vaccination of millions of people.2 Acquired Thrombotic Thrombocytopenic Purpura (aTTP) is one of the adverse syndromes that has been progressively reported in the literature. This form of thrombotic microangiopathy (TMA) is associated with presence of autoantibodies against ADAMTS13,3 resulting in formation of platelet thrombi within the microcirculation. Case reports showed that several vaccines against SARS-CoV-2 triggered a de novo or relapse episode of aTTP as summarized by Buetler et al.4 Effective treatment needs to be provided as soon as possible to patients with TTP as it can be a fatal disease. Here, we describe four cases of a newly aTTP diagnosis who had received ChAdOx1 nCov-19, the heterologous recombinant adenovirus combination rAd26 and rAd5 (Gam-COVID-Vac, Sputnik-V) or the inactivated whole virus (BBIBP-CorV, Sinopharm) vaccines...Fil: Dos Santos, Célia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Castera, Santiago. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; ArgentinaFil: Fernandez, José. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Rosales, Julieta Soledad. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Crescitelli, Franco Jose. Hospital Italiano Regional del Sur; ArgentinaFil: Boughen, Santiago. Hospital Italiano Regional del Sur; ArgentinaFil: Iastrebner, Marcelo. Sanatorio Sagrado Corazón; ArgentinaFil: Guerrero, Osvaldo. Sanatorio Sagrado Corazón; ArgentinaFil: Amell Menco, Carlos. Sanatorio Sagrado Corazón; ArgentinaFil: Gomez, Mariela. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Gonzalez, Natalia Jacqueline. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Carlos Durand; ArgentinaFil: Alberto, Maria Fabiana. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; ArgentinaFil: Sánchez Luceros, Analía Gabriela. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaElsevier2024-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/265943Dos Santos, Célia; Castera, Santiago; Fernandez, José; Rosales, Julieta Soledad; Crescitelli, Franco Jose; et al.; Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases; Elsevier; Hematology, Transfusion and Cell Therapy; 46; 4; 10-2024; 511-5152531-13792531-1387CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.htct.2023.11.008info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2531137923026056info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:45:08Zoai:ri.conicet.gov.ar:11336/265943instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:45:09.165CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases |
title |
Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases |
spellingShingle |
Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases Dos Santos, Célia TTP COVID-19 Vaccines |
title_short |
Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases |
title_full |
Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases |
title_fullStr |
Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases |
title_full_unstemmed |
Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases |
title_sort |
Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases |
dc.creator.none.fl_str_mv |
Dos Santos, Célia Castera, Santiago Fernandez, José Rosales, Julieta Soledad Crescitelli, Franco Jose Boughen, Santiago Iastrebner, Marcelo Guerrero, Osvaldo Amell Menco, Carlos Gomez, Mariela Gonzalez, Natalia Jacqueline Alberto, Maria Fabiana Sánchez Luceros, Analía Gabriela |
author |
Dos Santos, Célia |
author_facet |
Dos Santos, Célia Castera, Santiago Fernandez, José Rosales, Julieta Soledad Crescitelli, Franco Jose Boughen, Santiago Iastrebner, Marcelo Guerrero, Osvaldo Amell Menco, Carlos Gomez, Mariela Gonzalez, Natalia Jacqueline Alberto, Maria Fabiana Sánchez Luceros, Analía Gabriela |
author_role |
author |
author2 |
Castera, Santiago Fernandez, José Rosales, Julieta Soledad Crescitelli, Franco Jose Boughen, Santiago Iastrebner, Marcelo Guerrero, Osvaldo Amell Menco, Carlos Gomez, Mariela Gonzalez, Natalia Jacqueline Alberto, Maria Fabiana Sánchez Luceros, Analía Gabriela |
author2_role |
author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
TTP COVID-19 Vaccines |
topic |
TTP COVID-19 Vaccines |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.5 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to vaccine deployment in record time.1 Very rare cases of thrombotic events associated with thrombocytopenia have only emerged after vaccination of millions of people.2 Acquired Thrombotic Thrombocytopenic Purpura (aTTP) is one of the adverse syndromes that has been progressively reported in the literature. This form of thrombotic microangiopathy (TMA) is associated with presence of autoantibodies against ADAMTS13,3 resulting in formation of platelet thrombi within the microcirculation. Case reports showed that several vaccines against SARS-CoV-2 triggered a de novo or relapse episode of aTTP as summarized by Buetler et al.4 Effective treatment needs to be provided as soon as possible to patients with TTP as it can be a fatal disease. Here, we describe four cases of a newly aTTP diagnosis who had received ChAdOx1 nCov-19, the heterologous recombinant adenovirus combination rAd26 and rAd5 (Gam-COVID-Vac, Sputnik-V) or the inactivated whole virus (BBIBP-CorV, Sinopharm) vaccines... Fil: Dos Santos, Célia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Castera, Santiago. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina Fil: Fernandez, José. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina Fil: Rosales, Julieta Soledad. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina Fil: Crescitelli, Franco Jose. Hospital Italiano Regional del Sur; Argentina Fil: Boughen, Santiago. Hospital Italiano Regional del Sur; Argentina Fil: Iastrebner, Marcelo. Sanatorio Sagrado Corazón; Argentina Fil: Guerrero, Osvaldo. Sanatorio Sagrado Corazón; Argentina Fil: Amell Menco, Carlos. Sanatorio Sagrado Corazón; Argentina Fil: Gomez, Mariela. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Gonzalez, Natalia Jacqueline. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Carlos Durand; Argentina Fil: Alberto, Maria Fabiana. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina Fil: Sánchez Luceros, Analía Gabriela. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina |
description |
The global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to vaccine deployment in record time.1 Very rare cases of thrombotic events associated with thrombocytopenia have only emerged after vaccination of millions of people.2 Acquired Thrombotic Thrombocytopenic Purpura (aTTP) is one of the adverse syndromes that has been progressively reported in the literature. This form of thrombotic microangiopathy (TMA) is associated with presence of autoantibodies against ADAMTS13,3 resulting in formation of platelet thrombi within the microcirculation. Case reports showed that several vaccines against SARS-CoV-2 triggered a de novo or relapse episode of aTTP as summarized by Buetler et al.4 Effective treatment needs to be provided as soon as possible to patients with TTP as it can be a fatal disease. Here, we describe four cases of a newly aTTP diagnosis who had received ChAdOx1 nCov-19, the heterologous recombinant adenovirus combination rAd26 and rAd5 (Gam-COVID-Vac, Sputnik-V) or the inactivated whole virus (BBIBP-CorV, Sinopharm) vaccines... |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/265943 Dos Santos, Célia; Castera, Santiago; Fernandez, José; Rosales, Julieta Soledad; Crescitelli, Franco Jose; et al.; Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases; Elsevier; Hematology, Transfusion and Cell Therapy; 46; 4; 10-2024; 511-515 2531-1379 2531-1387 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/265943 |
identifier_str_mv |
Dos Santos, Célia; Castera, Santiago; Fernandez, José; Rosales, Julieta Soledad; Crescitelli, Franco Jose; et al.; Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases; Elsevier; Hematology, Transfusion and Cell Therapy; 46; 4; 10-2024; 511-515 2531-1379 2531-1387 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.htct.2023.11.008 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2531137923026056 |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
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openAccess |
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https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
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application/pdf application/pdf application/pdf |
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Elsevier |
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Elsevier |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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