Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases

Autores
Dos Santos, Célia; Castera, Santiago; Fernandez, José; Rosales, Julieta Soledad; Crescitelli, Franco Jose; Boughen, Santiago; Iastrebner, Marcelo; Guerrero, Osvaldo; Amell Menco, Carlos; Gomez, Mariela; Gonzalez, Natalia Jacqueline; Alberto, Maria Fabiana; Sánchez Luceros, Analía Gabriela
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to vaccine deployment in record time.1 Very rare cases of thrombotic events associated with thrombocytopenia have only emerged after vaccination of millions of people.2 Acquired Thrombotic Thrombocytopenic Purpura (aTTP) is one of the adverse syndromes that has been progressively reported in the literature. This form of thrombotic microangiopathy (TMA) is associated with presence of autoantibodies against ADAMTS13,3 resulting in formation of platelet thrombi within the microcirculation. Case reports showed that several vaccines against SARS-CoV-2 triggered a de novo or relapse episode of aTTP as summarized by Buetler et al.4 Effective treatment needs to be provided as soon as possible to patients with TTP as it can be a fatal disease. Here, we describe four cases of a newly aTTP diagnosis who had received ChAdOx1 nCov-19, the heterologous recombinant adenovirus combination rAd26 and rAd5 (Gam-COVID-Vac, Sputnik-V) or the inactivated whole virus (BBIBP-CorV, Sinopharm) vaccines...
Fil: Dos Santos, Célia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Castera, Santiago. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Fernandez, José. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Rosales, Julieta Soledad. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Crescitelli, Franco Jose. Hospital Italiano Regional del Sur; Argentina
Fil: Boughen, Santiago. Hospital Italiano Regional del Sur; Argentina
Fil: Iastrebner, Marcelo. Sanatorio Sagrado Corazón; Argentina
Fil: Guerrero, Osvaldo. Sanatorio Sagrado Corazón; Argentina
Fil: Amell Menco, Carlos. Sanatorio Sagrado Corazón; Argentina
Fil: Gomez, Mariela. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Gonzalez, Natalia Jacqueline. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Carlos Durand; Argentina
Fil: Alberto, Maria Fabiana. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Sánchez Luceros, Analía Gabriela. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Materia
TTP
COVID-19
Vaccines
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/265943

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network_name_str CONICET Digital (CONICET)
spelling Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 casesDos Santos, CéliaCastera, SantiagoFernandez, JoséRosales, Julieta SoledadCrescitelli, Franco JoseBoughen, SantiagoIastrebner, MarceloGuerrero, OsvaldoAmell Menco, CarlosGomez, MarielaGonzalez, Natalia JacquelineAlberto, Maria FabianaSánchez Luceros, Analía GabrielaTTPCOVID-19Vaccineshttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3The global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to vaccine deployment in record time.1 Very rare cases of thrombotic events associated with thrombocytopenia have only emerged after vaccination of millions of people.2 Acquired Thrombotic Thrombocytopenic Purpura (aTTP) is one of the adverse syndromes that has been progressively reported in the literature. This form of thrombotic microangiopathy (TMA) is associated with presence of autoantibodies against ADAMTS13,3 resulting in formation of platelet thrombi within the microcirculation. Case reports showed that several vaccines against SARS-CoV-2 triggered a de novo or relapse episode of aTTP as summarized by Buetler et al.4 Effective treatment needs to be provided as soon as possible to patients with TTP as it can be a fatal disease. Here, we describe four cases of a newly aTTP diagnosis who had received ChAdOx1 nCov-19, the heterologous recombinant adenovirus combination rAd26 and rAd5 (Gam-COVID-Vac, Sputnik-V) or the inactivated whole virus (BBIBP-CorV, Sinopharm) vaccines...Fil: Dos Santos, Célia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Castera, Santiago. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; ArgentinaFil: Fernandez, José. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Rosales, Julieta Soledad. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Crescitelli, Franco Jose. Hospital Italiano Regional del Sur; ArgentinaFil: Boughen, Santiago. Hospital Italiano Regional del Sur; ArgentinaFil: Iastrebner, Marcelo. Sanatorio Sagrado Corazón; ArgentinaFil: Guerrero, Osvaldo. Sanatorio Sagrado Corazón; ArgentinaFil: Amell Menco, Carlos. Sanatorio Sagrado Corazón; ArgentinaFil: Gomez, Mariela. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Gonzalez, Natalia Jacqueline. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Carlos Durand; ArgentinaFil: Alberto, Maria Fabiana. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; ArgentinaFil: Sánchez Luceros, Analía Gabriela. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaElsevier2024-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/265943Dos Santos, Célia; Castera, Santiago; Fernandez, José; Rosales, Julieta Soledad; Crescitelli, Franco Jose; et al.; Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases; Elsevier; Hematology, Transfusion and Cell Therapy; 46; 4; 10-2024; 511-5152531-13792531-1387CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.htct.2023.11.008info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2531137923026056info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:45:08Zoai:ri.conicet.gov.ar:11336/265943instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:45:09.165CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases
title Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases
spellingShingle Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases
Dos Santos, Célia
TTP
COVID-19
Vaccines
title_short Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases
title_full Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases
title_fullStr Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases
title_full_unstemmed Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases
title_sort Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases
dc.creator.none.fl_str_mv Dos Santos, Célia
Castera, Santiago
Fernandez, José
Rosales, Julieta Soledad
Crescitelli, Franco Jose
Boughen, Santiago
Iastrebner, Marcelo
Guerrero, Osvaldo
Amell Menco, Carlos
Gomez, Mariela
Gonzalez, Natalia Jacqueline
Alberto, Maria Fabiana
Sánchez Luceros, Analía Gabriela
author Dos Santos, Célia
author_facet Dos Santos, Célia
Castera, Santiago
Fernandez, José
Rosales, Julieta Soledad
Crescitelli, Franco Jose
Boughen, Santiago
Iastrebner, Marcelo
Guerrero, Osvaldo
Amell Menco, Carlos
Gomez, Mariela
Gonzalez, Natalia Jacqueline
Alberto, Maria Fabiana
Sánchez Luceros, Analía Gabriela
author_role author
author2 Castera, Santiago
Fernandez, José
Rosales, Julieta Soledad
Crescitelli, Franco Jose
Boughen, Santiago
Iastrebner, Marcelo
Guerrero, Osvaldo
Amell Menco, Carlos
Gomez, Mariela
Gonzalez, Natalia Jacqueline
Alberto, Maria Fabiana
Sánchez Luceros, Analía Gabriela
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv TTP
COVID-19
Vaccines
topic TTP
COVID-19
Vaccines
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to vaccine deployment in record time.1 Very rare cases of thrombotic events associated with thrombocytopenia have only emerged after vaccination of millions of people.2 Acquired Thrombotic Thrombocytopenic Purpura (aTTP) is one of the adverse syndromes that has been progressively reported in the literature. This form of thrombotic microangiopathy (TMA) is associated with presence of autoantibodies against ADAMTS13,3 resulting in formation of platelet thrombi within the microcirculation. Case reports showed that several vaccines against SARS-CoV-2 triggered a de novo or relapse episode of aTTP as summarized by Buetler et al.4 Effective treatment needs to be provided as soon as possible to patients with TTP as it can be a fatal disease. Here, we describe four cases of a newly aTTP diagnosis who had received ChAdOx1 nCov-19, the heterologous recombinant adenovirus combination rAd26 and rAd5 (Gam-COVID-Vac, Sputnik-V) or the inactivated whole virus (BBIBP-CorV, Sinopharm) vaccines...
Fil: Dos Santos, Célia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Castera, Santiago. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Fernandez, José. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Rosales, Julieta Soledad. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Crescitelli, Franco Jose. Hospital Italiano Regional del Sur; Argentina
Fil: Boughen, Santiago. Hospital Italiano Regional del Sur; Argentina
Fil: Iastrebner, Marcelo. Sanatorio Sagrado Corazón; Argentina
Fil: Guerrero, Osvaldo. Sanatorio Sagrado Corazón; Argentina
Fil: Amell Menco, Carlos. Sanatorio Sagrado Corazón; Argentina
Fil: Gomez, Mariela. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Gonzalez, Natalia Jacqueline. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Carlos Durand; Argentina
Fil: Alberto, Maria Fabiana. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Sánchez Luceros, Analía Gabriela. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
description The global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to vaccine deployment in record time.1 Very rare cases of thrombotic events associated with thrombocytopenia have only emerged after vaccination of millions of people.2 Acquired Thrombotic Thrombocytopenic Purpura (aTTP) is one of the adverse syndromes that has been progressively reported in the literature. This form of thrombotic microangiopathy (TMA) is associated with presence of autoantibodies against ADAMTS13,3 resulting in formation of platelet thrombi within the microcirculation. Case reports showed that several vaccines against SARS-CoV-2 triggered a de novo or relapse episode of aTTP as summarized by Buetler et al.4 Effective treatment needs to be provided as soon as possible to patients with TTP as it can be a fatal disease. Here, we describe four cases of a newly aTTP diagnosis who had received ChAdOx1 nCov-19, the heterologous recombinant adenovirus combination rAd26 and rAd5 (Gam-COVID-Vac, Sputnik-V) or the inactivated whole virus (BBIBP-CorV, Sinopharm) vaccines...
publishDate 2024
dc.date.none.fl_str_mv 2024-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/265943
Dos Santos, Célia; Castera, Santiago; Fernandez, José; Rosales, Julieta Soledad; Crescitelli, Franco Jose; et al.; Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases; Elsevier; Hematology, Transfusion and Cell Therapy; 46; 4; 10-2024; 511-515
2531-1379
2531-1387
CONICET Digital
CONICET
url http://hdl.handle.net/11336/265943
identifier_str_mv Dos Santos, Célia; Castera, Santiago; Fernandez, José; Rosales, Julieta Soledad; Crescitelli, Franco Jose; et al.; Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: Apropos of 4 cases; Elsevier; Hematology, Transfusion and Cell Therapy; 46; 4; 10-2024; 511-515
2531-1379
2531-1387
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2531137923026056
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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