Recommendations for Long-Term Follow-up of Adults with Heritable Retinoblastoma

• Autores: Tonorezos, Emily S.; Friedman, Danielle Novetsky; Barnea, Dana; Bosscha, Machteld I.; Chantada, Guillermo Luis; Dommering, Charlotte J.; de Graaf, Pim; Dunkel, Ira J.; Fabius, Armida W.M.; Francis, Jasmine H.; Greer, Mary Louise C.; Kleinerman, Ruth A.; Kors, Wijnanda A.; Laughlin, Suzanne; Moll, Annette C.; Morton, Lindsay M.; Temming, Petra; Tucker, Margaret A.; van Leeuwen, Flora E.; Walsh, Michael F.; Oeffinger, Kevin C.; Abramson, David
• Año de publicación: 2020
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: Retinoblastoma; Second tumors; Survivor; Radiotherapy
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Purpose: To generate recommendations for long-term follow-up of adult survivors of heritable retinoblastoma. Design: We convened a meeting of providers from retinoblastoma centers around the world to review the state of the science and to evaluate the published evidence. Participants: Retinoblastoma is a rare childhood cancer of the retina. Approximately 40% of retinoblastoma cases are heritable, resulting from a germline mutation in RB1. Dramatic improvements in treatment and supportive care have resulted in a growing adult survivor population. However, survivors of heritable retinoblastoma have a significantly increased risk of subsequent malignant neoplasms, particularly bone and soft tissue sarcomas, uterine leiomyosarcoma, melanomas, and radiotherapy-related central nervous system tumors, which are associated with excess morbidity and mortality. Despite these risks, no surveillance recommendations for this population currently are in place, and surveillance practices vary widely by center. Methods: Following the Institute of Medicine procedure for clinical practice guideline development, a PubMed, EMBASE, and Web of Science search was performed, resulting in 139 articles; after abstract and full-text review, 37 articles underwent detailed data abstraction to quantify risk and evidence regarding surveillance, if available. During an in-person meeting, evidence was presented and discussed, resulting in consensus recommendations. Main Outcome Measures: Diagnosis and mortality from subsequent neoplasm. Results: Although evidence for risk of subsequent neoplasm, especially sarcoma and melanoma, was significant, evidence supporting routine testing of asymptomatic survivors was not identified. Skin examination for melanoma and prompt evaluation of signs and symptoms of head and neck disease were determined to be prudent. Conclusions: This review of the literature confirmed some of the common second cancers in retinoblastoma survivors but found little evidence for a benefit from currently available surveillance for these malignancies. Future research should incorporate international partners, patients, and family members.
Fil: Tonorezos, Emily S.. Memorial Sloan Kettering Cancer Center; Estados Unidos. Weill Cornell Medical College; Estados Unidos
Fil: Friedman, Danielle Novetsky. Memorial Sloan Kettering Cancer Center; Estados Unidos
Fil: Barnea, Dana. Tel Aviv Sourasky Medical Center; Israel
Fil: Bosscha, Machteld I.. Vrije Universiteit Amsterdam; Países Bajos
Fil: Chantada, Guillermo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Dommering, Charlotte J.. Vrije Universiteit Amsterdam; Países Bajos
Fil: de Graaf, Pim. Vrije Universiteit Amsterdam; Países Bajos
Fil: Dunkel, Ira J.. Weill Cornell Medicine; Estados Unidos. Memorial Sloan Kettering Cancer Center; Estados Unidos
Fil: Fabius, Armida W.M.. Vrije Universiteit Amsterdam; Países Bajos
Fil: Francis, Jasmine H.. Memorial Sloan Kettering Cancer Center; Estados Unidos
Fil: Greer, Mary Louise C.. University Of Toronto. Hospital For Sick Children; Canadá
Fil: Kleinerman, Ruth A.. National Institutes of Health; Estados Unidos
Fil: Kors, Wijnanda A.. Vrije Universiteit Amsterdam; Países Bajos
Fil: Laughlin, Suzanne. University Of Toronto. Hospital For Sick Children; Canadá
Fil: Moll, Annette C.. Vrije Universiteit Amsterdam; Países Bajos
Fil: Morton, Lindsay M.. National Institutes of Health; Estados Unidos
Fil: Temming, Petra. Universitat Essen; Alemania
Fil: Tucker, Margaret A.. National Institutes of Health; Estados Unidos
Fil: van Leeuwen, Flora E.. The Netherlands Cancer Institute; Países Bajos
Fil: Walsh, Michael F.. Memorial Sloan-kettering Cancer Center; España
Fil: Oeffinger, Kevin C.. University of Duke; Estados Unidos
Fil: Abramson, David. Memorial Sloan-kettering Cancer Center; España. Weill Cornell Medicine; Estados Unidos