PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational stu...

Autores
Willacker, L.; Raiser, T. M.; Bassi, M.; Bender, A.; Comanducci, A.; Rosanova, M.; Sobel, N.; Arzi, A.; Belloli, Laouen Mayal Louan; Casarotto, S.; Colombo, M.; Derchi, C. C.; Fló Rama, E.; Grill, E.; Hohl, M.; Kuehlmeyer, K.; Manasova, D.; Rosenfelder, M. J.; Valota, C.; Sitt, J. D.
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Disorders of consciousness (DoC) are severe neurological conditions in which consciousness is impaired to various degrees. They are caused by injury or malfunction of neural systems regulating arousal and awareness. Over the last decades, major efforts in improving and individualizing diagnostic and prognostic accuracy for patients affected by DoC have been made, mainly focusing on introducing multimodal assessments to complement behavioral examination. The present EU-funded multicentric research project “PerBrain” is aimed at developing an individualized diagnostic hierarchical pathway guided by both behavior and multimodal neurodiagnostics for DoC patients. Methods: In this project, each enrolled patient undergoes repetitive behavioral, clinical, and neurodiagnostic assessments according to a patient-tailored multi-layer workflow. Multimodal diagnostic acquisitions using state-of-the-art techniques at different stages of the patients’ clinical evolution are performed. The techniques applied comprise well-established behavioral scales, innovative neurophysiological techniques (such as quantitative electroencephalography and transcranial magnetic stimulation combined with electroencephalography), structural and resting-state functional magnetic resonance imaging, and measurements of physiological activity (i.e. nasal airflow respiration). In addition, the well-being and treatment decision attitudes of patients’ informal caregivers (primarily family members) are investigated. Patient and caregiver assessments are performed at multiple time points within one year after acquired brain injury, starting at the acute disease phase. Discussion: Accurate classification and outcome prediction of DoC are of crucial importance for affected patients as well as their caregivers, as individual rehabilitation strategies and treatment decisions are critically dependent on the latter. The PerBrain project aims at optimizing individual DoC diagnosis and accuracy of outcome prediction by integrating data from the suggested multimodal examination methods into a personalized hierarchical diagnosis and prognosis procedure. Using the parallel tracking of both patients’ neurological status and their caregivers’ mental situation, well-being, and treatment decision attitudes from the acute to the chronic phase of the disease and across different countries, this project aims at significantly contributing to the current clinical routine of DoC patients and their family members.
Fil: Willacker, L.. Ludwig Maximilians Universitat; Alemania
Fil: Raiser, T. M.. Ludwig Maximilians Universitat; Alemania
Fil: Bassi, M.. Università degli Studi di Milano; Italia
Fil: Bender, A.. Ludwig Maximilians Universitat; Alemania
Fil: Comanducci, A.. Università degli Studi di Milano; Italia
Fil: Rosanova, M.. Università degli Studi di Milano; Italia
Fil: Sobel, N.. Weizmann Institute of Science; Israel
Fil: Arzi, A.. Inserm; Francia
Fil: Belloli, Laouen Mayal Louan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Investigación en Ciencias de la Computación. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Investigación en Ciencias de la Computación; Argentina
Fil: Casarotto, S.. Università degli Studi di Milano; Italia
Fil: Colombo, M.. No especifíca;
Fil: Derchi, C. C.. Inserm; Francia
Fil: Fló Rama, E.. Weizmann Institute Of Science.; Israel
Fil: Grill, E.. Technische Universitat München; Alemania
Fil: Hohl, M.. Centre de Recherche de I'Institut du Cerveau et de la Moelle Epinière; Francia
Fil: Kuehlmeyer, K.. Ludwig Maximilians Universitat; Alemania
Fil: Manasova, D.. Inserm; Francia
Fil: Rosenfelder, M. J.. Universitat Ulm; Alemania
Fil: Valota, C.. Università degli Studi di Milano; Italia
Fil: Sitt, J. D.. Inserm; Francia
Materia
Disorders of Consciousness
Study protocol
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/275320
Acceder
id CONICETDig_4d5df114ce60341bec36dac029e28b51
oai_identifier_str oai:ri.conicet.gov.ar:11336/275320
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational studyWillacker, L.Raiser, T. M.Bassi, M.Bender, A.Comanducci, A.Rosanova, M.Sobel, N.Arzi, A.Belloli, Laouen Mayal LouanCasarotto, S.Colombo, M.Derchi, C. C.Fló Rama, E.Grill, E.Hohl, M.Kuehlmeyer, K.Manasova, D.Rosenfelder, M. J.Valota, C.Sitt, J. D.Disorders of ConsciousnessStudy protocolhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: Disorders of consciousness (DoC) are severe neurological conditions in which consciousness is impaired to various degrees. They are caused by injury or malfunction of neural systems regulating arousal and awareness. Over the last decades, major efforts in improving and individualizing diagnostic and prognostic accuracy for patients affected by DoC have been made, mainly focusing on introducing multimodal assessments to complement behavioral examination. The present EU-funded multicentric research project “PerBrain” is aimed at developing an individualized diagnostic hierarchical pathway guided by both behavior and multimodal neurodiagnostics for DoC patients. Methods: In this project, each enrolled patient undergoes repetitive behavioral, clinical, and neurodiagnostic assessments according to a patient-tailored multi-layer workflow. Multimodal diagnostic acquisitions using state-of-the-art techniques at different stages of the patients’ clinical evolution are performed. The techniques applied comprise well-established behavioral scales, innovative neurophysiological techniques (such as quantitative electroencephalography and transcranial magnetic stimulation combined with electroencephalography), structural and resting-state functional magnetic resonance imaging, and measurements of physiological activity (i.e. nasal airflow respiration). In addition, the well-being and treatment decision attitudes of patients’ informal caregivers (primarily family members) are investigated. Patient and caregiver assessments are performed at multiple time points within one year after acquired brain injury, starting at the acute disease phase. Discussion: Accurate classification and outcome prediction of DoC are of crucial importance for affected patients as well as their caregivers, as individual rehabilitation strategies and treatment decisions are critically dependent on the latter. The PerBrain project aims at optimizing individual DoC diagnosis and accuracy of outcome prediction by integrating data from the suggested multimodal examination methods into a personalized hierarchical diagnosis and prognosis procedure. Using the parallel tracking of both patients’ neurological status and their caregivers’ mental situation, well-being, and treatment decision attitudes from the acute to the chronic phase of the disease and across different countries, this project aims at significantly contributing to the current clinical routine of DoC patients and their family members.Fil: Willacker, L.. Ludwig Maximilians Universitat; AlemaniaFil: Raiser, T. M.. Ludwig Maximilians Universitat; AlemaniaFil: Bassi, M.. Università degli Studi di Milano; ItaliaFil: Bender, A.. Ludwig Maximilians Universitat; AlemaniaFil: Comanducci, A.. Università degli Studi di Milano; ItaliaFil: Rosanova, M.. Università degli Studi di Milano; ItaliaFil: Sobel, N.. Weizmann Institute of Science; IsraelFil: Arzi, A.. Inserm; FranciaFil: Belloli, Laouen Mayal Louan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Investigación en Ciencias de la Computación. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Investigación en Ciencias de la Computación; ArgentinaFil: Casarotto, S.. Università degli Studi di Milano; ItaliaFil: Colombo, M.. No especifíca;Fil: Derchi, C. C.. Inserm; FranciaFil: Fló Rama, E.. Weizmann Institute Of Science.; IsraelFil: Grill, E.. Technische Universitat München; AlemaniaFil: Hohl, M.. Centre de Recherche de I'Institut du Cerveau et de la Moelle Epinière; FranciaFil: Kuehlmeyer, K.. Ludwig Maximilians Universitat; AlemaniaFil: Manasova, D.. Inserm; FranciaFil: Rosenfelder, M. J.. Universitat Ulm; AlemaniaFil: Valota, C.. Università degli Studi di Milano; ItaliaFil: Sitt, J. D.. Inserm; FranciaBioMed Central2022-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/275320Willacker, L.; Raiser, T. M.; Bassi, M.; Bender, A.; Comanducci, A.; et al.; PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study; BioMed Central; Bmc Neurology; 22; 1; 12-2022; 1-111471-2377CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-022-02958-xinfo:eu-repo/semantics/altIdentifier/doi/10.1186/s12883-022-02958-xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-12-03T09:00:42Zoai:ri.conicet.gov.ar:11336/275320instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-12-03 09:00:43.216CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study
title PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study
spellingShingle PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study
Willacker, L.
Disorders of Consciousness
Study protocol
title_short PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study
title_full PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study
title_fullStr PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study
title_full_unstemmed PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study
title_sort PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study
dc.creator.none.fl_str_mv Willacker, L.
Raiser, T. M.
Bassi, M.
Bender, A.
Comanducci, A.
Rosanova, M.
Sobel, N.
Arzi, A.
Belloli, Laouen Mayal Louan
Casarotto, S.
Colombo, M.
Derchi, C. C.
Fló Rama, E.
Grill, E.
Hohl, M.
Kuehlmeyer, K.
Manasova, D.
Rosenfelder, M. J.
Valota, C.
Sitt, J. D.
author Willacker, L.
author_facet Willacker, L.
Raiser, T. M.
Bassi, M.
Bender, A.
Comanducci, A.
Rosanova, M.
Sobel, N.
Arzi, A.
Belloli, Laouen Mayal Louan
Casarotto, S.
Colombo, M.
Derchi, C. C.
Fló Rama, E.
Grill, E.
Hohl, M.
Kuehlmeyer, K.
Manasova, D.
Rosenfelder, M. J.
Valota, C.
Sitt, J. D.
author_role author
author2 Raiser, T. M.
Bassi, M.
Bender, A.
Comanducci, A.
Rosanova, M.
Sobel, N.
Arzi, A.
Belloli, Laouen Mayal Louan
Casarotto, S.
Colombo, M.
Derchi, C. C.
Fló Rama, E.
Grill, E.
Hohl, M.
Kuehlmeyer, K.
Manasova, D.
Rosenfelder, M. J.
Valota, C.
Sitt, J. D.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Disorders of Consciousness
Study protocol
topic Disorders of Consciousness
Study protocol
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Disorders of consciousness (DoC) are severe neurological conditions in which consciousness is impaired to various degrees. They are caused by injury or malfunction of neural systems regulating arousal and awareness. Over the last decades, major efforts in improving and individualizing diagnostic and prognostic accuracy for patients affected by DoC have been made, mainly focusing on introducing multimodal assessments to complement behavioral examination. The present EU-funded multicentric research project “PerBrain” is aimed at developing an individualized diagnostic hierarchical pathway guided by both behavior and multimodal neurodiagnostics for DoC patients. Methods: In this project, each enrolled patient undergoes repetitive behavioral, clinical, and neurodiagnostic assessments according to a patient-tailored multi-layer workflow. Multimodal diagnostic acquisitions using state-of-the-art techniques at different stages of the patients’ clinical evolution are performed. The techniques applied comprise well-established behavioral scales, innovative neurophysiological techniques (such as quantitative electroencephalography and transcranial magnetic stimulation combined with electroencephalography), structural and resting-state functional magnetic resonance imaging, and measurements of physiological activity (i.e. nasal airflow respiration). In addition, the well-being and treatment decision attitudes of patients’ informal caregivers (primarily family members) are investigated. Patient and caregiver assessments are performed at multiple time points within one year after acquired brain injury, starting at the acute disease phase. Discussion: Accurate classification and outcome prediction of DoC are of crucial importance for affected patients as well as their caregivers, as individual rehabilitation strategies and treatment decisions are critically dependent on the latter. The PerBrain project aims at optimizing individual DoC diagnosis and accuracy of outcome prediction by integrating data from the suggested multimodal examination methods into a personalized hierarchical diagnosis and prognosis procedure. Using the parallel tracking of both patients’ neurological status and their caregivers’ mental situation, well-being, and treatment decision attitudes from the acute to the chronic phase of the disease and across different countries, this project aims at significantly contributing to the current clinical routine of DoC patients and their family members.
Fil: Willacker, L.. Ludwig Maximilians Universitat; Alemania
Fil: Raiser, T. M.. Ludwig Maximilians Universitat; Alemania
Fil: Bassi, M.. Università degli Studi di Milano; Italia
Fil: Bender, A.. Ludwig Maximilians Universitat; Alemania
Fil: Comanducci, A.. Università degli Studi di Milano; Italia
Fil: Rosanova, M.. Università degli Studi di Milano; Italia
Fil: Sobel, N.. Weizmann Institute of Science; Israel
Fil: Arzi, A.. Inserm; Francia
Fil: Belloli, Laouen Mayal Louan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Investigación en Ciencias de la Computación. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Investigación en Ciencias de la Computación; Argentina
Fil: Casarotto, S.. Università degli Studi di Milano; Italia
Fil: Colombo, M.. No especifíca;
Fil: Derchi, C. C.. Inserm; Francia
Fil: Fló Rama, E.. Weizmann Institute Of Science.; Israel
Fil: Grill, E.. Technische Universitat München; Alemania
Fil: Hohl, M.. Centre de Recherche de I'Institut du Cerveau et de la Moelle Epinière; Francia
Fil: Kuehlmeyer, K.. Ludwig Maximilians Universitat; Alemania
Fil: Manasova, D.. Inserm; Francia
Fil: Rosenfelder, M. J.. Universitat Ulm; Alemania
Fil: Valota, C.. Università degli Studi di Milano; Italia
Fil: Sitt, J. D.. Inserm; Francia
description Background: Disorders of consciousness (DoC) are severe neurological conditions in which consciousness is impaired to various degrees. They are caused by injury or malfunction of neural systems regulating arousal and awareness. Over the last decades, major efforts in improving and individualizing diagnostic and prognostic accuracy for patients affected by DoC have been made, mainly focusing on introducing multimodal assessments to complement behavioral examination. The present EU-funded multicentric research project “PerBrain” is aimed at developing an individualized diagnostic hierarchical pathway guided by both behavior and multimodal neurodiagnostics for DoC patients. Methods: In this project, each enrolled patient undergoes repetitive behavioral, clinical, and neurodiagnostic assessments according to a patient-tailored multi-layer workflow. Multimodal diagnostic acquisitions using state-of-the-art techniques at different stages of the patients’ clinical evolution are performed. The techniques applied comprise well-established behavioral scales, innovative neurophysiological techniques (such as quantitative electroencephalography and transcranial magnetic stimulation combined with electroencephalography), structural and resting-state functional magnetic resonance imaging, and measurements of physiological activity (i.e. nasal airflow respiration). In addition, the well-being and treatment decision attitudes of patients’ informal caregivers (primarily family members) are investigated. Patient and caregiver assessments are performed at multiple time points within one year after acquired brain injury, starting at the acute disease phase. Discussion: Accurate classification and outcome prediction of DoC are of crucial importance for affected patients as well as their caregivers, as individual rehabilitation strategies and treatment decisions are critically dependent on the latter. The PerBrain project aims at optimizing individual DoC diagnosis and accuracy of outcome prediction by integrating data from the suggested multimodal examination methods into a personalized hierarchical diagnosis and prognosis procedure. Using the parallel tracking of both patients’ neurological status and their caregivers’ mental situation, well-being, and treatment decision attitudes from the acute to the chronic phase of the disease and across different countries, this project aims at significantly contributing to the current clinical routine of DoC patients and their family members.
publishDate 2022
dc.date.none.fl_str_mv 2022-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/275320
Willacker, L.; Raiser, T. M.; Bassi, M.; Bender, A.; Comanducci, A.; et al.; PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study; BioMed Central; Bmc Neurology; 22; 1; 12-2022; 1-11
1471-2377
CONICET Digital
CONICET
url http://hdl.handle.net/11336/275320
identifier_str_mv Willacker, L.; Raiser, T. M.; Bassi, M.; Bender, A.; Comanducci, A.; et al.; PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study; BioMed Central; Bmc Neurology; 22; 1; 12-2022; 1-11
1471-2377
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-022-02958-x
info:eu-repo/semantics/altIdentifier/doi/10.1186/s12883-022-02958-x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1850505180772040704
score 13.275514

Publicaciones similares