Lipogenic enzyme activities and glucose uptake in fat tissue of dyslipemic, insulin-resistant rats: Effects of fish oil

Autores
Rossi, Andrea Silvana; Lombardo, Yolanda B.; Chicco, Adriana Graciela
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: The purposes of the present work were twofold: (1) investigate same mechanisms involvedin the development of fat cell hypertrophy in the experimental model of dyslipidemia andwhole-body insulin resistance induced in rats chronically fed a sucrose-rich diet (SRD); and (2) analyzethe possible beneficial effect of fish oil on these mechanisms.Methods: For 6 mo, male Wistar rats received a sucrose-rich diet (62.5% w/w sucrose, 8% corn oil)or a control diet in which sucrose was replaced by starch. After this period, the sucrose-fed animalswere divided randomly into two groups: the first one continued with the same diet up to 8 mo andthe second one received the same diet, but with corn oil replaced by 7% fish oil þ 1 % corn oil.Rats were fed with this diet for the next 2 mo.Results: Although an enlarged fat cell lipolysis and an impaired insulin-stimulated glucose uptakewere present in the fat cells of SRD-fed rats, an increase of several key enzymes of the novo lipogenesiscould be one of the possible mechanisms involved in visceral adiposity. The addition of dietaryfish oil restored or improved the above abnormalities.Conclusion: This study shows possible mechanisms conditioning the influence of nutrients on thedevelopment and management of dyslipidemia, insulin sensitivity, and fat cell accretion, all abnormalitiespresent in the metabolic syndrome.
Fil: Rossi, Andrea Silvana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina
Fil: Lombardo, Yolanda B.. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina
Fil: Chicco, Adriana Graciela. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina
Materia
ADIPOSE TISSUE LIPOGENESIS
GLUCOSE UPTAKE
N-3 FATTY ACID
SUCROSE DIET
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/103439
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/103439
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Lipogenic enzyme activities and glucose uptake in fat tissue of dyslipemic, insulin-resistant rats: Effects of fish oilRossi, Andrea SilvanaLombardo, Yolanda B.Chicco, Adriana GracielaADIPOSE TISSUE LIPOGENESISGLUCOSE UPTAKEN-3 FATTY ACIDSUCROSE DIEThttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objective: The purposes of the present work were twofold: (1) investigate same mechanisms involvedin the development of fat cell hypertrophy in the experimental model of dyslipidemia andwhole-body insulin resistance induced in rats chronically fed a sucrose-rich diet (SRD); and (2) analyzethe possible beneficial effect of fish oil on these mechanisms.Methods: For 6 mo, male Wistar rats received a sucrose-rich diet (62.5% w/w sucrose, 8% corn oil)or a control diet in which sucrose was replaced by starch. After this period, the sucrose-fed animalswere divided randomly into two groups: the first one continued with the same diet up to 8 mo andthe second one received the same diet, but with corn oil replaced by 7% fish oil þ 1 % corn oil.Rats were fed with this diet for the next 2 mo.Results: Although an enlarged fat cell lipolysis and an impaired insulin-stimulated glucose uptakewere present in the fat cells of SRD-fed rats, an increase of several key enzymes of the novo lipogenesiscould be one of the possible mechanisms involved in visceral adiposity. The addition of dietaryfish oil restored or improved the above abnormalities.Conclusion: This study shows possible mechanisms conditioning the influence of nutrients on thedevelopment and management of dyslipidemia, insulin sensitivity, and fat cell accretion, all abnormalitiespresent in the metabolic syndrome.Fil: Rossi, Andrea Silvana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; ArgentinaFil: Lombardo, Yolanda B.. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; ArgentinaFil: Chicco, Adriana Graciela. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; ArgentinaElsevier Science Inc2010-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/103439Rossi, Andrea Silvana; Lombardo, Yolanda B.; Chicco, Adriana Graciela; Lipogenic enzyme activities and glucose uptake in fat tissue of dyslipemic, insulin-resistant rats: Effects of fish oil; Elsevier Science Inc; Nutrition; 26; 2; 2-2010; 209-2170899-9007CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.nut.2009.04.006info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:16Zoai:ri.conicet.gov.ar:11336/103439instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:16.489CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Lipogenic enzyme activities and glucose uptake in fat tissue of dyslipemic, insulin-resistant rats: Effects of fish oil
title Lipogenic enzyme activities and glucose uptake in fat tissue of dyslipemic, insulin-resistant rats: Effects of fish oil
spellingShingle Lipogenic enzyme activities and glucose uptake in fat tissue of dyslipemic, insulin-resistant rats: Effects of fish oil
Rossi, Andrea Silvana
ADIPOSE TISSUE LIPOGENESIS
GLUCOSE UPTAKE
N-3 FATTY ACID
SUCROSE DIET
title_short Lipogenic enzyme activities and glucose uptake in fat tissue of dyslipemic, insulin-resistant rats: Effects of fish oil
title_full Lipogenic enzyme activities and glucose uptake in fat tissue of dyslipemic, insulin-resistant rats: Effects of fish oil
title_fullStr Lipogenic enzyme activities and glucose uptake in fat tissue of dyslipemic, insulin-resistant rats: Effects of fish oil
title_full_unstemmed Lipogenic enzyme activities and glucose uptake in fat tissue of dyslipemic, insulin-resistant rats: Effects of fish oil
title_sort Lipogenic enzyme activities and glucose uptake in fat tissue of dyslipemic, insulin-resistant rats: Effects of fish oil
dc.creator.none.fl_str_mv Rossi, Andrea Silvana
Lombardo, Yolanda B.
Chicco, Adriana Graciela
author Rossi, Andrea Silvana
author_facet Rossi, Andrea Silvana
Lombardo, Yolanda B.
Chicco, Adriana Graciela
author_role author
author2 Lombardo, Yolanda B.
Chicco, Adriana Graciela
author2_role author
author
dc.subject.none.fl_str_mv ADIPOSE TISSUE LIPOGENESIS
GLUCOSE UPTAKE
N-3 FATTY ACID
SUCROSE DIET
topic ADIPOSE TISSUE LIPOGENESIS
GLUCOSE UPTAKE
N-3 FATTY ACID
SUCROSE DIET
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: The purposes of the present work were twofold: (1) investigate same mechanisms involvedin the development of fat cell hypertrophy in the experimental model of dyslipidemia andwhole-body insulin resistance induced in rats chronically fed a sucrose-rich diet (SRD); and (2) analyzethe possible beneficial effect of fish oil on these mechanisms.Methods: For 6 mo, male Wistar rats received a sucrose-rich diet (62.5% w/w sucrose, 8% corn oil)or a control diet in which sucrose was replaced by starch. After this period, the sucrose-fed animalswere divided randomly into two groups: the first one continued with the same diet up to 8 mo andthe second one received the same diet, but with corn oil replaced by 7% fish oil þ 1 % corn oil.Rats were fed with this diet for the next 2 mo.Results: Although an enlarged fat cell lipolysis and an impaired insulin-stimulated glucose uptakewere present in the fat cells of SRD-fed rats, an increase of several key enzymes of the novo lipogenesiscould be one of the possible mechanisms involved in visceral adiposity. The addition of dietaryfish oil restored or improved the above abnormalities.Conclusion: This study shows possible mechanisms conditioning the influence of nutrients on thedevelopment and management of dyslipidemia, insulin sensitivity, and fat cell accretion, all abnormalitiespresent in the metabolic syndrome.
Fil: Rossi, Andrea Silvana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina
Fil: Lombardo, Yolanda B.. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina
Fil: Chicco, Adriana Graciela. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina
description Objective: The purposes of the present work were twofold: (1) investigate same mechanisms involvedin the development of fat cell hypertrophy in the experimental model of dyslipidemia andwhole-body insulin resistance induced in rats chronically fed a sucrose-rich diet (SRD); and (2) analyzethe possible beneficial effect of fish oil on these mechanisms.Methods: For 6 mo, male Wistar rats received a sucrose-rich diet (62.5% w/w sucrose, 8% corn oil)or a control diet in which sucrose was replaced by starch. After this period, the sucrose-fed animalswere divided randomly into two groups: the first one continued with the same diet up to 8 mo andthe second one received the same diet, but with corn oil replaced by 7% fish oil þ 1 % corn oil.Rats were fed with this diet for the next 2 mo.Results: Although an enlarged fat cell lipolysis and an impaired insulin-stimulated glucose uptakewere present in the fat cells of SRD-fed rats, an increase of several key enzymes of the novo lipogenesiscould be one of the possible mechanisms involved in visceral adiposity. The addition of dietaryfish oil restored or improved the above abnormalities.Conclusion: This study shows possible mechanisms conditioning the influence of nutrients on thedevelopment and management of dyslipidemia, insulin sensitivity, and fat cell accretion, all abnormalitiespresent in the metabolic syndrome.
publishDate 2010
dc.date.none.fl_str_mv 2010-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/103439
Rossi, Andrea Silvana; Lombardo, Yolanda B.; Chicco, Adriana Graciela; Lipogenic enzyme activities and glucose uptake in fat tissue of dyslipemic, insulin-resistant rats: Effects of fish oil; Elsevier Science Inc; Nutrition; 26; 2; 2-2010; 209-217
0899-9007
CONICET Digital
CONICET
url http://hdl.handle.net/11336/103439
identifier_str_mv Rossi, Andrea Silvana; Lombardo, Yolanda B.; Chicco, Adriana Graciela; Lipogenic enzyme activities and glucose uptake in fat tissue of dyslipemic, insulin-resistant rats: Effects of fish oil; Elsevier Science Inc; Nutrition; 26; 2; 2-2010; 209-217
0899-9007
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nut.2009.04.006
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268654695088128
score 13.13397

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