Vascular Repair and Remodeling: A Review

Autores
Renna, Nicolas Federico; García, Rodrigo Damián; Ramírez, Jésica; Miatello, Roberto Miguel
Año de publicación
2018
Idioma
inglés
Tipo de recurso
parte de libro
Estado
versión publicada
Descripción
Cardiovascular diseases (CVDs) such as ischemic heart disease (IHD), stroke, and peripheral artery disease (PAS) are the leading cause of mortality and morbidity around the world: about 30% of global deaths and 10% of global disease burden a year are due to CVDs.In this chapter, we will analyze the classic concepts of vascular remodeling, to later expand the concepts and physiopathological mechanisms of vascular inflammation. The role of immunomodulation from IL-6R alpha and the JAK / STAT3 intracellular cascade, as an activator of vascular remodeling mechanisms. In addition, the role of new drugs such as LCZ696 and immunomodulators involved in the local inflammatory response will also be analyzed.The concept of remodeling and vascular inflammation, which a decade ago was only important at the level of basic research, step by step has proved crucial in the appearance of atherosclerosis, called subclinical atherosclerosis. Much progress has been made in the treatment and discovery of pathophysiological mechanisms, rest improve the studies of deterrence and its correlation with the reduction of cardiovascular risk, this is perhaps, the decade in which we can advance in this.
Fil: Renna, Nicolas Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: García, Rodrigo Damián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Ramírez, Jésica. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: Miatello, Roberto Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Materia
Vascular remodeling
Vascular inflammation
Insulin resistance
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/105557
Acceder
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spelling Vascular Repair and Remodeling: A ReviewRenna, Nicolas FedericoGarcía, Rodrigo DamiánRamírez, JésicaMiatello, Roberto MiguelVascular remodelingVascular inflammationInsulin resistancehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Cardiovascular diseases (CVDs) such as ischemic heart disease (IHD), stroke, and peripheral artery disease (PAS) are the leading cause of mortality and morbidity around the world: about 30% of global deaths and 10% of global disease burden a year are due to CVDs.In this chapter, we will analyze the classic concepts of vascular remodeling, to later expand the concepts and physiopathological mechanisms of vascular inflammation. The role of immunomodulation from IL-6R alpha and the JAK / STAT3 intracellular cascade, as an activator of vascular remodeling mechanisms. In addition, the role of new drugs such as LCZ696 and immunomodulators involved in the local inflammatory response will also be analyzed.The concept of remodeling and vascular inflammation, which a decade ago was only important at the level of basic research, step by step has proved crucial in the appearance of atherosclerosis, called subclinical atherosclerosis. Much progress has been made in the treatment and discovery of pathophysiological mechanisms, rest improve the studies of deterrence and its correlation with the reduction of cardiovascular risk, this is perhaps, the decade in which we can advance in this.Fil: Renna, Nicolas Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; ArgentinaFil: García, Rodrigo Damián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Ramírez, Jésica. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; ArgentinaFil: Miatello, Roberto Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; ArgentinaIntechOpenSimionescu, DanSimionescu, Agneta2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookParthttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/105557Renna, Nicolas Federico; García, Rodrigo Damián; Ramírez, Jésica; Miatello, Roberto Miguel; Vascular Repair and Remodeling: A Review; IntechOpen; 2018; 195-212978-953-51-6158-5CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.5772/67485info:eu-repo/semantics/altIdentifier/url/https://www.intechopen.com/books/physiologic-and-pathologic-angiogenesis-signaling-mechanisms-and-targeted-therapy/vascular-repair-and-remodeling-a-reviewinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:10Zoai:ri.conicet.gov.ar:11336/105557instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:11.084CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Vascular Repair and Remodeling: A Review
title Vascular Repair and Remodeling: A Review
spellingShingle Vascular Repair and Remodeling: A Review
Renna, Nicolas Federico
Vascular remodeling
Vascular inflammation
Insulin resistance
title_short Vascular Repair and Remodeling: A Review
title_full Vascular Repair and Remodeling: A Review
title_fullStr Vascular Repair and Remodeling: A Review
title_full_unstemmed Vascular Repair and Remodeling: A Review
title_sort Vascular Repair and Remodeling: A Review
dc.creator.none.fl_str_mv Renna, Nicolas Federico
García, Rodrigo Damián
Ramírez, Jésica
Miatello, Roberto Miguel
author Renna, Nicolas Federico
author_facet Renna, Nicolas Federico
García, Rodrigo Damián
Ramírez, Jésica
Miatello, Roberto Miguel
author_role author
author2 García, Rodrigo Damián
Ramírez, Jésica
Miatello, Roberto Miguel
author2_role author
author
author
dc.contributor.none.fl_str_mv Simionescu, Dan
Simionescu, Agneta
dc.subject.none.fl_str_mv Vascular remodeling
Vascular inflammation
Insulin resistance
topic Vascular remodeling
Vascular inflammation
Insulin resistance
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Cardiovascular diseases (CVDs) such as ischemic heart disease (IHD), stroke, and peripheral artery disease (PAS) are the leading cause of mortality and morbidity around the world: about 30% of global deaths and 10% of global disease burden a year are due to CVDs.In this chapter, we will analyze the classic concepts of vascular remodeling, to later expand the concepts and physiopathological mechanisms of vascular inflammation. The role of immunomodulation from IL-6R alpha and the JAK / STAT3 intracellular cascade, as an activator of vascular remodeling mechanisms. In addition, the role of new drugs such as LCZ696 and immunomodulators involved in the local inflammatory response will also be analyzed.The concept of remodeling and vascular inflammation, which a decade ago was only important at the level of basic research, step by step has proved crucial in the appearance of atherosclerosis, called subclinical atherosclerosis. Much progress has been made in the treatment and discovery of pathophysiological mechanisms, rest improve the studies of deterrence and its correlation with the reduction of cardiovascular risk, this is perhaps, the decade in which we can advance in this.
Fil: Renna, Nicolas Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: García, Rodrigo Damián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Ramírez, Jésica. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: Miatello, Roberto Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
description Cardiovascular diseases (CVDs) such as ischemic heart disease (IHD), stroke, and peripheral artery disease (PAS) are the leading cause of mortality and morbidity around the world: about 30% of global deaths and 10% of global disease burden a year are due to CVDs.In this chapter, we will analyze the classic concepts of vascular remodeling, to later expand the concepts and physiopathological mechanisms of vascular inflammation. The role of immunomodulation from IL-6R alpha and the JAK / STAT3 intracellular cascade, as an activator of vascular remodeling mechanisms. In addition, the role of new drugs such as LCZ696 and immunomodulators involved in the local inflammatory response will also be analyzed.The concept of remodeling and vascular inflammation, which a decade ago was only important at the level of basic research, step by step has proved crucial in the appearance of atherosclerosis, called subclinical atherosclerosis. Much progress has been made in the treatment and discovery of pathophysiological mechanisms, rest improve the studies of deterrence and its correlation with the reduction of cardiovascular risk, this is perhaps, the decade in which we can advance in this.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/bookPart
http://purl.org/coar/resource_type/c_3248
info:ar-repo/semantics/parteDeLibro
status_str publishedVersion
format bookPart
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/105557
Renna, Nicolas Federico; García, Rodrigo Damián; Ramírez, Jésica; Miatello, Roberto Miguel; Vascular Repair and Remodeling: A Review; IntechOpen; 2018; 195-212
978-953-51-6158-5
CONICET Digital
CONICET
url http://hdl.handle.net/11336/105557
identifier_str_mv Renna, Nicolas Federico; García, Rodrigo Damián; Ramírez, Jésica; Miatello, Roberto Miguel; Vascular Repair and Remodeling: A Review; IntechOpen; 2018; 195-212
978-953-51-6158-5
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.5772/67485
info:eu-repo/semantics/altIdentifier/url/https://www.intechopen.com/books/physiologic-and-pathologic-angiogenesis-signaling-mechanisms-and-targeted-therapy/vascular-repair-and-remodeling-a-review
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv IntechOpen
publisher.none.fl_str_mv IntechOpen
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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