Novel Role for Lysophosphatidic Acid in Vascular Remodeling at the Maternal-Fetal Interface

Autores
Beltrame, Jimena Soledad; Cañumil, Vanesa Alejandra; Sordelli, Micaela Soledad; Ribeiro, Maria Laura
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Lysophosphatidic acid (LPA) belongs to the group of phosphorylated lipids reported as crucial mediators in the physiology of reproduction. LPA binds to G-protein coupled receptors and regulates a wide range of female reproductive functions. This bioactive lipid has been also implicated in vascular functions during physiological and pathological conditions. In this regard, the establishment of a successful pregnancy requires proper coordination of vascular processes and remodeling of maternal blood vessels during early gestation. During this process, first trimester cytotrophoblast changes from an invasive to an endovascular phenotype and transforms uterine spiral arteries which are the nutrient supply for placenta and fetus. Here we present an overview of LPA participation in vascular remodeling and highlight the importance of LPA-LPA3 signaling during early gestation at the maternal-fetal interface.
Fil: Beltrame, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Cañumil, Vanesa Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Sordelli, Micaela Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Ribeiro, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Materia
LYSOPHOSPHATIDIC ACID
VASCULAR REMODELING
IMPLANTATION
LPA3
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/120091
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Novel Role for Lysophosphatidic Acid in Vascular Remodeling at the Maternal-Fetal InterfaceBeltrame, Jimena SoledadCañumil, Vanesa AlejandraSordelli, Micaela SoledadRibeiro, Maria LauraLYSOPHOSPHATIDIC ACIDVASCULAR REMODELINGIMPLANTATIONLPA3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Lysophosphatidic acid (LPA) belongs to the group of phosphorylated lipids reported as crucial mediators in the physiology of reproduction. LPA binds to G-protein coupled receptors and regulates a wide range of female reproductive functions. This bioactive lipid has been also implicated in vascular functions during physiological and pathological conditions. In this regard, the establishment of a successful pregnancy requires proper coordination of vascular processes and remodeling of maternal blood vessels during early gestation. During this process, first trimester cytotrophoblast changes from an invasive to an endovascular phenotype and transforms uterine spiral arteries which are the nutrient supply for placenta and fetus. Here we present an overview of LPA participation in vascular remodeling and highlight the importance of LPA-LPA3 signaling during early gestation at the maternal-fetal interface.Fil: Beltrame, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Cañumil, Vanesa Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Sordelli, Micaela Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Ribeiro, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaBioScientifica2019-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/120091Beltrame, Jimena Soledad; Cañumil, Vanesa Alejandra; Sordelli, Micaela Soledad; Ribeiro, Maria Laura; Novel Role for Lysophosphatidic Acid in Vascular Remodeling at the Maternal-Fetal Interface; BioScientifica; Reproduction; 159; 2; 8-2019; 1-131470-1626CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://rep.bioscientifica.com/view/journals/rep/aop/rep-18-0570.xmlinfo:eu-repo/semantics/altIdentifier/doi/10.1530/REP-18-0570info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:08:42Zoai:ri.conicet.gov.ar:11336/120091instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:08:43.349CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Novel Role for Lysophosphatidic Acid in Vascular Remodeling at the Maternal-Fetal Interface
title Novel Role for Lysophosphatidic Acid in Vascular Remodeling at the Maternal-Fetal Interface
spellingShingle Novel Role for Lysophosphatidic Acid in Vascular Remodeling at the Maternal-Fetal Interface
Beltrame, Jimena Soledad
LYSOPHOSPHATIDIC ACID
VASCULAR REMODELING
IMPLANTATION
LPA3
title_short Novel Role for Lysophosphatidic Acid in Vascular Remodeling at the Maternal-Fetal Interface
title_full Novel Role for Lysophosphatidic Acid in Vascular Remodeling at the Maternal-Fetal Interface
title_fullStr Novel Role for Lysophosphatidic Acid in Vascular Remodeling at the Maternal-Fetal Interface
title_full_unstemmed Novel Role for Lysophosphatidic Acid in Vascular Remodeling at the Maternal-Fetal Interface
title_sort Novel Role for Lysophosphatidic Acid in Vascular Remodeling at the Maternal-Fetal Interface
dc.creator.none.fl_str_mv Beltrame, Jimena Soledad
Cañumil, Vanesa Alejandra
Sordelli, Micaela Soledad
Ribeiro, Maria Laura
author Beltrame, Jimena Soledad
author_facet Beltrame, Jimena Soledad
Cañumil, Vanesa Alejandra
Sordelli, Micaela Soledad
Ribeiro, Maria Laura
author_role author
author2 Cañumil, Vanesa Alejandra
Sordelli, Micaela Soledad
Ribeiro, Maria Laura
author2_role author
author
author
dc.subject.none.fl_str_mv LYSOPHOSPHATIDIC ACID
VASCULAR REMODELING
IMPLANTATION
LPA3
topic LYSOPHOSPHATIDIC ACID
VASCULAR REMODELING
IMPLANTATION
LPA3
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Lysophosphatidic acid (LPA) belongs to the group of phosphorylated lipids reported as crucial mediators in the physiology of reproduction. LPA binds to G-protein coupled receptors and regulates a wide range of female reproductive functions. This bioactive lipid has been also implicated in vascular functions during physiological and pathological conditions. In this regard, the establishment of a successful pregnancy requires proper coordination of vascular processes and remodeling of maternal blood vessels during early gestation. During this process, first trimester cytotrophoblast changes from an invasive to an endovascular phenotype and transforms uterine spiral arteries which are the nutrient supply for placenta and fetus. Here we present an overview of LPA participation in vascular remodeling and highlight the importance of LPA-LPA3 signaling during early gestation at the maternal-fetal interface.
Fil: Beltrame, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Cañumil, Vanesa Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Sordelli, Micaela Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Ribeiro, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
description Lysophosphatidic acid (LPA) belongs to the group of phosphorylated lipids reported as crucial mediators in the physiology of reproduction. LPA binds to G-protein coupled receptors and regulates a wide range of female reproductive functions. This bioactive lipid has been also implicated in vascular functions during physiological and pathological conditions. In this regard, the establishment of a successful pregnancy requires proper coordination of vascular processes and remodeling of maternal blood vessels during early gestation. During this process, first trimester cytotrophoblast changes from an invasive to an endovascular phenotype and transforms uterine spiral arteries which are the nutrient supply for placenta and fetus. Here we present an overview of LPA participation in vascular remodeling and highlight the importance of LPA-LPA3 signaling during early gestation at the maternal-fetal interface.
publishDate 2019
dc.date.none.fl_str_mv 2019-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/120091
Beltrame, Jimena Soledad; Cañumil, Vanesa Alejandra; Sordelli, Micaela Soledad; Ribeiro, Maria Laura; Novel Role for Lysophosphatidic Acid in Vascular Remodeling at the Maternal-Fetal Interface; BioScientifica; Reproduction; 159; 2; 8-2019; 1-13
1470-1626
CONICET Digital
CONICET
url http://hdl.handle.net/11336/120091
identifier_str_mv Beltrame, Jimena Soledad; Cañumil, Vanesa Alejandra; Sordelli, Micaela Soledad; Ribeiro, Maria Laura; Novel Role for Lysophosphatidic Acid in Vascular Remodeling at the Maternal-Fetal Interface; BioScientifica; Reproduction; 159; 2; 8-2019; 1-13
1470-1626
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1530/REP-18-0570
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioScientifica
publisher.none.fl_str_mv BioScientifica
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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