Effect of SGLT2-Inhibitors on Epicardial Adipose Tissue: A Meta-Analysis

Autores
Masson, Walter; Lavalle Cobo, Augusto; Nogueira, Juan Patricio
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
(1) Sodium–glucose cotransporter-2 inhibitors (SGLT2-i) reduce adipose tissue and cardiovascular events in patients with type 2 diabetes (T2D). Accumulation of epicardial adipose tissue (EAT) is associated with increased cardio-metabolic risks and obstructive coronary disease events in patients with T2D. (2) We performed a systematic review and meta-analysis of SGLT2-i therapy on T2D patients, reporting data on changes in EAT after searching the PubMed/MEDLINE, Embase, Science Direct, Scopus, Google Scholar, and Cochrane databases. A random effects or fixed effects model meta-analysis was then applied. (3) Results: A total of three studies (n = 64 patients with SGLT2-i, n = 62 with standard therapy) were included in the final analysis. SGLT2 inhibitors reduced EAT (SMD: −0.82 (−1.49; −0.15); p < 0.0001). An exploratory analysis showed that HbA1c was significantly reduced with SGLT2-i use, while body mass index was not significantly reduced with this drug. (4) Conclusions: This meta-analysis suggests that the amount of EAT is significantly reduced in T2D patients with SGLT2-i treatment.
Fil: Masson, Walter. No especifíca;
Fil: Lavalle Cobo, Augusto. No especifíca;
Fil: Nogueira, Juan Patricio. Universidad Nacional de Formosa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
Materia
EPICARDIAL ADIPOSE TISSUE
META-ANALYSIS
SODIUM–GLUCOSE CO-TRANSPORTER-2 INHIBITORS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/167457
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/167457
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effect of SGLT2-Inhibitors on Epicardial Adipose Tissue: A Meta-AnalysisMasson, WalterLavalle Cobo, AugustoNogueira, Juan PatricioEPICARDIAL ADIPOSE TISSUEMETA-ANALYSISSODIUM–GLUCOSE CO-TRANSPORTER-2 INHIBITORShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3(1) Sodium–glucose cotransporter-2 inhibitors (SGLT2-i) reduce adipose tissue and cardiovascular events in patients with type 2 diabetes (T2D). Accumulation of epicardial adipose tissue (EAT) is associated with increased cardio-metabolic risks and obstructive coronary disease events in patients with T2D. (2) We performed a systematic review and meta-analysis of SGLT2-i therapy on T2D patients, reporting data on changes in EAT after searching the PubMed/MEDLINE, Embase, Science Direct, Scopus, Google Scholar, and Cochrane databases. A random effects or fixed effects model meta-analysis was then applied. (3) Results: A total of three studies (n = 64 patients with SGLT2-i, n = 62 with standard therapy) were included in the final analysis. SGLT2 inhibitors reduced EAT (SMD: −0.82 (−1.49; −0.15); p < 0.0001). An exploratory analysis showed that HbA1c was significantly reduced with SGLT2-i use, while body mass index was not significantly reduced with this drug. (4) Conclusions: This meta-analysis suggests that the amount of EAT is significantly reduced in T2D patients with SGLT2-i treatment.Fil: Masson, Walter. No especifíca;Fil: Lavalle Cobo, Augusto. No especifíca;Fil: Nogueira, Juan Patricio. Universidad Nacional de Formosa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; ArgentinaMDPI2021-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/167457Masson, Walter; Lavalle Cobo, Augusto; Nogueira, Juan Patricio; Effect of SGLT2-Inhibitors on Epicardial Adipose Tissue: A Meta-Analysis; MDPI; Cells; 10; 8; 8-2021; 1-102073-4409CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/cells10082150info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:52Zoai:ri.conicet.gov.ar:11336/167457instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:53.286CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of SGLT2-Inhibitors on Epicardial Adipose Tissue: A Meta-Analysis
title Effect of SGLT2-Inhibitors on Epicardial Adipose Tissue: A Meta-Analysis
spellingShingle Effect of SGLT2-Inhibitors on Epicardial Adipose Tissue: A Meta-Analysis
Masson, Walter
EPICARDIAL ADIPOSE TISSUE
META-ANALYSIS
SODIUM–GLUCOSE CO-TRANSPORTER-2 INHIBITORS
title_short Effect of SGLT2-Inhibitors on Epicardial Adipose Tissue: A Meta-Analysis
title_full Effect of SGLT2-Inhibitors on Epicardial Adipose Tissue: A Meta-Analysis
title_fullStr Effect of SGLT2-Inhibitors on Epicardial Adipose Tissue: A Meta-Analysis
title_full_unstemmed Effect of SGLT2-Inhibitors on Epicardial Adipose Tissue: A Meta-Analysis
title_sort Effect of SGLT2-Inhibitors on Epicardial Adipose Tissue: A Meta-Analysis
dc.creator.none.fl_str_mv Masson, Walter
Lavalle Cobo, Augusto
Nogueira, Juan Patricio
author Masson, Walter
author_facet Masson, Walter
Lavalle Cobo, Augusto
Nogueira, Juan Patricio
author_role author
author2 Lavalle Cobo, Augusto
Nogueira, Juan Patricio
author2_role author
author
dc.subject.none.fl_str_mv EPICARDIAL ADIPOSE TISSUE
META-ANALYSIS
SODIUM–GLUCOSE CO-TRANSPORTER-2 INHIBITORS
topic EPICARDIAL ADIPOSE TISSUE
META-ANALYSIS
SODIUM–GLUCOSE CO-TRANSPORTER-2 INHIBITORS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv (1) Sodium–glucose cotransporter-2 inhibitors (SGLT2-i) reduce adipose tissue and cardiovascular events in patients with type 2 diabetes (T2D). Accumulation of epicardial adipose tissue (EAT) is associated with increased cardio-metabolic risks and obstructive coronary disease events in patients with T2D. (2) We performed a systematic review and meta-analysis of SGLT2-i therapy on T2D patients, reporting data on changes in EAT after searching the PubMed/MEDLINE, Embase, Science Direct, Scopus, Google Scholar, and Cochrane databases. A random effects or fixed effects model meta-analysis was then applied. (3) Results: A total of three studies (n = 64 patients with SGLT2-i, n = 62 with standard therapy) were included in the final analysis. SGLT2 inhibitors reduced EAT (SMD: −0.82 (−1.49; −0.15); p < 0.0001). An exploratory analysis showed that HbA1c was significantly reduced with SGLT2-i use, while body mass index was not significantly reduced with this drug. (4) Conclusions: This meta-analysis suggests that the amount of EAT is significantly reduced in T2D patients with SGLT2-i treatment.
Fil: Masson, Walter. No especifíca;
Fil: Lavalle Cobo, Augusto. No especifíca;
Fil: Nogueira, Juan Patricio. Universidad Nacional de Formosa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
description (1) Sodium–glucose cotransporter-2 inhibitors (SGLT2-i) reduce adipose tissue and cardiovascular events in patients with type 2 diabetes (T2D). Accumulation of epicardial adipose tissue (EAT) is associated with increased cardio-metabolic risks and obstructive coronary disease events in patients with T2D. (2) We performed a systematic review and meta-analysis of SGLT2-i therapy on T2D patients, reporting data on changes in EAT after searching the PubMed/MEDLINE, Embase, Science Direct, Scopus, Google Scholar, and Cochrane databases. A random effects or fixed effects model meta-analysis was then applied. (3) Results: A total of three studies (n = 64 patients with SGLT2-i, n = 62 with standard therapy) were included in the final analysis. SGLT2 inhibitors reduced EAT (SMD: −0.82 (−1.49; −0.15); p < 0.0001). An exploratory analysis showed that HbA1c was significantly reduced with SGLT2-i use, while body mass index was not significantly reduced with this drug. (4) Conclusions: This meta-analysis suggests that the amount of EAT is significantly reduced in T2D patients with SGLT2-i treatment.
publishDate 2021
dc.date.none.fl_str_mv 2021-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/167457
Masson, Walter; Lavalle Cobo, Augusto; Nogueira, Juan Patricio; Effect of SGLT2-Inhibitors on Epicardial Adipose Tissue: A Meta-Analysis; MDPI; Cells; 10; 8; 8-2021; 1-10
2073-4409
CONICET Digital
CONICET
url http://hdl.handle.net/11336/167457
identifier_str_mv Masson, Walter; Lavalle Cobo, Augusto; Nogueira, Juan Patricio; Effect of SGLT2-Inhibitors on Epicardial Adipose Tissue: A Meta-Analysis; MDPI; Cells; 10; 8; 8-2021; 1-10
2073-4409
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/cells10082150
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269312014876672
score 13.13397

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