Bladder Exstrophy: An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research, and an Overview of the Literature
- Autores
- Siffel, Csaba; Correa, Adolfo; Amar, Emmanuelle; Bakker, Marian K.; Bermejo Sanchez, Eva; Bianca, Sebastiano; Castilla, Eduardo Enrique; Clementi, Maurizio; Cocchi, Guido; Csaky Szunyogh, Melinda; Feldkamp, Marcia L.; Landau, Danielle; Leoncini, Emanuele; Li, Zhu; Lowry, R. Brian; Marengo, Lisa K.; Mastroiacovo, Pierpaolo; Morgan, Margery; Mutchinick, Osvaldo M.; Pierini, Anna; Rissmann, Anke; Ritvanen, Annukka; Scarano, Gioacchino; Szabova, Elena; Olney, Richard S.
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Bladder exstrophy (BE) is a complex congenital anomaly characterized by a defect in the closure of the lower abdominal wall and bladder. We aimed to provide an overview of the literature and conduct an epidemiologic study to describe the prevalence, and maternal and case characteristics of BE. We used data from 22 participating member programs of the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR). All cases were reviewed and classified as isolated, syndrome, and multiple congenital anomalies. We estimated the total prevalence of BE and calculated the frequency and odds ratios for various maternal and case characteristics. A total of 546 cases with BE were identified among 26,355,094 births. The total prevalence of BE was 2.07 per 100,000 births (95% CI: 1.90–2.25) and varied between 0.52 and 4.63 among surveillance programs participating in the study. BE was nearly twice as common among male as among female cases. The proportion of isolated cases was 71%. Prevalence appeared to increase with increasing categories of maternal age, particularly among isolated cases. The total prevalence of BE showed some variations by geographical region, which is most likely attributable to differences in registration of cases. The higher total prevalence among male cases and older mothers, especially among isolated cases, warrants further attention.
Fil: Siffel, Csaba. National Center on Birth Defects and Developmental Disabilities; Estados Unidos
Fil: Correa, Adolfo. National Center on Birth Defects and Developmental Disabilities; Estados Unidos
Fil: Amar, Emmanuelle. Rhone-alps Registry Of Birth Defects Remera; Francia
Fil: Bakker, Marian K.. University of Groningen; Países Bajos
Fil: Bermejo Sanchez, Eva. Instituto de Salud Carlos III; España
Fil: Bianca, Sebastiano. Centro di Consulenza Genetica e di Teratologia della Riproduzione; Italia
Fil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Fundación Oswaldo Cruz; Brasil
Fil: Clementi, Maurizio. Università di Padova; Italia
Fil: Cocchi, Guido. Bologna University; Italia
Fil: Csaky Szunyogh, Melinda. National Center for Healthcare Audit and Inspection; Hungría
Fil: Feldkamp, Marcia L.. University of Utah School of Medicine; Estados Unidos
Fil: Landau, Danielle. Soroka University Medical Center; Israel
Fil: Leoncini, Emanuele. Centre of the International Clearinghouse for Birth Defects Surveillance and Research; Italia
Fil: Li, Zhu. Peking University; República de China
Fil: Lowry, R. Brian. Alberta Health & Wellness; Canadá
Fil: Marengo, Lisa K.. Birth Defects Epidemiology and Surveillance Branch; Estados Unidos
Fil: Mastroiacovo, Pierpaolo. Centre of the International Clearinghouse for Birth Defects Surveillance and Research; Italia
Fil: Morgan, Margery. the Congenital Anomaly Register for Wales; Reino Unido
Fil: Mutchinick, Osvaldo M.. Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”; México
Fil: Pierini, Anna. Tuscany Region “Gabriele Monasterio” Foundation; Italia. Consiglio Nazionale delle Ricerche; Italia
Fil: Rissmann, Anke. University Magdeburg; Alemania
Fil: Ritvanen, Annukka. National Institute for Health and Welfare; Finlandia
Fil: Scarano, Gioacchino. General Hospital “G. Rummo” Benevento; Italia
Fil: Szabova, Elena. Slovak Medical University; Eslovaquia
Fil: Olney, Richard S.. National Center on Birth Defects and Developmental Disabilities; Estados Unidos - Materia
-
bladder exstrophy;
prevalence;
sex ratio;
maternal age - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/195391
Ver los metadatos del registro completo
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Bladder Exstrophy: An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research, and an Overview of the LiteratureSiffel, CsabaCorrea, AdolfoAmar, EmmanuelleBakker, Marian K.Bermejo Sanchez, EvaBianca, SebastianoCastilla, Eduardo EnriqueClementi, MaurizioCocchi, GuidoCsaky Szunyogh, MelindaFeldkamp, Marcia L.Landau, DanielleLeoncini, EmanueleLi, ZhuLowry, R. BrianMarengo, Lisa K.Mastroiacovo, PierpaoloMorgan, MargeryMutchinick, Osvaldo M.Pierini, AnnaRissmann, AnkeRitvanen, AnnukkaScarano, GioacchinoSzabova, ElenaOlney, Richard S.bladder exstrophy;prevalence;sex ratio;maternal agehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Bladder exstrophy (BE) is a complex congenital anomaly characterized by a defect in the closure of the lower abdominal wall and bladder. We aimed to provide an overview of the literature and conduct an epidemiologic study to describe the prevalence, and maternal and case characteristics of BE. We used data from 22 participating member programs of the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR). All cases were reviewed and classified as isolated, syndrome, and multiple congenital anomalies. We estimated the total prevalence of BE and calculated the frequency and odds ratios for various maternal and case characteristics. A total of 546 cases with BE were identified among 26,355,094 births. The total prevalence of BE was 2.07 per 100,000 births (95% CI: 1.90–2.25) and varied between 0.52 and 4.63 among surveillance programs participating in the study. BE was nearly twice as common among male as among female cases. The proportion of isolated cases was 71%. Prevalence appeared to increase with increasing categories of maternal age, particularly among isolated cases. The total prevalence of BE showed some variations by geographical region, which is most likely attributable to differences in registration of cases. The higher total prevalence among male cases and older mothers, especially among isolated cases, warrants further attention.Fil: Siffel, Csaba. National Center on Birth Defects and Developmental Disabilities; Estados UnidosFil: Correa, Adolfo. National Center on Birth Defects and Developmental Disabilities; Estados UnidosFil: Amar, Emmanuelle. Rhone-alps Registry Of Birth Defects Remera; FranciaFil: Bakker, Marian K.. University of Groningen; Países BajosFil: Bermejo Sanchez, Eva. Instituto de Salud Carlos III; EspañaFil: Bianca, Sebastiano. Centro di Consulenza Genetica e di Teratologia della Riproduzione; ItaliaFil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Fundación Oswaldo Cruz; BrasilFil: Clementi, Maurizio. Università di Padova; ItaliaFil: Cocchi, Guido. Bologna University; ItaliaFil: Csaky Szunyogh, Melinda. National Center for Healthcare Audit and Inspection; HungríaFil: Feldkamp, Marcia L.. University of Utah School of Medicine; Estados UnidosFil: Landau, Danielle. Soroka University Medical Center; IsraelFil: Leoncini, Emanuele. Centre of the International Clearinghouse for Birth Defects Surveillance and Research; ItaliaFil: Li, Zhu. Peking University; República de ChinaFil: Lowry, R. Brian. Alberta Health & Wellness; CanadáFil: Marengo, Lisa K.. Birth Defects Epidemiology and Surveillance Branch; Estados UnidosFil: Mastroiacovo, Pierpaolo. Centre of the International Clearinghouse for Birth Defects Surveillance and Research; ItaliaFil: Morgan, Margery. the Congenital Anomaly Register for Wales; Reino UnidoFil: Mutchinick, Osvaldo M.. Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”; MéxicoFil: Pierini, Anna. Tuscany Region “Gabriele Monasterio” Foundation; Italia. Consiglio Nazionale delle Ricerche; ItaliaFil: Rissmann, Anke. University Magdeburg; AlemaniaFil: Ritvanen, Annukka. National Institute for Health and Welfare; FinlandiaFil: Scarano, Gioacchino. General Hospital “G. Rummo” Benevento; ItaliaFil: Szabova, Elena. Slovak Medical University; EslovaquiaFil: Olney, Richard S.. National Center on Birth Defects and Developmental Disabilities; Estados UnidosWiley-liss, div John Wiley & Sons Inc.2011-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/195391Siffel, Csaba; Correa, Adolfo; Amar, Emmanuelle; Bakker, Marian K.; Bermejo Sanchez, Eva; et al.; Bladder Exstrophy: An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research, and an Overview of the Literature; Wiley-liss, div John Wiley & Sons Inc.; American Journal Of Medical Genetics Part C-seminars In Medical Genetics; 157; 8-2011; 321-3321552-4868CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ajmg.c.30316info:eu-repo/semantics/altIdentifier/doi/10.1002/ajmg.c.30316info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:51:24Zoai:ri.conicet.gov.ar:11336/195391instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:51:24.933CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Bladder Exstrophy: An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research, and an Overview of the Literature |
| title |
Bladder Exstrophy: An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research, and an Overview of the Literature |
| spellingShingle |
Bladder Exstrophy: An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research, and an Overview of the Literature Siffel, Csaba bladder exstrophy; prevalence; sex ratio; maternal age |
| title_short |
Bladder Exstrophy: An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research, and an Overview of the Literature |
| title_full |
Bladder Exstrophy: An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research, and an Overview of the Literature |
| title_fullStr |
Bladder Exstrophy: An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research, and an Overview of the Literature |
| title_full_unstemmed |
Bladder Exstrophy: An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research, and an Overview of the Literature |
| title_sort |
Bladder Exstrophy: An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research, and an Overview of the Literature |
| dc.creator.none.fl_str_mv |
Siffel, Csaba Correa, Adolfo Amar, Emmanuelle Bakker, Marian K. Bermejo Sanchez, Eva Bianca, Sebastiano Castilla, Eduardo Enrique Clementi, Maurizio Cocchi, Guido Csaky Szunyogh, Melinda Feldkamp, Marcia L. Landau, Danielle Leoncini, Emanuele Li, Zhu Lowry, R. Brian Marengo, Lisa K. Mastroiacovo, Pierpaolo Morgan, Margery Mutchinick, Osvaldo M. Pierini, Anna Rissmann, Anke Ritvanen, Annukka Scarano, Gioacchino Szabova, Elena Olney, Richard S. |
| author |
Siffel, Csaba |
| author_facet |
Siffel, Csaba Correa, Adolfo Amar, Emmanuelle Bakker, Marian K. Bermejo Sanchez, Eva Bianca, Sebastiano Castilla, Eduardo Enrique Clementi, Maurizio Cocchi, Guido Csaky Szunyogh, Melinda Feldkamp, Marcia L. Landau, Danielle Leoncini, Emanuele Li, Zhu Lowry, R. Brian Marengo, Lisa K. Mastroiacovo, Pierpaolo Morgan, Margery Mutchinick, Osvaldo M. Pierini, Anna Rissmann, Anke Ritvanen, Annukka Scarano, Gioacchino Szabova, Elena Olney, Richard S. |
| author_role |
author |
| author2 |
Correa, Adolfo Amar, Emmanuelle Bakker, Marian K. Bermejo Sanchez, Eva Bianca, Sebastiano Castilla, Eduardo Enrique Clementi, Maurizio Cocchi, Guido Csaky Szunyogh, Melinda Feldkamp, Marcia L. Landau, Danielle Leoncini, Emanuele Li, Zhu Lowry, R. Brian Marengo, Lisa K. Mastroiacovo, Pierpaolo Morgan, Margery Mutchinick, Osvaldo M. Pierini, Anna Rissmann, Anke Ritvanen, Annukka Scarano, Gioacchino Szabova, Elena Olney, Richard S. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
bladder exstrophy; prevalence; sex ratio; maternal age |
| topic |
bladder exstrophy; prevalence; sex ratio; maternal age |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Bladder exstrophy (BE) is a complex congenital anomaly characterized by a defect in the closure of the lower abdominal wall and bladder. We aimed to provide an overview of the literature and conduct an epidemiologic study to describe the prevalence, and maternal and case characteristics of BE. We used data from 22 participating member programs of the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR). All cases were reviewed and classified as isolated, syndrome, and multiple congenital anomalies. We estimated the total prevalence of BE and calculated the frequency and odds ratios for various maternal and case characteristics. A total of 546 cases with BE were identified among 26,355,094 births. The total prevalence of BE was 2.07 per 100,000 births (95% CI: 1.90–2.25) and varied between 0.52 and 4.63 among surveillance programs participating in the study. BE was nearly twice as common among male as among female cases. The proportion of isolated cases was 71%. Prevalence appeared to increase with increasing categories of maternal age, particularly among isolated cases. The total prevalence of BE showed some variations by geographical region, which is most likely attributable to differences in registration of cases. The higher total prevalence among male cases and older mothers, especially among isolated cases, warrants further attention. Fil: Siffel, Csaba. National Center on Birth Defects and Developmental Disabilities; Estados Unidos Fil: Correa, Adolfo. National Center on Birth Defects and Developmental Disabilities; Estados Unidos Fil: Amar, Emmanuelle. Rhone-alps Registry Of Birth Defects Remera; Francia Fil: Bakker, Marian K.. University of Groningen; Países Bajos Fil: Bermejo Sanchez, Eva. Instituto de Salud Carlos III; España Fil: Bianca, Sebastiano. Centro di Consulenza Genetica e di Teratologia della Riproduzione; Italia Fil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Fundación Oswaldo Cruz; Brasil Fil: Clementi, Maurizio. Università di Padova; Italia Fil: Cocchi, Guido. Bologna University; Italia Fil: Csaky Szunyogh, Melinda. National Center for Healthcare Audit and Inspection; Hungría Fil: Feldkamp, Marcia L.. University of Utah School of Medicine; Estados Unidos Fil: Landau, Danielle. Soroka University Medical Center; Israel Fil: Leoncini, Emanuele. Centre of the International Clearinghouse for Birth Defects Surveillance and Research; Italia Fil: Li, Zhu. Peking University; República de China Fil: Lowry, R. Brian. Alberta Health & Wellness; Canadá Fil: Marengo, Lisa K.. Birth Defects Epidemiology and Surveillance Branch; Estados Unidos Fil: Mastroiacovo, Pierpaolo. Centre of the International Clearinghouse for Birth Defects Surveillance and Research; Italia Fil: Morgan, Margery. the Congenital Anomaly Register for Wales; Reino Unido Fil: Mutchinick, Osvaldo M.. Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”; México Fil: Pierini, Anna. Tuscany Region “Gabriele Monasterio” Foundation; Italia. Consiglio Nazionale delle Ricerche; Italia Fil: Rissmann, Anke. University Magdeburg; Alemania Fil: Ritvanen, Annukka. National Institute for Health and Welfare; Finlandia Fil: Scarano, Gioacchino. General Hospital “G. Rummo” Benevento; Italia Fil: Szabova, Elena. Slovak Medical University; Eslovaquia Fil: Olney, Richard S.. National Center on Birth Defects and Developmental Disabilities; Estados Unidos |
| description |
Bladder exstrophy (BE) is a complex congenital anomaly characterized by a defect in the closure of the lower abdominal wall and bladder. We aimed to provide an overview of the literature and conduct an epidemiologic study to describe the prevalence, and maternal and case characteristics of BE. We used data from 22 participating member programs of the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR). All cases were reviewed and classified as isolated, syndrome, and multiple congenital anomalies. We estimated the total prevalence of BE and calculated the frequency and odds ratios for various maternal and case characteristics. A total of 546 cases with BE were identified among 26,355,094 births. The total prevalence of BE was 2.07 per 100,000 births (95% CI: 1.90–2.25) and varied between 0.52 and 4.63 among surveillance programs participating in the study. BE was nearly twice as common among male as among female cases. The proportion of isolated cases was 71%. Prevalence appeared to increase with increasing categories of maternal age, particularly among isolated cases. The total prevalence of BE showed some variations by geographical region, which is most likely attributable to differences in registration of cases. The higher total prevalence among male cases and older mothers, especially among isolated cases, warrants further attention. |
| publishDate |
2011 |
| dc.date.none.fl_str_mv |
2011-08 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/195391 Siffel, Csaba; Correa, Adolfo; Amar, Emmanuelle; Bakker, Marian K.; Bermejo Sanchez, Eva; et al.; Bladder Exstrophy: An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research, and an Overview of the Literature; Wiley-liss, div John Wiley & Sons Inc.; American Journal Of Medical Genetics Part C-seminars In Medical Genetics; 157; 8-2011; 321-332 1552-4868 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/195391 |
| identifier_str_mv |
Siffel, Csaba; Correa, Adolfo; Amar, Emmanuelle; Bakker, Marian K.; Bermejo Sanchez, Eva; et al.; Bladder Exstrophy: An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research, and an Overview of the Literature; Wiley-liss, div John Wiley & Sons Inc.; American Journal Of Medical Genetics Part C-seminars In Medical Genetics; 157; 8-2011; 321-332 1552-4868 CONICET Digital CONICET |
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eng |
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eng |
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Wiley-liss, div John Wiley & Sons Inc. |
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