Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird

Autores
Levy, Hila; Fiddaman, Steven R.; Vianna, Juliana A.; Noll, Daly; Clucas, Gemma V.; Sidhu, Jasmine K.H.; Polito, Michael J.; Bost, Charles A.; Phillips, Richard A.; Crofts, Sarah; Miller, Gary D.; Pistorius, Pierre; Bonnadonna, Francesco; Le Bohec, Celine; Barbosa, Andres; Trathan, Phil; Raya Rey, Andrea Nélida; Frantz, Laurent A.F.; Hart, Tom; Smith, Adrian L.
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Over evolutionary time,pathogen challenge shapes theimmunephenotype of the host tobetterrespondtoanincipient threat. The extent and direction of this selection pressure depend on the local pathogen composition, which is in turn determined by biotic and abiotic features of the environment. However, little is known about adaptation to local pathogen threats in wild animals. The Gentoo penguin (Pygoscelis papua) is a species complex that lends itself to the study of immune adaptation becauseof its circumpolardistributionover a large latitudinal range, with littleornoadmixturebetweendifferent clades. Inthis study,we examine thediversity ina key family of innateimmunegenes-theToll-like receptors (TLRs)-across the range of the Gentoo penguin. The three TLRs that we investigated present varying levels of diversity, with TLR4 and TLR5 greatly exceeding the diversity of TLR7.We present evidence of positive selection in TLR4 and TLR5,which points to pathogen-driven adaptation to the local pathogen milieu. Finally, we demonstrate that two positively selected cosegregating sites in TLR5 are sufficient to alter the responsiveness of the receptor to its bacterial ligand, flagellin. Taken together, these results suggest that Gentoo penguins have experienced distinct pathogen-driven selection pressures in different environments, which may be important given the role of the Gentoo penguin as a sentinel species in some of the world's most rapidly changing environments.
Fil: Levy, Hila. University of Oxford; Reino Unido
Fil: Fiddaman, Steven R.. University of Oxford; Reino Unido
Fil: Vianna, Juliana A.. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Noll, Daly. Pontificia Universidad Católica de Chile; Chile. Universidad de Chile; Chile
Fil: Clucas, Gemma V.. Cornell University; Estados Unidos
Fil: Sidhu, Jasmine K.H.. University of Oxford; Reino Unido
Fil: Polito, Michael J.. Louisiana State University; Estados Unidos
Fil: Bost, Charles A.. Centre D'etudes Biologiques de Chizé; Francia
Fil: Phillips, Richard A.. British Antarctic Survey; Reino Unido
Fil: Crofts, Sarah. Falklands Conservation; Reino Unido
Fil: Miller, Gary D.. University of Western Australia; Australia
Fil: Pistorius, Pierre. Nelson Mandela University; Sudáfrica
Fil: Bonnadonna, Francesco. Université de Montpellier; Francia
Fil: Le Bohec, Celine. Université de Strasbourg; Francia
Fil: Barbosa, Andres. Consejo Superior de Investigaciones Científicas. Museo Nacional de Ciencias Naturales; España
Fil: Trathan, Phil. British Antarctic Survey; Reino Unido
Fil: Raya Rey, Andrea Nélida. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; Argentina
Fil: Frantz, Laurent A.F.. University of London; Reino Unido
Fil: Hart, Tom. University of Oxford; Reino Unido
Fil: Smith, Adrian L.. University of Oxford; Reino Unido
Materia
ANTARCTICA AND SOUTHERN OCEAN
GENTOO PENGUIN
IMMUNOGENETICS
PATHOGEN-MEDIATED SELECTION
POSITIVE SELECTION
TOLL-LIKE RECEPTORS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/141119
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/141119
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabirdLevy, HilaFiddaman, Steven R.Vianna, Juliana A.Noll, DalyClucas, Gemma V.Sidhu, Jasmine K.H.Polito, Michael J.Bost, Charles A.Phillips, Richard A.Crofts, SarahMiller, Gary D.Pistorius, PierreBonnadonna, FrancescoLe Bohec, CelineBarbosa, AndresTrathan, PhilRaya Rey, Andrea NélidaFrantz, Laurent A.F.Hart, TomSmith, Adrian L.ANTARCTICA AND SOUTHERN OCEANGENTOO PENGUINIMMUNOGENETICSPATHOGEN-MEDIATED SELECTIONPOSITIVE SELECTIONTOLL-LIKE RECEPTORShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Over evolutionary time,pathogen challenge shapes theimmunephenotype of the host tobetterrespondtoanincipient threat. The extent and direction of this selection pressure depend on the local pathogen composition, which is in turn determined by biotic and abiotic features of the environment. However, little is known about adaptation to local pathogen threats in wild animals. The Gentoo penguin (Pygoscelis papua) is a species complex that lends itself to the study of immune adaptation becauseof its circumpolardistributionover a large latitudinal range, with littleornoadmixturebetweendifferent clades. Inthis study,we examine thediversity ina key family of innateimmunegenes-theToll-like receptors (TLRs)-across the range of the Gentoo penguin. The three TLRs that we investigated present varying levels of diversity, with TLR4 and TLR5 greatly exceeding the diversity of TLR7.We present evidence of positive selection in TLR4 and TLR5,which points to pathogen-driven adaptation to the local pathogen milieu. Finally, we demonstrate that two positively selected cosegregating sites in TLR5 are sufficient to alter the responsiveness of the receptor to its bacterial ligand, flagellin. Taken together, these results suggest that Gentoo penguins have experienced distinct pathogen-driven selection pressures in different environments, which may be important given the role of the Gentoo penguin as a sentinel species in some of the world's most rapidly changing environments.Fil: Levy, Hila. University of Oxford; Reino UnidoFil: Fiddaman, Steven R.. University of Oxford; Reino UnidoFil: Vianna, Juliana A.. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Noll, Daly. Pontificia Universidad Católica de Chile; Chile. Universidad de Chile; ChileFil: Clucas, Gemma V.. Cornell University; Estados UnidosFil: Sidhu, Jasmine K.H.. University of Oxford; Reino UnidoFil: Polito, Michael J.. Louisiana State University; Estados UnidosFil: Bost, Charles A.. Centre D'etudes Biologiques de Chizé; FranciaFil: Phillips, Richard A.. British Antarctic Survey; Reino UnidoFil: Crofts, Sarah. Falklands Conservation; Reino UnidoFil: Miller, Gary D.. University of Western Australia; AustraliaFil: Pistorius, Pierre. Nelson Mandela University; SudáfricaFil: Bonnadonna, Francesco. Université de Montpellier; FranciaFil: Le Bohec, Celine. Université de Strasbourg; FranciaFil: Barbosa, Andres. Consejo Superior de Investigaciones Científicas. Museo Nacional de Ciencias Naturales; EspañaFil: Trathan, Phil. British Antarctic Survey; Reino UnidoFil: Raya Rey, Andrea Nélida. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; ArgentinaFil: Frantz, Laurent A.F.. University of London; Reino UnidoFil: Hart, Tom. University of Oxford; Reino UnidoFil: Smith, Adrian L.. University of Oxford; Reino UnidoOxford University Press2020-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/141119Levy, Hila; Fiddaman, Steven R.; Vianna, Juliana A.; Noll, Daly; Clucas, Gemma V.; et al.; Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird; Oxford University Press; Molecular Biology and Evolution; 37; 6; 2-2020; 1708-17260737-4038CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/molbev/msaa040info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/mbe/article/37/6/1708/5756218info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:22:34Zoai:ri.conicet.gov.ar:11336/141119instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:22:35.203CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird
title Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird
spellingShingle Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird
Levy, Hila
ANTARCTICA AND SOUTHERN OCEAN
GENTOO PENGUIN
IMMUNOGENETICS
PATHOGEN-MEDIATED SELECTION
POSITIVE SELECTION
TOLL-LIKE RECEPTORS
title_short Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird
title_full Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird
title_fullStr Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird
title_full_unstemmed Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird
title_sort Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird
dc.creator.none.fl_str_mv Levy, Hila
Fiddaman, Steven R.
Vianna, Juliana A.
Noll, Daly
Clucas, Gemma V.
Sidhu, Jasmine K.H.
Polito, Michael J.
Bost, Charles A.
Phillips, Richard A.
Crofts, Sarah
Miller, Gary D.
Pistorius, Pierre
Bonnadonna, Francesco
Le Bohec, Celine
Barbosa, Andres
Trathan, Phil
Raya Rey, Andrea Nélida
Frantz, Laurent A.F.
Hart, Tom
Smith, Adrian L.
author Levy, Hila
author_facet Levy, Hila
Fiddaman, Steven R.
Vianna, Juliana A.
Noll, Daly
Clucas, Gemma V.
Sidhu, Jasmine K.H.
Polito, Michael J.
Bost, Charles A.
Phillips, Richard A.
Crofts, Sarah
Miller, Gary D.
Pistorius, Pierre
Bonnadonna, Francesco
Le Bohec, Celine
Barbosa, Andres
Trathan, Phil
Raya Rey, Andrea Nélida
Frantz, Laurent A.F.
Hart, Tom
Smith, Adrian L.
author_role author
author2 Fiddaman, Steven R.
Vianna, Juliana A.
Noll, Daly
Clucas, Gemma V.
Sidhu, Jasmine K.H.
Polito, Michael J.
Bost, Charles A.
Phillips, Richard A.
Crofts, Sarah
Miller, Gary D.
Pistorius, Pierre
Bonnadonna, Francesco
Le Bohec, Celine
Barbosa, Andres
Trathan, Phil
Raya Rey, Andrea Nélida
Frantz, Laurent A.F.
Hart, Tom
Smith, Adrian L.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTARCTICA AND SOUTHERN OCEAN
GENTOO PENGUIN
IMMUNOGENETICS
PATHOGEN-MEDIATED SELECTION
POSITIVE SELECTION
TOLL-LIKE RECEPTORS
topic ANTARCTICA AND SOUTHERN OCEAN
GENTOO PENGUIN
IMMUNOGENETICS
PATHOGEN-MEDIATED SELECTION
POSITIVE SELECTION
TOLL-LIKE RECEPTORS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Over evolutionary time,pathogen challenge shapes theimmunephenotype of the host tobetterrespondtoanincipient threat. The extent and direction of this selection pressure depend on the local pathogen composition, which is in turn determined by biotic and abiotic features of the environment. However, little is known about adaptation to local pathogen threats in wild animals. The Gentoo penguin (Pygoscelis papua) is a species complex that lends itself to the study of immune adaptation becauseof its circumpolardistributionover a large latitudinal range, with littleornoadmixturebetweendifferent clades. Inthis study,we examine thediversity ina key family of innateimmunegenes-theToll-like receptors (TLRs)-across the range of the Gentoo penguin. The three TLRs that we investigated present varying levels of diversity, with TLR4 and TLR5 greatly exceeding the diversity of TLR7.We present evidence of positive selection in TLR4 and TLR5,which points to pathogen-driven adaptation to the local pathogen milieu. Finally, we demonstrate that two positively selected cosegregating sites in TLR5 are sufficient to alter the responsiveness of the receptor to its bacterial ligand, flagellin. Taken together, these results suggest that Gentoo penguins have experienced distinct pathogen-driven selection pressures in different environments, which may be important given the role of the Gentoo penguin as a sentinel species in some of the world's most rapidly changing environments.
Fil: Levy, Hila. University of Oxford; Reino Unido
Fil: Fiddaman, Steven R.. University of Oxford; Reino Unido
Fil: Vianna, Juliana A.. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Noll, Daly. Pontificia Universidad Católica de Chile; Chile. Universidad de Chile; Chile
Fil: Clucas, Gemma V.. Cornell University; Estados Unidos
Fil: Sidhu, Jasmine K.H.. University of Oxford; Reino Unido
Fil: Polito, Michael J.. Louisiana State University; Estados Unidos
Fil: Bost, Charles A.. Centre D'etudes Biologiques de Chizé; Francia
Fil: Phillips, Richard A.. British Antarctic Survey; Reino Unido
Fil: Crofts, Sarah. Falklands Conservation; Reino Unido
Fil: Miller, Gary D.. University of Western Australia; Australia
Fil: Pistorius, Pierre. Nelson Mandela University; Sudáfrica
Fil: Bonnadonna, Francesco. Université de Montpellier; Francia
Fil: Le Bohec, Celine. Université de Strasbourg; Francia
Fil: Barbosa, Andres. Consejo Superior de Investigaciones Científicas. Museo Nacional de Ciencias Naturales; España
Fil: Trathan, Phil. British Antarctic Survey; Reino Unido
Fil: Raya Rey, Andrea Nélida. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; Argentina
Fil: Frantz, Laurent A.F.. University of London; Reino Unido
Fil: Hart, Tom. University of Oxford; Reino Unido
Fil: Smith, Adrian L.. University of Oxford; Reino Unido
description Over evolutionary time,pathogen challenge shapes theimmunephenotype of the host tobetterrespondtoanincipient threat. The extent and direction of this selection pressure depend on the local pathogen composition, which is in turn determined by biotic and abiotic features of the environment. However, little is known about adaptation to local pathogen threats in wild animals. The Gentoo penguin (Pygoscelis papua) is a species complex that lends itself to the study of immune adaptation becauseof its circumpolardistributionover a large latitudinal range, with littleornoadmixturebetweendifferent clades. Inthis study,we examine thediversity ina key family of innateimmunegenes-theToll-like receptors (TLRs)-across the range of the Gentoo penguin. The three TLRs that we investigated present varying levels of diversity, with TLR4 and TLR5 greatly exceeding the diversity of TLR7.We present evidence of positive selection in TLR4 and TLR5,which points to pathogen-driven adaptation to the local pathogen milieu. Finally, we demonstrate that two positively selected cosegregating sites in TLR5 are sufficient to alter the responsiveness of the receptor to its bacterial ligand, flagellin. Taken together, these results suggest that Gentoo penguins have experienced distinct pathogen-driven selection pressures in different environments, which may be important given the role of the Gentoo penguin as a sentinel species in some of the world's most rapidly changing environments.
publishDate 2020
dc.date.none.fl_str_mv 2020-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/141119
Levy, Hila; Fiddaman, Steven R.; Vianna, Juliana A.; Noll, Daly; Clucas, Gemma V.; et al.; Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird; Oxford University Press; Molecular Biology and Evolution; 37; 6; 2-2020; 1708-1726
0737-4038
CONICET Digital
CONICET
url http://hdl.handle.net/11336/141119
identifier_str_mv Levy, Hila; Fiddaman, Steven R.; Vianna, Juliana A.; Noll, Daly; Clucas, Gemma V.; et al.; Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird; Oxford University Press; Molecular Biology and Evolution; 37; 6; 2-2020; 1708-1726
0737-4038
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/molbev/msaa040
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/mbe/article/37/6/1708/5756218
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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