Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice...

Autores: Canosa, Ivana Sofía; Silveyra, Gabriela Romina; Lofrano, Juliana Leticia; Medesani, Daniel Alberto; Rodriguez, Enrique Marcelo
Año de publicación: 2022
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: Adult females of the crab Neohelice granulata sampled at from Samborombón Bay (Buenos Aires Province, Argentina), were used. Several in vitro tests were carried out during the pre-reproductive period, in order to evaluate the growth of the isolated ovary in the presence of the herbicide (in its commercial formulation Roundup) and/or extracts of neuroendocrine organs or inhibitors of prostaglandin synthesis. For each assay, 12 females were used, assigning a different treatment to each portion of the ovary of the same female (randomized block design). The ovary pieces were incubated for 24 h in M199 culture medium, at 24 ºC and controlled atmosphere. At the end of each assay, the ovaries were processed either for histological analysis or to determine the levels of vitellogenin (Vg) using the ELISA technique. The results of the assays conducted with extracts of eyestalk or thoracic ganglion indicated that Roundup (RUP) addition did not significantly (p>0.05) modify the effect of such extracts on ovarian growth. However, in order to assess whether the effect of RUP on isolated ovaries is related to the hormonal signaling exerted by prostaglandins (PG), an in vitro assay with ibuprofen (IBF, inhibitor of PG synthesis) was performed. The level of Vg in the treatment with RUP 0.2 mg/L + IBF 10 mg/L was significantly lower (p<0.05) than that of the Control, RUP 0.2 mg/L, or IBF 10 mg groups. Although RUP per se produced a decrease (p<0.05) in Vg levels, compared to control, its combination with IBF caused a higher (p<0.05) decrease. Given the additivity of inhibitory effects observed between ibuprofen and the RUP, it is plausible to propose that the mode of action of the RUP could be due to the inhibition of the endogenous synthesis of PGs in the ovary, although the possible interference of the RUP with the PGs receptor, or the inhibition of some step in the prostaglandin hormone transduction pathway, cannot yet be ruled out.
Adult females of the crab Neohelice granulata sampled at from Samborombón Bay (Buenos Aires Province, Argentina), were used. Several in vitro tests were carried out during the pre-reproductive period, in order to evaluate the growth of the isolated ovary in the presence of the herbicide (in its commercial formulation Roundup) and/or extracts of neuroendocrine organs or inhibitors of prostaglandin synthesis. For each assay, 12 females were used, assigning a different treatment to each portion of the ovary of the same female (randomized block design). The ovary pieces were incubated for 24 h in M199 culture medium, at 24 ºC and controlled atmosphere. At the end of each assay, the ovaries were processed either for histological analysis or to determine the levels of vitellogenin (Vg) using the ELISA technique. The results of the assays conducted with extracts of eyestalk or thoracic ganglion indicated that Roundup (RUP) addition did not significantly (p>0.05) modify the effect of such extracts on ovarian growth. However, in order to assess whether the effect of RUP on isolated ovaries is related to the hormonal signaling exerted by prostaglandins (PG), an in vitro assay with ibuprofen (IBF, inhibitor of PG synthesis) was performed. The level of Vg in the treatment with RUP 0.2 mg/L + IBF 10 mg/L was significantly lower (p<0.05) than that of the Control, RUP 0.2 mg/L, or IBF 10 mg groups. Although RUP per se produced a decrease (p<0.05) in Vg levels, compared to control, its combination with IBF caused a higher (p<0.05) decrease. Given the additivity of inhibitory effects observed between ibuprofen and the RUP, it is plausible to propose that the mode of action of the RUP could be due to the inhibition of the endogenous synthesis of PGs in the ovary, although the possible interference of the RUP with the PGs receptor, or the inhibition of some step in the prostaglandin hormone transduction pathway, cannot yet be ruled out.
Fil: Canosa, Ivana Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina
Fil: Silveyra, Gabriela Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina
Fil: Lofrano, Juliana Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina
Fil: Medesani, Daniel Alberto. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Fisiologia de Crustáceos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina
Fil: Rodriguez, Enrique Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Fisiologia de Crustáceos; Argentina
Materia: GLYPHOSATE
CRUSTACEANS
OVARY
HORMONES
PROSTAGLANDINS
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/212908

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spelling	Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulataIn vitro evaluation of the interference of the the herbicide glyphosate on the endocrine control of ovarian growth, by neurohomones and prostaglandins, in the estuarine crab Neohelice granulataCanosa, Ivana SofíaSilveyra, Gabriela RominaLofrano, Juliana LeticiaMedesani, Daniel AlbertoRodriguez, Enrique MarceloGLYPHOSATECRUSTACEANSOVARYHORMONESPROSTAGLANDINShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Adult females of the crab Neohelice granulata sampled at from Samborombón Bay (Buenos Aires Province, Argentina), were used. Several in vitro tests were carried out during the pre-reproductive period, in order to evaluate the growth of the isolated ovary in the presence of the herbicide (in its commercial formulation Roundup) and/or extracts of neuroendocrine organs or inhibitors of prostaglandin synthesis. For each assay, 12 females were used, assigning a different treatment to each portion of the ovary of the same female (randomized block design). The ovary pieces were incubated for 24 h in M199 culture medium, at 24 ºC and controlled atmosphere. At the end of each assay, the ovaries were processed either for histological analysis or to determine the levels of vitellogenin (Vg) using the ELISA technique. The results of the assays conducted with extracts of eyestalk or thoracic ganglion indicated that Roundup (RUP) addition did not significantly (p>0.05) modify the effect of such extracts on ovarian growth. However, in order to assess whether the effect of RUP on isolated ovaries is related to the hormonal signaling exerted by prostaglandins (PG), an in vitro assay with ibuprofen (IBF, inhibitor of PG synthesis) was performed. The level of Vg in the treatment with RUP 0.2 mg/L + IBF 10 mg/L was significantly lower (p<0.05) than that of the Control, RUP 0.2 mg/L, or IBF 10 mg groups. Although RUP per se produced a decrease (p<0.05) in Vg levels, compared to control, its combination with IBF caused a higher (p<0.05) decrease. Given the additivity of inhibitory effects observed between ibuprofen and the RUP, it is plausible to propose that the mode of action of the RUP could be due to the inhibition of the endogenous synthesis of PGs in the ovary, although the possible interference of the RUP with the PGs receptor, or the inhibition of some step in the prostaglandin hormone transduction pathway, cannot yet be ruled out.Adult females of the crab Neohelice granulata sampled at from Samborombón Bay (Buenos Aires Province, Argentina), were used. Several in vitro tests were carried out during the pre-reproductive period, in order to evaluate the growth of the isolated ovary in the presence of the herbicide (in its commercial formulation Roundup) and/or extracts of neuroendocrine organs or inhibitors of prostaglandin synthesis. For each assay, 12 females were used, assigning a different treatment to each portion of the ovary of the same female (randomized block design). The ovary pieces were incubated for 24 h in M199 culture medium, at 24 ºC and controlled atmosphere. At the end of each assay, the ovaries were processed either for histological analysis or to determine the levels of vitellogenin (Vg) using the ELISA technique. The results of the assays conducted with extracts of eyestalk or thoracic ganglion indicated that Roundup (RUP) addition did not significantly (p>0.05) modify the effect of such extracts on ovarian growth. However, in order to assess whether the effect of RUP on isolated ovaries is related to the hormonal signaling exerted by prostaglandins (PG), an in vitro assay with ibuprofen (IBF, inhibitor of PG synthesis) was performed. The level of Vg in the treatment with RUP 0.2 mg/L + IBF 10 mg/L was significantly lower (p<0.05) than that of the Control, RUP 0.2 mg/L, or IBF 10 mg groups. Although RUP per se produced a decrease (p<0.05) in Vg levels, compared to control, its combination with IBF caused a higher (p<0.05) decrease. Given the additivity of inhibitory effects observed between ibuprofen and the RUP, it is plausible to propose that the mode of action of the RUP could be due to the inhibition of the endogenous synthesis of PGs in the ovary, although the possible interference of the RUP with the PGs receptor, or the inhibition of some step in the prostaglandin hormone transduction pathway, cannot yet be ruled out.Fil: Canosa, Ivana Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; ArgentinaFil: Silveyra, Gabriela Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; ArgentinaFil: Lofrano, Juliana Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; ArgentinaFil: Medesani, Daniel Alberto. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Fisiologia de Crustáceos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; ArgentinaFil: Rodriguez, Enrique Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Fisiologia de Crustáceos; ArgentinaBrazilian Journals Publicações de Periódicos e Editora2022-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/212908Canosa, Ivana Sofía; Silveyra, Gabriela Romina; Lofrano, Juliana Leticia; Medesani, Daniel Alberto; Rodriguez, Enrique Marcelo; Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata; Brazilian Journals Publicações de Periódicos e Editora; Brazilian Journal of Animal and Environment Research; 5; 4; 11-2022; 3782-37962595-573XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.34188/bjaerv5n4-027info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:09:37Zoai:ri.conicet.gov.ar:11336/212908instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:09:37.925CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata In vitro evaluation of the interference of the the herbicide glyphosate on the endocrine control of ovarian growth, by neurohomones and prostaglandins, in the estuarine crab Neohelice granulata
title	Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata
spellingShingle	Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata Canosa, Ivana Sofía GLYPHOSATE CRUSTACEANS OVARY HORMONES PROSTAGLANDINS
title_short	Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata
title_full	Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata
title_fullStr	Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata
title_full_unstemmed	Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata
title_sort	Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata
dc.creator.none.fl_str_mv	Canosa, Ivana Sofía Silveyra, Gabriela Romina Lofrano, Juliana Leticia Medesani, Daniel Alberto Rodriguez, Enrique Marcelo
author	Canosa, Ivana Sofía
author_facet	Canosa, Ivana Sofía Silveyra, Gabriela Romina Lofrano, Juliana Leticia Medesani, Daniel Alberto Rodriguez, Enrique Marcelo
author_role	author
author2	Silveyra, Gabriela Romina Lofrano, Juliana Leticia Medesani, Daniel Alberto Rodriguez, Enrique Marcelo
author2_role	author author author author
dc.subject.none.fl_str_mv	GLYPHOSATE CRUSTACEANS OVARY HORMONES PROSTAGLANDINS
topic	GLYPHOSATE CRUSTACEANS OVARY HORMONES PROSTAGLANDINS
purl_subject.fl_str_mv	https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv	Adult females of the crab Neohelice granulata sampled at from Samborombón Bay (Buenos Aires Province, Argentina), were used. Several in vitro tests were carried out during the pre-reproductive period, in order to evaluate the growth of the isolated ovary in the presence of the herbicide (in its commercial formulation Roundup) and/or extracts of neuroendocrine organs or inhibitors of prostaglandin synthesis. For each assay, 12 females were used, assigning a different treatment to each portion of the ovary of the same female (randomized block design). The ovary pieces were incubated for 24 h in M199 culture medium, at 24 ºC and controlled atmosphere. At the end of each assay, the ovaries were processed either for histological analysis or to determine the levels of vitellogenin (Vg) using the ELISA technique. The results of the assays conducted with extracts of eyestalk or thoracic ganglion indicated that Roundup (RUP) addition did not significantly (p>0.05) modify the effect of such extracts on ovarian growth. However, in order to assess whether the effect of RUP on isolated ovaries is related to the hormonal signaling exerted by prostaglandins (PG), an in vitro assay with ibuprofen (IBF, inhibitor of PG synthesis) was performed. The level of Vg in the treatment with RUP 0.2 mg/L + IBF 10 mg/L was significantly lower (p<0.05) than that of the Control, RUP 0.2 mg/L, or IBF 10 mg groups. Although RUP per se produced a decrease (p<0.05) in Vg levels, compared to control, its combination with IBF caused a higher (p<0.05) decrease. Given the additivity of inhibitory effects observed between ibuprofen and the RUP, it is plausible to propose that the mode of action of the RUP could be due to the inhibition of the endogenous synthesis of PGs in the ovary, although the possible interference of the RUP with the PGs receptor, or the inhibition of some step in the prostaglandin hormone transduction pathway, cannot yet be ruled out. Adult females of the crab Neohelice granulata sampled at from Samborombón Bay (Buenos Aires Province, Argentina), were used. Several in vitro tests were carried out during the pre-reproductive period, in order to evaluate the growth of the isolated ovary in the presence of the herbicide (in its commercial formulation Roundup) and/or extracts of neuroendocrine organs or inhibitors of prostaglandin synthesis. For each assay, 12 females were used, assigning a different treatment to each portion of the ovary of the same female (randomized block design). The ovary pieces were incubated for 24 h in M199 culture medium, at 24 ºC and controlled atmosphere. At the end of each assay, the ovaries were processed either for histological analysis or to determine the levels of vitellogenin (Vg) using the ELISA technique. The results of the assays conducted with extracts of eyestalk or thoracic ganglion indicated that Roundup (RUP) addition did not significantly (p>0.05) modify the effect of such extracts on ovarian growth. However, in order to assess whether the effect of RUP on isolated ovaries is related to the hormonal signaling exerted by prostaglandins (PG), an in vitro assay with ibuprofen (IBF, inhibitor of PG synthesis) was performed. The level of Vg in the treatment with RUP 0.2 mg/L + IBF 10 mg/L was significantly lower (p<0.05) than that of the Control, RUP 0.2 mg/L, or IBF 10 mg groups. Although RUP per se produced a decrease (p<0.05) in Vg levels, compared to control, its combination with IBF caused a higher (p<0.05) decrease. Given the additivity of inhibitory effects observed between ibuprofen and the RUP, it is plausible to propose that the mode of action of the RUP could be due to the inhibition of the endogenous synthesis of PGs in the ovary, although the possible interference of the RUP with the PGs receptor, or the inhibition of some step in the prostaglandin hormone transduction pathway, cannot yet be ruled out. Fil: Canosa, Ivana Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina Fil: Silveyra, Gabriela Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina Fil: Lofrano, Juliana Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina Fil: Medesani, Daniel Alberto. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Fisiologia de Crustáceos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina Fil: Rodriguez, Enrique Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Fisiologia de Crustáceos; Argentina
description	Adult females of the crab Neohelice granulata sampled at from Samborombón Bay (Buenos Aires Province, Argentina), were used. Several in vitro tests were carried out during the pre-reproductive period, in order to evaluate the growth of the isolated ovary in the presence of the herbicide (in its commercial formulation Roundup) and/or extracts of neuroendocrine organs or inhibitors of prostaglandin synthesis. For each assay, 12 females were used, assigning a different treatment to each portion of the ovary of the same female (randomized block design). The ovary pieces were incubated for 24 h in M199 culture medium, at 24 ºC and controlled atmosphere. At the end of each assay, the ovaries were processed either for histological analysis or to determine the levels of vitellogenin (Vg) using the ELISA technique. The results of the assays conducted with extracts of eyestalk or thoracic ganglion indicated that Roundup (RUP) addition did not significantly (p>0.05) modify the effect of such extracts on ovarian growth. However, in order to assess whether the effect of RUP on isolated ovaries is related to the hormonal signaling exerted by prostaglandins (PG), an in vitro assay with ibuprofen (IBF, inhibitor of PG synthesis) was performed. The level of Vg in the treatment with RUP 0.2 mg/L + IBF 10 mg/L was significantly lower (p<0.05) than that of the Control, RUP 0.2 mg/L, or IBF 10 mg groups. Although RUP per se produced a decrease (p<0.05) in Vg levels, compared to control, its combination with IBF caused a higher (p<0.05) decrease. Given the additivity of inhibitory effects observed between ibuprofen and the RUP, it is plausible to propose that the mode of action of the RUP could be due to the inhibition of the endogenous synthesis of PGs in the ovary, although the possible interference of the RUP with the PGs receptor, or the inhibition of some step in the prostaglandin hormone transduction pathway, cannot yet be ruled out.
publishDate	2022
dc.date.none.fl_str_mv	2022-11
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/212908 Canosa, Ivana Sofía; Silveyra, Gabriela Romina; Lofrano, Juliana Leticia; Medesani, Daniel Alberto; Rodriguez, Enrique Marcelo; Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata; Brazilian Journals Publicações de Periódicos e Editora; Brazilian Journal of Animal and Environment Research; 5; 4; 11-2022; 3782-3796 2595-573X CONICET Digital CONICET
url	http://hdl.handle.net/11336/212908
identifier_str_mv	Canosa, Ivana Sofía; Silveyra, Gabriela Romina; Lofrano, Juliana Leticia; Medesani, Daniel Alberto; Rodriguez, Enrique Marcelo; Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata; Brazilian Journals Publicações de Periódicos e Editora; Brazilian Journal of Animal and Environment Research; 5; 4; 11-2022; 3782-3796 2595-573X CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/doi/10.34188/bjaerv5n4-027
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	Brazilian Journals Publicações de Periódicos e Editora
publisher.none.fl_str_mv	Brazilian Journals Publicações de Periódicos e Editora
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instname_str	Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice...

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