Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice...
- Autores
- Canosa, Ivana Sofía; Silveyra, Gabriela Romina; Lofrano, Juliana Leticia; Medesani, Daniel Alberto; Rodriguez, Enrique Marcelo
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Adult females of the crab Neohelice granulata sampled at from Samborombón Bay (Buenos Aires Province, Argentina), were used. Several in vitro tests were carried out during the pre-reproductive period, in order to evaluate the growth of the isolated ovary in the presence of the herbicide (in its commercial formulation Roundup) and/or extracts of neuroendocrine organs or inhibitors of prostaglandin synthesis. For each assay, 12 females were used, assigning a different treatment to each portion of the ovary of the same female (randomized block design). The ovary pieces were incubated for 24 h in M199 culture medium, at 24 ºC and controlled atmosphere. At the end of each assay, the ovaries were processed either for histological analysis or to determine the levels of vitellogenin (Vg) using the ELISA technique. The results of the assays conducted with extracts of eyestalk or thoracic ganglion indicated that Roundup (RUP) addition did not significantly (p>0.05) modify the effect of such extracts on ovarian growth. However, in order to assess whether the effect of RUP on isolated ovaries is related to the hormonal signaling exerted by prostaglandins (PG), an in vitro assay with ibuprofen (IBF, inhibitor of PG synthesis) was performed. The level of Vg in the treatment with RUP 0.2 mg/L + IBF 10 mg/L was significantly lower (p<0.05) than that of the Control, RUP 0.2 mg/L, or IBF 10 mg groups. Although RUP per se produced a decrease (p<0.05) in Vg levels, compared to control, its combination with IBF caused a higher (p<0.05) decrease. Given the additivity of inhibitory effects observed between ibuprofen and the RUP, it is plausible to propose that the mode of action of the RUP could be due to the inhibition of the endogenous synthesis of PGs in the ovary, although the possible interference of the RUP with the PGs receptor, or the inhibition of some step in the prostaglandin hormone transduction pathway, cannot yet be ruled out.
Adult females of the crab Neohelice granulata sampled at from Samborombón Bay (Buenos Aires Province, Argentina), were used. Several in vitro tests were carried out during the pre-reproductive period, in order to evaluate the growth of the isolated ovary in the presence of the herbicide (in its commercial formulation Roundup) and/or extracts of neuroendocrine organs or inhibitors of prostaglandin synthesis. For each assay, 12 females were used, assigning a different treatment to each portion of the ovary of the same female (randomized block design). The ovary pieces were incubated for 24 h in M199 culture medium, at 24 ºC and controlled atmosphere. At the end of each assay, the ovaries were processed either for histological analysis or to determine the levels of vitellogenin (Vg) using the ELISA technique. The results of the assays conducted with extracts of eyestalk or thoracic ganglion indicated that Roundup (RUP) addition did not significantly (p>0.05) modify the effect of such extracts on ovarian growth. However, in order to assess whether the effect of RUP on isolated ovaries is related to the hormonal signaling exerted by prostaglandins (PG), an in vitro assay with ibuprofen (IBF, inhibitor of PG synthesis) was performed. The level of Vg in the treatment with RUP 0.2 mg/L + IBF 10 mg/L was significantly lower (p<0.05) than that of the Control, RUP 0.2 mg/L, or IBF 10 mg groups. Although RUP per se produced a decrease (p<0.05) in Vg levels, compared to control, its combination with IBF caused a higher (p<0.05) decrease. Given the additivity of inhibitory effects observed between ibuprofen and the RUP, it is plausible to propose that the mode of action of the RUP could be due to the inhibition of the endogenous synthesis of PGs in the ovary, although the possible interference of the RUP with the PGs receptor, or the inhibition of some step in the prostaglandin hormone transduction pathway, cannot yet be ruled out.
Fil: Canosa, Ivana Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina
Fil: Silveyra, Gabriela Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina
Fil: Lofrano, Juliana Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina
Fil: Medesani, Daniel Alberto. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Fisiologia de Crustáceos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina
Fil: Rodriguez, Enrique Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Fisiologia de Crustáceos; Argentina - Materia
-
GLYPHOSATE
CRUSTACEANS
OVARY
HORMONES
PROSTAGLANDINS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/212908
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Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulataIn vitro evaluation of the interference of the the herbicide glyphosate on the endocrine control of ovarian growth, by neurohomones and prostaglandins, in the estuarine crab Neohelice granulataCanosa, Ivana SofíaSilveyra, Gabriela RominaLofrano, Juliana LeticiaMedesani, Daniel AlbertoRodriguez, Enrique MarceloGLYPHOSATECRUSTACEANSOVARYHORMONESPROSTAGLANDINShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Adult females of the crab Neohelice granulata sampled at from Samborombón Bay (Buenos Aires Province, Argentina), were used. Several in vitro tests were carried out during the pre-reproductive period, in order to evaluate the growth of the isolated ovary in the presence of the herbicide (in its commercial formulation Roundup) and/or extracts of neuroendocrine organs or inhibitors of prostaglandin synthesis. For each assay, 12 females were used, assigning a different treatment to each portion of the ovary of the same female (randomized block design). The ovary pieces were incubated for 24 h in M199 culture medium, at 24 ºC and controlled atmosphere. At the end of each assay, the ovaries were processed either for histological analysis or to determine the levels of vitellogenin (Vg) using the ELISA technique. The results of the assays conducted with extracts of eyestalk or thoracic ganglion indicated that Roundup (RUP) addition did not significantly (p>0.05) modify the effect of such extracts on ovarian growth. However, in order to assess whether the effect of RUP on isolated ovaries is related to the hormonal signaling exerted by prostaglandins (PG), an in vitro assay with ibuprofen (IBF, inhibitor of PG synthesis) was performed. The level of Vg in the treatment with RUP 0.2 mg/L + IBF 10 mg/L was significantly lower (p<0.05) than that of the Control, RUP 0.2 mg/L, or IBF 10 mg groups. Although RUP per se produced a decrease (p<0.05) in Vg levels, compared to control, its combination with IBF caused a higher (p<0.05) decrease. Given the additivity of inhibitory effects observed between ibuprofen and the RUP, it is plausible to propose that the mode of action of the RUP could be due to the inhibition of the endogenous synthesis of PGs in the ovary, although the possible interference of the RUP with the PGs receptor, or the inhibition of some step in the prostaglandin hormone transduction pathway, cannot yet be ruled out.Adult females of the crab Neohelice granulata sampled at from Samborombón Bay (Buenos Aires Province, Argentina), were used. Several in vitro tests were carried out during the pre-reproductive period, in order to evaluate the growth of the isolated ovary in the presence of the herbicide (in its commercial formulation Roundup) and/or extracts of neuroendocrine organs or inhibitors of prostaglandin synthesis. For each assay, 12 females were used, assigning a different treatment to each portion of the ovary of the same female (randomized block design). The ovary pieces were incubated for 24 h in M199 culture medium, at 24 ºC and controlled atmosphere. At the end of each assay, the ovaries were processed either for histological analysis or to determine the levels of vitellogenin (Vg) using the ELISA technique. The results of the assays conducted with extracts of eyestalk or thoracic ganglion indicated that Roundup (RUP) addition did not significantly (p>0.05) modify the effect of such extracts on ovarian growth. However, in order to assess whether the effect of RUP on isolated ovaries is related to the hormonal signaling exerted by prostaglandins (PG), an in vitro assay with ibuprofen (IBF, inhibitor of PG synthesis) was performed. The level of Vg in the treatment with RUP 0.2 mg/L + IBF 10 mg/L was significantly lower (p<0.05) than that of the Control, RUP 0.2 mg/L, or IBF 10 mg groups. Although RUP per se produced a decrease (p<0.05) in Vg levels, compared to control, its combination with IBF caused a higher (p<0.05) decrease. Given the additivity of inhibitory effects observed between ibuprofen and the RUP, it is plausible to propose that the mode of action of the RUP could be due to the inhibition of the endogenous synthesis of PGs in the ovary, although the possible interference of the RUP with the PGs receptor, or the inhibition of some step in the prostaglandin hormone transduction pathway, cannot yet be ruled out.Fil: Canosa, Ivana Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; ArgentinaFil: Silveyra, Gabriela Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; ArgentinaFil: Lofrano, Juliana Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; ArgentinaFil: Medesani, Daniel Alberto. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Fisiologia de Crustáceos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; ArgentinaFil: Rodriguez, Enrique Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Fisiologia de Crustáceos; ArgentinaBrazilian Journals Publicações de Periódicos e Editora2022-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/212908Canosa, Ivana Sofía; Silveyra, Gabriela Romina; Lofrano, Juliana Leticia; Medesani, Daniel Alberto; Rodriguez, Enrique Marcelo; Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata; Brazilian Journals Publicações de Periódicos e Editora; Brazilian Journal of Animal and Environment Research; 5; 4; 11-2022; 3782-37962595-573XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.34188/bjaerv5n4-027info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:12:32Zoai:ri.conicet.gov.ar:11336/212908instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:12:32.513CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata In vitro evaluation of the interference of the the herbicide glyphosate on the endocrine control of ovarian growth, by neurohomones and prostaglandins, in the estuarine crab Neohelice granulata |
title |
Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata |
spellingShingle |
Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata Canosa, Ivana Sofía GLYPHOSATE CRUSTACEANS OVARY HORMONES PROSTAGLANDINS |
title_short |
Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata |
title_full |
Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata |
title_fullStr |
Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata |
title_full_unstemmed |
Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata |
title_sort |
Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata |
dc.creator.none.fl_str_mv |
Canosa, Ivana Sofía Silveyra, Gabriela Romina Lofrano, Juliana Leticia Medesani, Daniel Alberto Rodriguez, Enrique Marcelo |
author |
Canosa, Ivana Sofía |
author_facet |
Canosa, Ivana Sofía Silveyra, Gabriela Romina Lofrano, Juliana Leticia Medesani, Daniel Alberto Rodriguez, Enrique Marcelo |
author_role |
author |
author2 |
Silveyra, Gabriela Romina Lofrano, Juliana Leticia Medesani, Daniel Alberto Rodriguez, Enrique Marcelo |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
GLYPHOSATE CRUSTACEANS OVARY HORMONES PROSTAGLANDINS |
topic |
GLYPHOSATE CRUSTACEANS OVARY HORMONES PROSTAGLANDINS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Adult females of the crab Neohelice granulata sampled at from Samborombón Bay (Buenos Aires Province, Argentina), were used. Several in vitro tests were carried out during the pre-reproductive period, in order to evaluate the growth of the isolated ovary in the presence of the herbicide (in its commercial formulation Roundup) and/or extracts of neuroendocrine organs or inhibitors of prostaglandin synthesis. For each assay, 12 females were used, assigning a different treatment to each portion of the ovary of the same female (randomized block design). The ovary pieces were incubated for 24 h in M199 culture medium, at 24 ºC and controlled atmosphere. At the end of each assay, the ovaries were processed either for histological analysis or to determine the levels of vitellogenin (Vg) using the ELISA technique. The results of the assays conducted with extracts of eyestalk or thoracic ganglion indicated that Roundup (RUP) addition did not significantly (p>0.05) modify the effect of such extracts on ovarian growth. However, in order to assess whether the effect of RUP on isolated ovaries is related to the hormonal signaling exerted by prostaglandins (PG), an in vitro assay with ibuprofen (IBF, inhibitor of PG synthesis) was performed. The level of Vg in the treatment with RUP 0.2 mg/L + IBF 10 mg/L was significantly lower (p<0.05) than that of the Control, RUP 0.2 mg/L, or IBF 10 mg groups. Although RUP per se produced a decrease (p<0.05) in Vg levels, compared to control, its combination with IBF caused a higher (p<0.05) decrease. Given the additivity of inhibitory effects observed between ibuprofen and the RUP, it is plausible to propose that the mode of action of the RUP could be due to the inhibition of the endogenous synthesis of PGs in the ovary, although the possible interference of the RUP with the PGs receptor, or the inhibition of some step in the prostaglandin hormone transduction pathway, cannot yet be ruled out. Adult females of the crab Neohelice granulata sampled at from Samborombón Bay (Buenos Aires Province, Argentina), were used. Several in vitro tests were carried out during the pre-reproductive period, in order to evaluate the growth of the isolated ovary in the presence of the herbicide (in its commercial formulation Roundup) and/or extracts of neuroendocrine organs or inhibitors of prostaglandin synthesis. For each assay, 12 females were used, assigning a different treatment to each portion of the ovary of the same female (randomized block design). The ovary pieces were incubated for 24 h in M199 culture medium, at 24 ºC and controlled atmosphere. At the end of each assay, the ovaries were processed either for histological analysis or to determine the levels of vitellogenin (Vg) using the ELISA technique. The results of the assays conducted with extracts of eyestalk or thoracic ganglion indicated that Roundup (RUP) addition did not significantly (p>0.05) modify the effect of such extracts on ovarian growth. However, in order to assess whether the effect of RUP on isolated ovaries is related to the hormonal signaling exerted by prostaglandins (PG), an in vitro assay with ibuprofen (IBF, inhibitor of PG synthesis) was performed. The level of Vg in the treatment with RUP 0.2 mg/L + IBF 10 mg/L was significantly lower (p<0.05) than that of the Control, RUP 0.2 mg/L, or IBF 10 mg groups. Although RUP per se produced a decrease (p<0.05) in Vg levels, compared to control, its combination with IBF caused a higher (p<0.05) decrease. Given the additivity of inhibitory effects observed between ibuprofen and the RUP, it is plausible to propose that the mode of action of the RUP could be due to the inhibition of the endogenous synthesis of PGs in the ovary, although the possible interference of the RUP with the PGs receptor, or the inhibition of some step in the prostaglandin hormone transduction pathway, cannot yet be ruled out. Fil: Canosa, Ivana Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina Fil: Silveyra, Gabriela Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina Fil: Lofrano, Juliana Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina Fil: Medesani, Daniel Alberto. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Fisiologia de Crustáceos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina Fil: Rodriguez, Enrique Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Fisiologia de Crustáceos; Argentina |
description |
Adult females of the crab Neohelice granulata sampled at from Samborombón Bay (Buenos Aires Province, Argentina), were used. Several in vitro tests were carried out during the pre-reproductive period, in order to evaluate the growth of the isolated ovary in the presence of the herbicide (in its commercial formulation Roundup) and/or extracts of neuroendocrine organs or inhibitors of prostaglandin synthesis. For each assay, 12 females were used, assigning a different treatment to each portion of the ovary of the same female (randomized block design). The ovary pieces were incubated for 24 h in M199 culture medium, at 24 ºC and controlled atmosphere. At the end of each assay, the ovaries were processed either for histological analysis or to determine the levels of vitellogenin (Vg) using the ELISA technique. The results of the assays conducted with extracts of eyestalk or thoracic ganglion indicated that Roundup (RUP) addition did not significantly (p>0.05) modify the effect of such extracts on ovarian growth. However, in order to assess whether the effect of RUP on isolated ovaries is related to the hormonal signaling exerted by prostaglandins (PG), an in vitro assay with ibuprofen (IBF, inhibitor of PG synthesis) was performed. The level of Vg in the treatment with RUP 0.2 mg/L + IBF 10 mg/L was significantly lower (p<0.05) than that of the Control, RUP 0.2 mg/L, or IBF 10 mg groups. Although RUP per se produced a decrease (p<0.05) in Vg levels, compared to control, its combination with IBF caused a higher (p<0.05) decrease. Given the additivity of inhibitory effects observed between ibuprofen and the RUP, it is plausible to propose that the mode of action of the RUP could be due to the inhibition of the endogenous synthesis of PGs in the ovary, although the possible interference of the RUP with the PGs receptor, or the inhibition of some step in the prostaglandin hormone transduction pathway, cannot yet be ruled out. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/212908 Canosa, Ivana Sofía; Silveyra, Gabriela Romina; Lofrano, Juliana Leticia; Medesani, Daniel Alberto; Rodriguez, Enrique Marcelo; Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata; Brazilian Journals Publicações de Periódicos e Editora; Brazilian Journal of Animal and Environment Research; 5; 4; 11-2022; 3782-3796 2595-573X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/212908 |
identifier_str_mv |
Canosa, Ivana Sofía; Silveyra, Gabriela Romina; Lofrano, Juliana Leticia; Medesani, Daniel Alberto; Rodriguez, Enrique Marcelo; Avaliação in vitro da interferência do herbicida glyphosate no controle endócrino do crescimento ovariano por neuro-hormônios e prostaglandinas, no caranguejo do estuário Neohelice granulata; Brazilian Journals Publicações de Periódicos e Editora; Brazilian Journal of Animal and Environment Research; 5; 4; 11-2022; 3782-3796 2595-573X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.34188/bjaerv5n4-027 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614033862295552 |
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13.070432 |