The therapeutic potential of bone marrow-derived mesenchymal stromal cells on hepatocellular carcinoma

Autores
Bayo Fina, Juan Miguel; Marrodán, María Dolores; Aquino, Jorge Benjamin; Silva, Marcelo David; García, Mariana Gabriela; Mazzolini Rizzo, Guillermo Daniel
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mesenchymal stromal cells (MSCs) are more often obtained from adult and extraembryonic tissues, with the latter sources being likely better from a therapeutic perspective. MSCs show tropism towards inflamed or tumourigenic sites. Mechanisms involved in MSC recruitment into tumours are comprehensively analysed, including chemoattractant signalling axes, endothelial adhesion and transmigration. In addition, signals derived from hepatocellular carcinoma (HCC) tumour microenvironment and their influence in MSC tropism and tumour recruitment are dissected, as well as the present controversy regarding their influence on tumour growth and/or metastasis. Finally, evidences available on the use of MSCs and other selected progenitor/stem cells as vehicles of antitumourigenic genes are discussed. A better knowledge of the mechanisms involved in progenitor/stem cell recruitment to HCC tumours is proposed in order to enhance their tumour targeting which may result in improvements in cell-based gene therapy strategies.
Fil: Bayo Fina, Juan Miguel. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Terapia Genética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Marrodán, María Dolores. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Terapia Genética; Argentina
Fil: Aquino, Jorge Benjamin. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Terapia Genética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Silva, Marcelo David. Hospital Universitario Austral; Argentina
Fil: García, Mariana Gabriela. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Terapia Genética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mazzolini Rizzo, Guillermo Daniel. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Terapia Genética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Universitario Austral; Argentina
Materia
Cell Therapy
Chemokines
Hepatocellular Carcinoma
Mesenchymal Stromal Cells
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/25467
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The therapeutic potential of bone marrow-derived mesenchymal stromal cells on hepatocellular carcinomaBayo Fina, Juan MiguelMarrodán, María DoloresAquino, Jorge BenjaminSilva, Marcelo DavidGarcía, Mariana GabrielaMazzolini Rizzo, Guillermo DanielCell TherapyChemokinesHepatocellular CarcinomaMesenchymal Stromal Cellshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Mesenchymal stromal cells (MSCs) are more often obtained from adult and extraembryonic tissues, with the latter sources being likely better from a therapeutic perspective. MSCs show tropism towards inflamed or tumourigenic sites. Mechanisms involved in MSC recruitment into tumours are comprehensively analysed, including chemoattractant signalling axes, endothelial adhesion and transmigration. In addition, signals derived from hepatocellular carcinoma (HCC) tumour microenvironment and their influence in MSC tropism and tumour recruitment are dissected, as well as the present controversy regarding their influence on tumour growth and/or metastasis. Finally, evidences available on the use of MSCs and other selected progenitor/stem cells as vehicles of antitumourigenic genes are discussed. A better knowledge of the mechanisms involved in progenitor/stem cell recruitment to HCC tumours is proposed in order to enhance their tumour targeting which may result in improvements in cell-based gene therapy strategies.Fil: Bayo Fina, Juan Miguel. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Terapia Genética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Marrodán, María Dolores. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Terapia Genética; ArgentinaFil: Aquino, Jorge Benjamin. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Terapia Genética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Silva, Marcelo David. Hospital Universitario Austral; ArgentinaFil: García, Mariana Gabriela. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Terapia Genética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mazzolini Rizzo, Guillermo Daniel. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Terapia Genética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Universitario Austral; ArgentinaWiley2013-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25467Bayo Fina, Juan Miguel; Marrodán, María Dolores; Aquino, Jorge Benjamin; Silva, Marcelo David; García, Mariana Gabriela; et al.; The therapeutic potential of bone marrow-derived mesenchymal stromal cells on hepatocellular carcinoma; Wiley; Liver International; 34; 3; 10-2013; 330-3421478-3223CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/liv.12338/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1111/liv.12338info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:20:27Zoai:ri.conicet.gov.ar:11336/25467instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:20:27.378CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The therapeutic potential of bone marrow-derived mesenchymal stromal cells on hepatocellular carcinoma
title The therapeutic potential of bone marrow-derived mesenchymal stromal cells on hepatocellular carcinoma
spellingShingle The therapeutic potential of bone marrow-derived mesenchymal stromal cells on hepatocellular carcinoma
Bayo Fina, Juan Miguel
Cell Therapy
Chemokines
Hepatocellular Carcinoma
Mesenchymal Stromal Cells
title_short The therapeutic potential of bone marrow-derived mesenchymal stromal cells on hepatocellular carcinoma
title_full The therapeutic potential of bone marrow-derived mesenchymal stromal cells on hepatocellular carcinoma
title_fullStr The therapeutic potential of bone marrow-derived mesenchymal stromal cells on hepatocellular carcinoma
title_full_unstemmed The therapeutic potential of bone marrow-derived mesenchymal stromal cells on hepatocellular carcinoma
title_sort The therapeutic potential of bone marrow-derived mesenchymal stromal cells on hepatocellular carcinoma
dc.creator.none.fl_str_mv Bayo Fina, Juan Miguel
Marrodán, María Dolores
Aquino, Jorge Benjamin
Silva, Marcelo David
García, Mariana Gabriela
Mazzolini Rizzo, Guillermo Daniel
author Bayo Fina, Juan Miguel
author_facet Bayo Fina, Juan Miguel
Marrodán, María Dolores
Aquino, Jorge Benjamin
Silva, Marcelo David
García, Mariana Gabriela
Mazzolini Rizzo, Guillermo Daniel
author_role author
author2 Marrodán, María Dolores
Aquino, Jorge Benjamin
Silva, Marcelo David
García, Mariana Gabriela
Mazzolini Rizzo, Guillermo Daniel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Cell Therapy
Chemokines
Hepatocellular Carcinoma
Mesenchymal Stromal Cells
topic Cell Therapy
Chemokines
Hepatocellular Carcinoma
Mesenchymal Stromal Cells
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Mesenchymal stromal cells (MSCs) are more often obtained from adult and extraembryonic tissues, with the latter sources being likely better from a therapeutic perspective. MSCs show tropism towards inflamed or tumourigenic sites. Mechanisms involved in MSC recruitment into tumours are comprehensively analysed, including chemoattractant signalling axes, endothelial adhesion and transmigration. In addition, signals derived from hepatocellular carcinoma (HCC) tumour microenvironment and their influence in MSC tropism and tumour recruitment are dissected, as well as the present controversy regarding their influence on tumour growth and/or metastasis. Finally, evidences available on the use of MSCs and other selected progenitor/stem cells as vehicles of antitumourigenic genes are discussed. A better knowledge of the mechanisms involved in progenitor/stem cell recruitment to HCC tumours is proposed in order to enhance their tumour targeting which may result in improvements in cell-based gene therapy strategies.
Fil: Bayo Fina, Juan Miguel. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Terapia Genética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Marrodán, María Dolores. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Terapia Genética; Argentina
Fil: Aquino, Jorge Benjamin. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Terapia Genética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Silva, Marcelo David. Hospital Universitario Austral; Argentina
Fil: García, Mariana Gabriela. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Terapia Genética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mazzolini Rizzo, Guillermo Daniel. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Terapia Genética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Universitario Austral; Argentina
description Mesenchymal stromal cells (MSCs) are more often obtained from adult and extraembryonic tissues, with the latter sources being likely better from a therapeutic perspective. MSCs show tropism towards inflamed or tumourigenic sites. Mechanisms involved in MSC recruitment into tumours are comprehensively analysed, including chemoattractant signalling axes, endothelial adhesion and transmigration. In addition, signals derived from hepatocellular carcinoma (HCC) tumour microenvironment and their influence in MSC tropism and tumour recruitment are dissected, as well as the present controversy regarding their influence on tumour growth and/or metastasis. Finally, evidences available on the use of MSCs and other selected progenitor/stem cells as vehicles of antitumourigenic genes are discussed. A better knowledge of the mechanisms involved in progenitor/stem cell recruitment to HCC tumours is proposed in order to enhance their tumour targeting which may result in improvements in cell-based gene therapy strategies.
publishDate 2013
dc.date.none.fl_str_mv 2013-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/25467
Bayo Fina, Juan Miguel; Marrodán, María Dolores; Aquino, Jorge Benjamin; Silva, Marcelo David; García, Mariana Gabriela; et al.; The therapeutic potential of bone marrow-derived mesenchymal stromal cells on hepatocellular carcinoma; Wiley; Liver International; 34; 3; 10-2013; 330-342
1478-3223
CONICET Digital
CONICET
url http://hdl.handle.net/11336/25467
identifier_str_mv Bayo Fina, Juan Miguel; Marrodán, María Dolores; Aquino, Jorge Benjamin; Silva, Marcelo David; García, Mariana Gabriela; et al.; The therapeutic potential of bone marrow-derived mesenchymal stromal cells on hepatocellular carcinoma; Wiley; Liver International; 34; 3; 10-2013; 330-342
1478-3223
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/liv.12338/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1111/liv.12338
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.48226

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