Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production

Autores
Monsalve Bravo, Gloria Milena; Garelli, Fabricio; Mozumder, Salatul Islam; Alvarez, Hernán; de Battista, Hernan
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This work presents a general model-based methodology to scale-up fed-batch bioprocesses. The idea behind this approach is to establish a dynamics hierarchy, based on a model of the process, that allows the designer to determine the proper scale factors as well as at which point of the fed-batch the process should be scaled up. Here, concepts and tools of linear control theory, such as the singular value decomposition of the Hankel matrix, are exploited in the context of process design. The proposed scale-up methodology is first described in a bioprocesses general framework highlighting its main features, key variables and parameters. Then, it is applied to a polyhydroxybutyrate (PHB) fed-batch bioreactor and compared with three empirical criteria, that are traditionally employed to determine the scale factors of these processes, showing the usefulness and distinctive features of this proposal. Moreover, this methodology provides theoretical support to a frequently used empirical rule: scale-up aerobic bioreactors at constant volumetric oxygen transfer coefficient. Finally, similar process dynamic behavior and PHB production set at the laboratory scale are predicted at the new operating scale, while it is also determined that is rarely possible to reproduce similar dynamic behavior of the bioreactor using empirical scale-up criteria.
Fil: Monsalve Bravo, Gloria Milena. Universidad Nacional de Colombia; Colombia. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina
Fil: Garelli, Fabricio. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mozumder, Salatul Islam. University of Ghent; Bélgica. Flemish Institute for Technological Research; Bélgica
Fil: Alvarez, Hernán. Universidad Nacional de Colombia; Colombia
Fil: de Battista, Hernan. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Scale Up
Bioprocess
Hankel Matrix
Dynamics Hierarchy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13736

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network_name_str CONICET Digital (CONICET)
spelling Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) productionMonsalve Bravo, Gloria MilenaGarelli, FabricioMozumder, Salatul IslamAlvarez, Hernánde Battista, HernanScale UpBioprocessHankel MatrixDynamics Hierarchyhttps://purl.org/becyt/ford/2.2https://purl.org/becyt/ford/2This work presents a general model-based methodology to scale-up fed-batch bioprocesses. The idea behind this approach is to establish a dynamics hierarchy, based on a model of the process, that allows the designer to determine the proper scale factors as well as at which point of the fed-batch the process should be scaled up. Here, concepts and tools of linear control theory, such as the singular value decomposition of the Hankel matrix, are exploited in the context of process design. The proposed scale-up methodology is first described in a bioprocesses general framework highlighting its main features, key variables and parameters. Then, it is applied to a polyhydroxybutyrate (PHB) fed-batch bioreactor and compared with three empirical criteria, that are traditionally employed to determine the scale factors of these processes, showing the usefulness and distinctive features of this proposal. Moreover, this methodology provides theoretical support to a frequently used empirical rule: scale-up aerobic bioreactors at constant volumetric oxygen transfer coefficient. Finally, similar process dynamic behavior and PHB production set at the laboratory scale are predicted at the new operating scale, while it is also determined that is rarely possible to reproduce similar dynamic behavior of the bioreactor using empirical scale-up criteria.Fil: Monsalve Bravo, Gloria Milena. Universidad Nacional de Colombia; Colombia. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; ArgentinaFil: Garelli, Fabricio. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mozumder, Salatul Islam. University of Ghent; Bélgica. Flemish Institute for Technological Research; BélgicaFil: Alvarez, Hernán. Universidad Nacional de Colombia; ColombiaFil: de Battista, Hernan. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaSpringer Verlag Berlín2015-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13736Monsalve Bravo, Gloria Milena; Garelli, Fabricio; Mozumder, Salatul Islam; Alvarez, Hernán; de Battista, Hernan; Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production; Springer Verlag Berlín; Bioprocess And Biosystems Engineering; 38; 6; 6-2015; 1179-11901615-75911615-7605enginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00449-015-1360-4info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00449-015-1360-4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:35:13Zoai:ri.conicet.gov.ar:11336/13736instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:35:13.384CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
title Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
spellingShingle Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
Monsalve Bravo, Gloria Milena
Scale Up
Bioprocess
Hankel Matrix
Dynamics Hierarchy
title_short Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
title_full Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
title_fullStr Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
title_full_unstemmed Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
title_sort Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
dc.creator.none.fl_str_mv Monsalve Bravo, Gloria Milena
Garelli, Fabricio
Mozumder, Salatul Islam
Alvarez, Hernán
de Battista, Hernan
author Monsalve Bravo, Gloria Milena
author_facet Monsalve Bravo, Gloria Milena
Garelli, Fabricio
Mozumder, Salatul Islam
Alvarez, Hernán
de Battista, Hernan
author_role author
author2 Garelli, Fabricio
Mozumder, Salatul Islam
Alvarez, Hernán
de Battista, Hernan
author2_role author
author
author
author
dc.subject.none.fl_str_mv Scale Up
Bioprocess
Hankel Matrix
Dynamics Hierarchy
topic Scale Up
Bioprocess
Hankel Matrix
Dynamics Hierarchy
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.2
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv This work presents a general model-based methodology to scale-up fed-batch bioprocesses. The idea behind this approach is to establish a dynamics hierarchy, based on a model of the process, that allows the designer to determine the proper scale factors as well as at which point of the fed-batch the process should be scaled up. Here, concepts and tools of linear control theory, such as the singular value decomposition of the Hankel matrix, are exploited in the context of process design. The proposed scale-up methodology is first described in a bioprocesses general framework highlighting its main features, key variables and parameters. Then, it is applied to a polyhydroxybutyrate (PHB) fed-batch bioreactor and compared with three empirical criteria, that are traditionally employed to determine the scale factors of these processes, showing the usefulness and distinctive features of this proposal. Moreover, this methodology provides theoretical support to a frequently used empirical rule: scale-up aerobic bioreactors at constant volumetric oxygen transfer coefficient. Finally, similar process dynamic behavior and PHB production set at the laboratory scale are predicted at the new operating scale, while it is also determined that is rarely possible to reproduce similar dynamic behavior of the bioreactor using empirical scale-up criteria.
Fil: Monsalve Bravo, Gloria Milena. Universidad Nacional de Colombia; Colombia. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina
Fil: Garelli, Fabricio. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mozumder, Salatul Islam. University of Ghent; Bélgica. Flemish Institute for Technological Research; Bélgica
Fil: Alvarez, Hernán. Universidad Nacional de Colombia; Colombia
Fil: de Battista, Hernan. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description This work presents a general model-based methodology to scale-up fed-batch bioprocesses. The idea behind this approach is to establish a dynamics hierarchy, based on a model of the process, that allows the designer to determine the proper scale factors as well as at which point of the fed-batch the process should be scaled up. Here, concepts and tools of linear control theory, such as the singular value decomposition of the Hankel matrix, are exploited in the context of process design. The proposed scale-up methodology is first described in a bioprocesses general framework highlighting its main features, key variables and parameters. Then, it is applied to a polyhydroxybutyrate (PHB) fed-batch bioreactor and compared with three empirical criteria, that are traditionally employed to determine the scale factors of these processes, showing the usefulness and distinctive features of this proposal. Moreover, this methodology provides theoretical support to a frequently used empirical rule: scale-up aerobic bioreactors at constant volumetric oxygen transfer coefficient. Finally, similar process dynamic behavior and PHB production set at the laboratory scale are predicted at the new operating scale, while it is also determined that is rarely possible to reproduce similar dynamic behavior of the bioreactor using empirical scale-up criteria.
publishDate 2015
dc.date.none.fl_str_mv 2015-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13736
Monsalve Bravo, Gloria Milena; Garelli, Fabricio; Mozumder, Salatul Islam; Alvarez, Hernán; de Battista, Hernan; Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production; Springer Verlag Berlín; Bioprocess And Biosystems Engineering; 38; 6; 6-2015; 1179-1190
1615-7591
1615-7605
url http://hdl.handle.net/11336/13736
identifier_str_mv Monsalve Bravo, Gloria Milena; Garelli, Fabricio; Mozumder, Salatul Islam; Alvarez, Hernán; de Battista, Hernan; Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production; Springer Verlag Berlín; Bioprocess And Biosystems Engineering; 38; 6; 6-2015; 1179-1190
1615-7591
1615-7605
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s00449-015-1360-4
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00449-015-1360-4
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Verlag Berlín
publisher.none.fl_str_mv Springer Verlag Berlín
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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