Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
- Autores
- Monsalve Bravo, Gloria Milena; Garelli, Fabricio; Mozumder, Salatul Islam; Alvarez, Hernán; de Battista, Hernan
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- This work presents a general model-based methodology to scale-up fed-batch bioprocesses. The idea behind this approach is to establish a dynamics hierarchy, based on a model of the process, that allows the designer to determine the proper scale factors as well as at which point of the fed-batch the process should be scaled up. Here, concepts and tools of linear control theory, such as the singular value decomposition of the Hankel matrix, are exploited in the context of process design. The proposed scale-up methodology is first described in a bioprocesses general framework highlighting its main features, key variables and parameters. Then, it is applied to a polyhydroxybutyrate (PHB) fed-batch bioreactor and compared with three empirical criteria, that are traditionally employed to determine the scale factors of these processes, showing the usefulness and distinctive features of this proposal. Moreover, this methodology provides theoretical support to a frequently used empirical rule: scale-up aerobic bioreactors at constant volumetric oxygen transfer coefficient. Finally, similar process dynamic behavior and PHB production set at the laboratory scale are predicted at the new operating scale, while it is also determined that is rarely possible to reproduce similar dynamic behavior of the bioreactor using empirical scale-up criteria.
Fil: Monsalve Bravo, Gloria Milena. Universidad Nacional de Colombia; Colombia. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina
Fil: Garelli, Fabricio. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mozumder, Salatul Islam. University of Ghent; Bélgica. Flemish Institute for Technological Research; Bélgica
Fil: Alvarez, Hernán. Universidad Nacional de Colombia; Colombia
Fil: de Battista, Hernan. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
Scale Up
Bioprocess
Hankel Matrix
Dynamics Hierarchy - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/13736
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Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) productionMonsalve Bravo, Gloria MilenaGarelli, FabricioMozumder, Salatul IslamAlvarez, Hernánde Battista, HernanScale UpBioprocessHankel MatrixDynamics Hierarchyhttps://purl.org/becyt/ford/2.2https://purl.org/becyt/ford/2This work presents a general model-based methodology to scale-up fed-batch bioprocesses. The idea behind this approach is to establish a dynamics hierarchy, based on a model of the process, that allows the designer to determine the proper scale factors as well as at which point of the fed-batch the process should be scaled up. Here, concepts and tools of linear control theory, such as the singular value decomposition of the Hankel matrix, are exploited in the context of process design. The proposed scale-up methodology is first described in a bioprocesses general framework highlighting its main features, key variables and parameters. Then, it is applied to a polyhydroxybutyrate (PHB) fed-batch bioreactor and compared with three empirical criteria, that are traditionally employed to determine the scale factors of these processes, showing the usefulness and distinctive features of this proposal. Moreover, this methodology provides theoretical support to a frequently used empirical rule: scale-up aerobic bioreactors at constant volumetric oxygen transfer coefficient. Finally, similar process dynamic behavior and PHB production set at the laboratory scale are predicted at the new operating scale, while it is also determined that is rarely possible to reproduce similar dynamic behavior of the bioreactor using empirical scale-up criteria.Fil: Monsalve Bravo, Gloria Milena. Universidad Nacional de Colombia; Colombia. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; ArgentinaFil: Garelli, Fabricio. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mozumder, Salatul Islam. University of Ghent; Bélgica. Flemish Institute for Technological Research; BélgicaFil: Alvarez, Hernán. Universidad Nacional de Colombia; ColombiaFil: de Battista, Hernan. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaSpringer Verlag Berlín2015-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13736Monsalve Bravo, Gloria Milena; Garelli, Fabricio; Mozumder, Salatul Islam; Alvarez, Hernán; de Battista, Hernan; Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production; Springer Verlag Berlín; Bioprocess And Biosystems Engineering; 38; 6; 6-2015; 1179-11901615-75911615-7605enginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00449-015-1360-4info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00449-015-1360-4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:35:13Zoai:ri.conicet.gov.ar:11336/13736instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:35:13.384CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production |
title |
Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production |
spellingShingle |
Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production Monsalve Bravo, Gloria Milena Scale Up Bioprocess Hankel Matrix Dynamics Hierarchy |
title_short |
Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production |
title_full |
Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production |
title_fullStr |
Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production |
title_full_unstemmed |
Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production |
title_sort |
Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production |
dc.creator.none.fl_str_mv |
Monsalve Bravo, Gloria Milena Garelli, Fabricio Mozumder, Salatul Islam Alvarez, Hernán de Battista, Hernan |
author |
Monsalve Bravo, Gloria Milena |
author_facet |
Monsalve Bravo, Gloria Milena Garelli, Fabricio Mozumder, Salatul Islam Alvarez, Hernán de Battista, Hernan |
author_role |
author |
author2 |
Garelli, Fabricio Mozumder, Salatul Islam Alvarez, Hernán de Battista, Hernan |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Scale Up Bioprocess Hankel Matrix Dynamics Hierarchy |
topic |
Scale Up Bioprocess Hankel Matrix Dynamics Hierarchy |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.2 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
This work presents a general model-based methodology to scale-up fed-batch bioprocesses. The idea behind this approach is to establish a dynamics hierarchy, based on a model of the process, that allows the designer to determine the proper scale factors as well as at which point of the fed-batch the process should be scaled up. Here, concepts and tools of linear control theory, such as the singular value decomposition of the Hankel matrix, are exploited in the context of process design. The proposed scale-up methodology is first described in a bioprocesses general framework highlighting its main features, key variables and parameters. Then, it is applied to a polyhydroxybutyrate (PHB) fed-batch bioreactor and compared with three empirical criteria, that are traditionally employed to determine the scale factors of these processes, showing the usefulness and distinctive features of this proposal. Moreover, this methodology provides theoretical support to a frequently used empirical rule: scale-up aerobic bioreactors at constant volumetric oxygen transfer coefficient. Finally, similar process dynamic behavior and PHB production set at the laboratory scale are predicted at the new operating scale, while it is also determined that is rarely possible to reproduce similar dynamic behavior of the bioreactor using empirical scale-up criteria. Fil: Monsalve Bravo, Gloria Milena. Universidad Nacional de Colombia; Colombia. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina Fil: Garelli, Fabricio. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Mozumder, Salatul Islam. University of Ghent; Bélgica. Flemish Institute for Technological Research; Bélgica Fil: Alvarez, Hernán. Universidad Nacional de Colombia; Colombia Fil: de Battista, Hernan. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
This work presents a general model-based methodology to scale-up fed-batch bioprocesses. The idea behind this approach is to establish a dynamics hierarchy, based on a model of the process, that allows the designer to determine the proper scale factors as well as at which point of the fed-batch the process should be scaled up. Here, concepts and tools of linear control theory, such as the singular value decomposition of the Hankel matrix, are exploited in the context of process design. The proposed scale-up methodology is first described in a bioprocesses general framework highlighting its main features, key variables and parameters. Then, it is applied to a polyhydroxybutyrate (PHB) fed-batch bioreactor and compared with three empirical criteria, that are traditionally employed to determine the scale factors of these processes, showing the usefulness and distinctive features of this proposal. Moreover, this methodology provides theoretical support to a frequently used empirical rule: scale-up aerobic bioreactors at constant volumetric oxygen transfer coefficient. Finally, similar process dynamic behavior and PHB production set at the laboratory scale are predicted at the new operating scale, while it is also determined that is rarely possible to reproduce similar dynamic behavior of the bioreactor using empirical scale-up criteria. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/13736 Monsalve Bravo, Gloria Milena; Garelli, Fabricio; Mozumder, Salatul Islam; Alvarez, Hernán; de Battista, Hernan; Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production; Springer Verlag Berlín; Bioprocess And Biosystems Engineering; 38; 6; 6-2015; 1179-1190 1615-7591 1615-7605 |
url |
http://hdl.handle.net/11336/13736 |
identifier_str_mv |
Monsalve Bravo, Gloria Milena; Garelli, Fabricio; Mozumder, Salatul Islam; Alvarez, Hernán; de Battista, Hernan; Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production; Springer Verlag Berlín; Bioprocess And Biosystems Engineering; 38; 6; 6-2015; 1179-1190 1615-7591 1615-7605 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00449-015-1360-4 info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00449-015-1360-4 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Springer Verlag Berlín |
publisher.none.fl_str_mv |
Springer Verlag Berlín |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844613095338541056 |
score |
13.070432 |