Androgen receptor expression in pituitary of male viscacha in relation to growth and reproductive cycle

Autores
Filippa, Veronica Palmira; Rosales, Gabriela Judith; Cruceño, Albana Andrea Marina; Mohamed, Fabian Heber
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this work was to study the androgen receptors (AR) expression in pituitary pars distalis (PD) of male viscachas in relation to age and reproductive cycle. AR were detected by immunocytochemistry and quantified by image analysis. Pituitary glands from fetus, immature, prepubertal and adult viscachas during their reproductive cycle were used. In the fetal PD, the immunoreactivity (ir) was mainly cytoplasmic. In immature and prepubertal animals, AR-ir was cytoplasmic (ARc-ir) and nuclear (ARn-ir) in medial region. In adult animals, ARn-ir cells were numerous at caudal end. AR regionalization varied between the PD zones in relation to age. In immature animals, the ARn-ir increased whereas the cytoplasmic expression decreased in relation to the fetal glands. The percentage of ARc-ir cells increased in prepubertal animals whereas the nuclear AR expression was predominant in adult viscachas. The increase of nuclear AR expression was directly related with testosterone levels. The AR expression changed in adults, showing minimum percentage in the gonadal regression period according to testosterone levels. These results demonstrated variations in the immunostaining pattern, regionalization, and number of AR-ir cells throughout development, growth, and reproductive cycle, suggesting the involvement of AR in the regulation of the pituitary activity of male viscacha.
Fil: Filippa, Veronica Palmira. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis; Argentina
Fil: Rosales, Gabriela Judith. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Cruceño, Albana Andrea Marina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; Argentina
Fil: Mohamed, Fabian Heber. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; Argentina
Materia
LAGOSTOMUS
PITUITARY
ANDROGEN
RECEPTOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/7137
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Androgen receptor expression in pituitary of male viscacha in relation to growth and reproductive cycleFilippa, Veronica PalmiraRosales, Gabriela JudithCruceño, Albana Andrea MarinaMohamed, Fabian HeberLAGOSTOMUSPITUITARYANDROGENRECEPTORhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The aim of this work was to study the androgen receptors (AR) expression in pituitary pars distalis (PD) of male viscachas in relation to age and reproductive cycle. AR were detected by immunocytochemistry and quantified by image analysis. Pituitary glands from fetus, immature, prepubertal and adult viscachas during their reproductive cycle were used. In the fetal PD, the immunoreactivity (ir) was mainly cytoplasmic. In immature and prepubertal animals, AR-ir was cytoplasmic (ARc-ir) and nuclear (ARn-ir) in medial region. In adult animals, ARn-ir cells were numerous at caudal end. AR regionalization varied between the PD zones in relation to age. In immature animals, the ARn-ir increased whereas the cytoplasmic expression decreased in relation to the fetal glands. The percentage of ARc-ir cells increased in prepubertal animals whereas the nuclear AR expression was predominant in adult viscachas. The increase of nuclear AR expression was directly related with testosterone levels. The AR expression changed in adults, showing minimum percentage in the gonadal regression period according to testosterone levels. These results demonstrated variations in the immunostaining pattern, regionalization, and number of AR-ir cells throughout development, growth, and reproductive cycle, suggesting the involvement of AR in the regulation of the pituitary activity of male viscacha.Fil: Filippa, Veronica Palmira. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis; ArgentinaFil: Rosales, Gabriela Judith. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Cruceño, Albana Andrea Marina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; ArgentinaFil: Mohamed, Fabian Heber. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; ArgentinaHindawi Publishing Corporation2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7137Filippa, Veronica Palmira; Rosales, Gabriela Judith; Cruceño, Albana Andrea Marina; Mohamed, Fabian Heber; Androgen receptor expression in pituitary of male viscacha in relation to growth and reproductive cycle; Hindawi Publishing Corporation; International Journal of Endocrinology; 2015; 3-2015; 1-111687-8345enginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1155/2015/168047info:eu-repo/semantics/altIdentifier/url/http://www.hindawi.com/journals/ije/aip/168047/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:10Zoai:ri.conicet.gov.ar:11336/7137instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:11.784CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Androgen receptor expression in pituitary of male viscacha in relation to growth and reproductive cycle
title Androgen receptor expression in pituitary of male viscacha in relation to growth and reproductive cycle
spellingShingle Androgen receptor expression in pituitary of male viscacha in relation to growth and reproductive cycle
Filippa, Veronica Palmira
LAGOSTOMUS
PITUITARY
ANDROGEN
RECEPTOR
title_short Androgen receptor expression in pituitary of male viscacha in relation to growth and reproductive cycle
title_full Androgen receptor expression in pituitary of male viscacha in relation to growth and reproductive cycle
title_fullStr Androgen receptor expression in pituitary of male viscacha in relation to growth and reproductive cycle
title_full_unstemmed Androgen receptor expression in pituitary of male viscacha in relation to growth and reproductive cycle
title_sort Androgen receptor expression in pituitary of male viscacha in relation to growth and reproductive cycle
dc.creator.none.fl_str_mv Filippa, Veronica Palmira
Rosales, Gabriela Judith
Cruceño, Albana Andrea Marina
Mohamed, Fabian Heber
author Filippa, Veronica Palmira
author_facet Filippa, Veronica Palmira
Rosales, Gabriela Judith
Cruceño, Albana Andrea Marina
Mohamed, Fabian Heber
author_role author
author2 Rosales, Gabriela Judith
Cruceño, Albana Andrea Marina
Mohamed, Fabian Heber
author2_role author
author
author
dc.subject.none.fl_str_mv LAGOSTOMUS
PITUITARY
ANDROGEN
RECEPTOR
topic LAGOSTOMUS
PITUITARY
ANDROGEN
RECEPTOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The aim of this work was to study the androgen receptors (AR) expression in pituitary pars distalis (PD) of male viscachas in relation to age and reproductive cycle. AR were detected by immunocytochemistry and quantified by image analysis. Pituitary glands from fetus, immature, prepubertal and adult viscachas during their reproductive cycle were used. In the fetal PD, the immunoreactivity (ir) was mainly cytoplasmic. In immature and prepubertal animals, AR-ir was cytoplasmic (ARc-ir) and nuclear (ARn-ir) in medial region. In adult animals, ARn-ir cells were numerous at caudal end. AR regionalization varied between the PD zones in relation to age. In immature animals, the ARn-ir increased whereas the cytoplasmic expression decreased in relation to the fetal glands. The percentage of ARc-ir cells increased in prepubertal animals whereas the nuclear AR expression was predominant in adult viscachas. The increase of nuclear AR expression was directly related with testosterone levels. The AR expression changed in adults, showing minimum percentage in the gonadal regression period according to testosterone levels. These results demonstrated variations in the immunostaining pattern, regionalization, and number of AR-ir cells throughout development, growth, and reproductive cycle, suggesting the involvement of AR in the regulation of the pituitary activity of male viscacha.
Fil: Filippa, Veronica Palmira. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis; Argentina
Fil: Rosales, Gabriela Judith. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Cruceño, Albana Andrea Marina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; Argentina
Fil: Mohamed, Fabian Heber. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; Argentina
description The aim of this work was to study the androgen receptors (AR) expression in pituitary pars distalis (PD) of male viscachas in relation to age and reproductive cycle. AR were detected by immunocytochemistry and quantified by image analysis. Pituitary glands from fetus, immature, prepubertal and adult viscachas during their reproductive cycle were used. In the fetal PD, the immunoreactivity (ir) was mainly cytoplasmic. In immature and prepubertal animals, AR-ir was cytoplasmic (ARc-ir) and nuclear (ARn-ir) in medial region. In adult animals, ARn-ir cells were numerous at caudal end. AR regionalization varied between the PD zones in relation to age. In immature animals, the ARn-ir increased whereas the cytoplasmic expression decreased in relation to the fetal glands. The percentage of ARc-ir cells increased in prepubertal animals whereas the nuclear AR expression was predominant in adult viscachas. The increase of nuclear AR expression was directly related with testosterone levels. The AR expression changed in adults, showing minimum percentage in the gonadal regression period according to testosterone levels. These results demonstrated variations in the immunostaining pattern, regionalization, and number of AR-ir cells throughout development, growth, and reproductive cycle, suggesting the involvement of AR in the regulation of the pituitary activity of male viscacha.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/7137
Filippa, Veronica Palmira; Rosales, Gabriela Judith; Cruceño, Albana Andrea Marina; Mohamed, Fabian Heber; Androgen receptor expression in pituitary of male viscacha in relation to growth and reproductive cycle; Hindawi Publishing Corporation; International Journal of Endocrinology; 2015; 3-2015; 1-11
1687-8345
url http://hdl.handle.net/11336/7137
identifier_str_mv Filippa, Veronica Palmira; Rosales, Gabriela Judith; Cruceño, Albana Andrea Marina; Mohamed, Fabian Heber; Androgen receptor expression in pituitary of male viscacha in relation to growth and reproductive cycle; Hindawi Publishing Corporation; International Journal of Endocrinology; 2015; 3-2015; 1-11
1687-8345
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2015/168047
info:eu-repo/semantics/altIdentifier/url/http://www.hindawi.com/journals/ije/aip/168047/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268841218932736
score 13.13397

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