Influence of herbal extracts in physicochemical properties and stability of antibacterial gels

Autores
Pérez Zamora, Cristina Marisel; Michaluk, Ariel Germán; Torres, Carola Analía; Mouriño, Viviana Silvia Lourdes; Chiappetta, Diego Andrés; Nuñez, María Beatriz
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The use of plants to treat diseases and heal wounds is a custom that dates back thousands of years and is a legacy of ancient civilizations. Although a significant proportion of the planet's plant biodiversity is found on theAmerican continent, there are very few pharmaceutical products developed from it. This work aimed to develop and characterize topical formulations (gels and emulgels), including a combination of plant extracts with recognized antibacterial activity. Hydroalcoholic extracts of Lippia turbinata Griseb. and Lippia alba (Mill.) N. E. Brown were obtained by leaching. The excipients used were Carbopol® 934 and 940, Sepigel® 305, sodium carboxymethylcellulose, methylcellulose, propylene glycol, and ethanol. The finished product was characterized by properties: organoleptic characteristics, extensibility, pH, texture profile, permeation performance, and microbiological quality. Then, they were subjected to stability studies in different conditions of temperature and humidity. They had a characteristic smell of plant species, color brown, without the presence of lumps, and with good extensibility. The gels had an in vitro permeation of porcine skin of up to 30% and low retention in the epithelium (<15%). They did not present microbial contamination and were stable for six months. Of the gels formulated, the gel with Sepigel® 4% (w/w) presented a better appearance. These results demonstrate the feasibility of transporting non-hydro soluble extracts in a gel formulation. All formulations are appropriate to preserve the antibacterial effect of original extracts. They maintain stability over time without the use of antimicrobial preservatives.
Fil: Pérez Zamora, Cristina Marisel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Chaco Austral. Departamento de Ciencias Básicas y Aplicadas; Argentina
Fil: Michaluk, Ariel Germán. Universidad Nacional del Chaco Austral; Argentina
Fil: Torres, Carola Analía. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Nordeste. Instituto de Investigaciones En Procesos Tecnologicos Avanzados. - Universidad Nacional del Chaco Austral. Instituto de Investigaciones En Procesos Tecnologicos Avanzados.; Argentina
Fil: Mouriño, Viviana Silvia Lourdes. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chiappetta, Diego Andrés. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Nuñez, María Beatriz. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Nordeste. Instituto de Investigaciones En Procesos Tecnologicos Avanzados. - Universidad Nacional del Chaco Austral. Instituto de Investigaciones En Procesos Tecnologicos Avanzados.; Argentina. Universidad Nacional del Chaco Austral. Departamento de Ciencias Básicas y Aplicadas; Argentina
Materia
ANTIBACTERIAL FORMULATION
HERBAL GEL
NATURAL PRODUCT
TOPICAL FORMULATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/220706
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/220706
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Influence of herbal extracts in physicochemical properties and stability of antibacterial gelsPérez Zamora, Cristina MariselMichaluk, Ariel GermánTorres, Carola AnalíaMouriño, Viviana Silvia LourdesChiappetta, Diego AndrésNuñez, María BeatrizANTIBACTERIAL FORMULATIONHERBAL GELNATURAL PRODUCTTOPICAL FORMULATIONhttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2The use of plants to treat diseases and heal wounds is a custom that dates back thousands of years and is a legacy of ancient civilizations. Although a significant proportion of the planet's plant biodiversity is found on theAmerican continent, there are very few pharmaceutical products developed from it. This work aimed to develop and characterize topical formulations (gels and emulgels), including a combination of plant extracts with recognized antibacterial activity. Hydroalcoholic extracts of Lippia turbinata Griseb. and Lippia alba (Mill.) N. E. Brown were obtained by leaching. The excipients used were Carbopol® 934 and 940, Sepigel® 305, sodium carboxymethylcellulose, methylcellulose, propylene glycol, and ethanol. The finished product was characterized by properties: organoleptic characteristics, extensibility, pH, texture profile, permeation performance, and microbiological quality. Then, they were subjected to stability studies in different conditions of temperature and humidity. They had a characteristic smell of plant species, color brown, without the presence of lumps, and with good extensibility. The gels had an in vitro permeation of porcine skin of up to 30% and low retention in the epithelium (<15%). They did not present microbial contamination and were stable for six months. Of the gels formulated, the gel with Sepigel® 4% (w/w) presented a better appearance. These results demonstrate the feasibility of transporting non-hydro soluble extracts in a gel formulation. All formulations are appropriate to preserve the antibacterial effect of original extracts. They maintain stability over time without the use of antimicrobial preservatives.Fil: Pérez Zamora, Cristina Marisel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Chaco Austral. Departamento de Ciencias Básicas y Aplicadas; ArgentinaFil: Michaluk, Ariel Germán. Universidad Nacional del Chaco Austral; ArgentinaFil: Torres, Carola Analía. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Nordeste. Instituto de Investigaciones En Procesos Tecnologicos Avanzados. - Universidad Nacional del Chaco Austral. Instituto de Investigaciones En Procesos Tecnologicos Avanzados.; ArgentinaFil: Mouriño, Viviana Silvia Lourdes. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Chiappetta, Diego Andrés. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Nuñez, María Beatriz. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Nordeste. Instituto de Investigaciones En Procesos Tecnologicos Avanzados. - Universidad Nacional del Chaco Austral. Instituto de Investigaciones En Procesos Tecnologicos Avanzados.; Argentina. Universidad Nacional del Chaco Austral. Departamento de Ciencias Básicas y Aplicadas; ArgentinaSPER2023-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/220706Pérez Zamora, Cristina Marisel; Michaluk, Ariel Germán; Torres, Carola Analía; Mouriño, Viviana Silvia Lourdes; Chiappetta, Diego Andrés; et al.; Influence of herbal extracts in physicochemical properties and stability of antibacterial gels; SPER; Journal of Advanced Pharmacy Education and Research; 13; 4; 10-2023; 16-242249-3379CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://japer.in/article/influence-of-herbal-extracts-in-physicochemical-properties-and-stability-of-antibacterial-gels-wfljegx8oha4runinfo:eu-repo/semantics/altIdentifier/doi/10.51847/hUu6HHPZZainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:51:55Zoai:ri.conicet.gov.ar:11336/220706instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:51:55.45CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Influence of herbal extracts in physicochemical properties and stability of antibacterial gels
title Influence of herbal extracts in physicochemical properties and stability of antibacterial gels
spellingShingle Influence of herbal extracts in physicochemical properties and stability of antibacterial gels
Pérez Zamora, Cristina Marisel
ANTIBACTERIAL FORMULATION
HERBAL GEL
NATURAL PRODUCT
TOPICAL FORMULATION
title_short Influence of herbal extracts in physicochemical properties and stability of antibacterial gels
title_full Influence of herbal extracts in physicochemical properties and stability of antibacterial gels
title_fullStr Influence of herbal extracts in physicochemical properties and stability of antibacterial gels
title_full_unstemmed Influence of herbal extracts in physicochemical properties and stability of antibacterial gels
title_sort Influence of herbal extracts in physicochemical properties and stability of antibacterial gels
dc.creator.none.fl_str_mv Pérez Zamora, Cristina Marisel
Michaluk, Ariel Germán
Torres, Carola Analía
Mouriño, Viviana Silvia Lourdes
Chiappetta, Diego Andrés
Nuñez, María Beatriz
author Pérez Zamora, Cristina Marisel
author_facet Pérez Zamora, Cristina Marisel
Michaluk, Ariel Germán
Torres, Carola Analía
Mouriño, Viviana Silvia Lourdes
Chiappetta, Diego Andrés
Nuñez, María Beatriz
author_role author
author2 Michaluk, Ariel Germán
Torres, Carola Analía
Mouriño, Viviana Silvia Lourdes
Chiappetta, Diego Andrés
Nuñez, María Beatriz
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ANTIBACTERIAL FORMULATION
HERBAL GEL
NATURAL PRODUCT
TOPICAL FORMULATION
topic ANTIBACTERIAL FORMULATION
HERBAL GEL
NATURAL PRODUCT
TOPICAL FORMULATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.11
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The use of plants to treat diseases and heal wounds is a custom that dates back thousands of years and is a legacy of ancient civilizations. Although a significant proportion of the planet's plant biodiversity is found on theAmerican continent, there are very few pharmaceutical products developed from it. This work aimed to develop and characterize topical formulations (gels and emulgels), including a combination of plant extracts with recognized antibacterial activity. Hydroalcoholic extracts of Lippia turbinata Griseb. and Lippia alba (Mill.) N. E. Brown were obtained by leaching. The excipients used were Carbopol® 934 and 940, Sepigel® 305, sodium carboxymethylcellulose, methylcellulose, propylene glycol, and ethanol. The finished product was characterized by properties: organoleptic characteristics, extensibility, pH, texture profile, permeation performance, and microbiological quality. Then, they were subjected to stability studies in different conditions of temperature and humidity. They had a characteristic smell of plant species, color brown, without the presence of lumps, and with good extensibility. The gels had an in vitro permeation of porcine skin of up to 30% and low retention in the epithelium (<15%). They did not present microbial contamination and were stable for six months. Of the gels formulated, the gel with Sepigel® 4% (w/w) presented a better appearance. These results demonstrate the feasibility of transporting non-hydro soluble extracts in a gel formulation. All formulations are appropriate to preserve the antibacterial effect of original extracts. They maintain stability over time without the use of antimicrobial preservatives.
Fil: Pérez Zamora, Cristina Marisel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Chaco Austral. Departamento de Ciencias Básicas y Aplicadas; Argentina
Fil: Michaluk, Ariel Germán. Universidad Nacional del Chaco Austral; Argentina
Fil: Torres, Carola Analía. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Nordeste. Instituto de Investigaciones En Procesos Tecnologicos Avanzados. - Universidad Nacional del Chaco Austral. Instituto de Investigaciones En Procesos Tecnologicos Avanzados.; Argentina
Fil: Mouriño, Viviana Silvia Lourdes. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chiappetta, Diego Andrés. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Nuñez, María Beatriz. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Nordeste. Instituto de Investigaciones En Procesos Tecnologicos Avanzados. - Universidad Nacional del Chaco Austral. Instituto de Investigaciones En Procesos Tecnologicos Avanzados.; Argentina. Universidad Nacional del Chaco Austral. Departamento de Ciencias Básicas y Aplicadas; Argentina
description The use of plants to treat diseases and heal wounds is a custom that dates back thousands of years and is a legacy of ancient civilizations. Although a significant proportion of the planet's plant biodiversity is found on theAmerican continent, there are very few pharmaceutical products developed from it. This work aimed to develop and characterize topical formulations (gels and emulgels), including a combination of plant extracts with recognized antibacterial activity. Hydroalcoholic extracts of Lippia turbinata Griseb. and Lippia alba (Mill.) N. E. Brown were obtained by leaching. The excipients used were Carbopol® 934 and 940, Sepigel® 305, sodium carboxymethylcellulose, methylcellulose, propylene glycol, and ethanol. The finished product was characterized by properties: organoleptic characteristics, extensibility, pH, texture profile, permeation performance, and microbiological quality. Then, they were subjected to stability studies in different conditions of temperature and humidity. They had a characteristic smell of plant species, color brown, without the presence of lumps, and with good extensibility. The gels had an in vitro permeation of porcine skin of up to 30% and low retention in the epithelium (<15%). They did not present microbial contamination and were stable for six months. Of the gels formulated, the gel with Sepigel® 4% (w/w) presented a better appearance. These results demonstrate the feasibility of transporting non-hydro soluble extracts in a gel formulation. All formulations are appropriate to preserve the antibacterial effect of original extracts. They maintain stability over time without the use of antimicrobial preservatives.
publishDate 2023
dc.date.none.fl_str_mv 2023-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/220706
Pérez Zamora, Cristina Marisel; Michaluk, Ariel Germán; Torres, Carola Analía; Mouriño, Viviana Silvia Lourdes; Chiappetta, Diego Andrés; et al.; Influence of herbal extracts in physicochemical properties and stability of antibacterial gels; SPER; Journal of Advanced Pharmacy Education and Research; 13; 4; 10-2023; 16-24
2249-3379
CONICET Digital
CONICET
url http://hdl.handle.net/11336/220706
identifier_str_mv Pérez Zamora, Cristina Marisel; Michaluk, Ariel Germán; Torres, Carola Analía; Mouriño, Viviana Silvia Lourdes; Chiappetta, Diego Andrés; et al.; Influence of herbal extracts in physicochemical properties and stability of antibacterial gels; SPER; Journal of Advanced Pharmacy Education and Research; 13; 4; 10-2023; 16-24
2249-3379
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://japer.in/article/influence-of-herbal-extracts-in-physicochemical-properties-and-stability-of-antibacterial-gels-wfljegx8oha4run
info:eu-repo/semantics/altIdentifier/doi/10.51847/hUu6HHPZZa
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv SPER
publisher.none.fl_str_mv SPER
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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